id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323710-cmbg0ty8	Mühlebach, Michael D.	Development of Recombinant Measles Virus-Based Vaccines	2016-11-26		.txt	text/plain	4306	258	48	For this purpose, the foreign antigen-encoding genes are cloned into additional transcription units of plasmid based full-length MV vaccine strain genomes, which in turn are used to rescue recombinant MV by providing both full-length viral RNA genomes respective anti-genomes together with all protein components of the viral ribonucleoprotein complex after transient transfection of the so-called rescue cells. After demonstrating efficacy in appropriate mouse and primate animal models [8] , this recombinant vaccine delivered proof of Triggered antigen-specific immune responses after immunization determined by measuring total antibodies (ELISA), neutralizing antibodies (nAbs), or reactive T cells determined by ELISpot or intracellular cytokine staining (ICS) c Protective capacity of vaccine-induced immune responses after challenge of the appropriate animal model determined by reduction of pathogen load or attenuation of etiopathology principle for safety and immunogenicity in human patients, irrespective of preformed anti-measles immunity [9] .	./cache/cord-323710-cmbg0ty8.txt	./txt/cord-323710-cmbg0ty8.txt