id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328621-3jda0k2u	Laporte, Manon	Airway proteases: an emerging drug target for influenza and other respiratory virus infections	2017-04-14		.txt	text/plain	4302	213	38	Since the catalytic sites of the diverse serine proteases linked to influenza, parainfluenzaand coronavirus activation are structurally similar, active site inhibitors of these airway proteases could have broad therapeutic applicability against multiple respiratory viruses. Since the catalytic sites of the diverse serine proteases linked to influenza, parainfluenza-and coronavirus activation are structurally similar, active site inhibitors of these airway proteases could have broad therapeutic applicability against multiple respiratory viruses. The best inhibitor (92 in Table 2 ) had a K i value of 0.9 nM and, interestingly, produced clear inhibition of HA0 cleavage and virus replication in Calu-3 cells, which endogenously express HA0-activating proteases like TMPRSS2. Trypsin-like proteases of the human airways represent unique targets to suppress infections with influenza or other respiratory viruses which rely on these enzymes for their replication. Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium	./cache/cord-328621-3jda0k2u.txt	./txt/cord-328621-3jda0k2u.txt