id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291534-c6cjxq07	Gwyer Findlay, Emily	Cationic Host Defence Peptides: Potential as Antiviral Therapeutics	2013-05-07		.txt	text/plain	8778	410	39	In addition, various a-defensins are described as having additional, non-microbicidal properties, including chemotaxis for effector cells of the innate and adaptive immune systems [24, 25] , inhibition of macrophage pro-inflammatory cytokines [26] , modulation of the intestinal microbiome [27] and the formation of protective peptide nanonets [28] . In particular, it demonstrated direct antiviral activity of HNP1 against HSV-1 in a temperature-and pH-dependent manner, inhibited by serum, but interestingly less sensitive to the inhibitory effects of cations than the more broadly studied antibacterial properties. Thus, although b-defensins can inhibit influenza virus infectivity (albeit less potently than the a-defensins or LL-37) [89] , immunomodulatory properties, perhaps also including up-regulation of IAV uptake by neutrophils [84] , may prove to be key to their protective function against this virus in vivo and future therapeutic developments. Both rhesus h-defensins and retrocyclins (including RTD3, RC1 and RC2) have been found to inhibit HSV-1 and HSV-2 infection of human cervical epithelial cell lines following pre-incubation of virus and peptide [66] .	./cache/cord-291534-c6cjxq07.txt	./txt/cord-291534-c6cjxq07.txt