id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341923-jwckbdnb	To, Kelvin Kai-Wang	Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management	2010-04-28		.txt	text/plain	5849	306	44	Although most patients infected with this novel strain present with mild upper respiratory tract symptoms [6] , the higher fatality rate in children and young adults clearly differentiate this virus from seasonal influenza virus [7, 8] . Known virulence factors in H5N1 virus include Lys627 of PB2, which increases the viral replication; an Asn66Ser substitution in PB1-F2, a protein that induces apoptosis, enhances inflammation in mice, and predisposes to secondary bacterial infection; NS1, which antagonizes the antiviral effect of interferon; and a multibasic HA cleavage sequence, which allows cleavage by ubiquitous proteases [36] . A higher viral load in respiratory tract samples was associated with fatal disease from H5N1 [41] and with disease severity in infection due to respiratory syncytial virus and human metapneumovirus [42] . Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection	./cache/cord-341923-jwckbdnb.txt	./txt/cord-341923-jwckbdnb.txt