id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103451-h7986yl9	Drodge, D. R.	Causal analysis shows evidence of atopic dermatitis leading to an increase in vitamin D levels	2020-04-23		.txt	text/plain	3422	185	49	There was little evidence for vitamin D levels causally influencing the risk of AD (odds ratio per SD change in log-transformed 25-OHD levels = 1.233, 95% CI 0.927 to 1.639, P-value =0.150), a finding in keeping with the 2017 analysis which found an effect size of 1.12, (95% CI 0.92 to1.37, P-value =0.270) (Manousaki et al. To investigate the causal effect of genetically predicted vitamin D levels upon AD risk, a genetic instrument for 25-OHD levels was derived from SNPs reported to be most strongly associated (Pvalue < 5x10 -8 ) in the most current GWA study by Manousaki and colleagues (N=443,734) (Manousaki et al. Our genetic instrument for vitamin D levels was used to assess the causal effect upon AD risk using summary GWAS data from the most recent AD GWAS meta-analysis (Paternoster et al.	./cache/cord-103451-h7986yl9.txt	./txt/cord-103451-h7986yl9.txt