id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333463-u7je0d1o	Diaz-Salazar, Carlos	Natural killer cell responses to emerging viruses of zoonotic origin	2020-08-09		.txt	text/plain	6193	353	43	Nearly all emerging viruses, including Ebola, Dengue, Nipah, West Nile, Zika, and coronaviruses (including SARS-Cov2, the causative agent of the current COVID-19 pandemic), have zoonotic origins, indicating that animal-to-human transmission constitutes a primary mode of acquisition of novel infectious diseases. Natural killer (NK) cells are innate lymphocytes that play a critical role in the early antiviral response, secreting effector cytokines and clearing infected cells. This review describes the role of Natural killer (NK) cells, a critical component of early antiviral immunity, in the establishment of tolerance to viral infections in natural hosts, as well as their role in the development of disease in nonnatural hosts. Altogether, it is believed that quick control of viral infections and reduced induction of pro-inflammatory cytokines have allowed bat viruses to rapidly co-evolve with their host without provoking major immuneThe careful study of the immune system in reservoirs of zoonotic diseases will certainly offer insights into how these animals carry high viral loads while remaining asymptomatic.	./cache/cord-333463-u7je0d1o.txt	./txt/cord-333463-u7je0d1o.txt