id author title date pages extension mime words sentences flesch summary cache txt cord-309067-aemjbkfj Kennedy, Melissa Methodology in diagnostic virology 2005-03-01 .txt text/plain 5885 370 49 Detection of the virus that causes an infection uses one of several methods: The virus may be propagated in the laboratory and characterized; the virus may be visualized by electron microscopy; the viral proteins may be detected using specific antibody; the viral nucleic acid may be detected; or an activity of the virus, such as red blood cell agglutination, may be assayed. Antigen detection assays involve the use of virus-specific antibody to detect or bind to the viral protein or antigen in the sample. The assays vary in the sample substrate, how the binding of antibody to antigen is visualized, sensitivity, and specificity. Most use pathogen-specific antibody for capture and detection as for IFA assays (Fig. 4B) . Variations on this protocol may be found with different assays, but the underlying technique of pathogen-specific antibody binding the virus in the sample is similar in all (Fig. 4) [1, 3, 4] . ./cache/cord-309067-aemjbkfj.txt ./txt/cord-309067-aemjbkfj.txt