id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324984-ojrpsdt9	Ji, Xingyue	Medicinal chemistry strategies toward host targeting antiviral agents	2020-02-14		.txt	text/plain	16814	825	43	In addition, host proteins are not under the genetic control of viral genome, and hence HTAs possess much higher genetic barrier to drug resistance as compared with DAAs. In recent years, much progress has been made to the development of HTAs with the approval of chemokine receptor type 5 antagonist maraviroc for human immunodeficiency virus treatment and more in the pipeline for other viral infections. 3 Altogether, targeting host factors is a very promising strategy with possibility to address the critical challenges faced with the DAAs. In this review, we summarize the recent advances made in HTAs from a medicinal chemistry standpoint, and the host targets are generally classified into three different categories based on the development stage of their corresponding inhibitors/modulators, namely the ones which reached Food and Drug Administration (FDA) approval, that have entered clinical trials and those in preclinical studies.	./cache/cord-324984-ojrpsdt9.txt	./txt/cord-324984-ojrpsdt9.txt