id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350703-vrqltz3s	nan	ISAR News	2016-01-31		.txt	text/plain	11202	497	45	She is studying the response of primary human mononuclear cells to dengue virus infection, aiming to establish a more relevant in vitro model for antiviral drug testing and to identify potential new antiviral targets, using genome-wide transcriptomic analysis. According to ISAR member Robert Jordan, who heads the Gilead team developing antivirals against respiratory viruses, the parent compound was originally discovered as part of the hepatitis C program, targeting the HCV polymerase, but the strong clinical efficacy of sofosbuvir, especially in combination with ledipasvir, resulted in the molecule being evaluated for other indications, including respiratory viruses such as respiratory syncytial virus (RSV). ISAR members know Andrea (standing, above, with Cardiff colleague Salvatore Ferla) as the winner of the 2013 Prusoff Young Investigator Award, but not all of us are familiar with the direction of his career, which has increasingly explored the use of computer-based methods to design new antivirals and anticancer drugs.	./cache/cord-350703-vrqltz3s.txt	./txt/cord-350703-vrqltz3s.txt