id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325280-4whzcmqv	Takizawa, Naoki	Current landscape and future prospects of antiviral drugs derived from microbial products	2017-10-11		.txt	text/plain	6601	365	34	In this review, we summarize antiviral microbial products discovered by Institute of Microbial Chemistry (IMC) and discuss antiviral compounds against influenza virus and HBV, because these two viruses threaten global human health now and antiviral drug against these two viruses have been developed. THE CONTRIBUTIONS OF IMC TO ANTIVIRAL RESEARCH Nucleos(t)ide analogs are a major class of approved antiviral drugs that exert therapeutic effects through incorporation into viral DNA and RNA to inhibit virus replication. Viral polymerase complex is a promising target for the development of anti-influenza drugs, because transcription and replication are critical steps for virus propagation. Potential applications of microbial products in anti-HBV drug development Approved nucleos(t)ide analogs competitively inhibit DNA elongation of viral polymerase after the conversion to triphosphate form by cellular enzymes.	./cache/cord-325280-4whzcmqv.txt	./txt/cord-325280-4whzcmqv.txt