id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325915-dw989txm	Wolf, Michael W	Downstream processing of cell culture-derived virus particles	2014-01-09		.txt	text/plain	11861	655	34	The number of publications [24, [38] [39] [40] [41] [42] [43] [44] [45] [46] and patents [301] [302] [303] describing the purification or concentration of virus particles by centrifugation methods demonstrates that these procedures are extensively used at industrial-and small-scale levels for viral vectors and vaccine production processes. In summary, the main advantages of ultrafiltration compared with other methods are their high-throughput and (for the concentration of active virus particles) the gentle processing at optimal operating conditions [43, 47] that results in improved efficacies for purification of viral vectors for gene therapy. Considering a complete purification train for the production of vaccines or gene therapy vectors (Figure 1) , current improvements of the dynamic binding capacities in chromatography media might facilitate the removal of the initial concentration step within the downstream process.	./cache/cord-325915-dw989txm.txt	./txt/cord-325915-dw989txm.txt