id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302021-42vqmndl	Stanley, Mathew	Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases	2011-04-08		.txt	text/plain	3461	207	55	Besides sialidases, the haemagglutinin-esterases (HE) of influenza C virus, isavirus, betacoronaviruses and toroviruses represent another class of RDEs. They are sialate-O-acetylesterases (SOAE) hydrolysing O-acetyl esters of O-acetylated sialic acid derivatives (Fig. 1) . Alkylation of 7 under Williamson-conditions followed by acid-mediated ketal hydrolysis and basic saponification of the methyl ester gave crude inhibitor 1 which was purified by gel permeation chromatography. Inhibition of the SOAE activity of three viruses, influenza C virus (INF-C), bovine coronavirus (BCoV) and mouse hepatitis virus strain S (MHV-S) and of two chimeric recombinant viral haemagglutinin esterases, from influenza C/Cal/78 virus (HE12-GFP) and sialodacryoadenitis virus (SDAV-HE) was investigated. The crude product was purified by flash chromatography (EA / EA:MeOH; 5:1) to yield the 9-O-methyl ether ( The ether (5 mg, 0.0132 mmol) was dissolved in dioxane (0.5 mL) and NaOH (0.05M, 0.5 mL) was added with stirring.	./cache/cord-302021-42vqmndl.txt	./txt/cord-302021-42vqmndl.txt