id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346063-7u1a198p	De Clercq, Erik	Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention	2007-05-04		.txt	text/plain	3496	184	42	We have recently reviewed the antiviral agents that are active against influenza viruses and that could be used, either therapeutically and/or prophylactically, in an influenza virus pandemic, whether it be human, avian, equine, porcine or other [1] . Even if based only on the currently available drugs, there are several double-, tripleand quadruple-drug combinations that could be envisaged for the prevention and treatment of avian H5N1 (Figure 3 ) -including the combination of oseltamivir and zanamivir (because their resistance profiles overlap only partially), the combination of these neuraminidase inhibitors with M2 ion channel blockers, and further extension of these combinations to include pegylated interferon and ribavirin. In addition to viral RNA polymerase and/or endonuclease, mentioned earlier as potential targets for new anti-influenza-virus agents, there are some other clues regarding the virulence of H5N1 viruses in humans [41] that could be considered as points of attack for chemotherapeutic intervention.	./cache/cord-346063-7u1a198p.txt	./txt/cord-346063-7u1a198p.txt