id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-298733-jole21wq	Tyrrell, D.A.J.	A view from the common cold unit	1992-06-30		.txt	text/plain	9565	394	50	Furthermore, the old empirical idea of the existence of 'the common cold virus' was soon replaced by data collected by epidemiologically controlled field studies in which infection was detected with a range of viruses following which their pathogenicity was confirmed and studied by inoculating them into volunteers and observing their effects. Thus, after years of frustration the work of the Unit developed to the point where relevant human infections could be produced at will and precisely documented by clinical and laboratory methods -this was the ideal setting for preliminary trials of the efficacy of antiviral drugs or vaccines without which nowadays it would rarely be justifiable to go on to a field study of naturally acquired colds. When natural and recombinant interferons were tested in this way against experimental influenza and rhinovirus infections in volunteers, they were no longer effective, possibly because by then the subject was already producing substantial amounts.	./cache/cord-298733-jole21wq.txt	./txt/cord-298733-jole21wq.txt