id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320713-b37c8aye	Roberts, Lisa O.	Chapter 9 Viral Strategies to Subvert the Mammalian Translation Machinery	2009-10-27		.txt	text/plain	20205	1067	48	6 The rate of translation initiation in mammalian cells is also controlled by sequence elements within the 5 0 -and 3 0 -UTRs of mRNAs which regulate this process by providing sites for interaction of regulatory proteins and RNAs. These include upstream open reading frames (uORFs), microRNA (miRNA) target sites, and polyadenylation elements. 5 It was suggested that alternative eIF4F complexes lacking PABP could selectively promote the synthesis of viral, but not host, proteins, so that KSHV-encoded mRNAs would compete more effectively for host translation machinery in infected cells. Picornavirus translation is directed by internal ribosome entry sites (IRESs) within the 5 0 -UTRs of the viral RNAs. The central one-third of eIF4G, containing the eIF3 and one eIF4A-binding domain, is sufficient to support translation initiation from these IRESs. 43 This allows picornavirus RNAs to compete effectively for the host translation machinery following infection, although the situation appears to be more complicated than this (see Section III).	./cache/cord-320713-b37c8aye.txt	./txt/cord-320713-b37c8aye.txt