id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341050-hnuogpqn	Acharya, Dhiraj	An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection	2016-05-18		.txt	text/plain	10713	490	37	Among these structural proteins, E protein mediates crucial roles in binding to cellular receptors, membrane fusion, and entry of WNV into host cells, making it a key target for the development of vaccines, neutralizing antibodies, and entry inhibitors . In addition, a recent successful clinical trial of a hepatitis C virus NS5A inhibitor suggests that targeting non-structural proteins may be an ideal strategy to develop therapeutics against other fl aviviruses, including WNV [ 71 ] . In addition, better understanding of the pathogenesis of WNV and other fl aviviruses has offered new opportunities for designing many different classes of promising antiviral therapeutics by targeting both viral replication and the host cell metabolism. Several natural and synthetic compounds, antiviral peptides and siRNAs have been identifi ed to target both structural and nonstructural proteins of WNV and evaluated for their potential therapeutic roles. A VLP-based vaccine targeting domain III of the West Nile virus E protein protects from lethal infection in mice	./cache/cord-341050-hnuogpqn.txt	./txt/cord-341050-hnuogpqn.txt