id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339230-cc7gcy5b	Smith, Amber M.	Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis	2014-07-16		.txt	text/plain	10381	576	34	Several different animal models have been used to study the effect that influenza viruses have on bacterial transmission and colonization and on invasive diseases, such as acute otitis media and pneumonia (Wherry and Butterfield 1921; Shope 1931; Francis and de Torregrosa 1945; Berendt et al. Although the precise mechanisms responsible for enhancing the transmission profile that influenza viruses provide pneumococci are currently unknown, it is likely due to an increase in pathogen density and frequency of secretion events (e.g., sneezing and coughing) in the infected individual combined with a decrease in immunity and resistance from natural barriers breaking down in the person who is newly exposed. The PB1-F2 protein of some influenza viruses increases pathologic effects by causing cell death, increasing viral replication, and altering inflammatory responses to primary viral infections and to bacterial coinfections (Conenello et al.	./cache/cord-339230-cc7gcy5b.txt	./txt/cord-339230-cc7gcy5b.txt