id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341324-f9g9gitn	Rojas, José M.	Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway	2020-10-21		.txt	text/plain	10837	595	42	This includes for instance cooperating in PRR recognition of viral PAMPs, stabilizing signaling complexes to improve their resistance to degradation, stopping virus entry, blocking viral capsid formation, impairing trafficking and budding of virions from the infected cells, but also modulating the IFN response to avoid the toxicity of these potent immune mediators. The phosphorylated STAT1/STAT2 heterodimer associates with interferon regulatory factor 9 (IRF9) to form the transcriptional factor complex ISGF3, which translocate to the nucleus and binds the IFN-response elements (ISRE) in ISG promoters leading to the expression of ISG products [36] (Fig. 2 The oligoadenylate synthetase (OAS)-latent RNase (RNase L) pathway is another IFN-inducible pathway that provides the cell with an effector mechanism upon recognition of viral dsRNA (reviewed in [44] ).	./cache/cord-341324-f9g9gitn.txt	./txt/cord-341324-f9g9gitn.txt