id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330131-yfhrmbvx	Danchin, Antoine	Cytosine drives evolution of SARS‐CoV‐2	2020-04-27		.txt	text/plain	5318	244	42	In this article, we show, in the specific case of SARS-CoV-2, that the role of cytosine-based metabolites used as cell growth coordinators is central to understanding both innate antiviral immunity and the evolution of the virus. Here we (i) highlight the deviation of SARS-CoV-2 RNA chemical composition compared with that of its human host; (ii) formulate a hypothesis grounded on the canonical organization of cytosine metabolism as a way to coordinate non-homothetic growth of cells-i.e., the simultaneous growth of the cytoplasm (three dimensions), the membrane (two dimensions) and the genome (one dimension)-, and point out the emergence of the endogenous antinucleotide viperin as a cognate adaptive antiviral metabolite and (iii) predict evolutionary trends of CoV-2 for maximizing compositional fitness-which seem to show up in ongoing mutation survey of radiative evolution.	./cache/cord-330131-yfhrmbvx.txt	./txt/cord-330131-yfhrmbvx.txt