id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311823-85wj08gr	Katze, Michael G.	Innate immune modulation by RNA viruses: emerging insights from functional genomics	2008		.txt	text/plain	9154	392	36	In this section, we review recent studies in which genomic approaches have been used to provide new information on how viruses trigger and regulate innate immune pathways, and to evaluate the use of type I IFN-based therapy as a means to enhance the innate immune response to HCV. In RIg-I-deficient cells, influenza virus fails to elicit the expression of IFNβ and of many ISgs, including key antiviral mediators such as IRF3, STAT1 (signal transducer and activator of transcription 1), IFIT1 (IFN-induced protein with tetratricopeptide repeats 1; also known as ISg56) and ISg54 (also known as IFIT2). Although these studies have provided considerable information regarding the genes activated downstream of TlR activation, it will be advantageous to extend genomic analyses in the context of viral infection using cells lacking the expression of specific TlRs. The ability of a virus to establish an infection depends, at least to some extent, on its ability to block the host innate immune response or to modulate the activity of antiviral effector proteins.	./cache/cord-311823-85wj08gr.txt	./txt/cord-311823-85wj08gr.txt