id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319210-yqimufdh	KENNEDY, P.G.E.	On the possible viral aetiology of multiple sclerosis	1994-09-17		.txt	text/plain	3980	181	42	1 The presence of inflammatory histological changes in the MS lesions such as perivenular lymphocytic infiltration, and the raised cerebrospinal fluid (CSF) immunoglobulins in an oligoclonal pattern detected in most MS patients are very suggestive of an immune basis for the disease, 23 one that may possibly be related to some kind of viral infection. Although by their very nature animal models of virus-induced demyelination only produce a form of indirect evidence for the viral aetiology of MS, nevertheless they can reveal important insights into the possible mechanisms by which a virus can initiate a pathogenetic cascade leading to CNS myelin destruction. 36 In the brains, only a small percentage of the oligodendrocytes are infected with the virus, so the main mechanism of demyelination is almost certainly indirect, presumably via the generation of Class II antigen-induced T cell responses and release of cytokines and/or toxic viral proteins.	./cache/cord-319210-yqimufdh.txt	./txt/cord-319210-yqimufdh.txt