id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323404-3mw4q7m3	Bomsel, Morgane	Entry of viruses through the epithelial barrier: pathogenic trickery	2003		.txt	text/plain	8104	428	43	In polarized monostratified epithelium -where the plasma membrane is divided into two domains that have a different lipid and protein composition and different membrane dynamics -viruses usually attach and penetrate the cell cytosol preferentially at the restricted pole of the by epithelial cells and cross the epithelial barrier using TRANSCYTOSIS (BOX 1), as has been described recently for the human immunodeficiency virus (HIV) 3, 4 . Similarly, human JC virus 49 and Sendai 50 virus, as well as sialyloligosaccharide-dependent strains of rotavirus 20 and reovirus, also attach themselves to epithelial cells to block or abuse normal cell processes and, as with bacteria 43 , the surface proteins of enveloped or naked viruses bind to host-cell molecules that have receptor functions. As the cell attachment receptors for numerous enveloped and naked viruses, the glycosyl epitopes of the epithelial-cell-surface proteoglycans mediate virus adhesion, in turn initiating signal transduction as described for the GLYCOSYNAPSE 54 .	./cache/cord-323404-3mw4q7m3.txt	./txt/cord-323404-3mw4q7m3.txt