id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340423-f8ab7413	Barr, J.N.	Genetic Instability of RNA Viruses	2016-09-09		.txt	text/plain	9777	454	45	We then discuss evidence that at least some RNA viruses have a replication fidelity that is poised to maximize genome sequence space without incurring catastrophic lethal mutations and describe how this can be exploited to control viral infections. The error-prone nature of polymerase activity, coupled with the absence of a proofreading mechanism, is the key reason why RNA virus genomes acquire mutations and exist as a swarm of genetic variants. The mutation rate of the viral polymerase, coupled with the replication mode that the virus employs (and extrinsic factors, described in the following text) will determine the extent of genetic variability of viruses released from an infected cell. Thus, it is possible that the high mutation rates of RNA viruses are simply a consequence of polymerases that are under selective pressure to replicate genomes very rapidly to ensure efficient viral infection [79] [80] [81] .	./cache/cord-340423-f8ab7413.txt	./txt/cord-340423-f8ab7413.txt