id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305807-n3fs7533	Ferreira, T B	Use of adenoviral vectors as veterinary vaccines	2005-10-18		.txt	text/plain	8466	437	40	11 Then recognition that purified replication-defective Ads could be propagated on 293 cells without helper viruses paved the way toward intentional production of genetically modified Ads. 12 The popularity of Ad as a recombinant viral vector is largely due to the successful and safe immunization of millions of US military recruits in 1971 with enterically coated Ad4 and Ad7 as a prevention against acute respiratory disease (ARD) outbreaks. Gonin et al, 37 10 years ago, constructed a replicationdefective HAd5, containing the envelope protein ENV gene of FIV; however, despite the fact that an antibody response to pseudorabies virus in cats showed the potential of rHAd5 vectors to be used in this species, cats injected with 10 10.8 -10 11.8 of 50% tissue culture infectious dose (TCID 50 ) adjuvanted with montanide ISA 708 (water in nonmineral oil) or with montanide ISA 206 (double water/mineral oil/water) of this rAd did not develop detectable antibody response against ENV.	./cache/cord-305807-n3fs7533.txt	./txt/cord-305807-n3fs7533.txt