id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349225-504kr50e	Alcami, Antonio	Viral mechanisms of immune evasion	2000-09-01		.txt	text/plain	3610	188	44	Viruses such as HIV, human cytomegalovirus (HCMV) and vaccinia virus (VV) utilize a clever strategy, 'borrowing' host cellular factors, including CD59, which normally protects cells from complement lysis, and incorporating them into the viral envelope. Additionally, several viruses inhibit the activity of IFN-␥, a key activator of cellular immunity, by blocking the synthesis or activity of factors required for its production, such as interleukin (IL)-18 or IL-12 (Table 4 ): CPV cytokine response modifier (Crm A) inhibits caspase-1, which processes the mature forms of IL-1␤ and IL-18 (Refs 2,6); various poxviruses encode soluble IL-18binding proteins (IL-18BPs) [8] [9] [10] ; measles virus (MeV) binds CD46 in macrophages and inhibits IL-12 production 1 ; and herpesviruses and poxviruses express IL-10 homologs that diminish the Th1 response by downregulating the production of IL-12 (Refs 1,11,12).	./cache/cord-349225-504kr50e.txt	./txt/cord-349225-504kr50e.txt