id author title date pages extension mime words sentences flesch summary cache txt cord-322082-80ym2rsq Monto, Arnold S Lessons From Influenza Pandemics of the Last 100 Years 2020-03-01 .txt text/plain 4089 229 46 Since this was the first true pandemic since 1918, there was immediate concern about its potential impact and great relief when it was found to resemble seasonal influenza with morbidity highest in children and mortality at the extremes of age [26, 27] (Figure 3 ). However, the new A(H3N2) virus completely replaced the previous subtype, and its variants, more than 50 years later, have been responsible for the greatest proportion of mortality from influenza viruses. In the United States, there was particular attention directed to nonpharmaceutical interventions, a result of the recognition that pandemic-specific vaccines would be available relatively late and that influenza-specific antiviral drugs, while important, would be limited in quantity. " The latter issue has been made worse by the repeated recognition of the pandemic potential of different avian influenza virus variants that have infected humans [63] [64] [65] . ./cache/cord-322082-80ym2rsq.txt ./txt/cord-322082-80ym2rsq.txt