id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017428-euzvhtax	Janssens, Wim	Vitamin D and Chronic Obstructive Pulmonary Disease	2012-02-17		.txt	text/plain	8830	371	41	A recent intervention trial with high-dose supplementation in COPD was only able to reduce exacerbation frequency in the subgroup of patients with lowest baseline vitamin D levels. Besides the well-known effect of vitamin D de fi ciency on bone loss in adults, accumulating evidence also links a low vitamin D nutritional status to highly prevalent chronic illnesses, including cancers, autoimmune diseases, infectious and cardiovascular diseases [1] [2] [3] . This chapter aims to discuss the prevalence and determinants of vitamin D de fi ciency in COPD, the wellknown effect of vitamin D in the development and treatment of COPD-associated osteoporosis and its potential role in the uncontrolled in fl ammatory cascade and systemic consequences of the disease. The fact that the majority of COPD patients are of older age, have many common risk factors for osteoporosis and are more likely to be de fi cient in vitamin D supports standard supplementation, especially at the more severe stages of disease.	./cache/cord-017428-euzvhtax.txt	./txt/cord-017428-euzvhtax.txt