id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340610-ex2yjyum	Wang, De-Yun	Upper Airway Stem Cells: Understanding the Nose and Role for Future Cell Therapy	2014-11-28		.txt	text/plain	5235	195	32	In addition to the physical barrier, nasal epithelial cells are known to play an active role in both the innate and acquired immune responses, which have been summarized in the European Position paper on rhinosinusitis and nasal polyps 2012 (EPOS 2012) [1••] as (l) expressing membrane-bound and cytoplasmic pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs), which are conserved molecular patterns found in parasites, viruses, yeasts, bacteria, and mycobacteria; (2) secreting a vast arsenal of host defense molecules, such as antimicrobial molecules in several classes of enzymes (lysozyme, chitinases, and peroxidases), opsonins (complement and pentraxin-3), permeabilizing proteins (A defensins, B defensins, and cathelicidins such as LL-37), collectins (surfactant protein-A, surfactant protein-D, and mannose-binding lectin), and binding proteins (lactoferrin and mucins); (3) producing a variety of inflammatory cytokines, such as IL-1, TNF-α, IFNα/β, GM-CSF, eotaxins, RANTES, IP-10, IL-6, IL-8, GRO-α, MDC, SCF, TARC, MCP-4, BAFF, osteopontin, IL-25, IL-32, IL-33, and thymic stromal lymphopoietin (TSLP), in response to stimulation of the antigens.	./cache/cord-340610-ex2yjyum.txt	./txt/cord-340610-ex2yjyum.txt