id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296309-i1mpov7k	Houldcroft, Charlotte J.	Clinical and biological insights from viral genome sequencing	2017-01-16		.txt	text/plain	9050	389	35	We will also explore two areas in which viral WGS has recently proven its clinical utility: metagenomic sequencing to identify viruses that cause encephalitis (BOX 1) ; and the role of WGS in molecular epidemiology and public health management of the Pan-American Zika virus outbreak (BOX 2) . However, the increasing number of resistance genes that are located across viral genomes, together with decreasing costs of sequencing and the use of sequence data for transmission studies, are driving a reappraisal of the need for WGS. The numerous phylogenetically informative variant sites that can be obtained from full-length or near full-length genomes removes the need for high-quality sequences, which enabled the robust linking of cases of Ebola virus infection and public health interventions in real time during the 2015 epidemic 39 . There are several methods that are available to achieve WGS of viruses from clinical samples; amplicon sequencing, target enrichment or metagenomics.	./cache/cord-296309-i1mpov7k.txt	./txt/cord-296309-i1mpov7k.txt