id author title date pages extension mime words sentences flesch summary cache txt cord-316951-1swlhdz5 Kennedy, Melissa General concepts of virology 2005-03-01 .txt text/plain 1643 107 50 Virus pathogenesis is defined as the mechanism by which a virus replicates in the cell, and in doing so, injures a cell and produces disease. The virus must first attach to a cell by way of a surface receptor, followed by entry or penetration into the cell The virus uncoats within the cell and releases its nucleic acid For most viruses, the next step is viral transcription to produce mRNA. Genetic characteristics of the host include species, breed, organ, tissue susceptibility, and function at the cellular level (eg, cell receptor types and intracellular hospitality to the virus). It is defined as the specific cells and tissue in the host in which the virus replicates in a natural infection. A basic understanding of viruses and how they replicate and produce disease can aid in the management of virus infections. A basic understanding of viruses and how they replicate and produce disease can aid in the management of virus infections. ./cache/cord-316951-1swlhdz5.txt ./txt/cord-316951-1swlhdz5.txt