id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297131-3a9vjpvn	Charlton Hume, Hayley K.	Synthetic biology for bioengineering virus‐like particle vaccines	2018-12-31		.txt	text/plain	6833	366	32	Current and developing technologies for the identification of novel target‐specific antigens and their usefulness for rational engineering of VLP functions (e.g., presentation of structurally diverse antigens, enhanced antigen immunogenicity, and improved vaccine stability) are described. Seconded by a multitude of tools, such as omics technologies, structural biology, system immunology, and bioinformatics and computational biology, one can now screen for pathogen-specific antigens with high immunogenic potential and apply that information to rationally design modern VLP vaccines ( Figure 1 ). Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development Synthetic biology design to display an 18 kDa rotavirus large antigen on a modular virus-like particle Integrated molecular and bioprocess engineering for bacterially produced immunogenic modular virus-like particle vaccine displaying 18 kDa rotavirus antigen A novel virus-like particle based vaccine platform displaying the placental malaria antigen VAR2CSA	./cache/cord-297131-3a9vjpvn.txt	./txt/cord-297131-3a9vjpvn.txt