id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302614-siyyve9e	Shigeta, Shiro	Anti-RNA virus activity of polyoxometalates	2006-05-24		.txt	text/plain	3511	165	52	Among these, HS-054 exhibited broad spectrum anti-myxovirus activity and its selectivity indices (SI) for FluV-A, RSV-A, MLSV and PfluV-2 were 333, 31, 167, and 111, respectively, which exceeded those of ribavirin for each virus. We examined anti-FluV A activity with several different ratio combination of PM-523 and ribavirin in vitro and compared this with the individual respective compounds in terms of the effective dose by several parameters of inhibition. We examined seven titanium or vanadium substituted polyoxotungstates (all have Keggin or Keggin All of the compounds exhibited broad spectrum anti-RNA virus activity except that PM-43, PM-518 and PM-523 did not have antiviral activities against PfluV 2, CDV and DFV, respectively. Although, as yet there are no reports of POMs in clinical use, most of the in vitro and some of the in vivo experiments have shown these compounds to be potent and broad spectrum in terms of their antiviral activities against acute respiratory disease viruses.	./cache/cord-302614-siyyve9e.txt	./txt/cord-302614-siyyve9e.txt