id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337149-cjon7ihb	Van Vliet, Kim M.	The Role of the Adeno-Associated Virus Capsid in Gene Transfer	2008		.txt	text/plain	10774	681	52	Adeno-associated virus (AAV) is one of the most promising viral gene transfer vectors that has been shown to effect long-term gene expression and disease correction with low toxicity in animal models, and is well tolerated in human clinical trials. Prior to developing a gene therapy strategy that utilizes AAV, the serotype should be carefully considered since each capsid exhibits a unique tissue tropism and transduction efficiency. Several approaches have been undertaken in an effort to target AAV vectors to specific cell types, including utilizing natural serotypes that target a desired cellular receptor, producing pseudotyped vectors, and engineering chimeric and mosaic AAV capsids. The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain	./cache/cord-337149-cjon7ihb.txt	./txt/cord-337149-cjon7ihb.txt