id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323358-05bk91lm	Bhaskar, Sathyamoorthy	Engineering protein nanocages as carriers for biomedical applications	2017-04-07		.txt	text/plain	9541	557	39	We review natural and synthetic protein nanocages that have been modified using chemical and genetic engineering techniques to impart non-natural functions that are responsive to the complex cellular microenvironment of malignant cells while delivering molecular cargos with improved efficiencies and minimal toxicity. 1, 3 Examples of naturederived nanocarriers include protein nanocages such as viruses, ferritin and many others that are formed by the self-assembly of protein subunits, resulting in a cage-like structure. 8 In this review, we focus on natural and synthetic protein scaffolds engineered with specific functional groups to impart non-native functions, including aiding the delivery of active molecules through targeting of malignant cells and overcoming cellular barriers. 3 In addition to cell targeting ability and gene delivery efficiency, these protein-based multifaceted systems have highly ordered spatial configurations, and the stability and functionality of these materials have already been established through intensive research with advances in understanding virus infection, replication and assembly pathways.	./cache/cord-323358-05bk91lm.txt	./txt/cord-323358-05bk91lm.txt