id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331217-uup16bhm	Murphy, Frederick A.	Adventitious Agents and Smallpox Vaccine in Strategic National Stockpile	2005-07-17		.txt	text/plain	2282	105	42	In keeping with current standards, we urge that old smallpox vaccines that were made in animal skin and are still a key part of our strategic national stockpile be tested for adventitious infectious agents. However, if these old vaccines are to be considered valid parts of our national stockpile we should expect not only continuing testing of potency and sterility but also testing for adventitious agents with methods that reflect the standards of today. We were unable to find a comprehensive list of possible adventitious agents when ovine materials are used, as is the case for the Lister strain smallpox vaccine produced in Europe and old vaccine stocks held by some European countries for biologic defense. Concerns about the possible presence of adventitious agents in old smallpox vaccine stocks are amplified further by current concerns about prions and the zoonotic potential of prion diseases.	./cache/cord-331217-uup16bhm.txt	./txt/cord-331217-uup16bhm.txt