id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341029-49360l2a	Nasir, Arshan	A phylogenomic data-driven exploration of viral origins and evolution	2015-09-25		.txt	text/plain	14410	794	49	Viruses harboring different replicon types and infecting distantly related hosts shared many metabolic and informational protein structural domains of ancient origin that were also widespread in cellular proteomes. Here, we analyzed a total of 5080 completely sequenced proteomes from cells and viruses and assigned FSF domains to their proteins using structure-based hidden Markov models (HMMs) defined by the SUPER-FAMILY database (version 1.75) (20) . Viral supergroup behaves similarly to cellular superkingdoms in terms of FSF sharing patterns A total of 1995 significant FSF domains (E < 0.0001) were detected iñ 11 million proteins of 5080 proteomes sampled from cells and viruses. It also suggests that viruses are very ancient and most likely infected the last common ancestor of each superkingdom because viral FSFs were present in a diverse array of cellular organisms ranging from small microbes to large eukaryotes.	./cache/cord-341029-49360l2a.txt	./txt/cord-341029-49360l2a.txt