id author title date pages extension mime words sentences flesch summary cache txt cord-339062-tq0f6d01 Weaver, Scott C. Transmission cycles, host range, evolution and emergence of arboviral disease 2004 .txt text/plain 7314 379 43 RNA viruses, including HIV 1,2 , dengue virus (DENV) 3, 4 and possibly the severe acute respiratory syndrome (SARS) coronavirus [5] [6] [7] , have caused recent pandemics by changing their host range to amplify in humans. In this review, we focus on selected viruses such as Venezuelan equine and Japanese encephalitis viruses (VEEV and JEV, respectively), which cause epidemics by adapting to domestic animals and exploiting them as amplification hosts. After identification of VEEV as a cause of human disease, experimental animal models revealed that equine infection results in a high titre VIRAEMIA; the animals therefore serve as highly efficient amplification hosts in the presence of abundant competent mosquito vectors 12 However, studies of dengue virus ecology in sylvatic habitats of west Africa 72 and Malaysia 73, 74 have identified transmission cycles involving non-human primates as reservoir hosts and arboreal, tree-hole dwelling Aedes (Stegomyia) spp. ./cache/cord-339062-tq0f6d01.txt ./txt/cord-339062-tq0f6d01.txt