id sid tid token lemma pos cord-004297-rm0zbgfm 1 1 key key NN cord-004297-rm0zbgfm 1 2 : : : cord-004297-rm0zbgfm 2 1 cord-004297-rm0zbgfm cord-004297-rm0zbgfm NFP cord-004297-rm0zbgfm 2 2 authors author NNS cord-004297-rm0zbgfm 2 3 : : : cord-004297-rm0zbgfm 2 4 Hemilä Hemilä NNP cord-004297-rm0zbgfm 2 5 , , , cord-004297-rm0zbgfm 2 6 Harri Harri NNP cord-004297-rm0zbgfm 2 7 ; ; : cord-004297-rm0zbgfm 2 8 Chalker Chalker NNP cord-004297-rm0zbgfm 2 9 , , , cord-004297-rm0zbgfm 2 10 Elizabeth Elizabeth NNP cord-004297-rm0zbgfm 2 11 title title NN cord-004297-rm0zbgfm 2 12 : : : cord-004297-rm0zbgfm 3 1 Vitamin vitamin NN cord-004297-rm0zbgfm 3 2 C c NN cord-004297-rm0zbgfm 3 3 may may MD cord-004297-rm0zbgfm 3 4 reduce reduce VB cord-004297-rm0zbgfm 3 5 the the DT cord-004297-rm0zbgfm 3 6 duration duration NN cord-004297-rm0zbgfm 3 7 of of IN cord-004297-rm0zbgfm 3 8 mechanical mechanical JJ cord-004297-rm0zbgfm 3 9 ventilation ventilation NN cord-004297-rm0zbgfm 3 10 in in IN cord-004297-rm0zbgfm 3 11 critically critically RB cord-004297-rm0zbgfm 3 12 ill ill JJ cord-004297-rm0zbgfm 3 13 patients patient NNS cord-004297-rm0zbgfm 3 14 : : : cord-004297-rm0zbgfm 3 15 a a DT cord-004297-rm0zbgfm 3 16 meta meta JJ cord-004297-rm0zbgfm 3 17 - - HYPH cord-004297-rm0zbgfm 3 18 regression regression JJ cord-004297-rm0zbgfm 3 19 analysis analysis NN cord-004297-rm0zbgfm 3 20 date date NN cord-004297-rm0zbgfm 3 21 : : : cord-004297-rm0zbgfm 3 22 2020 2020 CD cord-004297-rm0zbgfm 3 23 - - HYPH cord-004297-rm0zbgfm 3 24 02 02 CD cord-004297-rm0zbgfm 3 25 - - HYPH cord-004297-rm0zbgfm 3 26 07 07 CD cord-004297-rm0zbgfm 3 27 journal journal NN cord-004297-rm0zbgfm 3 28 : : : cord-004297-rm0zbgfm 3 29 J J NNP cord-004297-rm0zbgfm 3 30 Intensive Intensive NNP cord-004297-rm0zbgfm 3 31 Care Care NNP cord-004297-rm0zbgfm 3 32 DOI DOI NNP cord-004297-rm0zbgfm 3 33 : : : cord-004297-rm0zbgfm 3 34 10.1186 10.1186 CD cord-004297-rm0zbgfm 3 35 / / SYM cord-004297-rm0zbgfm 3 36 s40560 s40560 CD cord-004297-rm0zbgfm 3 37 - - HYPH cord-004297-rm0zbgfm 3 38 020 020 CD cord-004297-rm0zbgfm 3 39 - - HYPH cord-004297-rm0zbgfm 3 40 0432-y 0432-y CD cord-004297-rm0zbgfm 3 41 sha sha NNP cord-004297-rm0zbgfm 3 42 : : : cord-004297-rm0zbgfm 3 43 55d762875ac9c5b43832336f3a88d0e70ff8ab9c 55d762875ac9c5b43832336f3a88d0e70ff8ab9c NNP cord-004297-rm0zbgfm 3 44 doc_id doc_id CD cord-004297-rm0zbgfm 3 45 : : : cord-004297-rm0zbgfm 3 46 4297 4297 CD cord-004297-rm0zbgfm 4 1 cord_uid cord_uid NN cord-004297-rm0zbgfm 4 2 : : : cord-004297-rm0zbgfm 5 1 rm0zbgfm rm0zbgfm NNP cord-004297-rm0zbgfm 6 1 BACKGROUND background NN cord-004297-rm0zbgfm 6 2 : : : cord-004297-rm0zbgfm 7 1 Our -PRON- PRP$ cord-004297-rm0zbgfm 7 2 recent recent JJ cord-004297-rm0zbgfm 7 3 meta meta JJ cord-004297-rm0zbgfm 7 4 - - HYPH cord-004297-rm0zbgfm 7 5 analysis analysis NN cord-004297-rm0zbgfm 7 6 indicated indicate VBD cord-004297-rm0zbgfm 7 7 that that IN cord-004297-rm0zbgfm 7 8 vitamin vitamin NN cord-004297-rm0zbgfm 7 9 C c NN cord-004297-rm0zbgfm 7 10 may may MD cord-004297-rm0zbgfm 7 11 shorten shorten VB cord-004297-rm0zbgfm 7 12 the the DT cord-004297-rm0zbgfm 7 13 length length NN cord-004297-rm0zbgfm 7 14 of of IN cord-004297-rm0zbgfm 7 15 ICU ICU NNP cord-004297-rm0zbgfm 7 16 stay stay NN cord-004297-rm0zbgfm 7 17 and and CC cord-004297-rm0zbgfm 7 18 the the DT cord-004297-rm0zbgfm 7 19 duration duration NN cord-004297-rm0zbgfm 7 20 of of IN cord-004297-rm0zbgfm 7 21 mechanical mechanical JJ cord-004297-rm0zbgfm 7 22 ventilation ventilation NN cord-004297-rm0zbgfm 7 23 . . . cord-004297-rm0zbgfm 8 1 Here here RB cord-004297-rm0zbgfm 8 2 we -PRON- PRP cord-004297-rm0zbgfm 8 3 analyze analyze VBP cord-004297-rm0zbgfm 8 4 modification modification NN cord-004297-rm0zbgfm 8 5 of of IN cord-004297-rm0zbgfm 8 6 the the DT cord-004297-rm0zbgfm 8 7 vitamin vitamin NN cord-004297-rm0zbgfm 8 8 C c NN cord-004297-rm0zbgfm 8 9 effect effect NN cord-004297-rm0zbgfm 8 10 on on IN cord-004297-rm0zbgfm 8 11 ventilation ventilation NN cord-004297-rm0zbgfm 8 12 time time NN cord-004297-rm0zbgfm 8 13 , , , cord-004297-rm0zbgfm 8 14 by by IN cord-004297-rm0zbgfm 8 15 the the DT cord-004297-rm0zbgfm 8 16 control control NN cord-004297-rm0zbgfm 8 17 group group NN cord-004297-rm0zbgfm 8 18 ventilation ventilation NN cord-004297-rm0zbgfm 8 19 time time NN cord-004297-rm0zbgfm 8 20 ( ( -LRB- cord-004297-rm0zbgfm 8 21 which which WDT cord-004297-rm0zbgfm 8 22 we -PRON- PRP cord-004297-rm0zbgfm 8 23 used use VBD cord-004297-rm0zbgfm 8 24 as as IN cord-004297-rm0zbgfm 8 25 a a DT cord-004297-rm0zbgfm 8 26 proxy proxy NN cord-004297-rm0zbgfm 8 27 for for IN cord-004297-rm0zbgfm 8 28 severity severity NN cord-004297-rm0zbgfm 8 29 of of IN cord-004297-rm0zbgfm 8 30 disease disease NN cord-004297-rm0zbgfm 8 31 in in IN cord-004297-rm0zbgfm 8 32 the the DT cord-004297-rm0zbgfm 8 33 patients patient NNS cord-004297-rm0zbgfm 8 34 of of IN cord-004297-rm0zbgfm 8 35 each each DT cord-004297-rm0zbgfm 8 36 trial trial NN cord-004297-rm0zbgfm 8 37 ) ) -RRB- cord-004297-rm0zbgfm 8 38 . . . cord-004297-rm0zbgfm 9 1 METHODS methods NN cord-004297-rm0zbgfm 9 2 : : : cord-004297-rm0zbgfm 10 1 We -PRON- PRP cord-004297-rm0zbgfm 10 2 searched search VBD cord-004297-rm0zbgfm 10 3 MEDLINE MEDLINE NNP cord-004297-rm0zbgfm 10 4 , , , cord-004297-rm0zbgfm 10 5 Scopus Scopus NNP cord-004297-rm0zbgfm 10 6 , , , cord-004297-rm0zbgfm 10 7 and and CC cord-004297-rm0zbgfm 10 8 the the DT cord-004297-rm0zbgfm 10 9 Cochrane Cochrane NNP cord-004297-rm0zbgfm 10 10 Central Central NNP cord-004297-rm0zbgfm 10 11 Register Register NNP cord-004297-rm0zbgfm 10 12 of of IN cord-004297-rm0zbgfm 10 13 Controlled Controlled NNP cord-004297-rm0zbgfm 10 14 Trials Trials NNPS cord-004297-rm0zbgfm 10 15 and and CC cord-004297-rm0zbgfm 10 16 reference reference NN cord-004297-rm0zbgfm 10 17 lists list NNS cord-004297-rm0zbgfm 10 18 of of IN cord-004297-rm0zbgfm 10 19 relevant relevant JJ cord-004297-rm0zbgfm 10 20 publications publication NNS cord-004297-rm0zbgfm 10 21 . . . cord-004297-rm0zbgfm 11 1 We -PRON- PRP cord-004297-rm0zbgfm 11 2 included include VBD cord-004297-rm0zbgfm 11 3 controlled control VBN cord-004297-rm0zbgfm 11 4 trials trial NNS cord-004297-rm0zbgfm 11 5 in in IN cord-004297-rm0zbgfm 11 6 which which WDT cord-004297-rm0zbgfm 11 7 the the DT cord-004297-rm0zbgfm 11 8 administration administration NN cord-004297-rm0zbgfm 11 9 of of IN cord-004297-rm0zbgfm 11 10 vitamin vitamin NN cord-004297-rm0zbgfm 11 11 C C NNP cord-004297-rm0zbgfm 11 12 was be VBD cord-004297-rm0zbgfm 11 13 the the DT cord-004297-rm0zbgfm 11 14 only only JJ cord-004297-rm0zbgfm 11 15 difference difference NN cord-004297-rm0zbgfm 11 16 between between IN cord-004297-rm0zbgfm 11 17 the the DT cord-004297-rm0zbgfm 11 18 study study NN cord-004297-rm0zbgfm 11 19 groups group NNS cord-004297-rm0zbgfm 11 20 . . . cord-004297-rm0zbgfm 12 1 We -PRON- PRP cord-004297-rm0zbgfm 12 2 did do VBD cord-004297-rm0zbgfm 12 3 not not RB cord-004297-rm0zbgfm 12 4 limit limit VB cord-004297-rm0zbgfm 12 5 our -PRON- PRP$ cord-004297-rm0zbgfm 12 6 search search NN cord-004297-rm0zbgfm 12 7 to to IN cord-004297-rm0zbgfm 12 8 randomized randomized JJ cord-004297-rm0zbgfm 12 9 trials trial NNS cord-004297-rm0zbgfm 12 10 and and CC cord-004297-rm0zbgfm 12 11 did do VBD cord-004297-rm0zbgfm 12 12 not not RB cord-004297-rm0zbgfm 12 13 require require VB cord-004297-rm0zbgfm 12 14 placebo placebo NN cord-004297-rm0zbgfm 12 15 control control NN cord-004297-rm0zbgfm 12 16 . . . cord-004297-rm0zbgfm 13 1 We -PRON- PRP cord-004297-rm0zbgfm 13 2 included include VBD cord-004297-rm0zbgfm 13 3 all all DT cord-004297-rm0zbgfm 13 4 doses dose NNS cord-004297-rm0zbgfm 13 5 and and CC cord-004297-rm0zbgfm 13 6 all all DT cord-004297-rm0zbgfm 13 7 durations duration NNS cord-004297-rm0zbgfm 13 8 of of IN cord-004297-rm0zbgfm 13 9 vitamin vitamin NN cord-004297-rm0zbgfm 13 10 C C NNP cord-004297-rm0zbgfm 13 11 administration administration NN cord-004297-rm0zbgfm 13 12 . . . cord-004297-rm0zbgfm 14 1 One one CD cord-004297-rm0zbgfm 14 2 author author NN cord-004297-rm0zbgfm 14 3 extracted extract VBD cord-004297-rm0zbgfm 14 4 study study NN cord-004297-rm0zbgfm 14 5 characteristics characteristic NNS cord-004297-rm0zbgfm 14 6 and and CC cord-004297-rm0zbgfm 14 7 outcomes outcome NNS cord-004297-rm0zbgfm 14 8 from from IN cord-004297-rm0zbgfm 14 9 the the DT cord-004297-rm0zbgfm 14 10 trial trial NN cord-004297-rm0zbgfm 14 11 reports report NNS cord-004297-rm0zbgfm 14 12 and and CC cord-004297-rm0zbgfm 14 13 entered enter VBD cord-004297-rm0zbgfm 14 14 the the DT cord-004297-rm0zbgfm 14 15 data datum NNS cord-004297-rm0zbgfm 14 16 in in IN cord-004297-rm0zbgfm 14 17 a a DT cord-004297-rm0zbgfm 14 18 spreadsheet spreadsheet NN cord-004297-rm0zbgfm 14 19 . . . cord-004297-rm0zbgfm 15 1 Both both DT cord-004297-rm0zbgfm 15 2 authors author NNS cord-004297-rm0zbgfm 15 3 checked check VBD cord-004297-rm0zbgfm 15 4 the the DT cord-004297-rm0zbgfm 15 5 data datum NNS cord-004297-rm0zbgfm 15 6 entered enter VBN cord-004297-rm0zbgfm 15 7 against against IN cord-004297-rm0zbgfm 15 8 the the DT cord-004297-rm0zbgfm 15 9 original original JJ cord-004297-rm0zbgfm 15 10 reports report NNS cord-004297-rm0zbgfm 15 11 . . . cord-004297-rm0zbgfm 16 1 We -PRON- PRP cord-004297-rm0zbgfm 16 2 used use VBD cord-004297-rm0zbgfm 16 3 meta meta JJ cord-004297-rm0zbgfm 16 4 - - HYPH cord-004297-rm0zbgfm 16 5 regression regression NN cord-004297-rm0zbgfm 16 6 to to TO cord-004297-rm0zbgfm 16 7 examine examine VB cord-004297-rm0zbgfm 16 8 whether whether IN cord-004297-rm0zbgfm 16 9 the the DT cord-004297-rm0zbgfm 16 10 vitamin vitamin NN cord-004297-rm0zbgfm 16 11 C c NN cord-004297-rm0zbgfm 16 12 effect effect NN cord-004297-rm0zbgfm 16 13 on on IN cord-004297-rm0zbgfm 16 14 ventilation ventilation NN cord-004297-rm0zbgfm 16 15 time time NN cord-004297-rm0zbgfm 16 16 depends depend VBZ cord-004297-rm0zbgfm 16 17 on on IN cord-004297-rm0zbgfm 16 18 the the DT cord-004297-rm0zbgfm 16 19 duration duration NN cord-004297-rm0zbgfm 16 20 of of IN cord-004297-rm0zbgfm 16 21 ventilation ventilation NN cord-004297-rm0zbgfm 16 22 in in IN cord-004297-rm0zbgfm 16 23 the the DT cord-004297-rm0zbgfm 16 24 control control NN cord-004297-rm0zbgfm 16 25 group group NN cord-004297-rm0zbgfm 16 26 . . . cord-004297-rm0zbgfm 17 1 RESULTS result NNS cord-004297-rm0zbgfm 17 2 : : : cord-004297-rm0zbgfm 18 1 We -PRON- PRP cord-004297-rm0zbgfm 18 2 identified identify VBD cord-004297-rm0zbgfm 18 3 nine nine CD cord-004297-rm0zbgfm 18 4 potentially potentially RB cord-004297-rm0zbgfm 18 5 eligible eligible JJ cord-004297-rm0zbgfm 18 6 trials trial NNS cord-004297-rm0zbgfm 18 7 , , , cord-004297-rm0zbgfm 18 8 eight eight CD cord-004297-rm0zbgfm 18 9 of of IN cord-004297-rm0zbgfm 18 10 which which WDT cord-004297-rm0zbgfm 18 11 were be VBD cord-004297-rm0zbgfm 18 12 included include VBN cord-004297-rm0zbgfm 18 13 in in IN cord-004297-rm0zbgfm 18 14 the the DT cord-004297-rm0zbgfm 18 15 meta meta NNP cord-004297-rm0zbgfm 18 16 - - HYPH cord-004297-rm0zbgfm 18 17 analysis analysis NN cord-004297-rm0zbgfm 18 18 . . . cord-004297-rm0zbgfm 19 1 We -PRON- PRP cord-004297-rm0zbgfm 19 2 pooled pool VBD cord-004297-rm0zbgfm 19 3 the the DT cord-004297-rm0zbgfm 19 4 results result NNS cord-004297-rm0zbgfm 19 5 of of IN cord-004297-rm0zbgfm 19 6 the the DT cord-004297-rm0zbgfm 19 7 eight eight CD cord-004297-rm0zbgfm 19 8 trials trial NNS cord-004297-rm0zbgfm 19 9 , , , cord-004297-rm0zbgfm 19 10 including include VBG cord-004297-rm0zbgfm 19 11 685 685 CD cord-004297-rm0zbgfm 19 12 patients patient NNS cord-004297-rm0zbgfm 19 13 in in IN cord-004297-rm0zbgfm 19 14 total total NN cord-004297-rm0zbgfm 19 15 , , , cord-004297-rm0zbgfm 19 16 and and CC cord-004297-rm0zbgfm 19 17 found find VBD cord-004297-rm0zbgfm 19 18 that that IN cord-004297-rm0zbgfm 19 19 vitamin vitamin NN cord-004297-rm0zbgfm 19 20 C c NN cord-004297-rm0zbgfm 19 21 shortened shorten VBD cord-004297-rm0zbgfm 19 22 the the DT cord-004297-rm0zbgfm 19 23 length length NN cord-004297-rm0zbgfm 19 24 of of IN cord-004297-rm0zbgfm 19 25 mechanical mechanical JJ cord-004297-rm0zbgfm 19 26 ventilation ventilation NN cord-004297-rm0zbgfm 19 27 on on IN cord-004297-rm0zbgfm 19 28 average average JJ cord-004297-rm0zbgfm 19 29 by by IN cord-004297-rm0zbgfm 19 30 14 14 CD cord-004297-rm0zbgfm 19 31 % % NN cord-004297-rm0zbgfm 19 32 ( ( -LRB- cord-004297-rm0zbgfm 19 33 P p NN cord-004297-rm0zbgfm 19 34 = = SYM cord-004297-rm0zbgfm 19 35 0.00001 0.00001 CD cord-004297-rm0zbgfm 19 36 ) ) -RRB- cord-004297-rm0zbgfm 19 37 . . . cord-004297-rm0zbgfm 20 1 However however RB cord-004297-rm0zbgfm 20 2 , , , cord-004297-rm0zbgfm 20 3 there there EX cord-004297-rm0zbgfm 20 4 was be VBD cord-004297-rm0zbgfm 20 5 significant significant JJ cord-004297-rm0zbgfm 20 6 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 20 7 in in IN cord-004297-rm0zbgfm 20 8 the the DT cord-004297-rm0zbgfm 20 9 effect effect NN cord-004297-rm0zbgfm 20 10 of of IN cord-004297-rm0zbgfm 20 11 vitamin vitamin NN cord-004297-rm0zbgfm 20 12 C c NN cord-004297-rm0zbgfm 20 13 between between IN cord-004297-rm0zbgfm 20 14 the the DT cord-004297-rm0zbgfm 20 15 trials trial NNS cord-004297-rm0zbgfm 20 16 . . . cord-004297-rm0zbgfm 21 1 Heterogeneity heterogeneity NN cord-004297-rm0zbgfm 21 2 was be VBD cord-004297-rm0zbgfm 21 3 fully fully RB cord-004297-rm0zbgfm 21 4 explained explain VBN cord-004297-rm0zbgfm 21 5 by by IN cord-004297-rm0zbgfm 21 6 the the DT cord-004297-rm0zbgfm 21 7 ventilation ventilation NN cord-004297-rm0zbgfm 21 8 time time NN cord-004297-rm0zbgfm 21 9 in in IN cord-004297-rm0zbgfm 21 10 the the DT cord-004297-rm0zbgfm 21 11 untreated untreated JJ cord-004297-rm0zbgfm 21 12 control control NN cord-004297-rm0zbgfm 21 13 group group NN cord-004297-rm0zbgfm 21 14 . . . cord-004297-rm0zbgfm 22 1 Vitamin vitamin NN cord-004297-rm0zbgfm 22 2 C c NN cord-004297-rm0zbgfm 22 3 was be VBD cord-004297-rm0zbgfm 22 4 most most RBS cord-004297-rm0zbgfm 22 5 beneficial beneficial JJ cord-004297-rm0zbgfm 22 6 for for IN cord-004297-rm0zbgfm 22 7 patients patient NNS cord-004297-rm0zbgfm 22 8 with with IN cord-004297-rm0zbgfm 22 9 the the DT cord-004297-rm0zbgfm 22 10 longest long JJS cord-004297-rm0zbgfm 22 11 ventilation ventilation NN cord-004297-rm0zbgfm 22 12 , , , cord-004297-rm0zbgfm 22 13 corresponding correspond VBG cord-004297-rm0zbgfm 22 14 to to IN cord-004297-rm0zbgfm 22 15 the the DT cord-004297-rm0zbgfm 22 16 most most RBS cord-004297-rm0zbgfm 22 17 severely severely RB cord-004297-rm0zbgfm 22 18 ill ill JJ cord-004297-rm0zbgfm 22 19 patients patient NNS cord-004297-rm0zbgfm 22 20 . . . cord-004297-rm0zbgfm 23 1 In in IN cord-004297-rm0zbgfm 23 2 five five CD cord-004297-rm0zbgfm 23 3 trials trial NNS cord-004297-rm0zbgfm 23 4 including include VBG cord-004297-rm0zbgfm 23 5 471 471 CD cord-004297-rm0zbgfm 23 6 patients patient NNS cord-004297-rm0zbgfm 23 7 requiring require VBG cord-004297-rm0zbgfm 23 8 ventilation ventilation NN cord-004297-rm0zbgfm 23 9 for for IN cord-004297-rm0zbgfm 23 10 over over IN cord-004297-rm0zbgfm 23 11 10 10 CD cord-004297-rm0zbgfm 23 12 h h NN cord-004297-rm0zbgfm 23 13 , , , cord-004297-rm0zbgfm 23 14 a a DT cord-004297-rm0zbgfm 23 15 dosage dosage NN cord-004297-rm0zbgfm 23 16 of of IN cord-004297-rm0zbgfm 23 17 1–6 1–6 CD cord-004297-rm0zbgfm 23 18 g g NN cord-004297-rm0zbgfm 23 19 / / SYM cord-004297-rm0zbgfm 23 20 day day NN cord-004297-rm0zbgfm 23 21 of of IN cord-004297-rm0zbgfm 23 22 vitamin vitamin NN cord-004297-rm0zbgfm 23 23 C c NN cord-004297-rm0zbgfm 23 24 shortened shorten VBD cord-004297-rm0zbgfm 23 25 ventilation ventilation NN cord-004297-rm0zbgfm 23 26 time time NN cord-004297-rm0zbgfm 23 27 on on IN cord-004297-rm0zbgfm 23 28 average average JJ cord-004297-rm0zbgfm 23 29 by by IN cord-004297-rm0zbgfm 23 30 25 25 CD cord-004297-rm0zbgfm 23 31 % % NN cord-004297-rm0zbgfm 23 32 ( ( -LRB- cord-004297-rm0zbgfm 23 33 P p NN cord-004297-rm0zbgfm 23 34 < < XX cord-004297-rm0zbgfm 23 35 0.0001 0.0001 CD cord-004297-rm0zbgfm 23 36 ) ) -RRB- cord-004297-rm0zbgfm 23 37 . . . cord-004297-rm0zbgfm 24 1 CONCLUSIONS conclusion NNS cord-004297-rm0zbgfm 24 2 : : : cord-004297-rm0zbgfm 25 1 We -PRON- PRP cord-004297-rm0zbgfm 25 2 found find VBD cord-004297-rm0zbgfm 25 3 strong strong JJ cord-004297-rm0zbgfm 25 4 evidence evidence NN cord-004297-rm0zbgfm 25 5 that that IN cord-004297-rm0zbgfm 25 6 vitamin vitamin NN cord-004297-rm0zbgfm 25 7 C c NN cord-004297-rm0zbgfm 25 8 shortens shorten VBZ cord-004297-rm0zbgfm 25 9 the the DT cord-004297-rm0zbgfm 25 10 duration duration NN cord-004297-rm0zbgfm 25 11 of of IN cord-004297-rm0zbgfm 25 12 mechanical mechanical JJ cord-004297-rm0zbgfm 25 13 ventilation ventilation NN cord-004297-rm0zbgfm 25 14 , , , cord-004297-rm0zbgfm 25 15 but but CC cord-004297-rm0zbgfm 25 16 the the DT cord-004297-rm0zbgfm 25 17 magnitude magnitude NN cord-004297-rm0zbgfm 25 18 of of IN cord-004297-rm0zbgfm 25 19 the the DT cord-004297-rm0zbgfm 25 20 effect effect NN cord-004297-rm0zbgfm 25 21 seems seem VBZ cord-004297-rm0zbgfm 25 22 to to TO cord-004297-rm0zbgfm 25 23 depend depend VB cord-004297-rm0zbgfm 25 24 on on IN cord-004297-rm0zbgfm 25 25 the the DT cord-004297-rm0zbgfm 25 26 duration duration NN cord-004297-rm0zbgfm 25 27 of of IN cord-004297-rm0zbgfm 25 28 ventilation ventilation NN cord-004297-rm0zbgfm 25 29 in in IN cord-004297-rm0zbgfm 25 30 the the DT cord-004297-rm0zbgfm 25 31 untreated untreated JJ cord-004297-rm0zbgfm 25 32 control control NN cord-004297-rm0zbgfm 25 33 group group NN cord-004297-rm0zbgfm 25 34 . . . cord-004297-rm0zbgfm 26 1 The the DT cord-004297-rm0zbgfm 26 2 level level NN cord-004297-rm0zbgfm 26 3 of of IN cord-004297-rm0zbgfm 26 4 baseline baseline JJ cord-004297-rm0zbgfm 26 5 illness illness NN cord-004297-rm0zbgfm 26 6 severity severity NN cord-004297-rm0zbgfm 26 7 should should MD cord-004297-rm0zbgfm 26 8 be be VB cord-004297-rm0zbgfm 26 9 considered consider VBN cord-004297-rm0zbgfm 26 10 in in IN cord-004297-rm0zbgfm 26 11 further further JJ cord-004297-rm0zbgfm 26 12 research research NN cord-004297-rm0zbgfm 26 13 . . . cord-004297-rm0zbgfm 27 1 Different different JJ cord-004297-rm0zbgfm 27 2 doses dose NNS cord-004297-rm0zbgfm 27 3 should should MD cord-004297-rm0zbgfm 27 4 be be VB cord-004297-rm0zbgfm 27 5 compared compare VBN cord-004297-rm0zbgfm 27 6 directly directly RB cord-004297-rm0zbgfm 27 7 in in IN cord-004297-rm0zbgfm 27 8 future future JJ cord-004297-rm0zbgfm 27 9 trials trial NNS cord-004297-rm0zbgfm 27 10 . . . cord-004297-rm0zbgfm 28 1 In in IN cord-004297-rm0zbgfm 28 2 controlled control VBN cord-004297-rm0zbgfm 28 3 trials trial NNS cord-004297-rm0zbgfm 28 4 , , , cord-004297-rm0zbgfm 28 5 vitamin vitamin NN cord-004297-rm0zbgfm 28 6 C C NNP cord-004297-rm0zbgfm 28 7 has have VBZ cord-004297-rm0zbgfm 28 8 improved improve VBN cord-004297-rm0zbgfm 28 9 endothelial endothelial JJ cord-004297-rm0zbgfm 28 10 function function NN cord-004297-rm0zbgfm 28 11 , , , cord-004297-rm0zbgfm 28 12 lowered lower VBD cord-004297-rm0zbgfm 28 13 blood blood NN cord-004297-rm0zbgfm 28 14 pressure pressure NN cord-004297-rm0zbgfm 28 15 , , , cord-004297-rm0zbgfm 28 16 increased increase VBD cord-004297-rm0zbgfm 28 17 left leave VBN cord-004297-rm0zbgfm 28 18 ventricular ventricular JJ cord-004297-rm0zbgfm 28 19 ejection ejection NN cord-004297-rm0zbgfm 28 20 fraction fraction NN cord-004297-rm0zbgfm 28 21 , , , cord-004297-rm0zbgfm 28 22 decreased decrease VBD cord-004297-rm0zbgfm 28 23 the the DT cord-004297-rm0zbgfm 28 24 incidence incidence NN cord-004297-rm0zbgfm 28 25 of of IN cord-004297-rm0zbgfm 28 26 atrial atrial JJ cord-004297-rm0zbgfm 28 27 fibrillation fibrillation NN cord-004297-rm0zbgfm 28 28 , , , cord-004297-rm0zbgfm 28 29 decreased decrease VBD cord-004297-rm0zbgfm 28 30 bronchoconstriction bronchoconstriction NN cord-004297-rm0zbgfm 28 31 , , , cord-004297-rm0zbgfm 28 32 prevented prevent VBN cord-004297-rm0zbgfm 28 33 pain pain NN cord-004297-rm0zbgfm 28 34 , , , cord-004297-rm0zbgfm 28 35 shortened shorten VBD cord-004297-rm0zbgfm 28 36 the the DT cord-004297-rm0zbgfm 28 37 duration duration NN cord-004297-rm0zbgfm 28 38 of of IN cord-004297-rm0zbgfm 28 39 colds cold NNS cord-004297-rm0zbgfm 28 40 , , , cord-004297-rm0zbgfm 28 41 and and CC cord-004297-rm0zbgfm 28 42 decreased decrease VBD cord-004297-rm0zbgfm 28 43 the the DT cord-004297-rm0zbgfm 28 44 incidence incidence NN cord-004297-rm0zbgfm 28 45 of of IN cord-004297-rm0zbgfm 28 46 colds cold NNS cord-004297-rm0zbgfm 28 47 in in IN cord-004297-rm0zbgfm 28 48 physically physically RB cord-004297-rm0zbgfm 28 49 stressed stress VBN cord-004297-rm0zbgfm 28 50 people people NNS cord-004297-rm0zbgfm 28 51 , , , cord-004297-rm0zbgfm 28 52 and and CC cord-004297-rm0zbgfm 28 53 it -PRON- PRP cord-004297-rm0zbgfm 28 54 may may MD cord-004297-rm0zbgfm 28 55 also also RB cord-004297-rm0zbgfm 28 56 have have VB cord-004297-rm0zbgfm 28 57 beneficial beneficial JJ cord-004297-rm0zbgfm 28 58 effects effect NNS cord-004297-rm0zbgfm 28 59 against against IN cord-004297-rm0zbgfm 28 60 pneumonia pneumonia NN cord-004297-rm0zbgfm 28 61 , , , cord-004297-rm0zbgfm 28 62 see see VB cord-004297-rm0zbgfm 28 63 reference reference NN cord-004297-rm0zbgfm 28 64 [ [ -LRB- cord-004297-rm0zbgfm 28 65 1 1 CD cord-004297-rm0zbgfm 28 66 ] ] -RRB- cord-004297-rm0zbgfm 28 67 . . . cord-004297-rm0zbgfm 29 1 The the DT cord-004297-rm0zbgfm 29 2 average average JJ cord-004297-rm0zbgfm 29 3 person person NN cord-004297-rm0zbgfm 29 4 , , , cord-004297-rm0zbgfm 29 5 in in IN cord-004297-rm0zbgfm 29 6 good good JJ cord-004297-rm0zbgfm 29 7 health health NN cord-004297-rm0zbgfm 29 8 , , , cord-004297-rm0zbgfm 29 9 maintains maintain VBZ cord-004297-rm0zbgfm 29 10 normal normal JJ cord-004297-rm0zbgfm 29 11 plasma plasma NN cord-004297-rm0zbgfm 29 12 vitamin vitamin NN cord-004297-rm0zbgfm 29 13 C c NN cord-004297-rm0zbgfm 29 14 levels level NNS cord-004297-rm0zbgfm 29 15 with with IN cord-004297-rm0zbgfm 29 16 a a DT cord-004297-rm0zbgfm 29 17 daily daily JJ cord-004297-rm0zbgfm 29 18 intake intake NN cord-004297-rm0zbgfm 29 19 of of IN cord-004297-rm0zbgfm 29 20 about about RB cord-004297-rm0zbgfm 29 21 0.1 0.1 CD cord-004297-rm0zbgfm 29 22 g g NN cord-004297-rm0zbgfm 29 23 / / SYM cord-004297-rm0zbgfm 29 24 day day NN cord-004297-rm0zbgfm 29 25 . . . cord-004297-rm0zbgfm 30 1 However however RB cord-004297-rm0zbgfm 30 2 , , , cord-004297-rm0zbgfm 30 3 much much RB cord-004297-rm0zbgfm 30 4 higher high JJR cord-004297-rm0zbgfm 30 5 doses dose NNS cord-004297-rm0zbgfm 30 6 , , , cord-004297-rm0zbgfm 30 7 in in IN cord-004297-rm0zbgfm 30 8 the the DT cord-004297-rm0zbgfm 30 9 order order NN cord-004297-rm0zbgfm 30 10 of of IN cord-004297-rm0zbgfm 30 11 grams gram NNS cord-004297-rm0zbgfm 30 12 per per IN cord-004297-rm0zbgfm 30 13 day day NN cord-004297-rm0zbgfm 30 14 , , , cord-004297-rm0zbgfm 30 15 are be VBP cord-004297-rm0zbgfm 30 16 needed need VBN cord-004297-rm0zbgfm 30 17 for for IN cord-004297-rm0zbgfm 30 18 critically critically RB cord-004297-rm0zbgfm 30 19 ill ill JJ cord-004297-rm0zbgfm 30 20 patients patient NNS cord-004297-rm0zbgfm 30 21 to to TO cord-004297-rm0zbgfm 30 22 reach reach VB cord-004297-rm0zbgfm 30 23 normal normal JJ cord-004297-rm0zbgfm 30 24 plasma plasma NN cord-004297-rm0zbgfm 30 25 vitamin vitamin NN cord-004297-rm0zbgfm 30 26 C c NN cord-004297-rm0zbgfm 30 27 levels level NNS cord-004297-rm0zbgfm 30 28 [ [ -LRB- cord-004297-rm0zbgfm 30 29 2 2 CD cord-004297-rm0zbgfm 30 30 ] ] -RRB- cord-004297-rm0zbgfm 30 31 [ [ -LRB- cord-004297-rm0zbgfm 30 32 3 3 CD cord-004297-rm0zbgfm 30 33 ] ] -RRB- cord-004297-rm0zbgfm 30 34 [ [ -LRB- cord-004297-rm0zbgfm 30 35 4 4 CD cord-004297-rm0zbgfm 30 36 ] ] -RRB- cord-004297-rm0zbgfm 30 37 [ [ -LRB- cord-004297-rm0zbgfm 30 38 5 5 CD cord-004297-rm0zbgfm 30 39 ] ] -RRB- cord-004297-rm0zbgfm 30 40 . . . cord-004297-rm0zbgfm 31 1 Without without IN cord-004297-rm0zbgfm 31 2 supplementation supplementation NN cord-004297-rm0zbgfm 31 3 , , , cord-004297-rm0zbgfm 31 4 plasma plasma NN cord-004297-rm0zbgfm 31 5 vitamin vitamin NN cord-004297-rm0zbgfm 31 6 C c NN cord-004297-rm0zbgfm 31 7 levels level NNS cord-004297-rm0zbgfm 31 8 are be VBP cord-004297-rm0zbgfm 31 9 particularly particularly RB cord-004297-rm0zbgfm 31 10 low low JJ cord-004297-rm0zbgfm 31 11 in in IN cord-004297-rm0zbgfm 31 12 critically critically RB cord-004297-rm0zbgfm 31 13 ill ill JJ cord-004297-rm0zbgfm 31 14 patients patient NNS cord-004297-rm0zbgfm 31 15 [ [ -LRB- cord-004297-rm0zbgfm 31 16 6 6 CD cord-004297-rm0zbgfm 31 17 ] ] -RRB- cord-004297-rm0zbgfm 31 18 [ [ -LRB- cord-004297-rm0zbgfm 31 19 7 7 CD cord-004297-rm0zbgfm 31 20 ] ] -RRB- cord-004297-rm0zbgfm 31 21 [ [ -LRB- cord-004297-rm0zbgfm 31 22 8 8 CD cord-004297-rm0zbgfm 31 23 ] ] -RRB- cord-004297-rm0zbgfm 31 24 [ [ -LRB- cord-004297-rm0zbgfm 31 25 9 9 CD cord-004297-rm0zbgfm 31 26 ] ] -RRB- cord-004297-rm0zbgfm 31 27 [ [ -LRB- cord-004297-rm0zbgfm 31 28 10 10 CD cord-004297-rm0zbgfm 31 29 ] ] -RRB- cord-004297-rm0zbgfm 31 30 , , , cord-004297-rm0zbgfm 31 31 indicating indicate VBG cord-004297-rm0zbgfm 31 32 that that IN cord-004297-rm0zbgfm 31 33 the the DT cord-004297-rm0zbgfm 31 34 body body NN cord-004297-rm0zbgfm 31 35 may may MD cord-004297-rm0zbgfm 31 36 have have VB cord-004297-rm0zbgfm 31 37 a a DT cord-004297-rm0zbgfm 31 38 greater great JJR cord-004297-rm0zbgfm 31 39 need need NN cord-004297-rm0zbgfm 31 40 for for IN cord-004297-rm0zbgfm 31 41 vitamin vitamin NN cord-004297-rm0zbgfm 31 42 C c NN cord-004297-rm0zbgfm 31 43 when when WRB cord-004297-rm0zbgfm 31 44 under under IN cord-004297-rm0zbgfm 31 45 severe severe JJ cord-004297-rm0zbgfm 31 46 stress stress NN cord-004297-rm0zbgfm 31 47 such such JJ cord-004297-rm0zbgfm 31 48 as as IN cord-004297-rm0zbgfm 31 49 illness illness NN cord-004297-rm0zbgfm 31 50 requiring require VBG cord-004297-rm0zbgfm 31 51 intensive intensive JJ cord-004297-rm0zbgfm 31 52 care care NN cord-004297-rm0zbgfm 31 53 . . . cord-004297-rm0zbgfm 32 1 It -PRON- PRP cord-004297-rm0zbgfm 32 2 seems seem VBZ cord-004297-rm0zbgfm 32 3 evident evident JJ cord-004297-rm0zbgfm 32 4 that that IN cord-004297-rm0zbgfm 32 5 there there EX cord-004297-rm0zbgfm 32 6 are be VBP cord-004297-rm0zbgfm 32 7 gradual gradual JJ cord-004297-rm0zbgfm 32 8 changes change NNS cord-004297-rm0zbgfm 32 9 in in IN cord-004297-rm0zbgfm 32 10 vitamin vitamin NN cord-004297-rm0zbgfm 32 11 C c NN cord-004297-rm0zbgfm 32 12 metabolism metabolism NN cord-004297-rm0zbgfm 32 13 according accord VBG cord-004297-rm0zbgfm 32 14 to to IN cord-004297-rm0zbgfm 32 15 the the DT cord-004297-rm0zbgfm 32 16 severity severity NN cord-004297-rm0zbgfm 32 17 of of IN cord-004297-rm0zbgfm 32 18 disease disease NN cord-004297-rm0zbgfm 32 19 , , , cord-004297-rm0zbgfm 32 20 in in IN cord-004297-rm0zbgfm 32 21 that that IN cord-004297-rm0zbgfm 32 22 the the DT cord-004297-rm0zbgfm 32 23 sicker sick JJR cord-004297-rm0zbgfm 32 24 a a DT cord-004297-rm0zbgfm 32 25 patient patient NN cord-004297-rm0zbgfm 32 26 is be VBZ cord-004297-rm0zbgfm 32 27 , , , cord-004297-rm0zbgfm 32 28 the the DT cord-004297-rm0zbgfm 32 29 greater great JJR cord-004297-rm0zbgfm 32 30 the the DT cord-004297-rm0zbgfm 32 31 consumption consumption NN cord-004297-rm0zbgfm 32 32 of of IN cord-004297-rm0zbgfm 32 33 vitamin vitamin NN cord-004297-rm0zbgfm 32 34 C. c. NN cord-004297-rm0zbgfm 33 1 This this DT cord-004297-rm0zbgfm 33 2 further further RB cord-004297-rm0zbgfm 33 3 suggests suggest VBZ cord-004297-rm0zbgfm 33 4 that that IN cord-004297-rm0zbgfm 33 5 the the DT cord-004297-rm0zbgfm 33 6 sicker sick JJR cord-004297-rm0zbgfm 33 7 a a DT cord-004297-rm0zbgfm 33 8 patient patient NN cord-004297-rm0zbgfm 33 9 is be VBZ cord-004297-rm0zbgfm 33 10 , , , cord-004297-rm0zbgfm 33 11 the the DT cord-004297-rm0zbgfm 33 12 more more RBR cord-004297-rm0zbgfm 33 13 they -PRON- PRP cord-004297-rm0zbgfm 33 14 are be VBP cord-004297-rm0zbgfm 33 15 likely likely JJ cord-004297-rm0zbgfm 33 16 to to TO cord-004297-rm0zbgfm 33 17 benefit benefit VB cord-004297-rm0zbgfm 33 18 from from IN cord-004297-rm0zbgfm 33 19 additional additional JJ cord-004297-rm0zbgfm 33 20 vitamin vitamin NN cord-004297-rm0zbgfm 33 21 C. c. NN cord-004297-rm0zbgfm 34 1 Given give VBN cord-004297-rm0zbgfm 34 2 this this DT cord-004297-rm0zbgfm 34 3 background background NN cord-004297-rm0zbgfm 34 4 , , , cord-004297-rm0zbgfm 34 5 we -PRON- PRP cord-004297-rm0zbgfm 34 6 previously previously RB cord-004297-rm0zbgfm 34 7 examined examine VBD cord-004297-rm0zbgfm 34 8 whether whether IN cord-004297-rm0zbgfm 34 9 vitamin vitamin NN cord-004297-rm0zbgfm 34 10 C C NNP cord-004297-rm0zbgfm 34 11 administration administration NN cord-004297-rm0zbgfm 34 12 has have VBZ cord-004297-rm0zbgfm 34 13 an an DT cord-004297-rm0zbgfm 34 14 effect effect NN cord-004297-rm0zbgfm 34 15 on on IN cord-004297-rm0zbgfm 34 16 practical practical JJ cord-004297-rm0zbgfm 34 17 outcomes outcome NNS cord-004297-rm0zbgfm 34 18 such such JJ cord-004297-rm0zbgfm 34 19 as as IN cord-004297-rm0zbgfm 34 20 the the DT cord-004297-rm0zbgfm 34 21 length length NN cord-004297-rm0zbgfm 34 22 of of IN cord-004297-rm0zbgfm 34 23 ICU ICU NNP cord-004297-rm0zbgfm 34 24 stay stay NN cord-004297-rm0zbgfm 34 25 , , , cord-004297-rm0zbgfm 34 26 without without IN cord-004297-rm0zbgfm 34 27 looking look VBG cord-004297-rm0zbgfm 34 28 at at IN cord-004297-rm0zbgfm 34 29 specific specific JJ cord-004297-rm0zbgfm 34 30 medical medical JJ cord-004297-rm0zbgfm 34 31 conditions condition NNS cord-004297-rm0zbgfm 34 32 . . . cord-004297-rm0zbgfm 35 1 From from IN cord-004297-rm0zbgfm 35 2 the the DT cord-004297-rm0zbgfm 35 3 results result NNS cord-004297-rm0zbgfm 35 4 of of IN cord-004297-rm0zbgfm 35 5 12 12 CD cord-004297-rm0zbgfm 35 6 trials trial NNS cord-004297-rm0zbgfm 35 7 with with IN cord-004297-rm0zbgfm 35 8 1766 1766 CD cord-004297-rm0zbgfm 35 9 patients patient NNS cord-004297-rm0zbgfm 35 10 , , , cord-004297-rm0zbgfm 35 11 we -PRON- PRP cord-004297-rm0zbgfm 35 12 calculated calculate VBD cord-004297-rm0zbgfm 35 13 that that IN cord-004297-rm0zbgfm 35 14 vitamin vitamin NN cord-004297-rm0zbgfm 35 15 C c NN cord-004297-rm0zbgfm 35 16 reduced reduce VBD cord-004297-rm0zbgfm 35 17 the the DT cord-004297-rm0zbgfm 35 18 length length NN cord-004297-rm0zbgfm 35 19 of of IN cord-004297-rm0zbgfm 35 20 ICU ICU NNP cord-004297-rm0zbgfm 35 21 stay stay VBP cord-004297-rm0zbgfm 35 22 on on IN cord-004297-rm0zbgfm 35 23 average average JJ cord-004297-rm0zbgfm 35 24 by by IN cord-004297-rm0zbgfm 35 25 7.8 7.8 CD cord-004297-rm0zbgfm 35 26 % % NN cord-004297-rm0zbgfm 35 27 ( ( -LRB- cord-004297-rm0zbgfm 35 28 P p NN cord-004297-rm0zbgfm 35 29 < < XX cord-004297-rm0zbgfm 35 30 0.001 0.001 CD cord-004297-rm0zbgfm 35 31 ) ) -RRB- cord-004297-rm0zbgfm 36 1 [ [ -LRB- cord-004297-rm0zbgfm 36 2 1 1 CD cord-004297-rm0zbgfm 36 3 ] ] -RRB- cord-004297-rm0zbgfm 36 4 . . . cord-004297-rm0zbgfm 37 1 We -PRON- PRP cord-004297-rm0zbgfm 37 2 also also RB cord-004297-rm0zbgfm 37 3 found find VBD cord-004297-rm0zbgfm 37 4 that that IN cord-004297-rm0zbgfm 37 5 in in IN cord-004297-rm0zbgfm 37 6 trials trial NNS cord-004297-rm0zbgfm 37 7 in in IN cord-004297-rm0zbgfm 37 8 which which WDT cord-004297-rm0zbgfm 37 9 the the DT cord-004297-rm0zbgfm 37 10 control control NN cord-004297-rm0zbgfm 37 11 groups group NNS cord-004297-rm0zbgfm 37 12 were be VBD cord-004297-rm0zbgfm 37 13 ventilated ventilate VBN cord-004297-rm0zbgfm 37 14 for for IN cord-004297-rm0zbgfm 37 15 24 24 CD cord-004297-rm0zbgfm 37 16 h h NN cord-004297-rm0zbgfm 37 17 or or CC cord-004297-rm0zbgfm 37 18 more more JJR cord-004297-rm0zbgfm 37 19 , , , cord-004297-rm0zbgfm 37 20 vitamin vitamin NN cord-004297-rm0zbgfm 37 21 C c NN cord-004297-rm0zbgfm 37 22 shortened shorten VBD cord-004297-rm0zbgfm 37 23 the the DT cord-004297-rm0zbgfm 37 24 duration duration NN cord-004297-rm0zbgfm 37 25 of of IN cord-004297-rm0zbgfm 37 26 mechanical mechanical JJ cord-004297-rm0zbgfm 37 27 ventilation ventilation NN cord-004297-rm0zbgfm 37 28 by by IN cord-004297-rm0zbgfm 37 29 18 18 CD cord-004297-rm0zbgfm 37 30 % % NN cord-004297-rm0zbgfm 37 31 ( ( -LRB- cord-004297-rm0zbgfm 37 32 P p NN cord-004297-rm0zbgfm 37 33 = = SYM cord-004297-rm0zbgfm 37 34 0.001 0.001 CD cord-004297-rm0zbgfm 37 35 ) ) -RRB- cord-004297-rm0zbgfm 37 36 [ [ -LRB- cord-004297-rm0zbgfm 37 37 1 1 CD cord-004297-rm0zbgfm 37 38 ] ] -RRB- cord-004297-rm0zbgfm 37 39 . . . cord-004297-rm0zbgfm 38 1 However however RB cord-004297-rm0zbgfm 38 2 , , , cord-004297-rm0zbgfm 38 3 vitamin vitamin NN cord-004297-rm0zbgfm 38 4 C c NN cord-004297-rm0zbgfm 38 5 did do VBD cord-004297-rm0zbgfm 38 6 not not RB cord-004297-rm0zbgfm 38 7 have have VB cord-004297-rm0zbgfm 38 8 an an DT cord-004297-rm0zbgfm 38 9 effect effect NN cord-004297-rm0zbgfm 38 10 on on IN cord-004297-rm0zbgfm 38 11 the the DT cord-004297-rm0zbgfm 38 12 duration duration NN cord-004297-rm0zbgfm 38 13 of of IN cord-004297-rm0zbgfm 38 14 mechanical mechanical JJ cord-004297-rm0zbgfm 38 15 ventilation ventilation NN cord-004297-rm0zbgfm 38 16 in in IN cord-004297-rm0zbgfm 38 17 trials trial NNS cord-004297-rm0zbgfm 38 18 in in IN cord-004297-rm0zbgfm 38 19 which which WDT cord-004297-rm0zbgfm 38 20 control control NN cord-004297-rm0zbgfm 38 21 groups group NNS cord-004297-rm0zbgfm 38 22 were be VBD cord-004297-rm0zbgfm 38 23 ventilated ventilate VBN cord-004297-rm0zbgfm 38 24 for for IN cord-004297-rm0zbgfm 38 25 less less JJR cord-004297-rm0zbgfm 38 26 than than IN cord-004297-rm0zbgfm 38 27 24 24 CD cord-004297-rm0zbgfm 38 28 h h NN cord-004297-rm0zbgfm 38 29 , , , cord-004297-rm0zbgfm 38 30 i.e. i.e. FW cord-004297-rm0zbgfm 38 31 , , , cord-004297-rm0zbgfm 38 32 trials trial NNS cord-004297-rm0zbgfm 38 33 in in IN cord-004297-rm0zbgfm 38 34 patients patient NNS cord-004297-rm0zbgfm 38 35 with with IN cord-004297-rm0zbgfm 38 36 less less RBR cord-004297-rm0zbgfm 38 37 severe severe JJ cord-004297-rm0zbgfm 38 38 illness illness NN cord-004297-rm0zbgfm 38 39 . . . cord-004297-rm0zbgfm 39 1 In in IN cord-004297-rm0zbgfm 39 2 this this DT cord-004297-rm0zbgfm 39 3 study study NN cord-004297-rm0zbgfm 39 4 , , , cord-004297-rm0zbgfm 39 5 we -PRON- PRP cord-004297-rm0zbgfm 39 6 hypothesize hypothesize VBP cord-004297-rm0zbgfm 39 7 that that IN cord-004297-rm0zbgfm 39 8 there there EX cord-004297-rm0zbgfm 39 9 is be VBZ cord-004297-rm0zbgfm 39 10 a a DT cord-004297-rm0zbgfm 39 11 continuous continuous JJ cord-004297-rm0zbgfm 39 12 relationship relationship NN cord-004297-rm0zbgfm 39 13 between between IN cord-004297-rm0zbgfm 39 14 disease disease NN cord-004297-rm0zbgfm 39 15 severity severity NN cord-004297-rm0zbgfm 39 16 and and CC cord-004297-rm0zbgfm 39 17 the the DT cord-004297-rm0zbgfm 39 18 beneficial beneficial JJ cord-004297-rm0zbgfm 39 19 effect effect NN cord-004297-rm0zbgfm 39 20 of of IN cord-004297-rm0zbgfm 39 21 vitamin vitamin NN cord-004297-rm0zbgfm 39 22 C C NNP cord-004297-rm0zbgfm 39 23 administration administration NN cord-004297-rm0zbgfm 39 24 . . . cord-004297-rm0zbgfm 40 1 We -PRON- PRP cord-004297-rm0zbgfm 40 2 used use VBD cord-004297-rm0zbgfm 40 3 metaregression metaregression NN cord-004297-rm0zbgfm 40 4 to to TO cord-004297-rm0zbgfm 40 5 analyze analyze VB cord-004297-rm0zbgfm 40 6 the the DT cord-004297-rm0zbgfm 40 7 gradual gradual JJ cord-004297-rm0zbgfm 40 8 relationship relationship NN cord-004297-rm0zbgfm 40 9 between between IN cord-004297-rm0zbgfm 40 10 the the DT cord-004297-rm0zbgfm 40 11 effect effect NN cord-004297-rm0zbgfm 40 12 of of IN cord-004297-rm0zbgfm 40 13 vitamin vitamin NN cord-004297-rm0zbgfm 40 14 C c NN cord-004297-rm0zbgfm 40 15 in in IN cord-004297-rm0zbgfm 40 16 the the DT cord-004297-rm0zbgfm 40 17 treatment treatment NN cord-004297-rm0zbgfm 40 18 group group NN cord-004297-rm0zbgfm 40 19 and and CC cord-004297-rm0zbgfm 40 20 the the DT cord-004297-rm0zbgfm 40 21 duration duration NN cord-004297-rm0zbgfm 40 22 of of IN cord-004297-rm0zbgfm 40 23 mechanical mechanical JJ cord-004297-rm0zbgfm 40 24 ventilation ventilation NN cord-004297-rm0zbgfm 40 25 in in IN cord-004297-rm0zbgfm 40 26 untreated untreated JJ cord-004297-rm0zbgfm 40 27 patients patient NNS cord-004297-rm0zbgfm 40 28 of of IN cord-004297-rm0zbgfm 40 29 the the DT cord-004297-rm0zbgfm 40 30 control control NN cord-004297-rm0zbgfm 40 31 group group NN cord-004297-rm0zbgfm 40 32 , , , cord-004297-rm0zbgfm 40 33 which which WDT cord-004297-rm0zbgfm 40 34 we -PRON- PRP cord-004297-rm0zbgfm 40 35 used use VBD cord-004297-rm0zbgfm 40 36 as as IN cord-004297-rm0zbgfm 40 37 a a DT cord-004297-rm0zbgfm 40 38 proxy proxy NN cord-004297-rm0zbgfm 40 39 for for IN cord-004297-rm0zbgfm 40 40 the the DT cord-004297-rm0zbgfm 40 41 severity severity NN cord-004297-rm0zbgfm 40 42 of of IN cord-004297-rm0zbgfm 40 43 the the DT cord-004297-rm0zbgfm 40 44 disease disease NN cord-004297-rm0zbgfm 40 45 . . . cord-004297-rm0zbgfm 41 1 We -PRON- PRP cord-004297-rm0zbgfm 41 2 included include VBD cord-004297-rm0zbgfm 41 3 controlled control VBN cord-004297-rm0zbgfm 41 4 trials trial NNS cord-004297-rm0zbgfm 41 5 that that WDT cord-004297-rm0zbgfm 41 6 compared compare VBD cord-004297-rm0zbgfm 41 7 the the DT cord-004297-rm0zbgfm 41 8 length length NN cord-004297-rm0zbgfm 41 9 of of IN cord-004297-rm0zbgfm 41 10 mechanical mechanical JJ cord-004297-rm0zbgfm 41 11 ventilation ventilation NN cord-004297-rm0zbgfm 41 12 between between IN cord-004297-rm0zbgfm 41 13 vitamin vitamin NN cord-004297-rm0zbgfm 41 14 C c NN cord-004297-rm0zbgfm 41 15 and and CC cord-004297-rm0zbgfm 41 16 control control NN cord-004297-rm0zbgfm 41 17 groups group NNS cord-004297-rm0zbgfm 41 18 . . . cord-004297-rm0zbgfm 42 1 We -PRON- PRP cord-004297-rm0zbgfm 42 2 included include VBD cord-004297-rm0zbgfm 42 3 trials trial NNS cord-004297-rm0zbgfm 42 4 in in IN cord-004297-rm0zbgfm 42 5 which which WDT cord-004297-rm0zbgfm 42 6 the the DT cord-004297-rm0zbgfm 42 7 administration administration NN cord-004297-rm0zbgfm 42 8 of of IN cord-004297-rm0zbgfm 42 9 vitamin vitamin NN cord-004297-rm0zbgfm 42 10 C C NNP cord-004297-rm0zbgfm 42 11 was be VBD cord-004297-rm0zbgfm 42 12 the the DT cord-004297-rm0zbgfm 42 13 only only JJ cord-004297-rm0zbgfm 42 14 difference difference NN cord-004297-rm0zbgfm 42 15 between between IN cord-004297-rm0zbgfm 42 16 the the DT cord-004297-rm0zbgfm 42 17 study study NN cord-004297-rm0zbgfm 42 18 groups group NNS cord-004297-rm0zbgfm 42 19 ; ; : cord-004297-rm0zbgfm 42 20 trials trial NNS cord-004297-rm0zbgfm 42 21 that that WDT cord-004297-rm0zbgfm 42 22 administered administer VBD cord-004297-rm0zbgfm 42 23 other other JJ cord-004297-rm0zbgfm 42 24 therapies therapy NNS cord-004297-rm0zbgfm 42 25 as as RB cord-004297-rm0zbgfm 42 26 well well RB cord-004297-rm0zbgfm 42 27 as as IN cord-004297-rm0zbgfm 42 28 vitamin vitamin NN cord-004297-rm0zbgfm 42 29 C c NN cord-004297-rm0zbgfm 42 30 were be VBD cord-004297-rm0zbgfm 42 31 included include VBN cord-004297-rm0zbgfm 42 32 only only RB cord-004297-rm0zbgfm 42 33 if if IN cord-004297-rm0zbgfm 42 34 the the DT cord-004297-rm0zbgfm 42 35 other other JJ cord-004297-rm0zbgfm 42 36 therapies therapy NNS cord-004297-rm0zbgfm 42 37 were be VBD cord-004297-rm0zbgfm 42 38 the the DT cord-004297-rm0zbgfm 42 39 same same JJ cord-004297-rm0zbgfm 42 40 for for IN cord-004297-rm0zbgfm 42 41 both both DT cord-004297-rm0zbgfm 42 42 trial trial NN cord-004297-rm0zbgfm 42 43 groups group NNS cord-004297-rm0zbgfm 42 44 . . . cord-004297-rm0zbgfm 43 1 We -PRON- PRP cord-004297-rm0zbgfm 43 2 did do VBD cord-004297-rm0zbgfm 43 3 not not RB cord-004297-rm0zbgfm 43 4 limit limit VB cord-004297-rm0zbgfm 43 5 our -PRON- PRP$ cord-004297-rm0zbgfm 43 6 search search NN cord-004297-rm0zbgfm 43 7 to to IN cord-004297-rm0zbgfm 43 8 randomized randomized JJ cord-004297-rm0zbgfm 43 9 trials trial NNS cord-004297-rm0zbgfm 43 10 and and CC cord-004297-rm0zbgfm 43 11 did do VBD cord-004297-rm0zbgfm 43 12 not not RB cord-004297-rm0zbgfm 43 13 require require VB cord-004297-rm0zbgfm 43 14 placebo placebo NN cord-004297-rm0zbgfm 43 15 control control NN cord-004297-rm0zbgfm 43 16 . . . cord-004297-rm0zbgfm 44 1 We -PRON- PRP cord-004297-rm0zbgfm 44 2 included include VBD cord-004297-rm0zbgfm 44 3 all all DT cord-004297-rm0zbgfm 44 4 doses dose NNS cord-004297-rm0zbgfm 44 5 and and CC cord-004297-rm0zbgfm 44 6 all all DT cord-004297-rm0zbgfm 44 7 durations duration NNS cord-004297-rm0zbgfm 44 8 of of IN cord-004297-rm0zbgfm 44 9 vitamin vitamin NN cord-004297-rm0zbgfm 44 10 C C NNP cord-004297-rm0zbgfm 44 11 administration administration NN cord-004297-rm0zbgfm 44 12 . . . cord-004297-rm0zbgfm 45 1 We -PRON- PRP cord-004297-rm0zbgfm 45 2 searched search VBD cord-004297-rm0zbgfm 45 3 MEDLINE MEDLINE NNP cord-004297-rm0zbgfm 45 4 , , , cord-004297-rm0zbgfm 45 5 Scopus Scopus NNP cord-004297-rm0zbgfm 45 6 , , , cord-004297-rm0zbgfm 45 7 and and CC cord-004297-rm0zbgfm 45 8 the the DT cord-004297-rm0zbgfm 45 9 Cochrane Cochrane NNP cord-004297-rm0zbgfm 45 10 Register Register NNP cord-004297-rm0zbgfm 45 11 on on IN cord-004297-rm0zbgfm 45 12 13 13 CD cord-004297-rm0zbgfm 45 13 Nov Nov NNP cord-004297-rm0zbgfm 45 14 2019 2019 CD cord-004297-rm0zbgfm 45 15 with with IN cord-004297-rm0zbgfm 45 16 the the DT cord-004297-rm0zbgfm 45 17 search search NN cord-004297-rm0zbgfm 45 18 phrases phrase NNS cord-004297-rm0zbgfm 45 19 described describe VBN cord-004297-rm0zbgfm 45 20 in in IN cord-004297-rm0zbgfm 45 21 Fig Fig NNP cord-004297-rm0zbgfm 45 22 . . . cord-004297-rm0zbgfm 46 1 1 1 LS cord-004297-rm0zbgfm 46 2 . . . cord-004297-rm0zbgfm 47 1 We -PRON- PRP cord-004297-rm0zbgfm 47 2 had have VBD cord-004297-rm0zbgfm 47 3 previously previously RB cord-004297-rm0zbgfm 47 4 searched search VBN cord-004297-rm0zbgfm 47 5 the the DT cord-004297-rm0zbgfm 47 6 same same JJ cord-004297-rm0zbgfm 47 7 databases database NNS cord-004297-rm0zbgfm 47 8 for for IN cord-004297-rm0zbgfm 47 9 trials trial NNS cord-004297-rm0zbgfm 47 10 on on IN cord-004297-rm0zbgfm 47 11 vitamin vitamin NN cord-004297-rm0zbgfm 47 12 C c NN cord-004297-rm0zbgfm 47 13 and and CC cord-004297-rm0zbgfm 47 14 ICU ICU NNP cord-004297-rm0zbgfm 47 15 length length NN cord-004297-rm0zbgfm 47 16 of of IN cord-004297-rm0zbgfm 47 17 stay stay NN cord-004297-rm0zbgfm 47 18 on on IN cord-004297-rm0zbgfm 47 19 20 20 CD cord-004297-rm0zbgfm 47 20 Jan Jan NNP cord-004297-rm0zbgfm 47 21 2019 2019 CD cord-004297-rm0zbgfm 47 22 [ [ -LRB- cord-004297-rm0zbgfm 47 23 1 1 CD cord-004297-rm0zbgfm 47 24 ] ] -RRB- cord-004297-rm0zbgfm 47 25 ; ; : cord-004297-rm0zbgfm 47 26 from from IN cord-004297-rm0zbgfm 47 27 that that DT cord-004297-rm0zbgfm 47 28 search search NN cord-004297-rm0zbgfm 47 29 , , , cord-004297-rm0zbgfm 47 30 we -PRON- PRP cord-004297-rm0zbgfm 47 31 found find VBD cord-004297-rm0zbgfm 47 32 trials trial NNS cord-004297-rm0zbgfm 47 33 that that WDT cord-004297-rm0zbgfm 47 34 were be VBD cord-004297-rm0zbgfm 47 35 not not RB cord-004297-rm0zbgfm 47 36 well well RB cord-004297-rm0zbgfm 47 37 indexed index VBN cord-004297-rm0zbgfm 47 38 and and CC cord-004297-rm0zbgfm 47 39 so so RB cord-004297-rm0zbgfm 47 40 not not RB cord-004297-rm0zbgfm 47 41 identified identify VBN cord-004297-rm0zbgfm 47 42 in in IN cord-004297-rm0zbgfm 47 43 our -PRON- PRP$ cord-004297-rm0zbgfm 47 44 new new JJ cord-004297-rm0zbgfm 47 45 search search NN cord-004297-rm0zbgfm 47 46 specifically specifically RB cord-004297-rm0zbgfm 47 47 for for IN cord-004297-rm0zbgfm 47 48 trials trial NNS cord-004297-rm0zbgfm 47 49 on on IN cord-004297-rm0zbgfm 47 50 vitamin vitamin NN cord-004297-rm0zbgfm 47 51 C c NN cord-004297-rm0zbgfm 47 52 and and CC cord-004297-rm0zbgfm 47 53 mechanical mechanical JJ cord-004297-rm0zbgfm 47 54 ventilation ventilation NN cord-004297-rm0zbgfm 47 55 . . . cord-004297-rm0zbgfm 48 1 Finally finally RB cord-004297-rm0zbgfm 48 2 , , , cord-004297-rm0zbgfm 48 3 we -PRON- PRP cord-004297-rm0zbgfm 48 4 perused peruse VBD cord-004297-rm0zbgfm 48 5 the the DT cord-004297-rm0zbgfm 48 6 reference reference NN cord-004297-rm0zbgfm 48 7 lists list NNS cord-004297-rm0zbgfm 48 8 of of IN cord-004297-rm0zbgfm 48 9 the the DT cord-004297-rm0zbgfm 48 10 selected select VBN cord-004297-rm0zbgfm 48 11 trials trial NNS cord-004297-rm0zbgfm 48 12 and and CC cord-004297-rm0zbgfm 48 13 relevant relevant JJ cord-004297-rm0zbgfm 48 14 reviews review NNS cord-004297-rm0zbgfm 48 15 , , , cord-004297-rm0zbgfm 48 16 from from IN cord-004297-rm0zbgfm 48 17 which which WDT cord-004297-rm0zbgfm 48 18 we -PRON- PRP cord-004297-rm0zbgfm 48 19 discovered discover VBD cord-004297-rm0zbgfm 48 20 two two CD cord-004297-rm0zbgfm 48 21 more more JJR cord-004297-rm0zbgfm 48 22 trials trial NNS cord-004297-rm0zbgfm 48 23 . . . cord-004297-rm0zbgfm 49 1 We -PRON- PRP cord-004297-rm0zbgfm 49 2 identified identify VBD cord-004297-rm0zbgfm 49 3 nine nine CD cord-004297-rm0zbgfm 49 4 trials trial NNS cord-004297-rm0zbgfm 49 5 satisfying satisfy VBG cord-004297-rm0zbgfm 49 6 our -PRON- PRP$ cord-004297-rm0zbgfm 49 7 selection selection NN cord-004297-rm0zbgfm 49 8 criteria criterion NNS cord-004297-rm0zbgfm 49 9 [ [ -LRB- cord-004297-rm0zbgfm 49 10 11 11 CD cord-004297-rm0zbgfm 49 11 ] ] -RRB- cord-004297-rm0zbgfm 49 12 [ [ -LRB- cord-004297-rm0zbgfm 49 13 12 12 CD cord-004297-rm0zbgfm 49 14 ] ] -RRB- cord-004297-rm0zbgfm 49 15 [ [ -LRB- cord-004297-rm0zbgfm 49 16 13 13 CD cord-004297-rm0zbgfm 49 17 ] ] -RRB- cord-004297-rm0zbgfm 50 1 [ [ -LRB- cord-004297-rm0zbgfm 50 2 14 14 CD cord-004297-rm0zbgfm 50 3 ] ] -RRB- cord-004297-rm0zbgfm 51 1 [ [ -LRB- cord-004297-rm0zbgfm 51 2 15 15 CD cord-004297-rm0zbgfm 51 3 ] ] -RRB- cord-004297-rm0zbgfm 51 4 [ [ -LRB- cord-004297-rm0zbgfm 51 5 16 16 CD cord-004297-rm0zbgfm 51 6 ] ] -RRB- cord-004297-rm0zbgfm 51 7 [ [ -LRB- cord-004297-rm0zbgfm 51 8 17 17 CD cord-004297-rm0zbgfm 51 9 ] ] -RRB- cord-004297-rm0zbgfm 51 10 [ [ -LRB- cord-004297-rm0zbgfm 51 11 18 18 CD cord-004297-rm0zbgfm 51 12 ] ] -RRB- cord-004297-rm0zbgfm 51 13 [ [ -LRB- cord-004297-rm0zbgfm 51 14 19 19 CD cord-004297-rm0zbgfm 51 15 ] ] -RRB- cord-004297-rm0zbgfm 51 16 . . . cord-004297-rm0zbgfm 52 1 We -PRON- PRP cord-004297-rm0zbgfm 52 2 did do VBD cord-004297-rm0zbgfm 52 3 not not RB cord-004297-rm0zbgfm 52 4 include include VB cord-004297-rm0zbgfm 52 5 two two CD cord-004297-rm0zbgfm 52 6 further further JJ cord-004297-rm0zbgfm 52 7 trials trial NNS cord-004297-rm0zbgfm 52 8 that that WDT cord-004297-rm0zbgfm 52 9 reported report VBD cord-004297-rm0zbgfm 52 10 " " `` cord-004297-rm0zbgfm 52 11 ventilator ventilator NN cord-004297-rm0zbgfm 52 12 - - HYPH cord-004297-rm0zbgfm 52 13 free free JJ cord-004297-rm0zbgfm 52 14 days day NNS cord-004297-rm0zbgfm 52 15 " " '' cord-004297-rm0zbgfm 52 16 since since IN cord-004297-rm0zbgfm 52 17 we -PRON- PRP cord-004297-rm0zbgfm 52 18 were be VBD cord-004297-rm0zbgfm 52 19 unable unable JJ cord-004297-rm0zbgfm 52 20 to to TO cord-004297-rm0zbgfm 52 21 convert convert VB cord-004297-rm0zbgfm 52 22 this this DT cord-004297-rm0zbgfm 52 23 to to IN cord-004297-rm0zbgfm 52 24 our -PRON- PRP$ cord-004297-rm0zbgfm 52 25 outcome outcome NN cord-004297-rm0zbgfm 52 26 of of IN cord-004297-rm0zbgfm 52 27 interest interest NN cord-004297-rm0zbgfm 52 28 , , , cord-004297-rm0zbgfm 52 29 " " '' cord-004297-rm0zbgfm 52 30 duration duration NN cord-004297-rm0zbgfm 52 31 of of IN cord-004297-rm0zbgfm 52 32 mechanical mechanical JJ cord-004297-rm0zbgfm 52 33 ventilation ventilation NN cord-004297-rm0zbgfm 52 34 " " '' cord-004297-rm0zbgfm 52 35 [ [ -LRB- cord-004297-rm0zbgfm 52 36 20 20 CD cord-004297-rm0zbgfm 52 37 , , , cord-004297-rm0zbgfm 52 38 21 21 CD cord-004297-rm0zbgfm 52 39 ] ] -RRB- cord-004297-rm0zbgfm 52 40 . . . cord-004297-rm0zbgfm 53 1 Tanaka Tanaka NNP cord-004297-rm0zbgfm 53 2 et et NNP cord-004297-rm0zbgfm 53 3 al al NNP cord-004297-rm0zbgfm 53 4 . . . cord-004297-rm0zbgfm 54 1 administered administer VBN cord-004297-rm0zbgfm 54 2 vitamin vitamin NN cord-004297-rm0zbgfm 54 3 C C NNP cord-004297-rm0zbgfm 54 4 continuously continuously RB cord-004297-rm0zbgfm 54 5 with with IN cord-004297-rm0zbgfm 54 6 a a DT cord-004297-rm0zbgfm 54 7 dosage dosage NN cord-004297-rm0zbgfm 54 8 of of IN cord-004297-rm0zbgfm 54 9 66 66 CD cord-004297-rm0zbgfm 54 10 mg mg NNP cord-004297-rm0zbgfm 54 11 / / SYM cord-004297-rm0zbgfm 54 12 kg kg NNP cord-004297-rm0zbgfm 54 13 / / SYM cord-004297-rm0zbgfm 54 14 h h NN cord-004297-rm0zbgfm 54 15 for for IN cord-004297-rm0zbgfm 54 16 the the DT cord-004297-rm0zbgfm 54 17 first first JJ cord-004297-rm0zbgfm 54 18 24 24 CD cord-004297-rm0zbgfm 54 19 h h NN cord-004297-rm0zbgfm 54 20 only only RB cord-004297-rm0zbgfm 54 21 , , , cord-004297-rm0zbgfm 54 22 with with IN cord-004297-rm0zbgfm 54 23 the the DT cord-004297-rm0zbgfm 54 24 reported report VBN cord-004297-rm0zbgfm 54 25 mean mean JJ cord-004297-rm0zbgfm 54 26 weight weight NN cord-004297-rm0zbgfm 54 27 of of IN cord-004297-rm0zbgfm 54 28 patients patient NNS cord-004297-rm0zbgfm 54 29 being be VBG cord-004297-rm0zbgfm 54 30 57 57 CD cord-004297-rm0zbgfm 54 31 kg kg NNS cord-004297-rm0zbgfm 54 32 [ [ -LRB- cord-004297-rm0zbgfm 54 33 17 17 CD cord-004297-rm0zbgfm 54 34 ] ] -RRB- cord-004297-rm0zbgfm 54 35 . . . cord-004297-rm0zbgfm 55 1 Thus thus RB cord-004297-rm0zbgfm 55 2 , , , cord-004297-rm0zbgfm 55 3 we -PRON- PRP cord-004297-rm0zbgfm 55 4 The the DT cord-004297-rm0zbgfm 55 5 searches search NNS cord-004297-rm0zbgfm 55 6 were be VBD cord-004297-rm0zbgfm 55 7 carried carry VBN cord-004297-rm0zbgfm 55 8 out out RP cord-004297-rm0zbgfm 55 9 on on IN cord-004297-rm0zbgfm 55 10 13 13 CD cord-004297-rm0zbgfm 55 11 Nov Nov NNP cord-004297-rm0zbgfm 55 12 2019 2019 CD cord-004297-rm0zbgfm 55 13 . . . cord-004297-rm0zbgfm 56 1 The the DT cord-004297-rm0zbgfm 56 2 searches search NNS cord-004297-rm0zbgfm 56 3 identified identify VBD cord-004297-rm0zbgfm 56 4 nine nine CD cord-004297-rm0zbgfm 56 5 trials trial NNS cord-004297-rm0zbgfm 56 6 that that WDT cord-004297-rm0zbgfm 56 7 we -PRON- PRP cord-004297-rm0zbgfm 56 8 included include VBD cord-004297-rm0zbgfm 56 9 in in IN cord-004297-rm0zbgfm 56 10 our -PRON- PRP$ cord-004297-rm0zbgfm 56 11 systematic systematic JJ cord-004297-rm0zbgfm 56 12 review review NN cord-004297-rm0zbgfm 56 13 analysis analysis NN cord-004297-rm0zbgfm 56 14 [ [ -LRB- cord-004297-rm0zbgfm 56 15 11 11 CD cord-004297-rm0zbgfm 56 16 ] ] -RRB- cord-004297-rm0zbgfm 56 17 [ [ -LRB- cord-004297-rm0zbgfm 56 18 12 12 CD cord-004297-rm0zbgfm 56 19 ] ] -RRB- cord-004297-rm0zbgfm 56 20 [ [ -LRB- cord-004297-rm0zbgfm 56 21 13 13 CD cord-004297-rm0zbgfm 56 22 ] ] -RRB- cord-004297-rm0zbgfm 56 23 [ [ -LRB- cord-004297-rm0zbgfm 56 24 14 14 CD cord-004297-rm0zbgfm 56 25 ] ] -RRB- cord-004297-rm0zbgfm 56 26 [ [ -LRB- cord-004297-rm0zbgfm 56 27 15 15 CD cord-004297-rm0zbgfm 56 28 ] ] -RRB- cord-004297-rm0zbgfm 56 29 [ [ -LRB- cord-004297-rm0zbgfm 56 30 16 16 CD cord-004297-rm0zbgfm 56 31 ] ] -RRB- cord-004297-rm0zbgfm 56 32 [ [ -LRB- cord-004297-rm0zbgfm 56 33 17 17 CD cord-004297-rm0zbgfm 56 34 ] ] -RRB- cord-004297-rm0zbgfm 56 35 [ [ -LRB- cord-004297-rm0zbgfm 56 36 18 18 CD cord-004297-rm0zbgfm 56 37 ] ] -RRB- cord-004297-rm0zbgfm 56 38 [ [ -LRB- cord-004297-rm0zbgfm 56 39 19 19 CD cord-004297-rm0zbgfm 56 40 ] ] -RRB- cord-004297-rm0zbgfm 56 41 and and CC cord-004297-rm0zbgfm 56 42 eight eight CD cord-004297-rm0zbgfm 56 43 of of IN cord-004297-rm0zbgfm 56 44 them -PRON- PRP cord-004297-rm0zbgfm 56 45 were be VBD cord-004297-rm0zbgfm 56 46 included include VBN cord-004297-rm0zbgfm 56 47 in in IN cord-004297-rm0zbgfm 56 48 our -PRON- PRP$ cord-004297-rm0zbgfm 56 49 meta meta JJ cord-004297-rm0zbgfm 56 50 - - HYPH cord-004297-rm0zbgfm 56 51 analysis analysis NN cord-004297-rm0zbgfm 56 52 [ [ -LRB- cord-004297-rm0zbgfm 56 53 11 11 CD cord-004297-rm0zbgfm 56 54 ] ] -RRB- cord-004297-rm0zbgfm 56 55 [ [ -LRB- cord-004297-rm0zbgfm 56 56 12 12 CD cord-004297-rm0zbgfm 56 57 ] ] -RRB- cord-004297-rm0zbgfm 56 58 [ [ -LRB- cord-004297-rm0zbgfm 56 59 13 13 CD cord-004297-rm0zbgfm 56 60 ] ] -RRB- cord-004297-rm0zbgfm 57 1 [ [ -LRB- cord-004297-rm0zbgfm 57 2 14 14 CD cord-004297-rm0zbgfm 57 3 ] ] -RRB- cord-004297-rm0zbgfm 58 1 [ [ -LRB- cord-004297-rm0zbgfm 58 2 15 15 CD cord-004297-rm0zbgfm 58 3 ] ] -RRB- cord-004297-rm0zbgfm 58 4 [ [ -LRB- cord-004297-rm0zbgfm 58 5 16 16 CD cord-004297-rm0zbgfm 58 6 ] ] -RRB- cord-004297-rm0zbgfm 58 7 [ [ -LRB- cord-004297-rm0zbgfm 58 8 17 17 CD cord-004297-rm0zbgfm 58 9 ] ] -RRB- cord-004297-rm0zbgfm 59 1 [ [ -LRB- cord-004297-rm0zbgfm 59 2 18 18 CD cord-004297-rm0zbgfm 59 3 ] ] -RRB- cord-004297-rm0zbgfm 59 4 calculated calculate VBD cord-004297-rm0zbgfm 59 5 that that IN cord-004297-rm0zbgfm 59 6 the the DT cord-004297-rm0zbgfm 59 7 average average JJ cord-004297-rm0zbgfm 59 8 dose dose NN cord-004297-rm0zbgfm 59 9 was be VBD cord-004297-rm0zbgfm 59 10 90 90 CD cord-004297-rm0zbgfm 59 11 g g NN cord-004297-rm0zbgfm 59 12 / / SYM cord-004297-rm0zbgfm 59 13 day day NN cord-004297-rm0zbgfm 59 14 in in IN cord-004297-rm0zbgfm 59 15 the the DT cord-004297-rm0zbgfm 59 16 Tanaka Tanaka NNP cord-004297-rm0zbgfm 59 17 trial trial NN cord-004297-rm0zbgfm 59 18 . . . cord-004297-rm0zbgfm 60 1 Zabet Zabet NNP cord-004297-rm0zbgfm 60 2 et et FW cord-004297-rm0zbgfm 60 3 al al NNP cord-004297-rm0zbgfm 60 4 . . . cord-004297-rm0zbgfm 61 1 administered administer VBN cord-004297-rm0zbgfm 61 2 25 25 CD cord-004297-rm0zbgfm 61 3 mg mg NNP cord-004297-rm0zbgfm 61 4 / / SYM cord-004297-rm0zbgfm 61 5 kg kg NNP cord-004297-rm0zbgfm 61 6 every every DT cord-004297-rm0zbgfm 61 7 6 6 CD cord-004297-rm0zbgfm 61 8 h h NN cord-004297-rm0zbgfm 61 9 , , , cord-004297-rm0zbgfm 61 10 but but CC cord-004297-rm0zbgfm 61 11 the the DT cord-004297-rm0zbgfm 61 12 mean mean JJ cord-004297-rm0zbgfm 61 13 weight weight NN cord-004297-rm0zbgfm 61 14 was be VBD cord-004297-rm0zbgfm 61 15 not not RB cord-004297-rm0zbgfm 61 16 reported report VBN cord-004297-rm0zbgfm 61 17 [ [ -LRB- cord-004297-rm0zbgfm 61 18 18 18 CD cord-004297-rm0zbgfm 61 19 ] ] -RRB- cord-004297-rm0zbgfm 61 20 . . . cord-004297-rm0zbgfm 62 1 Assuming assume VBG cord-004297-rm0zbgfm 62 2 a a DT cord-004297-rm0zbgfm 62 3 mean mean JJ cord-004297-rm0zbgfm 62 4 weight weight NN cord-004297-rm0zbgfm 62 5 of of IN cord-004297-rm0zbgfm 62 6 60 60 CD cord-004297-rm0zbgfm 62 7 kg kg NNS cord-004297-rm0zbgfm 62 8 , , , cord-004297-rm0zbgfm 62 9 we -PRON- PRP cord-004297-rm0zbgfm 62 10 estimated estimate VBD cord-004297-rm0zbgfm 62 11 that that IN cord-004297-rm0zbgfm 62 12 the the DT cord-004297-rm0zbgfm 62 13 average average JJ cord-004297-rm0zbgfm 62 14 dose dose NN cord-004297-rm0zbgfm 62 15 was be VBD cord-004297-rm0zbgfm 62 16 6 6 CD cord-004297-rm0zbgfm 62 17 g g NN cord-004297-rm0zbgfm 62 18 / / SYM cord-004297-rm0zbgfm 62 19 day day NN cord-004297-rm0zbgfm 62 20 in in IN cord-004297-rm0zbgfm 62 21 the the DT cord-004297-rm0zbgfm 62 22 Zabet Zabet NNP cord-004297-rm0zbgfm 62 23 trial trial NN cord-004297-rm0zbgfm 62 24 . . . cord-004297-rm0zbgfm 63 1 We -PRON- PRP cord-004297-rm0zbgfm 63 2 use use VBP cord-004297-rm0zbgfm 63 3 these these DT cord-004297-rm0zbgfm 63 4 estimates estimate NNS cord-004297-rm0zbgfm 63 5 in in IN cord-004297-rm0zbgfm 63 6 our -PRON- PRP$ cord-004297-rm0zbgfm 63 7 text text NN cord-004297-rm0zbgfm 63 8 . . . cord-004297-rm0zbgfm 64 1 The the DT cord-004297-rm0zbgfm 64 2 outcome outcome NN cord-004297-rm0zbgfm 64 3 in in IN cord-004297-rm0zbgfm 64 4 this this DT cord-004297-rm0zbgfm 64 5 analysis analysis NN cord-004297-rm0zbgfm 64 6 is be VBZ cord-004297-rm0zbgfm 64 7 the the DT cord-004297-rm0zbgfm 64 8 length length NN cord-004297-rm0zbgfm 64 9 of of IN cord-004297-rm0zbgfm 64 10 mechanical mechanical JJ cord-004297-rm0zbgfm 64 11 ventilation ventilation NN cord-004297-rm0zbgfm 64 12 , , , cord-004297-rm0zbgfm 64 13 which which WDT cord-004297-rm0zbgfm 64 14 we -PRON- PRP cord-004297-rm0zbgfm 64 15 analyzed analyze VBD cord-004297-rm0zbgfm 64 16 on on IN cord-004297-rm0zbgfm 64 17 the the DT cord-004297-rm0zbgfm 64 18 relative relative JJ cord-004297-rm0zbgfm 64 19 scale scale NN cord-004297-rm0zbgfm 64 20 . . . cord-004297-rm0zbgfm 65 1 The the DT cord-004297-rm0zbgfm 65 2 relative relative JJ cord-004297-rm0zbgfm 65 3 scale scale NN cord-004297-rm0zbgfm 65 4 is be VBZ cord-004297-rm0zbgfm 65 5 usually usually RB cord-004297-rm0zbgfm 65 6 more more RBR cord-004297-rm0zbgfm 65 7 informative informative JJ cord-004297-rm0zbgfm 65 8 than than IN cord-004297-rm0zbgfm 65 9 the the DT cord-004297-rm0zbgfm 65 10 absolute absolute JJ cord-004297-rm0zbgfm 65 11 scale scale NN cord-004297-rm0zbgfm 65 12 for for IN cord-004297-rm0zbgfm 65 13 the the DT cord-004297-rm0zbgfm 65 14 analysis analysis NN cord-004297-rm0zbgfm 65 15 of of IN cord-004297-rm0zbgfm 65 16 treatment treatment NN cord-004297-rm0zbgfm 65 17 effects effect NNS cord-004297-rm0zbgfm 65 18 on on IN cord-004297-rm0zbgfm 65 19 continuous continuous JJ cord-004297-rm0zbgfm 65 20 outcomes outcome NNS cord-004297-rm0zbgfm 65 21 , , , cord-004297-rm0zbgfm 65 22 in in IN cord-004297-rm0zbgfm 65 23 particular particular JJ cord-004297-rm0zbgfm 65 24 , , , cord-004297-rm0zbgfm 65 25 for for IN cord-004297-rm0zbgfm 65 26 the the DT cord-004297-rm0zbgfm 65 27 analysis analysis NN cord-004297-rm0zbgfm 65 28 of of IN cord-004297-rm0zbgfm 65 29 duration duration NN cord-004297-rm0zbgfm 65 30 data datum NNS cord-004297-rm0zbgfm 65 31 [ [ -LRB- cord-004297-rm0zbgfm 65 32 1 1 CD cord-004297-rm0zbgfm 65 33 , , , cord-004297-rm0zbgfm 65 34 [ [ -LRB- cord-004297-rm0zbgfm 65 35 22 22 CD cord-004297-rm0zbgfm 65 36 ] ] -RRB- cord-004297-rm0zbgfm 65 37 [ [ -LRB- cord-004297-rm0zbgfm 65 38 23 23 CD cord-004297-rm0zbgfm 65 39 ] ] -RRB- cord-004297-rm0zbgfm 65 40 [ [ -LRB- cord-004297-rm0zbgfm 65 41 24 24 CD cord-004297-rm0zbgfm 65 42 ] ] -RRB- cord-004297-rm0zbgfm 65 43 . . . cord-004297-rm0zbgfm 66 1 We -PRON- PRP cord-004297-rm0zbgfm 66 2 used use VBD cord-004297-rm0zbgfm 66 3 the the DT cord-004297-rm0zbgfm 66 4 ratio ratio NN cord-004297-rm0zbgfm 66 5 of of IN cord-004297-rm0zbgfm 66 6 means mean NNS cord-004297-rm0zbgfm 66 7 ( ( -LRB- cord-004297-rm0zbgfm 66 8 RoM rom NN cord-004297-rm0zbgfm 66 9 ) ) -RRB- cord-004297-rm0zbgfm 66 10 to to TO cord-004297-rm0zbgfm 66 11 estimate estimate VB cord-004297-rm0zbgfm 66 12 the the DT cord-004297-rm0zbgfm 66 13 effect effect NN cord-004297-rm0zbgfm 66 14 of of IN cord-004297-rm0zbgfm 66 15 vitamin vitamin NN cord-004297-rm0zbgfm 66 16 C c NN cord-004297-rm0zbgfm 66 17 , , , cord-004297-rm0zbgfm 66 18 and and CC cord-004297-rm0zbgfm 66 19 the the DT cord-004297-rm0zbgfm 66 20 Taylor Taylor NNP cord-004297-rm0zbgfm 66 21 series series NN cord-004297-rm0zbgfm 66 22 - - HYPH cord-004297-rm0zbgfm 66 23 based base VBN cord-004297-rm0zbgfm 66 24 approach approach NN cord-004297-rm0zbgfm 66 25 to to TO cord-004297-rm0zbgfm 66 26 calculate calculate VB cord-004297-rm0zbgfm 66 27 the the DT cord-004297-rm0zbgfm 66 28 log(RoM log(RoM NNP cord-004297-rm0zbgfm 66 29 ) ) -RRB- cord-004297-rm0zbgfm 66 30 [ [ -LRB- cord-004297-rm0zbgfm 66 31 22 22 CD cord-004297-rm0zbgfm 66 32 ] ] -RRB- cord-004297-rm0zbgfm 66 33 . . . cord-004297-rm0zbgfm 67 1 We -PRON- PRP cord-004297-rm0zbgfm 67 2 pooled pool VBD cord-004297-rm0zbgfm 67 3 the the DT cord-004297-rm0zbgfm 67 4 selected select VBN cord-004297-rm0zbgfm 67 5 trials trial NNS cord-004297-rm0zbgfm 67 6 with with IN cord-004297-rm0zbgfm 67 7 the the DT cord-004297-rm0zbgfm 67 8 metagen metagen NNP cord-004297-rm0zbgfm 67 9 function function NN cord-004297-rm0zbgfm 67 10 of of IN cord-004297-rm0zbgfm 67 11 the the DT cord-004297-rm0zbgfm 67 12 meta meta NNP cord-004297-rm0zbgfm 67 13 package package NN cord-004297-rm0zbgfm 67 14 of of IN cord-004297-rm0zbgfm 67 15 the the DT cord-004297-rm0zbgfm 67 16 R R NNP cord-004297-rm0zbgfm 67 17 statistical statistical JJ cord-004297-rm0zbgfm 67 18 software software NN cord-004297-rm0zbgfm 67 19 [ [ -LRB- cord-004297-rm0zbgfm 67 20 25 25 CD cord-004297-rm0zbgfm 67 21 ] ] -RRB- cord-004297-rm0zbgfm 67 22 [ [ -LRB- cord-004297-rm0zbgfm 67 23 26 26 CD cord-004297-rm0zbgfm 67 24 ] ] -RRB- cord-004297-rm0zbgfm 67 25 [ [ -LRB- cord-004297-rm0zbgfm 67 26 27 27 CD cord-004297-rm0zbgfm 67 27 ] ] -RRB- cord-004297-rm0zbgfm 67 28 , , , cord-004297-rm0zbgfm 67 29 using use VBG cord-004297-rm0zbgfm 67 30 the the DT cord-004297-rm0zbgfm 67 31 inverse inverse JJ cord-004297-rm0zbgfm 67 32 variance variance NN cord-004297-rm0zbgfm 67 33 , , , cord-004297-rm0zbgfm 67 34 fixed fix VBN cord-004297-rm0zbgfm 67 35 effect effect NN cord-004297-rm0zbgfm 67 36 options option NNS cord-004297-rm0zbgfm 67 37 . . . cord-004297-rm0zbgfm 68 1 For for IN cord-004297-rm0zbgfm 68 2 metaregression metaregression NN cord-004297-rm0zbgfm 68 3 , , , cord-004297-rm0zbgfm 68 4 we -PRON- PRP cord-004297-rm0zbgfm 68 5 used use VBD cord-004297-rm0zbgfm 68 6 the the DT cord-004297-rm0zbgfm 68 7 metareg metareg JJ cord-004297-rm0zbgfm 68 8 function function NN cord-004297-rm0zbgfm 68 9 of of IN cord-004297-rm0zbgfm 68 10 the the DT cord-004297-rm0zbgfm 68 11 meta meta NNP cord-004297-rm0zbgfm 68 12 package package NN cord-004297-rm0zbgfm 68 13 . . . cord-004297-rm0zbgfm 69 1 We -PRON- PRP cord-004297-rm0zbgfm 69 2 used use VBD cord-004297-rm0zbgfm 69 3 the the DT cord-004297-rm0zbgfm 69 4 χ χ CD cord-004297-rm0zbgfm 69 5 2 2 CD cord-004297-rm0zbgfm 69 6 test test NN cord-004297-rm0zbgfm 69 7 and and CC cord-004297-rm0zbgfm 69 8 the the DT cord-004297-rm0zbgfm 69 9 I I NNP cord-004297-rm0zbgfm 69 10 2 2 CD cord-004297-rm0zbgfm 69 11 statistic statistic NN cord-004297-rm0zbgfm 69 12 to to TO cord-004297-rm0zbgfm 69 13 assess assess VB cord-004297-rm0zbgfm 69 14 statistical statistical JJ cord-004297-rm0zbgfm 69 15 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 69 16 among among IN cord-004297-rm0zbgfm 69 17 the the DT cord-004297-rm0zbgfm 69 18 trials trial NNS cord-004297-rm0zbgfm 69 19 in in IN cord-004297-rm0zbgfm 69 20 the the DT cord-004297-rm0zbgfm 69 21 metaanalysis metaanalysis NN cord-004297-rm0zbgfm 69 22 [ [ -LRB- cord-004297-rm0zbgfm 69 23 28 28 CD cord-004297-rm0zbgfm 69 24 ] ] -RRB- cord-004297-rm0zbgfm 69 25 . . . cord-004297-rm0zbgfm 70 1 Values value NNS cord-004297-rm0zbgfm 70 2 of of IN cord-004297-rm0zbgfm 70 3 I -PRON- PRP cord-004297-rm0zbgfm 70 4 2 2 CD cord-004297-rm0zbgfm 70 5 range range NN cord-004297-rm0zbgfm 70 6 from from IN cord-004297-rm0zbgfm 70 7 0 0 CD cord-004297-rm0zbgfm 70 8 % % NN cord-004297-rm0zbgfm 70 9 to to TO cord-004297-rm0zbgfm 70 10 100 100 CD cord-004297-rm0zbgfm 70 11 % % NN cord-004297-rm0zbgfm 70 12 . . . cord-004297-rm0zbgfm 71 1 A a DT cord-004297-rm0zbgfm 71 2 value value NN cord-004297-rm0zbgfm 71 3 close close JJ cord-004297-rm0zbgfm 71 4 to to IN cord-004297-rm0zbgfm 71 5 0 0 CD cord-004297-rm0zbgfm 71 6 % % NN cord-004297-rm0zbgfm 71 7 indicates indicate VBZ cord-004297-rm0zbgfm 71 8 very very RB cord-004297-rm0zbgfm 71 9 low low JJ cord-004297-rm0zbgfm 71 10 - - HYPH cord-004297-rm0zbgfm 71 11 level level NN cord-004297-rm0zbgfm 71 12 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 71 13 . . . cord-004297-rm0zbgfm 72 1 A a DT cord-004297-rm0zbgfm 72 2 value value NN cord-004297-rm0zbgfm 72 3 of of IN cord-004297-rm0zbgfm 72 4 more more JJR cord-004297-rm0zbgfm 72 5 than than IN cord-004297-rm0zbgfm 72 6 approximately approximately RB cord-004297-rm0zbgfm 72 7 50 50 CD cord-004297-rm0zbgfm 72 8 % % NN cord-004297-rm0zbgfm 72 9 indicates indicate VBZ cord-004297-rm0zbgfm 72 10 moderate moderate JJ cord-004297-rm0zbgfm 72 11 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 72 12 , , , cord-004297-rm0zbgfm 72 13 and and CC cord-004297-rm0zbgfm 72 14 a a DT cord-004297-rm0zbgfm 72 15 value value NN cord-004297-rm0zbgfm 72 16 over over IN cord-004297-rm0zbgfm 72 17 75 75 CD cord-004297-rm0zbgfm 72 18 % % NN cord-004297-rm0zbgfm 72 19 indicates indicate VBZ cord-004297-rm0zbgfm 72 20 highlevel highlevel JJ cord-004297-rm0zbgfm 72 21 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 72 22 . . . cord-004297-rm0zbgfm 73 1 Our -PRON- PRP$ cord-004297-rm0zbgfm 73 2 calculations calculation NNS cord-004297-rm0zbgfm 73 3 are be VBP cord-004297-rm0zbgfm 73 4 described describe VBN cord-004297-rm0zbgfm 73 5 in in IN cord-004297-rm0zbgfm 73 6 Additional additional JJ cord-004297-rm0zbgfm 73 7 files file NNS cord-004297-rm0zbgfm 73 8 1 1 CD cord-004297-rm0zbgfm 73 9 and and CC cord-004297-rm0zbgfm 73 10 2 2 CD cord-004297-rm0zbgfm 73 11 . . . cord-004297-rm0zbgfm 74 1 Nine nine CD cord-004297-rm0zbgfm 74 2 controlled control VBN cord-004297-rm0zbgfm 74 3 trials trial NNS cord-004297-rm0zbgfm 74 4 have have VBP cord-004297-rm0zbgfm 74 5 reported report VBN cord-004297-rm0zbgfm 74 6 on on IN cord-004297-rm0zbgfm 74 7 vitamin vitamin NN cord-004297-rm0zbgfm 74 8 C C NNP cord-004297-rm0zbgfm 74 9 administration administration NN cord-004297-rm0zbgfm 74 10 and and CC cord-004297-rm0zbgfm 74 11 the the DT cord-004297-rm0zbgfm 74 12 length length NN cord-004297-rm0zbgfm 74 13 of of IN cord-004297-rm0zbgfm 74 14 mechanical mechanical JJ cord-004297-rm0zbgfm 74 15 ventilation ventilation NN cord-004297-rm0zbgfm 74 16 ( ( -LRB- cord-004297-rm0zbgfm 74 17 Table table NN cord-004297-rm0zbgfm 74 18 1 1 CD cord-004297-rm0zbgfm 74 19 ; ; : cord-004297-rm0zbgfm 74 20 see see VB cord-004297-rm0zbgfm 74 21 Additional additional JJ cord-004297-rm0zbgfm 74 22 file file NN cord-004297-rm0zbgfm 74 23 1 1 CD cord-004297-rm0zbgfm 75 1 : : : cord-004297-rm0zbgfm 75 2 Table table NN cord-004297-rm0zbgfm 75 3 S1 s1 NN cord-004297-rm0zbgfm 75 4 for for IN cord-004297-rm0zbgfm 75 5 further further JJ cord-004297-rm0zbgfm 75 6 details detail NNS cord-004297-rm0zbgfm 75 7 of of IN cord-004297-rm0zbgfm 75 8 the the DT cord-004297-rm0zbgfm 75 9 trials trial NNS cord-004297-rm0zbgfm 75 10 ) ) -RRB- cord-004297-rm0zbgfm 75 11 . . . cord-004297-rm0zbgfm 76 1 The the DT cord-004297-rm0zbgfm 76 2 flow flow NN cord-004297-rm0zbgfm 76 3 diagram diagram NN cord-004297-rm0zbgfm 76 4 of of IN cord-004297-rm0zbgfm 76 5 our -PRON- PRP$ cord-004297-rm0zbgfm 76 6 search search NN cord-004297-rm0zbgfm 76 7 is be VBZ cord-004297-rm0zbgfm 76 8 shown show VBN cord-004297-rm0zbgfm 76 9 in in IN cord-004297-rm0zbgfm 76 10 Fig Fig NNP cord-004297-rm0zbgfm 76 11 . . . cord-004297-rm0zbgfm 77 1 1 1 LS cord-004297-rm0zbgfm 77 2 . . . cord-004297-rm0zbgfm 78 1 The the DT cord-004297-rm0zbgfm 78 2 total total JJ cord-004297-rm0zbgfm 78 3 number number NN cord-004297-rm0zbgfm 78 4 of of IN cord-004297-rm0zbgfm 78 5 patients patient NNS cord-004297-rm0zbgfm 78 6 was be VBD cord-004297-rm0zbgfm 78 7 975 975 CD cord-004297-rm0zbgfm 78 8 , , , cord-004297-rm0zbgfm 78 9 with with IN cord-004297-rm0zbgfm 78 10 810 810 CD cord-004297-rm0zbgfm 78 11 patients patient NNS cord-004297-rm0zbgfm 78 12 in in IN cord-004297-rm0zbgfm 78 13 six six CD cord-004297-rm0zbgfm 78 14 cardiac cardiac JJ cord-004297-rm0zbgfm 78 15 surgery surgery NN cord-004297-rm0zbgfm 78 16 trials trial NNS cord-004297-rm0zbgfm 78 17 , , , cord-004297-rm0zbgfm 78 18 128 128 CD cord-004297-rm0zbgfm 78 19 patients patient NNS cord-004297-rm0zbgfm 78 20 in in IN cord-004297-rm0zbgfm 78 21 two two CD cord-004297-rm0zbgfm 78 22 sepsis sepsis NN cord-004297-rm0zbgfm 78 23 trials trial NNS cord-004297-rm0zbgfm 78 24 , , , cord-004297-rm0zbgfm 78 25 and and CC cord-004297-rm0zbgfm 78 26 37 37 CD cord-004297-rm0zbgfm 78 27 patients patient NNS cord-004297-rm0zbgfm 78 28 in in IN cord-004297-rm0zbgfm 78 29 one one CD cord-004297-rm0zbgfm 78 30 trial trial NN cord-004297-rm0zbgfm 78 31 with with IN cord-004297-rm0zbgfm 78 32 burns burn NNS cord-004297-rm0zbgfm 78 33 patients patient NNS cord-004297-rm0zbgfm 78 34 ( ( -LRB- cord-004297-rm0zbgfm 78 35 Table table NN cord-004297-rm0zbgfm 78 36 1 1 CD cord-004297-rm0zbgfm 78 37 ) ) -RRB- cord-004297-rm0zbgfm 78 38 . . . cord-004297-rm0zbgfm 79 1 Vitamin vitamin NN cord-004297-rm0zbgfm 79 2 C c NN cord-004297-rm0zbgfm 79 3 was be VBD cord-004297-rm0zbgfm 79 4 administered administer VBN cord-004297-rm0zbgfm 79 5 orally orally RB cord-004297-rm0zbgfm 79 6 in in IN cord-004297-rm0zbgfm 79 7 four four CD cord-004297-rm0zbgfm 79 8 trials trial NNS cord-004297-rm0zbgfm 79 9 and and CC cord-004297-rm0zbgfm 79 10 intravenously intravenously RB cord-004297-rm0zbgfm 79 11 in in IN cord-004297-rm0zbgfm 79 12 five five CD cord-004297-rm0zbgfm 79 13 trials trial NNS cord-004297-rm0zbgfm 79 14 . . . cord-004297-rm0zbgfm 80 1 The the DT cord-004297-rm0zbgfm 80 2 Tanaka Tanaka NNP cord-004297-rm0zbgfm 80 3 [ [ -LRB- cord-004297-rm0zbgfm 80 4 17 17 CD cord-004297-rm0zbgfm 80 5 ] ] -RRB- cord-004297-rm0zbgfm 80 6 trial trial NN cord-004297-rm0zbgfm 80 7 administered administer VBD cord-004297-rm0zbgfm 80 8 90 90 CD cord-004297-rm0zbgfm 80 9 g g NN cord-004297-rm0zbgfm 80 10 / / SYM cord-004297-rm0zbgfm 80 11 day day NN cord-004297-rm0zbgfm 80 12 , , , cord-004297-rm0zbgfm 80 13 whereas whereas IN cord-004297-rm0zbgfm 80 14 the the DT cord-004297-rm0zbgfm 80 15 other other JJ cord-004297-rm0zbgfm 80 16 seven seven CD cord-004297-rm0zbgfm 80 17 trials trial NNS cord-004297-rm0zbgfm 80 18 administered administer VBN cord-004297-rm0zbgfm 80 19 from from IN cord-004297-rm0zbgfm 80 20 1 1 CD cord-004297-rm0zbgfm 80 21 to to IN cord-004297-rm0zbgfm 80 22 6 6 CD cord-004297-rm0zbgfm 80 23 g g NN cord-004297-rm0zbgfm 80 24 / / SYM cord-004297-rm0zbgfm 80 25 day day NN cord-004297-rm0zbgfm 80 26 . . . cord-004297-rm0zbgfm 81 1 Safaei Safaei NNP cord-004297-rm0zbgfm 81 2 et et NNP cord-004297-rm0zbgfm 81 3 al al NNP cord-004297-rm0zbgfm 81 4 . . . cord-004297-rm0zbgfm 82 1 [ [ -LRB- cord-004297-rm0zbgfm 82 2 15 15 CD cord-004297-rm0zbgfm 82 3 ] ] -RRB- cord-004297-rm0zbgfm 82 4 and and CC cord-004297-rm0zbgfm 82 5 Tanaka Tanaka NNP cord-004297-rm0zbgfm 82 6 et et NNP cord-004297-rm0zbgfm 82 7 al al NNP cord-004297-rm0zbgfm 82 8 . . . cord-004297-rm0zbgfm 83 1 [ [ -LRB- cord-004297-rm0zbgfm 83 2 17 17 CD cord-004297-rm0zbgfm 83 3 ] ] -RRB- cord-004297-rm0zbgfm 83 4 administered administer VBN cord-004297-rm0zbgfm 83 5 vitamin vitamin NN cord-004297-rm0zbgfm 83 6 C c NN cord-004297-rm0zbgfm 83 7 on on IN cord-004297-rm0zbgfm 83 8 a a DT cord-004297-rm0zbgfm 83 9 single single JJ cord-004297-rm0zbgfm 83 10 day day NN cord-004297-rm0zbgfm 83 11 only only RB cord-004297-rm0zbgfm 83 12 , , , cord-004297-rm0zbgfm 83 13 six six CD cord-004297-rm0zbgfm 83 14 trials trial NNS cord-004297-rm0zbgfm 83 15 administered administer VBN cord-004297-rm0zbgfm 83 16 for for IN cord-004297-rm0zbgfm 83 17 2 2 CD cord-004297-rm0zbgfm 83 18 - - SYM cord-004297-rm0zbgfm 83 19 5 5 CD cord-004297-rm0zbgfm 83 20 days day NNS cord-004297-rm0zbgfm 83 21 [ [ -LRB- cord-004297-rm0zbgfm 83 22 11 11 CD cord-004297-rm0zbgfm 83 23 - - SYM cord-004297-rm0zbgfm 83 24 13 13 CD cord-004297-rm0zbgfm 83 25 , , , cord-004297-rm0zbgfm 83 26 16 16 CD cord-004297-rm0zbgfm 83 27 , , , cord-004297-rm0zbgfm 83 28 18 18 CD cord-004297-rm0zbgfm 83 29 , , , cord-004297-rm0zbgfm 83 30 19 19 CD cord-004297-rm0zbgfm 83 31 ] ] -RRB- cord-004297-rm0zbgfm 83 32 , , , cord-004297-rm0zbgfm 83 33 and and CC cord-004297-rm0zbgfm 83 34 one one CD cord-004297-rm0zbgfm 83 35 administered administer VBN cord-004297-rm0zbgfm 83 36 " " '' cord-004297-rm0zbgfm 83 37 until until IN cord-004297-rm0zbgfm 83 38 ICU ICU NNP cord-004297-rm0zbgfm 83 39 discharge discharge NN cord-004297-rm0zbgfm 83 40 " " '' cord-004297-rm0zbgfm 83 41 for for IN cord-004297-rm0zbgfm 83 42 septic septic JJ cord-004297-rm0zbgfm 83 43 shock shock NN cord-004297-rm0zbgfm 83 44 patients patient NNS cord-004297-rm0zbgfm 83 45 [ [ -LRB- cord-004297-rm0zbgfm 83 46 14 14 CD cord-004297-rm0zbgfm 83 47 ] ] -RRB- cord-004297-rm0zbgfm 83 48 . . . cord-004297-rm0zbgfm 84 1 There there EX cord-004297-rm0zbgfm 84 2 is be VBZ cord-004297-rm0zbgfm 84 3 a a DT cord-004297-rm0zbgfm 84 4 250-fold 250-fold CD cord-004297-rm0zbgfm 84 5 variation variation NN cord-004297-rm0zbgfm 84 6 in in IN cord-004297-rm0zbgfm 84 7 the the DT cord-004297-rm0zbgfm 84 8 average average JJ cord-004297-rm0zbgfm 84 9 length length NN cord-004297-rm0zbgfm 84 10 of of IN cord-004297-rm0zbgfm 84 11 mechanical mechanical JJ cord-004297-rm0zbgfm 84 12 ventilation ventilation NN cord-004297-rm0zbgfm 84 13 in in IN cord-004297-rm0zbgfm 84 14 the the DT cord-004297-rm0zbgfm 84 15 untreated untreated JJ cord-004297-rm0zbgfm 84 16 groups group NNS cord-004297-rm0zbgfm 84 17 from from IN cord-004297-rm0zbgfm 84 18 2 2 CD cord-004297-rm0zbgfm 84 19 h h NN cord-004297-rm0zbgfm 84 20 [ [ -LRB- cord-004297-rm0zbgfm 84 21 16 16 CD cord-004297-rm0zbgfm 84 22 ] ] -RRB- cord-004297-rm0zbgfm 84 23 to to IN cord-004297-rm0zbgfm 84 24 511 511 CD cord-004297-rm0zbgfm 84 25 h h NN cord-004297-rm0zbgfm 84 26 [ [ -LRB- cord-004297-rm0zbgfm 84 27 17 17 CD cord-004297-rm0zbgfm 84 28 ] ] -RRB- cord-004297-rm0zbgfm 84 29 , , , cord-004297-rm0zbgfm 84 30 which which WDT cord-004297-rm0zbgfm 84 31 reflects reflect VBZ cord-004297-rm0zbgfm 84 32 great great JJ cord-004297-rm0zbgfm 84 33 variation variation NN cord-004297-rm0zbgfm 84 34 in in IN cord-004297-rm0zbgfm 84 35 the the DT cord-004297-rm0zbgfm 84 36 severity severity NN cord-004297-rm0zbgfm 84 37 of of IN cord-004297-rm0zbgfm 84 38 the the DT cord-004297-rm0zbgfm 84 39 baseline baseline JJ cord-004297-rm0zbgfm 84 40 medical medical JJ cord-004297-rm0zbgfm 84 41 condition condition NN cord-004297-rm0zbgfm 84 42 ( ( -LRB- cord-004297-rm0zbgfm 84 43 Table table NN cord-004297-rm0zbgfm 84 44 1 1 CD cord-004297-rm0zbgfm 84 45 ) ) -RRB- cord-004297-rm0zbgfm 84 46 . . . cord-004297-rm0zbgfm 85 1 Six six CD cord-004297-rm0zbgfm 85 2 trials trial NNS cord-004297-rm0zbgfm 85 3 were be VBD cord-004297-rm0zbgfm 85 4 randomized randomize VBN cord-004297-rm0zbgfm 85 5 [ [ -LRB- cord-004297-rm0zbgfm 85 6 11 11 CD cord-004297-rm0zbgfm 85 7 - - SYM cord-004297-rm0zbgfm 85 8 13 13 CD cord-004297-rm0zbgfm 85 9 , , , cord-004297-rm0zbgfm 85 10 15 15 CD cord-004297-rm0zbgfm 85 11 , , , cord-004297-rm0zbgfm 85 12 18 18 CD cord-004297-rm0zbgfm 85 13 , , , cord-004297-rm0zbgfm 85 14 19 19 CD cord-004297-rm0zbgfm 85 15 ] ] -RRB- cord-004297-rm0zbgfm 85 16 , , , cord-004297-rm0zbgfm 85 17 two two CD cord-004297-rm0zbgfm 85 18 used use VBN cord-004297-rm0zbgfm 85 19 alternative alternative NN cord-004297-rm0zbgfm 85 20 allocation allocation NN cord-004297-rm0zbgfm 85 21 [ [ -LRB- cord-004297-rm0zbgfm 85 22 14 14 CD cord-004297-rm0zbgfm 85 23 , , , cord-004297-rm0zbgfm 85 24 17 17 CD cord-004297-rm0zbgfm 85 25 ] ] -RRB- cord-004297-rm0zbgfm 85 26 , , , cord-004297-rm0zbgfm 85 27 and and CC cord-004297-rm0zbgfm 85 28 one one NN cord-004297-rm0zbgfm 85 29 did do VBD cord-004297-rm0zbgfm 85 30 not not RB cord-004297-rm0zbgfm 85 31 describe describe VB cord-004297-rm0zbgfm 85 32 the the DT cord-004297-rm0zbgfm 85 33 allocation allocation NN cord-004297-rm0zbgfm 85 34 method method NN cord-004297-rm0zbgfm 85 35 [ [ -LRB- cord-004297-rm0zbgfm 85 36 16 16 CD cord-004297-rm0zbgfm 85 37 ] ] -RRB- cord-004297-rm0zbgfm 85 38 . . . cord-004297-rm0zbgfm 86 1 The the DT cord-004297-rm0zbgfm 86 2 reported report VBN cord-004297-rm0zbgfm 86 3 baseline baseline JJ cord-004297-rm0zbgfm 86 4 variables variable NNS cord-004297-rm0zbgfm 86 5 for for IN cord-004297-rm0zbgfm 86 6 the the DT cord-004297-rm0zbgfm 86 7 treatment treatment NN cord-004297-rm0zbgfm 86 8 groups group NNS cord-004297-rm0zbgfm 86 9 were be VBD cord-004297-rm0zbgfm 86 10 balanced balance VBN cord-004297-rm0zbgfm 86 11 in in IN cord-004297-rm0zbgfm 86 12 all all DT cord-004297-rm0zbgfm 86 13 trials trial NNS cord-004297-rm0zbgfm 86 14 ( ( -LRB- cord-004297-rm0zbgfm 86 15 Additional additional JJ cord-004297-rm0zbgfm 86 16 file file NN cord-004297-rm0zbgfm 86 17 1 1 CD cord-004297-rm0zbgfm 86 18 : : : cord-004297-rm0zbgfm 86 19 Table Table NNP cord-004297-rm0zbgfm 86 20 S1 S1 NNP cord-004297-rm0zbgfm 86 21 ) ) -RRB- cord-004297-rm0zbgfm 86 22 . . . cord-004297-rm0zbgfm 87 1 The the DT cord-004297-rm0zbgfm 87 2 risk risk NN cord-004297-rm0zbgfm 87 3 of of IN cord-004297-rm0zbgfm 87 4 bias bias NN cord-004297-rm0zbgfm 87 5 assessment assessment NN cord-004297-rm0zbgfm 87 6 of of IN cord-004297-rm0zbgfm 87 7 the the DT cord-004297-rm0zbgfm 87 8 trials trial NNS cord-004297-rm0zbgfm 87 9 is be VBZ cord-004297-rm0zbgfm 87 10 shown show VBN cord-004297-rm0zbgfm 87 11 in in IN cord-004297-rm0zbgfm 87 12 Fig Fig NNP cord-004297-rm0zbgfm 87 13 . . . cord-004297-rm0zbgfm 88 1 2 2 LS cord-004297-rm0zbgfm 88 2 . . . cord-004297-rm0zbgfm 89 1 Four four CD cord-004297-rm0zbgfm 89 2 trials trial NNS cord-004297-rm0zbgfm 89 3 used use VBD cord-004297-rm0zbgfm 89 4 an an DT cord-004297-rm0zbgfm 89 5 explicit explicit JJ cord-004297-rm0zbgfm 89 6 placebo placebo NN cord-004297-rm0zbgfm 89 7 [ [ -LRB- cord-004297-rm0zbgfm 89 8 11 11 CD cord-004297-rm0zbgfm 89 9 , , , cord-004297-rm0zbgfm 89 10 16 16 CD cord-004297-rm0zbgfm 89 11 , , , cord-004297-rm0zbgfm 89 12 18 18 CD cord-004297-rm0zbgfm 89 13 , , , cord-004297-rm0zbgfm 89 14 19 19 CD cord-004297-rm0zbgfm 89 15 ] ] -RRB- cord-004297-rm0zbgfm 89 16 . . . cord-004297-rm0zbgfm 90 1 The the DT cord-004297-rm0zbgfm 90 2 trial trial NN cord-004297-rm0zbgfm 90 3 by by IN cord-004297-rm0zbgfm 90 4 Sadeghpour Sadeghpour NNP cord-004297-rm0zbgfm 90 5 et et FW cord-004297-rm0zbgfm 90 6 al al NNP cord-004297-rm0zbgfm 90 7 . . . cord-004297-rm0zbgfm 91 1 [ [ -LRB- cord-004297-rm0zbgfm 91 2 19 19 CD cord-004297-rm0zbgfm 91 3 ] ] -RRB- cord-004297-rm0zbgfm 91 4 had have VBD cord-004297-rm0zbgfm 91 5 a a DT cord-004297-rm0zbgfm 91 6 high high JJ cord-004297-rm0zbgfm 91 7 dropout dropout NN cord-004297-rm0zbgfm 91 8 rate rate NN cord-004297-rm0zbgfm 91 9 , , , cord-004297-rm0zbgfm 91 10 with with IN cord-004297-rm0zbgfm 91 11 500 500 CD cord-004297-rm0zbgfm 91 12 participants participant NNS cord-004297-rm0zbgfm 91 13 recruited recruit VBN cord-004297-rm0zbgfm 91 14 , , , cord-004297-rm0zbgfm 91 15 but but CC cord-004297-rm0zbgfm 91 16 results result NNS cord-004297-rm0zbgfm 91 17 were be VBD cord-004297-rm0zbgfm 91 18 reported report VBN cord-004297-rm0zbgfm 91 19 for for IN cord-004297-rm0zbgfm 91 20 just just RB cord-004297-rm0zbgfm 91 21 290 290 CD cord-004297-rm0zbgfm 91 22 participants participant NNS cord-004297-rm0zbgfm 91 23 [ [ -LRB- cord-004297-rm0zbgfm 91 24 1 1 CD cord-004297-rm0zbgfm 91 25 ] ] -RRB- cord-004297-rm0zbgfm 91 26 . . . cord-004297-rm0zbgfm 92 1 We -PRON- PRP cord-004297-rm0zbgfm 92 2 did do VBD cord-004297-rm0zbgfm 92 3 not not RB cord-004297-rm0zbgfm 92 4 include include VB cord-004297-rm0zbgfm 92 5 this this DT cord-004297-rm0zbgfm 92 6 trial trial NN cord-004297-rm0zbgfm 92 7 in in IN cord-004297-rm0zbgfm 92 8 our -PRON- PRP$ cord-004297-rm0zbgfm 92 9 statistical statistical JJ cord-004297-rm0zbgfm 92 10 models model NNS cord-004297-rm0zbgfm 92 11 , , , cord-004297-rm0zbgfm 92 12 but but CC cord-004297-rm0zbgfm 92 13 the the DT cord-004297-rm0zbgfm 92 14 results result NNS cord-004297-rm0zbgfm 92 15 are be VBP cord-004297-rm0zbgfm 92 16 presented present VBN cord-004297-rm0zbgfm 92 17 separately separately RB cord-004297-rm0zbgfm 92 18 . . . cord-004297-rm0zbgfm 93 1 In in IN cord-004297-rm0zbgfm 93 2 our -PRON- PRP$ cord-004297-rm0zbgfm 93 3 standard standard JJ cord-004297-rm0zbgfm 93 4 meta meta JJ cord-004297-rm0zbgfm 93 5 - - HYPH cord-004297-rm0zbgfm 93 6 analyses analysis NNS cord-004297-rm0zbgfm 93 7 , , , cord-004297-rm0zbgfm 93 8 we -PRON- PRP cord-004297-rm0zbgfm 93 9 pooled pool VBD cord-004297-rm0zbgfm 93 10 the the DT cord-004297-rm0zbgfm 93 11 results result NNS cord-004297-rm0zbgfm 93 12 of of IN cord-004297-rm0zbgfm 93 13 the the DT cord-004297-rm0zbgfm 93 14 trials trial NNS cord-004297-rm0zbgfm 93 15 on on IN cord-004297-rm0zbgfm 93 16 the the DT cord-004297-rm0zbgfm 93 17 relative relative JJ cord-004297-rm0zbgfm 93 18 scale scale NN cord-004297-rm0zbgfm 93 19 , , , cord-004297-rm0zbgfm 93 20 calculating calculate VBG cord-004297-rm0zbgfm 93 21 the the DT cord-004297-rm0zbgfm 93 22 ratio ratio NN cord-004297-rm0zbgfm 93 23 of of IN cord-004297-rm0zbgfm 93 24 means mean NNS cord-004297-rm0zbgfm 93 25 The the DT cord-004297-rm0zbgfm 93 26 trials trial NNS cord-004297-rm0zbgfm 93 27 are be VBP cord-004297-rm0zbgfm 93 28 listed list VBN cord-004297-rm0zbgfm 93 29 by by IN cord-004297-rm0zbgfm 93 30 the the DT cord-004297-rm0zbgfm 93 31 number number NN cord-004297-rm0zbgfm 93 32 of of IN cord-004297-rm0zbgfm 93 33 patients patient NNS cord-004297-rm0zbgfm 93 34 ( ( -LRB- cord-004297-rm0zbgfm 93 35 N N NNP cord-004297-rm0zbgfm 93 36 ) ) -RRB- cord-004297-rm0zbgfm 93 37 . . . cord-004297-rm0zbgfm 94 1 The the DT cord-004297-rm0zbgfm 94 2 mean mean JJ cord-004297-rm0zbgfm 94 3 age age NN cord-004297-rm0zbgfm 94 4 in in IN cord-004297-rm0zbgfm 94 5 the the DT cord-004297-rm0zbgfm 94 6 trials trial NNS cord-004297-rm0zbgfm 94 7 ranged range VBD cord-004297-rm0zbgfm 94 8 from from IN cord-004297-rm0zbgfm 94 9 42 42 CD cord-004297-rm0zbgfm 94 10 to to TO cord-004297-rm0zbgfm 94 11 64 64 CD cord-004297-rm0zbgfm 94 12 years year NNS cord-004297-rm0zbgfm 94 13 , , , cord-004297-rm0zbgfm 94 14 with with IN cord-004297-rm0zbgfm 94 15 a a DT cord-004297-rm0zbgfm 94 16 median median NN cord-004297-rm0zbgfm 94 17 of of IN cord-004297-rm0zbgfm 94 18 60 60 CD cord-004297-rm0zbgfm 94 19 years year NNS cord-004297-rm0zbgfm 94 20 . . . cord-004297-rm0zbgfm 95 1 The the DT cord-004297-rm0zbgfm 95 2 proportion proportion NN cord-004297-rm0zbgfm 95 3 of of IN cord-004297-rm0zbgfm 95 4 males male NNS cord-004297-rm0zbgfm 95 5 varied vary VBN cord-004297-rm0zbgfm 95 6 from from IN cord-004297-rm0zbgfm 95 7 58 58 CD cord-004297-rm0zbgfm 95 8 % % NN cord-004297-rm0zbgfm 95 9 to to TO cord-004297-rm0zbgfm 95 10 75 75 CD cord-004297-rm0zbgfm 95 11 % % NN cord-004297-rm0zbgfm 95 12 . . . cord-004297-rm0zbgfm 96 1 Five five CD cord-004297-rm0zbgfm 96 2 trials trial NNS cord-004297-rm0zbgfm 96 3 were be VBD cord-004297-rm0zbgfm 96 4 carried carry VBN cord-004297-rm0zbgfm 96 5 out out RP cord-004297-rm0zbgfm 96 6 in in IN cord-004297-rm0zbgfm 96 7 Iran Iran NNP cord-004297-rm0zbgfm 96 8 [ [ -LRB- cord-004297-rm0zbgfm 96 9 12 12 CD cord-004297-rm0zbgfm 96 10 , , , cord-004297-rm0zbgfm 96 11 13 13 CD cord-004297-rm0zbgfm 96 12 , , , cord-004297-rm0zbgfm 96 13 15 15 CD cord-004297-rm0zbgfm 96 14 , , , cord-004297-rm0zbgfm 96 15 18 18 CD cord-004297-rm0zbgfm 96 16 , , , cord-004297-rm0zbgfm 96 17 19 19 CD cord-004297-rm0zbgfm 96 18 ] ] -RRB- cord-004297-rm0zbgfm 96 19 , , , cord-004297-rm0zbgfm 96 20 two two CD cord-004297-rm0zbgfm 96 21 in in IN cord-004297-rm0zbgfm 96 22 Egypt Egypt NNP cord-004297-rm0zbgfm 96 23 [ [ -LRB- cord-004297-rm0zbgfm 96 24 14 14 CD cord-004297-rm0zbgfm 96 25 , , , cord-004297-rm0zbgfm 96 26 16 16 CD cord-004297-rm0zbgfm 96 27 ] ] -RRB- cord-004297-rm0zbgfm 96 28 , , , cord-004297-rm0zbgfm 96 29 one one CD cord-004297-rm0zbgfm 96 30 in in IN cord-004297-rm0zbgfm 96 31 the the DT cord-004297-rm0zbgfm 96 32 USA USA NNP cord-004297-rm0zbgfm 96 33 [ [ -LRB- cord-004297-rm0zbgfm 96 34 11 11 CD cord-004297-rm0zbgfm 96 35 ] ] -RRB- cord-004297-rm0zbgfm 96 36 , , , cord-004297-rm0zbgfm 96 37 and and CC cord-004297-rm0zbgfm 96 38 one one CD cord-004297-rm0zbgfm 96 39 in in IN cord-004297-rm0zbgfm 96 40 Japan Japan NNP cord-004297-rm0zbgfm 96 41 [ [ -LRB- cord-004297-rm0zbgfm 96 42 17 17 CD cord-004297-rm0zbgfm 96 43 ] ] -RRB- cord-004297-rm0zbgfm 96 44 . . . cord-004297-rm0zbgfm 97 1 For for IN cord-004297-rm0zbgfm 97 2 detailed detailed JJ cord-004297-rm0zbgfm 97 3 descriptions description NNS cord-004297-rm0zbgfm 97 4 of of IN cord-004297-rm0zbgfm 97 5 the the DT cord-004297-rm0zbgfm 97 6 trials trial NNS cord-004297-rm0zbgfm 97 7 , , , cord-004297-rm0zbgfm 97 8 see see VB cord-004297-rm0zbgfm 97 9 Additional additional JJ cord-004297-rm0zbgfm 97 10 file file NN cord-004297-rm0zbgfm 97 11 1 1 CD cord-004297-rm0zbgfm 97 12 : : : cord-004297-rm0zbgfm 97 13 Table table NN cord-004297-rm0zbgfm 97 14 S1 S1 NNP cord-004297-rm0zbgfm 97 15 . . . cord-004297-rm0zbgfm 98 1 The the DT cord-004297-rm0zbgfm 98 2 Amini Amini NNP cord-004297-rm0zbgfm 98 3 trial trial NN cord-004297-rm0zbgfm 98 4 [ [ -LRB- cord-004297-rm0zbgfm 98 5 12 12 CD cord-004297-rm0zbgfm 98 6 ] ] -RRB- cord-004297-rm0zbgfm 98 7 results result NNS cord-004297-rm0zbgfm 98 8 are be VBP cord-004297-rm0zbgfm 98 9 modified modify VBN cord-004297-rm0zbgfm 98 10 as as IN cord-004297-rm0zbgfm 98 11 described describe VBN cord-004297-rm0zbgfm 98 12 previously previously RB cord-004297-rm0zbgfm 98 13 [ [ -LRB- cord-004297-rm0zbgfm 98 14 1 1 CD cord-004297-rm0zbgfm 98 15 ] ] -RRB- cord-004297-rm0zbgfm 99 1 * * NFP cord-004297-rm0zbgfm 99 2 Estimated estimate VBN cord-004297-rm0zbgfm 99 3 vitamin vitamin NN cord-004297-rm0zbgfm 99 4 C C NNP cord-004297-rm0zbgfm 99 5 dose dose NN cord-004297-rm0zbgfm 99 6 , , , cord-004297-rm0zbgfm 99 7 see see VB cord-004297-rm0zbgfm 99 8 the the DT cord-004297-rm0zbgfm 99 9 " " `` cord-004297-rm0zbgfm 99 10 Methods method NNS cord-004297-rm0zbgfm 99 11 " " '' cord-004297-rm0zbgfm 99 12 section section NN cord-004297-rm0zbgfm 100 1 * * NFP cord-004297-rm0zbgfm 100 2 * * NFP cord-004297-rm0zbgfm 100 3 Sadeghpour Sadeghpour NNP cord-004297-rm0zbgfm 100 4 et et FW cord-004297-rm0zbgfm 100 5 al al NNP cord-004297-rm0zbgfm 100 6 . . . cord-004297-rm0zbgfm 101 1 [ [ -LRB- cord-004297-rm0zbgfm 101 2 19 19 CD cord-004297-rm0zbgfm 101 3 ] ] -RRB- cord-004297-rm0zbgfm 101 4 recruited recruit VBD cord-004297-rm0zbgfm 101 5 500 500 CD cord-004297-rm0zbgfm 101 6 participants participant NNS cord-004297-rm0zbgfm 101 7 but but CC cord-004297-rm0zbgfm 101 8 reported report VBD cord-004297-rm0zbgfm 101 9 the the DT cord-004297-rm0zbgfm 101 10 results result NNS cord-004297-rm0zbgfm 101 11 for for IN cord-004297-rm0zbgfm 101 12 just just RB cord-004297-rm0zbgfm 101 13 290 290 CD cord-004297-rm0zbgfm 101 14 participants participant NNS cord-004297-rm0zbgfm 101 15 [ [ -LRB- cord-004297-rm0zbgfm 101 16 1 1 CD cord-004297-rm0zbgfm 101 17 ] ] -RRB- cord-004297-rm0zbgfm 101 18 . . . cord-004297-rm0zbgfm 102 1 Because because IN cord-004297-rm0zbgfm 102 2 of of IN cord-004297-rm0zbgfm 102 3 the the DT cord-004297-rm0zbgfm 102 4 high high JJ cord-004297-rm0zbgfm 102 5 dropout dropout NN cord-004297-rm0zbgfm 102 6 rate rate NN cord-004297-rm0zbgfm 102 7 ( ( -LRB- cord-004297-rm0zbgfm 102 8 42 42 CD cord-004297-rm0zbgfm 102 9 % % NN cord-004297-rm0zbgfm 102 10 ) ) -RRB- cord-004297-rm0zbgfm 102 11 , , , cord-004297-rm0zbgfm 102 12 we -PRON- PRP cord-004297-rm0zbgfm 102 13 did do VBD cord-004297-rm0zbgfm 102 14 not not RB cord-004297-rm0zbgfm 102 15 include include VB cord-004297-rm0zbgfm 102 16 this this DT cord-004297-rm0zbgfm 102 17 trial trial NN cord-004297-rm0zbgfm 102 18 in in IN cord-004297-rm0zbgfm 102 19 our -PRON- PRP$ cord-004297-rm0zbgfm 102 20 calculations calculation NNS cord-004297-rm0zbgfm 102 21 , , , cord-004297-rm0zbgfm 102 22 but but CC cord-004297-rm0zbgfm 102 23 we -PRON- PRP cord-004297-rm0zbgfm 102 24 overlay overlay VBP cord-004297-rm0zbgfm 102 25 the the DT cord-004297-rm0zbgfm 102 26 findings finding NNS cord-004297-rm0zbgfm 102 27 in in IN cord-004297-rm0zbgfm 102 28 Fig Fig NNP cord-004297-rm0zbgfm 102 29 . . . cord-004297-rm0zbgfm 103 1 4 4 LS cord-004297-rm0zbgfm 104 1 iv iv LS cord-004297-rm0zbgfm 104 2 intravenous intravenous NNP cord-004297-rm0zbgfm 104 3 , , , cord-004297-rm0zbgfm 104 4 po po NNP cord-004297-rm0zbgfm 104 5 per per IN cord-004297-rm0zbgfm 104 6 oral oral JJ cord-004297-rm0zbgfm 104 7 , , , cord-004297-rm0zbgfm 104 8 RoM rom NN cord-004297-rm0zbgfm 104 9 ratio ratio NN cord-004297-rm0zbgfm 104 10 of of IN cord-004297-rm0zbgfm 104 11 means mean NNS cord-004297-rm0zbgfm 104 12 [ [ -LRB- cord-004297-rm0zbgfm 104 13 22 22 CD cord-004297-rm0zbgfm 104 14 ] ] -RRB- cord-004297-rm0zbgfm 104 15 : : : cord-004297-rm0zbgfm 104 16 e.g. e.g. RB cord-004297-rm0zbgfm 104 17 , , , cord-004297-rm0zbgfm 104 18 for for IN cord-004297-rm0zbgfm 104 19 the the DT cord-004297-rm0zbgfm 104 20 Bjordahl Bjordahl NNP cord-004297-rm0zbgfm 104 21 trial trial NN cord-004297-rm0zbgfm 104 22 [ [ -LRB- cord-004297-rm0zbgfm 104 23 11 11 CD cord-004297-rm0zbgfm 104 24 ] ] -RRB- cord-004297-rm0zbgfm 104 25 , , , cord-004297-rm0zbgfm 104 26 RoM rom NN cord-004297-rm0zbgfm 104 27 = = SYM cord-004297-rm0zbgfm 104 28 0.86 0.86 CD cord-004297-rm0zbgfm 104 29 , , , cord-004297-rm0zbgfm 104 30 based base VBN cord-004297-rm0zbgfm 104 31 on on IN cord-004297-rm0zbgfm 104 32 28.8/33.6 28.8/33.6 CD cord-004297-rm0zbgfm 104 33 , , , cord-004297-rm0zbgfm 104 34 and and CC cord-004297-rm0zbgfm 104 35 RoM rom NN cord-004297-rm0zbgfm 104 36 = = SYM cord-004297-rm0zbgfm 104 37 0.86 0.86 CD cord-004297-rm0zbgfm 104 38 indicates indicate VBZ cord-004297-rm0zbgfm 104 39 that that IN cord-004297-rm0zbgfm 104 40 ventilation ventilation NN cord-004297-rm0zbgfm 104 41 time time NN cord-004297-rm0zbgfm 104 42 in in IN cord-004297-rm0zbgfm 104 43 the the DT cord-004297-rm0zbgfm 104 44 vitamin vitamin NN cord-004297-rm0zbgfm 104 45 C C NNP cord-004297-rm0zbgfm 104 46 group group NN cord-004297-rm0zbgfm 104 47 was be VBD cord-004297-rm0zbgfm 104 48 14 14 CD cord-004297-rm0zbgfm 104 49 % % NN cord-004297-rm0zbgfm 104 50 shorter short JJR cord-004297-rm0zbgfm 104 51 than than IN cord-004297-rm0zbgfm 104 52 in in IN cord-004297-rm0zbgfm 104 53 the the DT cord-004297-rm0zbgfm 104 54 placebo placebo NN cord-004297-rm0zbgfm 104 55 group group NN cord-004297-rm0zbgfm 104 56 ( ( -LRB- cord-004297-rm0zbgfm 104 57 RoM rom NN cord-004297-rm0zbgfm 104 58 ) ) -RRB- cord-004297-rm0zbgfm 105 1 [ [ -LRB- cord-004297-rm0zbgfm 105 2 22 22 CD cord-004297-rm0zbgfm 105 3 ] ] -RRB- cord-004297-rm0zbgfm 105 4 . . . cord-004297-rm0zbgfm 106 1 For for IN cord-004297-rm0zbgfm 106 2 example example NN cord-004297-rm0zbgfm 106 3 , , , cord-004297-rm0zbgfm 106 4 in in IN cord-004297-rm0zbgfm 106 5 the the DT cord-004297-rm0zbgfm 106 6 Bjordahl Bjordahl NNP cord-004297-rm0zbgfm 106 7 trial trial NN cord-004297-rm0zbgfm 106 8 [ [ -LRB- cord-004297-rm0zbgfm 106 9 11 11 CD cord-004297-rm0zbgfm 106 10 ] ] -RRB- cord-004297-rm0zbgfm 106 11 , , , cord-004297-rm0zbgfm 106 12 the the DT cord-004297-rm0zbgfm 106 13 length length NN cord-004297-rm0zbgfm 106 14 of of IN cord-004297-rm0zbgfm 106 15 mechanical mechanical JJ cord-004297-rm0zbgfm 106 16 ventilation ventilation NN cord-004297-rm0zbgfm 106 17 was be VBD cord-004297-rm0zbgfm 106 18 28.8 28.8 CD cord-004297-rm0zbgfm 106 19 h h NN cord-004297-rm0zbgfm 106 20 in in IN cord-004297-rm0zbgfm 106 21 the the DT cord-004297-rm0zbgfm 106 22 vitamin vitamin NN cord-004297-rm0zbgfm 106 23 C C NNP cord-004297-rm0zbgfm 106 24 group group NN cord-004297-rm0zbgfm 106 25 and and CC cord-004297-rm0zbgfm 106 26 33.6 33.6 CD cord-004297-rm0zbgfm 106 27 h h NN cord-004297-rm0zbgfm 106 28 in in IN cord-004297-rm0zbgfm 106 29 the the DT cord-004297-rm0zbgfm 106 30 placebo placebo NN cord-004297-rm0zbgfm 106 31 group group NN cord-004297-rm0zbgfm 106 32 , , , cord-004297-rm0zbgfm 106 33 which which WDT cord-004297-rm0zbgfm 106 34 corresponds correspond VBZ cord-004297-rm0zbgfm 106 35 to to IN cord-004297-rm0zbgfm 106 36 RoM rom NN cord-004297-rm0zbgfm 106 37 = = SYM cord-004297-rm0zbgfm 106 38 0.86 0.86 CD cord-004297-rm0zbgfm 106 39 ( ( -LRB- cord-004297-rm0zbgfm 106 40 28.8/33.6 28.8/33.6 CD cord-004297-rm0zbgfm 106 41 ) ) -RRB- cord-004297-rm0zbgfm 107 1 ( ( -LRB- cord-004297-rm0zbgfm 107 2 Table table NN cord-004297-rm0zbgfm 107 3 1 1 CD cord-004297-rm0zbgfm 107 4 ) ) -RRB- cord-004297-rm0zbgfm 107 5 . . . cord-004297-rm0zbgfm 108 1 This this DT cord-004297-rm0zbgfm 108 2 represents represent VBZ cord-004297-rm0zbgfm 108 3 a a DT cord-004297-rm0zbgfm 108 4 14 14 CD cord-004297-rm0zbgfm 108 5 % % NN cord-004297-rm0zbgfm 108 6 shorter short JJR cord-004297-rm0zbgfm 108 7 ventilation ventilation NN cord-004297-rm0zbgfm 108 8 time time NN cord-004297-rm0zbgfm 108 9 in in IN cord-004297-rm0zbgfm 108 10 the the DT cord-004297-rm0zbgfm 108 11 vitamin vitamin NN cord-004297-rm0zbgfm 108 12 C C NNP cord-004297-rm0zbgfm 108 13 group group NN cord-004297-rm0zbgfm 108 14 . . . cord-004297-rm0zbgfm 109 1 Over over IN cord-004297-rm0zbgfm 109 2 the the DT cord-004297-rm0zbgfm 109 3 eight eight CD cord-004297-rm0zbgfm 109 4 included include VBD cord-004297-rm0zbgfm 109 5 trials trial NNS cord-004297-rm0zbgfm 109 6 with with IN cord-004297-rm0zbgfm 109 7 685 685 CD cord-004297-rm0zbgfm 109 8 patients patient NNS cord-004297-rm0zbgfm 109 9 in in IN cord-004297-rm0zbgfm 109 10 total total NN cord-004297-rm0zbgfm 109 11 , , , cord-004297-rm0zbgfm 109 12 vitamin vitamin NN cord-004297-rm0zbgfm 109 13 C c NN cord-004297-rm0zbgfm 109 14 shortened shorten VBD cord-004297-rm0zbgfm 109 15 the the DT cord-004297-rm0zbgfm 109 16 length length NN cord-004297-rm0zbgfm 109 17 of of IN cord-004297-rm0zbgfm 109 18 mechanical mechanical JJ cord-004297-rm0zbgfm 109 19 ventilation ventilation NN cord-004297-rm0zbgfm 109 20 on on IN cord-004297-rm0zbgfm 109 21 average average JJ cord-004297-rm0zbgfm 109 22 by by IN cord-004297-rm0zbgfm 109 23 14 14 CD cord-004297-rm0zbgfm 109 24 % % NN cord-004297-rm0zbgfm 110 1 ( ( -LRB- cord-004297-rm0zbgfm 110 2 P p NN cord-004297-rm0zbgfm 110 3 = = SYM cord-004297-rm0zbgfm 110 4 10 10 CD cord-004297-rm0zbgfm 110 5 −5 −5 NN cord-004297-rm0zbgfm 110 6 ) ) -RRB- cord-004297-rm0zbgfm 111 1 ( ( -LRB- cord-004297-rm0zbgfm 111 2 Fig Fig NNP cord-004297-rm0zbgfm 111 3 . . . cord-004297-rm0zbgfm 111 4 3 3 CD cord-004297-rm0zbgfm 111 5 ) ) -RRB- cord-004297-rm0zbgfm 111 6 . . . cord-004297-rm0zbgfm 112 1 However however RB cord-004297-rm0zbgfm 112 2 , , , cord-004297-rm0zbgfm 112 3 there there EX cord-004297-rm0zbgfm 112 4 was be VBD cord-004297-rm0zbgfm 112 5 highly highly RB cord-004297-rm0zbgfm 112 6 significant significant JJ cord-004297-rm0zbgfm 112 7 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 112 8 in in IN cord-004297-rm0zbgfm 112 9 the the DT cord-004297-rm0zbgfm 112 10 vitamin vitamin NN cord-004297-rm0zbgfm 112 11 C c NN cord-004297-rm0zbgfm 112 12 effect effect NN cord-004297-rm0zbgfm 112 13 between between IN cord-004297-rm0zbgfm 112 14 the the DT cord-004297-rm0zbgfm 112 15 trials trial NNS cord-004297-rm0zbgfm 112 16 with with IN cord-004297-rm0zbgfm 112 17 I i NN cord-004297-rm0zbgfm 112 18 2 2 CD cord-004297-rm0zbgfm 112 19 = = SYM cord-004297-rm0zbgfm 112 20 83 83 CD cord-004297-rm0zbgfm 112 21 % % NN cord-004297-rm0zbgfm 112 22 ( ( -LRB- cord-004297-rm0zbgfm 112 23 P p NN cord-004297-rm0zbgfm 112 24 = = SYM cord-004297-rm0zbgfm 112 25 4.8 4.8 CD cord-004297-rm0zbgfm 112 26 × × NN cord-004297-rm0zbgfm 112 27 10 10 CD cord-004297-rm0zbgfm 112 28 −7 −7 NNP cord-004297-rm0zbgfm 112 29 ) ) -RRB- cord-004297-rm0zbgfm 112 30 . . . cord-004297-rm0zbgfm 113 1 This this DT cord-004297-rm0zbgfm 113 2 indicates indicate VBZ cord-004297-rm0zbgfm 113 3 that that IN cord-004297-rm0zbgfm 113 4 the the DT cord-004297-rm0zbgfm 113 5 calculated calculate VBN cord-004297-rm0zbgfm 113 6 average average JJ cord-004297-rm0zbgfm 113 7 effect effect NN cord-004297-rm0zbgfm 113 8 of of IN cord-004297-rm0zbgfm 113 9 14 14 CD cord-004297-rm0zbgfm 113 10 % % NN cord-004297-rm0zbgfm 113 11 is be VBZ cord-004297-rm0zbgfm 113 12 not not RB cord-004297-rm0zbgfm 113 13 consistent consistent JJ cord-004297-rm0zbgfm 113 14 over over IN cord-004297-rm0zbgfm 113 15 all all PDT cord-004297-rm0zbgfm 113 16 the the DT cord-004297-rm0zbgfm 113 17 included include VBN cord-004297-rm0zbgfm 113 18 trials trial NNS cord-004297-rm0zbgfm 113 19 . . . cord-004297-rm0zbgfm 114 1 In in IN cord-004297-rm0zbgfm 114 2 a a DT cord-004297-rm0zbgfm 114 3 meta meta JJ cord-004297-rm0zbgfm 114 4 - - HYPH cord-004297-rm0zbgfm 114 5 regression regression NN cord-004297-rm0zbgfm 114 6 analysis analysis NN cord-004297-rm0zbgfm 114 7 , , , cord-004297-rm0zbgfm 114 8 we -PRON- PRP cord-004297-rm0zbgfm 114 9 found find VBD cord-004297-rm0zbgfm 114 10 that that IN cord-004297-rm0zbgfm 114 11 the the DT cord-004297-rm0zbgfm 114 12 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 114 13 between between IN cord-004297-rm0zbgfm 114 14 the the DT cord-004297-rm0zbgfm 114 15 trials trial NNS cord-004297-rm0zbgfm 114 16 was be VBD cord-004297-rm0zbgfm 114 17 explained explain VBN cord-004297-rm0zbgfm 114 18 by by IN cord-004297-rm0zbgfm 114 19 the the DT cord-004297-rm0zbgfm 114 20 length length NN cord-004297-rm0zbgfm 114 21 of of IN cord-004297-rm0zbgfm 114 22 mechanical mechanical JJ cord-004297-rm0zbgfm 114 23 ventilation ventilation NN cord-004297-rm0zbgfm 114 24 in in IN cord-004297-rm0zbgfm 114 25 the the DT cord-004297-rm0zbgfm 114 26 untreated untreated JJ cord-004297-rm0zbgfm 114 27 control control NN cord-004297-rm0zbgfm 114 28 group group NN cord-004297-rm0zbgfm 114 29 ( ( -LRB- cord-004297-rm0zbgfm 114 30 Fig Fig NNP cord-004297-rm0zbgfm 114 31 . . NNP cord-004297-rm0zbgfm 114 32 4 4 CD cord-004297-rm0zbgfm 114 33 ) ) -RRB- cord-004297-rm0zbgfm 114 34 . . . cord-004297-rm0zbgfm 115 1 The the DT cord-004297-rm0zbgfm 115 2 evidence evidence NN cord-004297-rm0zbgfm 115 3 for for IN cord-004297-rm0zbgfm 115 4 modification modification NN cord-004297-rm0zbgfm 115 5 of of IN cord-004297-rm0zbgfm 115 6 the the DT cord-004297-rm0zbgfm 115 7 vitamin vitamin NN cord-004297-rm0zbgfm 115 8 C c NN cord-004297-rm0zbgfm 115 9 effect effect NN cord-004297-rm0zbgfm 115 10 by by IN cord-004297-rm0zbgfm 115 11 the the DT cord-004297-rm0zbgfm 115 12 untreated untreated JJ cord-004297-rm0zbgfm 115 13 ventilation ventilation NN cord-004297-rm0zbgfm 115 14 time time NN cord-004297-rm0zbgfm 115 15 was be VBD cord-004297-rm0zbgfm 115 16 very very RB cord-004297-rm0zbgfm 115 17 strong strong JJ cord-004297-rm0zbgfm 116 1 ( ( -LRB- cord-004297-rm0zbgfm 116 2 P p NN cord-004297-rm0zbgfm 116 3 = = SYM cord-004297-rm0zbgfm 116 4 10 10 CD cord-004297-rm0zbgfm 116 5 −7 −7 NNP cord-004297-rm0zbgfm 116 6 ) ) -RRB- cord-004297-rm0zbgfm 116 7 . . . cord-004297-rm0zbgfm 117 1 There there EX cord-004297-rm0zbgfm 117 2 is be VBZ cord-004297-rm0zbgfm 117 3 little little JJ cord-004297-rm0zbgfm 117 4 residual residual JJ cord-004297-rm0zbgfm 117 5 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 117 6 around around IN cord-004297-rm0zbgfm 117 7 the the DT cord-004297-rm0zbgfm 117 8 regression regression NN cord-004297-rm0zbgfm 117 9 line line NN cord-004297-rm0zbgfm 117 10 with with IN cord-004297-rm0zbgfm 117 11 I i NN cord-004297-rm0zbgfm 117 12 2 2 CD cord-004297-rm0zbgfm 117 13 = = SYM cord-004297-rm0zbgfm 117 14 12 12 CD cord-004297-rm0zbgfm 117 15 % % NN cord-004297-rm0zbgfm 117 16 ( ( -LRB- cord-004297-rm0zbgfm 117 17 P p NN cord-004297-rm0zbgfm 117 18 = = SYM cord-004297-rm0zbgfm 117 19 0.3 0.3 CD cord-004297-rm0zbgfm 117 20 ) ) -RRB- cord-004297-rm0zbgfm 117 21 , , , cord-004297-rm0zbgfm 117 22 which which WDT cord-004297-rm0zbgfm 117 23 indicates indicate VBZ cord-004297-rm0zbgfm 117 24 that that IN cord-004297-rm0zbgfm 117 25 the the DT cord-004297-rm0zbgfm 117 26 meta meta JJ cord-004297-rm0zbgfm 117 27 - - HYPH cord-004297-rm0zbgfm 117 28 regression regression NN cord-004297-rm0zbgfm 117 29 in in IN cord-004297-rm0zbgfm 117 30 Fig Fig NNP cord-004297-rm0zbgfm 117 31 . . . cord-004297-rm0zbgfm 118 1 4 4 LS cord-004297-rm0zbgfm 118 2 much much RB cord-004297-rm0zbgfm 118 3 better well JJR cord-004297-rm0zbgfm 118 4 captures capture VBZ cord-004297-rm0zbgfm 118 5 the the DT cord-004297-rm0zbgfm 118 6 findings finding NNS cord-004297-rm0zbgfm 118 7 of of IN cord-004297-rm0zbgfm 118 8 the the DT cord-004297-rm0zbgfm 118 9 trials trial NNS cord-004297-rm0zbgfm 118 10 compared compare VBN cord-004297-rm0zbgfm 118 11 with with IN cord-004297-rm0zbgfm 118 12 the the DT cord-004297-rm0zbgfm 118 13 standard standard JJ cord-004297-rm0zbgfm 118 14 meta meta NNP cord-004297-rm0zbgfm 118 15 - - HYPH cord-004297-rm0zbgfm 118 16 analysis analysis NN cord-004297-rm0zbgfm 118 17 shown show VBN cord-004297-rm0zbgfm 118 18 in in IN cord-004297-rm0zbgfm 118 19 Fig Fig NNP cord-004297-rm0zbgfm 118 20 . . . cord-004297-rm0zbgfm 119 1 3 3 LS cord-004297-rm0zbgfm 119 2 . . . cord-004297-rm0zbgfm 120 1 The the DT cord-004297-rm0zbgfm 120 2 confidence confidence NN cord-004297-rm0zbgfm 120 3 intervals interval NNS cord-004297-rm0zbgfm 120 4 of of IN cord-004297-rm0zbgfm 120 5 all all DT cord-004297-rm0zbgfm 120 6 included include VBN cord-004297-rm0zbgfm 120 7 trials trial NNS cord-004297-rm0zbgfm 120 8 are be VBP cord-004297-rm0zbgfm 120 9 consistent consistent JJ cord-004297-rm0zbgfm 120 10 with with IN cord-004297-rm0zbgfm 120 11 the the DT cord-004297-rm0zbgfm 120 12 regression regression NN cord-004297-rm0zbgfm 120 13 line line NN cord-004297-rm0zbgfm 120 14 in in IN cord-004297-rm0zbgfm 120 15 Fig Fig NNP cord-004297-rm0zbgfm 120 16 . . . cord-004297-rm0zbgfm 121 1 4 4 LS cord-004297-rm0zbgfm 121 2 . . . cord-004297-rm0zbgfm 122 1 The the DT cord-004297-rm0zbgfm 122 2 Habib Habib NNP cord-004297-rm0zbgfm 122 3 [ [ -LRB- cord-004297-rm0zbgfm 122 4 14 14 CD cord-004297-rm0zbgfm 122 5 ] ] -RRB- cord-004297-rm0zbgfm 122 6 trial trial NN cord-004297-rm0zbgfm 122 7 contributed contribute VBD cord-004297-rm0zbgfm 122 8 considerable considerable JJ cord-004297-rm0zbgfm 122 9 weight weight NN cord-004297-rm0zbgfm 122 10 to to IN cord-004297-rm0zbgfm 122 11 the the DT cord-004297-rm0zbgfm 122 12 effect effect NN cord-004297-rm0zbgfm 122 13 of of IN cord-004297-rm0zbgfm 122 14 vitamin vitamin NN cord-004297-rm0zbgfm 122 15 C c NN cord-004297-rm0zbgfm 122 16 in in IN cord-004297-rm0zbgfm 122 17 Fig Fig NNP cord-004297-rm0zbgfm 122 18 . . . cord-004297-rm0zbgfm 123 1 4 4 LS cord-004297-rm0zbgfm 123 2 . . . cord-004297-rm0zbgfm 124 1 However however RB cord-004297-rm0zbgfm 124 2 , , , cord-004297-rm0zbgfm 124 3 even even RB cord-004297-rm0zbgfm 124 4 if if IN cord-004297-rm0zbgfm 124 5 both both DT cord-004297-rm0zbgfm 124 6 the the DT cord-004297-rm0zbgfm 124 7 Habib Habib NNP cord-004297-rm0zbgfm 124 8 [ [ -LRB- cord-004297-rm0zbgfm 124 9 14 14 CD cord-004297-rm0zbgfm 124 10 ] ] -RRB- cord-004297-rm0zbgfm 124 11 and and CC cord-004297-rm0zbgfm 124 12 Tanaka Tanaka NNP cord-004297-rm0zbgfm 124 13 [ [ -LRB- cord-004297-rm0zbgfm 124 14 17 17 CD cord-004297-rm0zbgfm 124 15 ] ] -RRB- cord-004297-rm0zbgfm 124 16 trials trial NNS cord-004297-rm0zbgfm 124 17 are be VBP cord-004297-rm0zbgfm 124 18 excluded exclude VBN cord-004297-rm0zbgfm 124 19 , , , cord-004297-rm0zbgfm 124 20 there there EX cord-004297-rm0zbgfm 124 21 is be VBZ cord-004297-rm0zbgfm 124 22 strong strong JJ cord-004297-rm0zbgfm 124 23 evidence evidence NN cord-004297-rm0zbgfm 124 24 from from IN cord-004297-rm0zbgfm 124 25 the the DT cord-004297-rm0zbgfm 124 26 six six CD cord-004297-rm0zbgfm 124 27 remaining remain VBG cord-004297-rm0zbgfm 124 28 trials trial NNS cord-004297-rm0zbgfm 124 29 that that WDT cord-004297-rm0zbgfm 124 30 the the DT cord-004297-rm0zbgfm 124 31 effect effect NN cord-004297-rm0zbgfm 124 32 of of IN cord-004297-rm0zbgfm 124 33 vitamin vitamin NN cord-004297-rm0zbgfm 124 34 C c NN cord-004297-rm0zbgfm 124 35 is be VBZ cord-004297-rm0zbgfm 124 36 modified modify VBN cord-004297-rm0zbgfm 124 37 by by IN cord-004297-rm0zbgfm 124 38 the the DT cord-004297-rm0zbgfm 124 39 ventilation ventilation NN cord-004297-rm0zbgfm 124 40 time time NN cord-004297-rm0zbgfm 124 41 in in IN cord-004297-rm0zbgfm 124 42 the the DT cord-004297-rm0zbgfm 124 43 untreated untreated JJ cord-004297-rm0zbgfm 124 44 control control NN cord-004297-rm0zbgfm 124 45 group group NN cord-004297-rm0zbgfm 124 46 ( ( -LRB- cord-004297-rm0zbgfm 124 47 P p NN cord-004297-rm0zbgfm 124 48 = = SYM cord-004297-rm0zbgfm 124 49 0.004 0.004 CD cord-004297-rm0zbgfm 124 50 ) ) -RRB- cord-004297-rm0zbgfm 124 51 ( ( -LRB- cord-004297-rm0zbgfm 124 52 see see VB cord-004297-rm0zbgfm 124 53 Additional additional JJ cord-004297-rm0zbgfm 124 54 file file NN cord-004297-rm0zbgfm 124 55 1 1 CD cord-004297-rm0zbgfm 124 56 ) ) -RRB- cord-004297-rm0zbgfm 124 57 . . . cord-004297-rm0zbgfm 125 1 Figure figure NN cord-004297-rm0zbgfm 125 2 4 4 CD cord-004297-rm0zbgfm 125 3 indicates indicate VBZ cord-004297-rm0zbgfm 125 4 that that IN cord-004297-rm0zbgfm 125 5 no no DT cord-004297-rm0zbgfm 125 6 meaningful meaningful JJ cord-004297-rm0zbgfm 125 7 benefit benefit NN cord-004297-rm0zbgfm 125 8 from from IN cord-004297-rm0zbgfm 125 9 vitamin vitamin NN cord-004297-rm0zbgfm 125 10 C C NNP cord-004297-rm0zbgfm 125 11 is be VBZ cord-004297-rm0zbgfm 125 12 expected expect VBN cord-004297-rm0zbgfm 125 13 for for IN cord-004297-rm0zbgfm 125 14 patients patient NNS cord-004297-rm0zbgfm 125 15 whose whose WP$ cord-004297-rm0zbgfm 125 16 ventilation ventilation NN cord-004297-rm0zbgfm 125 17 time time NN cord-004297-rm0zbgfm 125 18 is be VBZ cord-004297-rm0zbgfm 126 1 shorter short JJR cord-004297-rm0zbgfm 126 2 than than IN cord-004297-rm0zbgfm 126 3 10 10 CD cord-004297-rm0zbgfm 126 4 h. h. NN cord-004297-rm0zbgfm 127 1 On on IN cord-004297-rm0zbgfm 127 2 the the DT cord-004297-rm0zbgfm 127 3 other other JJ cord-004297-rm0zbgfm 127 4 hand hand NN cord-004297-rm0zbgfm 127 5 , , , cord-004297-rm0zbgfm 127 6 the the DT cord-004297-rm0zbgfm 127 7 regression regression NN cord-004297-rm0zbgfm 127 8 line line NN cord-004297-rm0zbgfm 127 9 in in IN cord-004297-rm0zbgfm 127 10 Fig Fig NNP cord-004297-rm0zbgfm 127 11 . . . cord-004297-rm0zbgfm 128 1 4 4 LS cord-004297-rm0zbgfm 128 2 predicts predict VBZ cord-004297-rm0zbgfm 128 3 that that IN cord-004297-rm0zbgfm 128 4 for for IN cord-004297-rm0zbgfm 128 5 patients patient NNS cord-004297-rm0zbgfm 128 6 ventilated ventilate VBN cord-004297-rm0zbgfm 128 7 for for IN cord-004297-rm0zbgfm 128 8 100 100 CD cord-004297-rm0zbgfm 128 9 h h NN cord-004297-rm0zbgfm 128 10 , , , cord-004297-rm0zbgfm 128 11 vitamin vitamin NN cord-004297-rm0zbgfm 128 12 C C NNP cord-004297-rm0zbgfm 128 13 reduces reduce VBZ cord-004297-rm0zbgfm 128 14 the the DT cord-004297-rm0zbgfm 128 15 ventilation ventilation NN cord-004297-rm0zbgfm 128 16 time time NN cord-004297-rm0zbgfm 128 17 on on IN cord-004297-rm0zbgfm 128 18 average average JJ cord-004297-rm0zbgfm 128 19 by by IN cord-004297-rm0zbgfm 128 20 31 31 CD cord-004297-rm0zbgfm 128 21 % % NN cord-004297-rm0zbgfm 128 22 ( ( -LRB- cord-004297-rm0zbgfm 128 23 RoM rom NN cord-004297-rm0zbgfm 128 24 = = SYM cord-004297-rm0zbgfm 128 25 0.69 0.69 CD cord-004297-rm0zbgfm 128 26 ) ) -RRB- cord-004297-rm0zbgfm 128 27 . . . cord-004297-rm0zbgfm 129 1 Three three CD cord-004297-rm0zbgfm 129 2 trials trial NNS cord-004297-rm0zbgfm 129 3 administered administer VBD cord-004297-rm0zbgfm 129 4 vitamin vitamin NN cord-004297-rm0zbgfm 129 5 C c NN cord-004297-rm0zbgfm 129 6 orally orally RB cord-004297-rm0zbgfm 129 7 and and CC cord-004297-rm0zbgfm 129 8 five five CD cord-004297-rm0zbgfm 129 9 intravenously intravenously RB cord-004297-rm0zbgfm 129 10 , , , cord-004297-rm0zbgfm 129 11 but but CC cord-004297-rm0zbgfm 129 12 both both DT cord-004297-rm0zbgfm 129 13 methods method NNS cord-004297-rm0zbgfm 129 14 are be VBP cord-004297-rm0zbgfm 129 15 consistent consistent JJ cord-004297-rm0zbgfm 129 16 with with IN cord-004297-rm0zbgfm 129 17 the the DT cord-004297-rm0zbgfm 129 18 single single JJ cord-004297-rm0zbgfm 129 19 regression regression NN cord-004297-rm0zbgfm 129 20 line line NN cord-004297-rm0zbgfm 129 21 in in IN cord-004297-rm0zbgfm 129 22 Fig Fig NNP cord-004297-rm0zbgfm 129 23 . . . cord-004297-rm0zbgfm 130 1 4 4 LS cord-004297-rm0zbgfm 130 2 . . . cord-004297-rm0zbgfm 131 1 Tanaka Tanaka NNP cord-004297-rm0zbgfm 131 2 et et NNP cord-004297-rm0zbgfm 131 3 al al NNP cord-004297-rm0zbgfm 131 4 . . . cord-004297-rm0zbgfm 132 1 [ [ -LRB- cord-004297-rm0zbgfm 132 2 17 17 CD cord-004297-rm0zbgfm 132 3 ] ] -RRB- cord-004297-rm0zbgfm 132 4 used use VBN cord-004297-rm0zbgfm 132 5 by by IN cord-004297-rm0zbgfm 132 6 far far RB cord-004297-rm0zbgfm 132 7 the the DT cord-004297-rm0zbgfm 132 8 highest high JJS cord-004297-rm0zbgfm 132 9 dose dose NN cord-004297-rm0zbgfm 132 10 of of IN cord-004297-rm0zbgfm 132 11 vitamin vitamin NN cord-004297-rm0zbgfm 132 12 C c NN cord-004297-rm0zbgfm 132 13 , , , cord-004297-rm0zbgfm 132 14 90 90 CD cord-004297-rm0zbgfm 132 15 g g NN cord-004297-rm0zbgfm 132 16 / / SYM cord-004297-rm0zbgfm 132 17 day day NN cord-004297-rm0zbgfm 132 18 . . . cord-004297-rm0zbgfm 133 1 Figure figure NN cord-004297-rm0zbgfm 133 2 4 4 CD cord-004297-rm0zbgfm 133 3 indicates indicate VBZ cord-004297-rm0zbgfm 133 4 that that IN cord-004297-rm0zbgfm 133 5 the the DT cord-004297-rm0zbgfm 133 6 substantial substantial JJ cord-004297-rm0zbgfm 133 7 benefit benefit NN cord-004297-rm0zbgfm 133 8 observed observe VBN cord-004297-rm0zbgfm 133 9 in in IN cord-004297-rm0zbgfm 133 10 that that DT cord-004297-rm0zbgfm 133 11 trial trial NN cord-004297-rm0zbgfm 133 12 may may MD cord-004297-rm0zbgfm 133 13 be be VB cord-004297-rm0zbgfm 133 14 explained explain VBN cord-004297-rm0zbgfm 133 15 by by IN cord-004297-rm0zbgfm 133 16 the the DT cord-004297-rm0zbgfm 133 17 particularly particularly RB cord-004297-rm0zbgfm 133 18 sick sick JJ cord-004297-rm0zbgfm 133 19 patients patient NNS cord-004297-rm0zbgfm 133 20 with with IN cord-004297-rm0zbgfm 133 21 burns burn NNS cord-004297-rm0zbgfm 133 22 requiring require VBG cord-004297-rm0zbgfm 133 23 very very RB cord-004297-rm0zbgfm 133 24 long long JJ cord-004297-rm0zbgfm 133 25 ventilation ventilation NN cord-004297-rm0zbgfm 133 26 , , , cord-004297-rm0zbgfm 133 27 rather rather RB cord-004297-rm0zbgfm 133 28 than than IN cord-004297-rm0zbgfm 133 29 by by IN cord-004297-rm0zbgfm 133 30 the the DT cord-004297-rm0zbgfm 133 31 very very RB cord-004297-rm0zbgfm 133 32 high high JJ cord-004297-rm0zbgfm 133 33 vitamin vitamin NN cord-004297-rm0zbgfm 133 34 C c NN cord-004297-rm0zbgfm 133 35 dose dose NN cord-004297-rm0zbgfm 133 36 . . . cord-004297-rm0zbgfm 134 1 We -PRON- PRP cord-004297-rm0zbgfm 134 2 found find VBD cord-004297-rm0zbgfm 134 3 that that IN cord-004297-rm0zbgfm 134 4 vitamin vitamin NN cord-004297-rm0zbgfm 134 5 C c NN cord-004297-rm0zbgfm 134 6 shortened shorten VBD cord-004297-rm0zbgfm 134 7 the the DT cord-004297-rm0zbgfm 134 8 length length NN cord-004297-rm0zbgfm 134 9 of of IN cord-004297-rm0zbgfm 134 10 ventilation ventilation NN cord-004297-rm0zbgfm 134 11 on on IN cord-004297-rm0zbgfm 134 12 average average JJ cord-004297-rm0zbgfm 134 13 by by IN cord-004297-rm0zbgfm 134 14 25 25 CD cord-004297-rm0zbgfm 134 15 % % NN cord-004297-rm0zbgfm 134 16 ( ( -LRB- cord-004297-rm0zbgfm 134 17 P p NN cord-004297-rm0zbgfm 134 18 = = SYM cord-004297-rm0zbgfm 134 19 10 10 CD cord-004297-rm0zbgfm 134 20 −10 −10 NNP cord-004297-rm0zbgfm 134 21 ) ) -RRB- cord-004297-rm0zbgfm 134 22 when when WRB cord-004297-rm0zbgfm 134 23 the the DT cord-004297-rm0zbgfm 134 24 Tanaka Tanaka NNP cord-004297-rm0zbgfm 134 25 trial trial NN cord-004297-rm0zbgfm 134 26 was be VBD cord-004297-rm0zbgfm 134 27 excluded exclude VBN cord-004297-rm0zbgfm 134 28 and and CC cord-004297-rm0zbgfm 134 29 the the DT cord-004297-rm0zbgfm 134 30 analysis analysis NN cord-004297-rm0zbgfm 134 31 was be VBD cord-004297-rm0zbgfm 134 32 restricted restrict VBN cord-004297-rm0zbgfm 134 33 to to IN cord-004297-rm0zbgfm 134 34 the the DT cord-004297-rm0zbgfm 134 35 five five CD cord-004297-rm0zbgfm 134 36 trials trial NNS cord-004297-rm0zbgfm 134 37 with with IN cord-004297-rm0zbgfm 134 38 dosage dosage NN cord-004297-rm0zbgfm 134 39 from from IN cord-004297-rm0zbgfm 134 40 1 1 CD cord-004297-rm0zbgfm 134 41 to to IN cord-004297-rm0zbgfm 134 42 6 6 CD cord-004297-rm0zbgfm 134 43 g g NN cord-004297-rm0zbgfm 134 44 / / SYM cord-004297-rm0zbgfm 134 45 day day NN cord-004297-rm0zbgfm 134 46 for for IN cord-004297-rm0zbgfm 134 47 patients patient NNS cord-004297-rm0zbgfm 134 48 ventilated ventilate VBN cord-004297-rm0zbgfm 134 49 for for IN cord-004297-rm0zbgfm 134 50 over over IN cord-004297-rm0zbgfm 134 51 10 10 CD cord-004297-rm0zbgfm 134 52 h h NN cord-004297-rm0zbgfm 134 53 [ [ -LRB- cord-004297-rm0zbgfm 134 54 11 11 CD cord-004297-rm0zbgfm 134 55 , , , cord-004297-rm0zbgfm 134 56 [ [ -LRB- cord-004297-rm0zbgfm 134 57 13 13 CD cord-004297-rm0zbgfm 134 58 ] ] -RRB- cord-004297-rm0zbgfm 135 1 [ [ -LRB- cord-004297-rm0zbgfm 135 2 14 14 CD cord-004297-rm0zbgfm 135 3 ] ] -RRB- cord-004297-rm0zbgfm 135 4 [ [ -LRB- cord-004297-rm0zbgfm 135 5 15 15 CD cord-004297-rm0zbgfm 135 6 ] ] -RRB- cord-004297-rm0zbgfm 135 7 18 18 CD cord-004297-rm0zbgfm 135 8 ] ] -RRB- cord-004297-rm0zbgfm 135 9 . . . cord-004297-rm0zbgfm 136 1 The the DT cord-004297-rm0zbgfm 136 2 Sadeghpour Sadeghpour NNP cord-004297-rm0zbgfm 136 3 trial trial NN cord-004297-rm0zbgfm 136 4 [ [ -LRB- cord-004297-rm0zbgfm 136 5 19 19 CD cord-004297-rm0zbgfm 136 6 ] ] -RRB- cord-004297-rm0zbgfm 136 7 is be VBZ cord-004297-rm0zbgfm 136 8 not not RB cord-004297-rm0zbgfm 136 9 included include VBN cord-004297-rm0zbgfm 136 10 in in IN cord-004297-rm0zbgfm 136 11 our -PRON- PRP$ cord-004297-rm0zbgfm 136 12 statistical statistical JJ cord-004297-rm0zbgfm 136 13 models model NNS cord-004297-rm0zbgfm 136 14 because because IN cord-004297-rm0zbgfm 136 15 of of IN cord-004297-rm0zbgfm 136 16 the the DT cord-004297-rm0zbgfm 136 17 high high JJ cord-004297-rm0zbgfm 136 18 dropout dropout NN cord-004297-rm0zbgfm 136 19 rate rate NN cord-004297-rm0zbgfm 136 20 , , , cord-004297-rm0zbgfm 136 21 but but CC cord-004297-rm0zbgfm 136 22 the the DT cord-004297-rm0zbgfm 136 23 results result NNS cord-004297-rm0zbgfm 136 24 are be VBP cord-004297-rm0zbgfm 136 25 shown show VBN cord-004297-rm0zbgfm 136 26 in in IN cord-004297-rm0zbgfm 136 27 Fig Fig NNP cord-004297-rm0zbgfm 136 28 . . . cord-004297-rm0zbgfm 137 1 4 4 LS cord-004297-rm0zbgfm 137 2 by by IN cord-004297-rm0zbgfm 137 3 the the DT cord-004297-rm0zbgfm 137 4 dashed dash VBN cord-004297-rm0zbgfm 137 5 line line NN cord-004297-rm0zbgfm 138 1 and and CC cord-004297-rm0zbgfm 138 2 they -PRON- PRP cord-004297-rm0zbgfm 138 3 are be VBP cord-004297-rm0zbgfm 138 4 consistent consistent JJ cord-004297-rm0zbgfm 138 5 with with IN cord-004297-rm0zbgfm 138 6 the the DT cord-004297-rm0zbgfm 138 7 findings finding NNS cord-004297-rm0zbgfm 138 8 of of IN cord-004297-rm0zbgfm 138 9 the the DT cord-004297-rm0zbgfm 138 10 other other JJ cord-004297-rm0zbgfm 138 11 trials trial NNS cord-004297-rm0zbgfm 138 12 . . . cord-004297-rm0zbgfm 139 1 Our -PRON- PRP$ cord-004297-rm0zbgfm 139 2 meta meta JJ cord-004297-rm0zbgfm 139 3 - - HYPH cord-004297-rm0zbgfm 139 4 regression regression NN cord-004297-rm0zbgfm 139 5 analysis analysis NN cord-004297-rm0zbgfm 139 6 above above RB cord-004297-rm0zbgfm 139 7 was be VBD cord-004297-rm0zbgfm 139 8 restricted restrict VBN cord-004297-rm0zbgfm 139 9 to to IN cord-004297-rm0zbgfm 139 10 studies study NNS cord-004297-rm0zbgfm 139 11 in in IN cord-004297-rm0zbgfm 139 12 which which WDT cord-004297-rm0zbgfm 139 13 vitamin vitamin NN cord-004297-rm0zbgfm 139 14 C C NNP cord-004297-rm0zbgfm 139 15 was be VBD cord-004297-rm0zbgfm 139 16 administered administer VBN cord-004297-rm0zbgfm 139 17 as as IN cord-004297-rm0zbgfm 139 18 the the DT cord-004297-rm0zbgfm 139 19 only only JJ cord-004297-rm0zbgfm 139 20 difference difference NN cord-004297-rm0zbgfm 139 21 between between IN cord-004297-rm0zbgfm 139 22 the the DT cord-004297-rm0zbgfm 139 23 study study NN cord-004297-rm0zbgfm 139 24 groups group NNS cord-004297-rm0zbgfm 139 25 . . . cord-004297-rm0zbgfm 140 1 We -PRON- PRP cord-004297-rm0zbgfm 140 2 did do VBD cord-004297-rm0zbgfm 140 3 not not RB cord-004297-rm0zbgfm 140 4 carry carry VB cord-004297-rm0zbgfm 140 5 out out RP cord-004297-rm0zbgfm 140 6 a a DT cord-004297-rm0zbgfm 140 7 systematic systematic JJ cord-004297-rm0zbgfm 140 8 search search NN cord-004297-rm0zbgfm 140 9 for for IN cord-004297-rm0zbgfm 140 10 trials trial NNS cord-004297-rm0zbgfm 140 11 on on IN cord-004297-rm0zbgfm 140 12 the the DT cord-004297-rm0zbgfm 140 13 combination combination NN cord-004297-rm0zbgfm 140 14 of of IN cord-004297-rm0zbgfm 140 15 vitamins vitamin NNS cord-004297-rm0zbgfm 140 16 C c NN cord-004297-rm0zbgfm 140 17 and and CC cord-004297-rm0zbgfm 140 18 E e NN cord-004297-rm0zbgfm 140 19 , , , cord-004297-rm0zbgfm 140 20 but but CC cord-004297-rm0zbgfm 140 21 in in IN cord-004297-rm0zbgfm 140 22 our -PRON- PRP$ cord-004297-rm0zbgfm 140 23 search search NN cord-004297-rm0zbgfm 140 24 for for IN cord-004297-rm0zbgfm 140 25 Fig Fig NNP cord-004297-rm0zbgfm 140 26 . . . cord-004297-rm0zbgfm 141 1 2 2 LS cord-004297-rm0zbgfm 141 2 Risk risk NN cord-004297-rm0zbgfm 141 3 of of IN cord-004297-rm0zbgfm 141 4 bias bias NN cord-004297-rm0zbgfm 141 5 summary summary NN cord-004297-rm0zbgfm 141 6 . . . cord-004297-rm0zbgfm 142 1 Review review NN cord-004297-rm0zbgfm 142 2 authors author NNS cord-004297-rm0zbgfm 142 3 ' ' POS cord-004297-rm0zbgfm 142 4 judgments judgment NNS cord-004297-rm0zbgfm 142 5 about about IN cord-004297-rm0zbgfm 142 6 each each DT cord-004297-rm0zbgfm 142 7 risk risk NN cord-004297-rm0zbgfm 142 8 of of IN cord-004297-rm0zbgfm 142 9 bias bias NN cord-004297-rm0zbgfm 142 10 item item NN cord-004297-rm0zbgfm 142 11 for for IN cord-004297-rm0zbgfm 142 12 each each DT cord-004297-rm0zbgfm 142 13 included include VBN cord-004297-rm0zbgfm 142 14 trial trial NN cord-004297-rm0zbgfm 142 15 . . . cord-004297-rm0zbgfm 143 1 A a DT cord-004297-rm0zbgfm 143 2 green green JJ cord-004297-rm0zbgfm 143 3 plus plus CC cord-004297-rm0zbgfm 143 4 sign sign NN cord-004297-rm0zbgfm 143 5 ( ( -LRB- cord-004297-rm0zbgfm 143 6 + + NFP cord-004297-rm0zbgfm 143 7 ) ) -RRB- cord-004297-rm0zbgfm 143 8 indicates indicate VBZ cord-004297-rm0zbgfm 143 9 that that IN cord-004297-rm0zbgfm 143 10 there there EX cord-004297-rm0zbgfm 143 11 is be VBZ cord-004297-rm0zbgfm 143 12 no no DT cord-004297-rm0zbgfm 143 13 substantial substantial JJ cord-004297-rm0zbgfm 143 14 concern concern NN cord-004297-rm0zbgfm 143 15 for for IN cord-004297-rm0zbgfm 143 16 bias bias NN cord-004297-rm0zbgfm 143 17 in in IN cord-004297-rm0zbgfm 143 18 the the DT cord-004297-rm0zbgfm 143 19 particular particular JJ cord-004297-rm0zbgfm 143 20 quality quality NN cord-004297-rm0zbgfm 143 21 item item NN cord-004297-rm0zbgfm 143 22 . . . cord-004297-rm0zbgfm 144 1 A a DT cord-004297-rm0zbgfm 144 2 question question NN cord-004297-rm0zbgfm 144 3 mark mark NN cord-004297-rm0zbgfm 144 4 ( ( -LRB- cord-004297-rm0zbgfm 144 5 ? ? . cord-004297-rm0zbgfm 144 6 ) ) -RRB- cord-004297-rm0zbgfm 144 7 indicates indicate VBZ cord-004297-rm0zbgfm 144 8 that that IN cord-004297-rm0zbgfm 144 9 conclusions conclusion NNS cord-004297-rm0zbgfm 144 10 are be VBP cord-004297-rm0zbgfm 144 11 unable unable JJ cord-004297-rm0zbgfm 144 12 to to TO cord-004297-rm0zbgfm 144 13 be be VB cord-004297-rm0zbgfm 144 14 drawn draw VBN cord-004297-rm0zbgfm 144 15 regarding regard VBG cord-004297-rm0zbgfm 144 16 potential potential JJ cord-004297-rm0zbgfm 144 17 bias bias NN cord-004297-rm0zbgfm 144 18 . . . cord-004297-rm0zbgfm 145 1 A a DT cord-004297-rm0zbgfm 145 2 red red JJ cord-004297-rm0zbgfm 145 3 minus minus NN cord-004297-rm0zbgfm 145 4 sign sign NN cord-004297-rm0zbgfm 145 5 ( ( -LRB- cord-004297-rm0zbgfm 145 6 − − NNP cord-004297-rm0zbgfm 145 7 ) ) -RRB- cord-004297-rm0zbgfm 145 8 indicates indicate VBZ cord-004297-rm0zbgfm 145 9 that that IN cord-004297-rm0zbgfm 145 10 there there EX cord-004297-rm0zbgfm 145 11 is be VBZ cord-004297-rm0zbgfm 145 12 an an DT cord-004297-rm0zbgfm 145 13 explicit explicit JJ cord-004297-rm0zbgfm 145 14 concern concern NN cord-004297-rm0zbgfm 145 15 regarding regard VBG cord-004297-rm0zbgfm 145 16 bias bias NN cord-004297-rm0zbgfm 145 17 . . . cord-004297-rm0zbgfm 146 1 In in IN cord-004297-rm0zbgfm 146 2 the the DT cord-004297-rm0zbgfm 146 3 Sadeghpour Sadeghpour NNP cord-004297-rm0zbgfm 146 4 trial trial NN cord-004297-rm0zbgfm 146 5 , , , cord-004297-rm0zbgfm 146 6 the the DT cord-004297-rm0zbgfm 146 7 dropout dropout NN cord-004297-rm0zbgfm 146 8 rate rate NN cord-004297-rm0zbgfm 146 9 was be VBD cord-004297-rm0zbgfm 146 10 very very RB cord-004297-rm0zbgfm 146 11 high high JJ cord-004297-rm0zbgfm 146 12 ( ( -LRB- cord-004297-rm0zbgfm 146 13 42 42 CD cord-004297-rm0zbgfm 146 14 % % NN cord-004297-rm0zbgfm 146 15 ) ) -RRB- cord-004297-rm0zbgfm 146 16 , , , cord-004297-rm0zbgfm 146 17 justifying justify VBG cord-004297-rm0zbgfm 146 18 the the DT cord-004297-rm0zbgfm 146 19 minus minus NN cord-004297-rm0zbgfm 146 20 sign sign NN cord-004297-rm0zbgfm 146 21 [ [ -LRB- cord-004297-rm0zbgfm 146 22 1 1 CD cord-004297-rm0zbgfm 146 23 ] ] -RRB- cord-004297-rm0zbgfm 146 24 . . . cord-004297-rm0zbgfm 147 1 The the DT cord-004297-rm0zbgfm 147 2 reference reference NN cord-004297-rm0zbgfm 147 3 numbers number NNS cord-004297-rm0zbgfm 147 4 to to IN cord-004297-rm0zbgfm 147 5 the the DT cord-004297-rm0zbgfm 147 6 trials trial NNS cord-004297-rm0zbgfm 147 7 are be VBP cord-004297-rm0zbgfm 147 8 shown show VBN cord-004297-rm0zbgfm 147 9 in in IN cord-004297-rm0zbgfm 147 10 Table table NN cord-004297-rm0zbgfm 147 11 1 1 CD cord-004297-rm0zbgfm 147 12 the the DT cord-004297-rm0zbgfm 147 13 vitamin vitamin NN cord-004297-rm0zbgfm 147 14 C c NN cord-004297-rm0zbgfm 147 15 trials trial NNS cord-004297-rm0zbgfm 147 16 , , , cord-004297-rm0zbgfm 147 17 we -PRON- PRP cord-004297-rm0zbgfm 147 18 found find VBD cord-004297-rm0zbgfm 147 19 three three CD cord-004297-rm0zbgfm 147 20 trials trial NNS cord-004297-rm0zbgfm 147 21 that that WDT cord-004297-rm0zbgfm 147 22 administered administer VBD cord-004297-rm0zbgfm 147 23 vitamins vitamin NNS cord-004297-rm0zbgfm 147 24 C c NN cord-004297-rm0zbgfm 147 25 and and CC cord-004297-rm0zbgfm 147 26 E e NN cord-004297-rm0zbgfm 147 27 together together RB cord-004297-rm0zbgfm 147 28 to to TO cord-004297-rm0zbgfm 147 29 critically critically RB cord-004297-rm0zbgfm 147 30 ill ill VB cord-004297-rm0zbgfm 147 31 patients patient NNS cord-004297-rm0zbgfm 147 32 [ [ -LRB- cord-004297-rm0zbgfm 147 33 29 29 CD cord-004297-rm0zbgfm 147 34 ] ] -RRB- cord-004297-rm0zbgfm 148 1 [ [ -LRB- cord-004297-rm0zbgfm 148 2 30 30 CD cord-004297-rm0zbgfm 148 3 ] ] -RRB- cord-004297-rm0zbgfm 148 4 [ [ -LRB- cord-004297-rm0zbgfm 148 5 31 31 CD cord-004297-rm0zbgfm 148 6 ] ] -RRB- cord-004297-rm0zbgfm 148 7 . . . cord-004297-rm0zbgfm 149 1 Given give VBN cord-004297-rm0zbgfm 149 2 that that IN cord-004297-rm0zbgfm 149 3 our -PRON- PRP$ cord-004297-rm0zbgfm 149 4 search search NN cord-004297-rm0zbgfm 149 5 for for IN cord-004297-rm0zbgfm 149 6 vitamin vitamin NN cord-004297-rm0zbgfm 149 7 C C NNP cord-004297-rm0zbgfm 149 8 also also RB cord-004297-rm0zbgfm 149 9 identifies identify VBZ cord-004297-rm0zbgfm 149 10 any any DT cord-004297-rm0zbgfm 149 11 combinations combination NNS cord-004297-rm0zbgfm 149 12 of of IN cord-004297-rm0zbgfm 149 13 vitamins vitamin NNS cord-004297-rm0zbgfm 149 14 C c NN cord-004297-rm0zbgfm 149 15 and and CC cord-004297-rm0zbgfm 149 16 E E NNP cord-004297-rm0zbgfm 149 17 , , , cord-004297-rm0zbgfm 149 18 it -PRON- PRP cord-004297-rm0zbgfm 149 19 is be VBZ cord-004297-rm0zbgfm 149 20 unlikely unlikely JJ cord-004297-rm0zbgfm 149 21 that that IN cord-004297-rm0zbgfm 149 22 there there EX cord-004297-rm0zbgfm 149 23 are be VBP cord-004297-rm0zbgfm 149 24 many many JJ cord-004297-rm0zbgfm 149 25 more more JJR cord-004297-rm0zbgfm 149 26 combination combination NN cord-004297-rm0zbgfm 149 27 trials trial NNS cord-004297-rm0zbgfm 149 28 . . . cord-004297-rm0zbgfm 150 1 As as IN cord-004297-rm0zbgfm 150 2 a a DT cord-004297-rm0zbgfm 150 3 secondary secondary JJ cord-004297-rm0zbgfm 150 4 analysis analysis NN cord-004297-rm0zbgfm 150 5 , , , cord-004297-rm0zbgfm 150 6 we -PRON- PRP cord-004297-rm0zbgfm 150 7 compared compare VBD cord-004297-rm0zbgfm 150 8 the the DT cord-004297-rm0zbgfm 150 9 findings finding NNS cord-004297-rm0zbgfm 150 10 of of IN cord-004297-rm0zbgfm 150 11 the the DT cord-004297-rm0zbgfm 150 12 three three CD cord-004297-rm0zbgfm 150 13 vitamin vitamin NN cord-004297-rm0zbgfm 150 14 C c NN cord-004297-rm0zbgfm 150 15 and and CC cord-004297-rm0zbgfm 150 16 E e NN cord-004297-rm0zbgfm 150 17 trials trial NNS cord-004297-rm0zbgfm 150 18 with with IN cord-004297-rm0zbgfm 150 19 our -PRON- PRP$ cord-004297-rm0zbgfm 150 20 meta meta JJ cord-004297-rm0zbgfm 150 21 - - HYPH cord-004297-rm0zbgfm 150 22 regression regression NN cord-004297-rm0zbgfm 150 23 model model NN cord-004297-rm0zbgfm 150 24 based base VBN cord-004297-rm0zbgfm 150 25 on on IN cord-004297-rm0zbgfm 150 26 the the DT cord-004297-rm0zbgfm 150 27 eight eight CD cord-004297-rm0zbgfm 150 28 trials trial NNS cord-004297-rm0zbgfm 150 29 using use VBG cord-004297-rm0zbgfm 150 30 vitamin vitamin NN cord-004297-rm0zbgfm 150 31 C c NN cord-004297-rm0zbgfm 150 32 alone alone JJ cord-004297-rm0zbgfm 151 1 ( ( -LRB- cord-004297-rm0zbgfm 151 2 Fig Fig NNP cord-004297-rm0zbgfm 151 3 . . NNP cord-004297-rm0zbgfm 151 4 5 5 CD cord-004297-rm0zbgfm 151 5 ) ) -RRB- cord-004297-rm0zbgfm 151 6 . . . cord-004297-rm0zbgfm 152 1 Nathens Nathens NNP cord-004297-rm0zbgfm 152 2 et et NNP cord-004297-rm0zbgfm 152 3 al al NNP cord-004297-rm0zbgfm 152 4 . . . cord-004297-rm0zbgfm 153 1 administered administer VBN cord-004297-rm0zbgfm 153 2 1 1 CD cord-004297-rm0zbgfm 153 3 g g NN cord-004297-rm0zbgfm 153 4 / / SYM cord-004297-rm0zbgfm 153 5 day day NN cord-004297-rm0zbgfm 153 6 vitamin vitamin NN cord-004297-rm0zbgfm 153 7 C C NNP cord-004297-rm0zbgfm 153 8 intravenously intravenously RB cord-004297-rm0zbgfm 153 9 and and CC cord-004297-rm0zbgfm 153 10 1000 1000 CD cord-004297-rm0zbgfm 153 11 IU IU NNP cord-004297-rm0zbgfm 153 12 / / SYM cord-004297-rm0zbgfm 153 13 day day NN cord-004297-rm0zbgfm 153 14 vitamin vitamin NN cord-004297-rm0zbgfm 153 15 E e NN cord-004297-rm0zbgfm 153 16 enterally enterally RB cord-004297-rm0zbgfm 153 17 [ [ -LRB- cord-004297-rm0zbgfm 153 18 29 29 CD cord-004297-rm0zbgfm 153 19 ] ] -RRB- cord-004297-rm0zbgfm 153 20 . . . cord-004297-rm0zbgfm 154 1 The the DT cord-004297-rm0zbgfm 154 2 duration duration NN cord-004297-rm0zbgfm 154 3 of of IN cord-004297-rm0zbgfm 154 4 mechanical mechanical JJ cord-004297-rm0zbgfm 154 5 ventilation ventilation NN cord-004297-rm0zbgfm 154 6 in in IN cord-004297-rm0zbgfm 154 7 the the DT cord-004297-rm0zbgfm 154 8 control control NN cord-004297-rm0zbgfm 154 9 group group NN cord-004297-rm0zbgfm 154 10 was be VBD cord-004297-rm0zbgfm 154 11 110 110 CD cord-004297-rm0zbgfm 154 12 h h NN cord-004297-rm0zbgfm 154 13 , , , cord-004297-rm0zbgfm 154 14 for for IN cord-004297-rm0zbgfm 154 15 which which WDT cord-004297-rm0zbgfm 154 16 our -PRON- PRP$ cord-004297-rm0zbgfm 154 17 model model NN cord-004297-rm0zbgfm 154 18 predicts predict VBZ cord-004297-rm0zbgfm 154 19 a a DT cord-004297-rm0zbgfm 154 20 32 32 CD cord-004297-rm0zbgfm 154 21 % % NN cord-004297-rm0zbgfm 154 22 decrease decrease NN cord-004297-rm0zbgfm 154 23 in in IN cord-004297-rm0zbgfm 154 24 the the DT cord-004297-rm0zbgfm 154 25 vitamin vitamin NN cord-004297-rm0zbgfm 154 26 C C NNP cord-004297-rm0zbgfm 154 27 group group NN cord-004297-rm0zbgfm 154 28 . . . cord-004297-rm0zbgfm 155 1 The the DT cord-004297-rm0zbgfm 155 2 observed observed JJ cord-004297-rm0zbgfm 155 3 decrease decrease NN cord-004297-rm0zbgfm 155 4 in in IN cord-004297-rm0zbgfm 155 5 the the DT cord-004297-rm0zbgfm 155 6 vitamins vitamin NNS cord-004297-rm0zbgfm 155 7 C c NN cord-004297-rm0zbgfm 155 8 and and CC cord-004297-rm0zbgfm 155 9 E e NN cord-004297-rm0zbgfm 155 10 group group NN cord-004297-rm0zbgfm 155 11 was be VBD cord-004297-rm0zbgfm 155 12 20 20 CD cord-004297-rm0zbgfm 155 13 % % NN cord-004297-rm0zbgfm 155 14 ( ( -LRB- cord-004297-rm0zbgfm 155 15 95 95 CD cord-004297-rm0zbgfm 155 16 % % NN cord-004297-rm0zbgfm 155 17 CI CI NNP cord-004297-rm0zbgfm 155 18 13 13 CD cord-004297-rm0zbgfm 155 19 % % NN cord-004297-rm0zbgfm 155 20 to to IN cord-004297-rm0zbgfm 155 21 26 26 CD cord-004297-rm0zbgfm 155 22 % % NN cord-004297-rm0zbgfm 155 23 ) ) -RRB- cord-004297-rm0zbgfm 155 24 . . . cord-004297-rm0zbgfm 156 1 Crimi Crimi NNP cord-004297-rm0zbgfm 156 2 et et NNP cord-004297-rm0zbgfm 156 3 al al NNP cord-004297-rm0zbgfm 156 4 . . . cord-004297-rm0zbgfm 157 1 administered administer VBN cord-004297-rm0zbgfm 157 2 0.5 0.5 CD cord-004297-rm0zbgfm 157 3 g g NN cord-004297-rm0zbgfm 157 4 / / SYM cord-004297-rm0zbgfm 157 5 day day NN cord-004297-rm0zbgfm 157 6 vitamin vitamin NN cord-004297-rm0zbgfm 157 7 C c NN cord-004297-rm0zbgfm 157 8 and and CC cord-004297-rm0zbgfm 157 9 400 400 CD cord-004297-rm0zbgfm 157 10 IU IU NNP cord-004297-rm0zbgfm 157 11 / / SYM cord-004297-rm0zbgfm 157 12 day day NN cord-004297-rm0zbgfm 157 13 vitamin vitamin NN cord-004297-rm0zbgfm 157 14 E e NN cord-004297-rm0zbgfm 157 15 enterally enterally RB cord-004297-rm0zbgfm 157 16 [ [ -LRB- cord-004297-rm0zbgfm 157 17 30 30 CD cord-004297-rm0zbgfm 157 18 ] ] -RRB- cord-004297-rm0zbgfm 157 19 . . . cord-004297-rm0zbgfm 158 1 Ventilation ventilation NN cord-004297-rm0zbgfm 158 2 time time NN cord-004297-rm0zbgfm 158 3 in in IN cord-004297-rm0zbgfm 158 4 the the DT cord-004297-rm0zbgfm 158 5 control control NN cord-004297-rm0zbgfm 158 6 group group NN cord-004297-rm0zbgfm 158 7 was be VBD cord-004297-rm0zbgfm 158 8 213 213 CD cord-004297-rm0zbgfm 158 9 h h NN cord-004297-rm0zbgfm 158 10 , , , cord-004297-rm0zbgfm 158 11 for for IN cord-004297-rm0zbgfm 158 12 which which WDT cord-004297-rm0zbgfm 158 13 our -PRON- PRP$ cord-004297-rm0zbgfm 158 14 model model NN cord-004297-rm0zbgfm 158 15 predicts predict VBZ cord-004297-rm0zbgfm 158 16 a a DT cord-004297-rm0zbgfm 158 17 Fig fig NN cord-004297-rm0zbgfm 158 18 . . . cord-004297-rm0zbgfm 158 19 3 3 CD cord-004297-rm0zbgfm 158 20 Effect effect NN cord-004297-rm0zbgfm 158 21 of of IN cord-004297-rm0zbgfm 158 22 vitamin vitamin NN cord-004297-rm0zbgfm 158 23 C c NN cord-004297-rm0zbgfm 158 24 on on IN cord-004297-rm0zbgfm 158 25 the the DT cord-004297-rm0zbgfm 158 26 duration duration NN cord-004297-rm0zbgfm 158 27 of of IN cord-004297-rm0zbgfm 158 28 ventilation ventilation NN cord-004297-rm0zbgfm 158 29 . . . cord-004297-rm0zbgfm 159 1 The the DT cord-004297-rm0zbgfm 159 2 horizontal horizontal JJ cord-004297-rm0zbgfm 159 3 lines line NNS cord-004297-rm0zbgfm 159 4 indicate indicate VBP cord-004297-rm0zbgfm 159 5 the the DT cord-004297-rm0zbgfm 159 6 95 95 CD cord-004297-rm0zbgfm 159 7 % % NN cord-004297-rm0zbgfm 159 8 CI CI NNP cord-004297-rm0zbgfm 159 9 for for IN cord-004297-rm0zbgfm 159 10 the the DT cord-004297-rm0zbgfm 159 11 vitamin vitamin NN cord-004297-rm0zbgfm 159 12 C C NNP cord-004297-rm0zbgfm 159 13 effect effect NN cord-004297-rm0zbgfm 159 14 and and CC cord-004297-rm0zbgfm 159 15 the the DT cord-004297-rm0zbgfm 159 16 blue blue JJ cord-004297-rm0zbgfm 159 17 squares square NNS cord-004297-rm0zbgfm 159 18 in in IN cord-004297-rm0zbgfm 159 19 the the DT cord-004297-rm0zbgfm 159 20 middle middle NN cord-004297-rm0zbgfm 159 21 of of IN cord-004297-rm0zbgfm 159 22 the the DT cord-004297-rm0zbgfm 159 23 horizontal horizontal JJ cord-004297-rm0zbgfm 159 24 lines line NNS cord-004297-rm0zbgfm 159 25 indicate indicate VBP cord-004297-rm0zbgfm 159 26 the the DT cord-004297-rm0zbgfm 159 27 point point NN cord-004297-rm0zbgfm 159 28 estimate estimate NN cord-004297-rm0zbgfm 159 29 of of IN cord-004297-rm0zbgfm 159 30 the the DT cord-004297-rm0zbgfm 159 31 effect effect NN cord-004297-rm0zbgfm 159 32 in in IN cord-004297-rm0zbgfm 159 33 the the DT cord-004297-rm0zbgfm 159 34 particular particular JJ cord-004297-rm0zbgfm 159 35 trial trial NN cord-004297-rm0zbgfm 159 36 . . . cord-004297-rm0zbgfm 160 1 The the DT cord-004297-rm0zbgfm 160 2 red red JJ cord-004297-rm0zbgfm 160 3 diamond diamond NN cord-004297-rm0zbgfm 160 4 shape shape NN cord-004297-rm0zbgfm 160 5 indicates indicate VBZ cord-004297-rm0zbgfm 160 6 the the DT cord-004297-rm0zbgfm 160 7 pooled pool VBN cord-004297-rm0zbgfm 160 8 effect effect NN cord-004297-rm0zbgfm 160 9 and and CC cord-004297-rm0zbgfm 160 10 its -PRON- PRP$ cord-004297-rm0zbgfm 160 11 95 95 CD cord-004297-rm0zbgfm 160 12 % % NN cord-004297-rm0zbgfm 160 13 CI CI NNP cord-004297-rm0zbgfm 160 14 . . . cord-004297-rm0zbgfm 161 1 The the DT cord-004297-rm0zbgfm 161 2 Sadeghpour Sadeghpour NNP cord-004297-rm0zbgfm 161 3 trial trial NN cord-004297-rm0zbgfm 161 4 [ [ -LRB- cord-004297-rm0zbgfm 161 5 19 19 CD cord-004297-rm0zbgfm 161 6 ] ] -RRB- cord-004297-rm0zbgfm 161 7 is be VBZ cord-004297-rm0zbgfm 161 8 not not RB cord-004297-rm0zbgfm 161 9 included include VBN cord-004297-rm0zbgfm 161 10 in in IN cord-004297-rm0zbgfm 161 11 the the DT cord-004297-rm0zbgfm 161 12 meta meta NNP cord-004297-rm0zbgfm 161 13 - - HYPH cord-004297-rm0zbgfm 161 14 analysis analysis NN cord-004297-rm0zbgfm 161 15 , , , cord-004297-rm0zbgfm 161 16 since since IN cord-004297-rm0zbgfm 161 17 the the DT cord-004297-rm0zbgfm 161 18 dropout dropout NN cord-004297-rm0zbgfm 161 19 rate rate NN cord-004297-rm0zbgfm 161 20 was be VBD cord-004297-rm0zbgfm 161 21 high high JJ cord-004297-rm0zbgfm 161 22 ( ( -LRB- cord-004297-rm0zbgfm 161 23 42 42 CD cord-004297-rm0zbgfm 161 24 % % NN cord-004297-rm0zbgfm 161 25 ) ) -RRB- cord-004297-rm0zbgfm 162 1 [ [ -LRB- cord-004297-rm0zbgfm 162 2 1 1 CD cord-004297-rm0zbgfm 162 3 ] ] -RRB- cord-004297-rm0zbgfm 162 4 . . . cord-004297-rm0zbgfm 163 1 RoM rom NN cord-004297-rm0zbgfm 163 2 ratio ratio NN cord-004297-rm0zbgfm 163 3 of of IN cord-004297-rm0zbgfm 163 4 means mean NNS cord-004297-rm0zbgfm 163 5 [ [ -LRB- cord-004297-rm0zbgfm 163 6 22 22 CD cord-004297-rm0zbgfm 163 7 ] ] -RRB- cord-004297-rm0zbgfm 164 1 [ [ -LRB- cord-004297-rm0zbgfm 164 2 19 19 CD cord-004297-rm0zbgfm 164 3 ] ] -RRB- cord-004297-rm0zbgfm 164 4 is be VBZ cord-004297-rm0zbgfm 164 5 not not RB cord-004297-rm0zbgfm 164 6 included include VBN cord-004297-rm0zbgfm 164 7 in in IN cord-004297-rm0zbgfm 164 8 the the DT cord-004297-rm0zbgfm 164 9 statistical statistical JJ cord-004297-rm0zbgfm 164 10 model model NN cord-004297-rm0zbgfm 164 11 , , , cord-004297-rm0zbgfm 164 12 since since IN cord-004297-rm0zbgfm 164 13 the the DT cord-004297-rm0zbgfm 164 14 dropout dropout NN cord-004297-rm0zbgfm 164 15 rate rate NN cord-004297-rm0zbgfm 164 16 was be VBD cord-004297-rm0zbgfm 164 17 high high JJ cord-004297-rm0zbgfm 164 18 ; ; : cord-004297-rm0zbgfm 164 19 however however RB cord-004297-rm0zbgfm 164 20 , , , cord-004297-rm0zbgfm 164 21 it -PRON- PRP cord-004297-rm0zbgfm 164 22 is be VBZ cord-004297-rm0zbgfm 164 23 overlaid overlay VBN cord-004297-rm0zbgfm 164 24 here here RB cord-004297-rm0zbgfm 164 25 for for IN cord-004297-rm0zbgfm 164 26 information information NN cord-004297-rm0zbgfm 164 27 . . . cord-004297-rm0zbgfm 165 1 For for IN cord-004297-rm0zbgfm 165 2 calculations calculation NNS cord-004297-rm0zbgfm 165 3 , , , cord-004297-rm0zbgfm 165 4 see see VB cord-004297-rm0zbgfm 165 5 Additional additional JJ cord-004297-rm0zbgfm 165 6 file file NN cord-004297-rm0zbgfm 165 7 2 2 CD cord-004297-rm0zbgfm 165 8 . . . cord-004297-rm0zbgfm 166 1 RoM rom NN cord-004297-rm0zbgfm 166 2 ratio ratio NN cord-004297-rm0zbgfm 166 3 of of IN cord-004297-rm0zbgfm 166 4 means mean NNS cord-004297-rm0zbgfm 166 5 [ [ -LRB- cord-004297-rm0zbgfm 166 6 22 22 CD cord-004297-rm0zbgfm 166 7 ] ] -RRB- cord-004297-rm0zbgfm 166 8 37 37 CD cord-004297-rm0zbgfm 166 9 % % NN cord-004297-rm0zbgfm 166 10 decrease decrease NN cord-004297-rm0zbgfm 166 11 in in IN cord-004297-rm0zbgfm 166 12 the the DT cord-004297-rm0zbgfm 166 13 vitamin vitamin NN cord-004297-rm0zbgfm 166 14 C C NNP cord-004297-rm0zbgfm 166 15 group group NN cord-004297-rm0zbgfm 166 16 . . . cord-004297-rm0zbgfm 167 1 The the DT cord-004297-rm0zbgfm 167 2 observed observed JJ cord-004297-rm0zbgfm 167 3 decrease decrease NN cord-004297-rm0zbgfm 167 4 was be VBD cord-004297-rm0zbgfm 167 5 30 30 CD cord-004297-rm0zbgfm 167 6 % % NN cord-004297-rm0zbgfm 167 7 ( ( -LRB- cord-004297-rm0zbgfm 167 8 95 95 CD cord-004297-rm0zbgfm 167 9 % % NN cord-004297-rm0zbgfm 167 10 CI ci NN cord-004297-rm0zbgfm 167 11 0 0 CD cord-004297-rm0zbgfm 167 12 % % NN cord-004297-rm0zbgfm 167 13 to to TO cord-004297-rm0zbgfm 167 14 61 61 CD cord-004297-rm0zbgfm 167 15 % % NN cord-004297-rm0zbgfm 167 16 ) ) -RRB- cord-004297-rm0zbgfm 167 17 . . . cord-004297-rm0zbgfm 168 1 Howe Howe NNP cord-004297-rm0zbgfm 168 2 et et NNP cord-004297-rm0zbgfm 168 3 al al NNP cord-004297-rm0zbgfm 168 4 . . . cord-004297-rm0zbgfm 169 1 administered administer VBN cord-004297-rm0zbgfm 169 2 1 1 CD cord-004297-rm0zbgfm 169 3 g g NN cord-004297-rm0zbgfm 169 4 / / SYM cord-004297-rm0zbgfm 169 5 day day NN cord-004297-rm0zbgfm 169 6 vitamin vitamin NN cord-004297-rm0zbgfm 169 7 C c NN cord-004297-rm0zbgfm 169 8 and and CC cord-004297-rm0zbgfm 169 9 1000 1000 CD cord-004297-rm0zbgfm 169 10 IU IU NNP cord-004297-rm0zbgfm 169 11 / / SYM cord-004297-rm0zbgfm 169 12 day day NN cord-004297-rm0zbgfm 169 13 vitamin vitamin NN cord-004297-rm0zbgfm 169 14 E e NN cord-004297-rm0zbgfm 169 15 enterally enterally RB cord-004297-rm0zbgfm 169 16 [ [ -LRB- cord-004297-rm0zbgfm 169 17 31 31 CD cord-004297-rm0zbgfm 169 18 ] ] -RRB- cord-004297-rm0zbgfm 169 19 . . . cord-004297-rm0zbgfm 170 1 Ventilation ventilation NN cord-004297-rm0zbgfm 170 2 time time NN cord-004297-rm0zbgfm 170 3 in in IN cord-004297-rm0zbgfm 170 4 the the DT cord-004297-rm0zbgfm 170 5 control control NN cord-004297-rm0zbgfm 170 6 group group NN cord-004297-rm0zbgfm 170 7 was be VBD cord-004297-rm0zbgfm 170 8 456 456 CD cord-004297-rm0zbgfm 170 9 h h NN cord-004297-rm0zbgfm 170 10 , , , cord-004297-rm0zbgfm 170 11 and and CC cord-004297-rm0zbgfm 170 12 our -PRON- PRP$ cord-004297-rm0zbgfm 170 13 model model NN cord-004297-rm0zbgfm 170 14 predicts predict VBZ cord-004297-rm0zbgfm 170 15 a a DT cord-004297-rm0zbgfm 170 16 42 42 CD cord-004297-rm0zbgfm 170 17 % % NN cord-004297-rm0zbgfm 170 18 decrease decrease NN cord-004297-rm0zbgfm 170 19 in in IN cord-004297-rm0zbgfm 170 20 the the DT cord-004297-rm0zbgfm 170 21 vitamin vitamin NN cord-004297-rm0zbgfm 170 22 C C NNP cord-004297-rm0zbgfm 170 23 group group NN cord-004297-rm0zbgfm 170 24 . . . cord-004297-rm0zbgfm 171 1 The the DT cord-004297-rm0zbgfm 171 2 observed observed JJ cord-004297-rm0zbgfm 171 3 decrease decrease NN cord-004297-rm0zbgfm 171 4 was be VBD cord-004297-rm0zbgfm 171 5 47 47 CD cord-004297-rm0zbgfm 171 6 % % NN cord-004297-rm0zbgfm 171 7 ( ( -LRB- cord-004297-rm0zbgfm 171 8 95 95 CD cord-004297-rm0zbgfm 171 9 % % NN cord-004297-rm0zbgfm 171 10 CI CI NNP cord-004297-rm0zbgfm 171 11 7 7 CD cord-004297-rm0zbgfm 171 12 % % NN cord-004297-rm0zbgfm 171 13 to to IN cord-004297-rm0zbgfm 171 14 87 87 CD cord-004297-rm0zbgfm 171 15 % % NN cord-004297-rm0zbgfm 171 16 ) ) -RRB- cord-004297-rm0zbgfm 171 17 . . . cord-004297-rm0zbgfm 172 1 In in IN cord-004297-rm0zbgfm 172 2 all all DT cord-004297-rm0zbgfm 172 3 three three CD cord-004297-rm0zbgfm 172 4 vitamin vitamin NN cord-004297-rm0zbgfm 172 5 C c NN cord-004297-rm0zbgfm 172 6 and and CC cord-004297-rm0zbgfm 172 7 E e NN cord-004297-rm0zbgfm 172 8 trials trial NNS cord-004297-rm0zbgfm 172 9 , , , cord-004297-rm0zbgfm 172 10 the the DT cord-004297-rm0zbgfm 172 11 observed observed JJ cord-004297-rm0zbgfm 172 12 effect effect NN cord-004297-rm0zbgfm 172 13 of of IN cord-004297-rm0zbgfm 172 14 treatment treatment NN cord-004297-rm0zbgfm 172 15 was be VBD cord-004297-rm0zbgfm 172 16 quite quite RB cord-004297-rm0zbgfm 172 17 close close JJ cord-004297-rm0zbgfm 172 18 to to IN cord-004297-rm0zbgfm 172 19 the the DT cord-004297-rm0zbgfm 172 20 effect effect NN cord-004297-rm0zbgfm 172 21 predicted predict VBN cord-004297-rm0zbgfm 172 22 by by IN cord-004297-rm0zbgfm 172 23 the the DT cord-004297-rm0zbgfm 172 24 trials trial NNS cord-004297-rm0zbgfm 172 25 using use VBG cord-004297-rm0zbgfm 172 26 only only RB cord-004297-rm0zbgfm 172 27 vitamin vitamin NN cord-004297-rm0zbgfm 172 28 C c NN cord-004297-rm0zbgfm 172 29 ( ( -LRB- cord-004297-rm0zbgfm 172 30 Fig Fig NNP cord-004297-rm0zbgfm 172 31 . . . cord-004297-rm0zbgfm 172 32 5 5 LS cord-004297-rm0zbgfm 172 33 ; ; : cord-004297-rm0zbgfm 172 34 see see VB cord-004297-rm0zbgfm 172 35 Additional additional JJ cord-004297-rm0zbgfm 172 36 files file NNS cord-004297-rm0zbgfm 172 37 1 1 CD cord-004297-rm0zbgfm 172 38 and and CC cord-004297-rm0zbgfm 172 39 2 2 CD cord-004297-rm0zbgfm 172 40 for for IN cord-004297-rm0zbgfm 172 41 the the DT cord-004297-rm0zbgfm 172 42 calculations calculation NNS cord-004297-rm0zbgfm 172 43 ) ) -RRB- cord-004297-rm0zbgfm 172 44 . . . cord-004297-rm0zbgfm 173 1 There there EX cord-004297-rm0zbgfm 173 2 is be VBZ cord-004297-rm0zbgfm 173 3 significant significant JJ cord-004297-rm0zbgfm 173 4 variation variation NN cord-004297-rm0zbgfm 173 5 in in IN cord-004297-rm0zbgfm 173 6 the the DT cord-004297-rm0zbgfm 173 7 severity severity NN cord-004297-rm0zbgfm 173 8 of of IN cord-004297-rm0zbgfm 173 9 disease disease NN cord-004297-rm0zbgfm 173 10 in in IN cord-004297-rm0zbgfm 173 11 patients patient NNS cord-004297-rm0zbgfm 173 12 who who WP cord-004297-rm0zbgfm 173 13 are be VBP cord-004297-rm0zbgfm 173 14 mechanically mechanically RB cord-004297-rm0zbgfm 173 15 ventilated ventilate VBN cord-004297-rm0zbgfm 173 16 . . . cord-004297-rm0zbgfm 174 1 One one CD cord-004297-rm0zbgfm 174 2 measure measure NN cord-004297-rm0zbgfm 174 3 of of IN cord-004297-rm0zbgfm 174 4 severity severity NN cord-004297-rm0zbgfm 174 5 is be VBZ cord-004297-rm0zbgfm 174 6 the the DT cord-004297-rm0zbgfm 174 7 mechanical mechanical JJ cord-004297-rm0zbgfm 174 8 ventilation ventilation NN cord-004297-rm0zbgfm 174 9 time time NN cord-004297-rm0zbgfm 174 10 required require VBN cord-004297-rm0zbgfm 174 11 by by IN cord-004297-rm0zbgfm 174 12 the the DT cord-004297-rm0zbgfm 174 13 patient patient NN cord-004297-rm0zbgfm 174 14 , , , cord-004297-rm0zbgfm 174 15 which which WDT cord-004297-rm0zbgfm 174 16 we -PRON- PRP cord-004297-rm0zbgfm 174 17 used use VBD cord-004297-rm0zbgfm 174 18 as as IN cord-004297-rm0zbgfm 174 19 a a DT cord-004297-rm0zbgfm 174 20 proxy proxy NN cord-004297-rm0zbgfm 174 21 for for IN cord-004297-rm0zbgfm 174 22 severity severity NN cord-004297-rm0zbgfm 174 23 . . . cord-004297-rm0zbgfm 175 1 In in IN cord-004297-rm0zbgfm 175 2 this this DT cord-004297-rm0zbgfm 175 3 study study NN cord-004297-rm0zbgfm 175 4 , , , cord-004297-rm0zbgfm 175 5 we -PRON- PRP cord-004297-rm0zbgfm 175 6 found find VBD cord-004297-rm0zbgfm 175 7 that that IN cord-004297-rm0zbgfm 175 8 the the DT cord-004297-rm0zbgfm 175 9 duration duration NN cord-004297-rm0zbgfm 175 10 of of IN cord-004297-rm0zbgfm 175 11 ventilation ventilation NN cord-004297-rm0zbgfm 175 12 in in IN cord-004297-rm0zbgfm 175 13 the the DT cord-004297-rm0zbgfm 175 14 untreated untreated JJ cord-004297-rm0zbgfm 175 15 control control NN cord-004297-rm0zbgfm 175 16 group group NN cord-004297-rm0zbgfm 175 17 explained explain VBD cord-004297-rm0zbgfm 175 18 most most JJS cord-004297-rm0zbgfm 175 19 of of IN cord-004297-rm0zbgfm 175 20 the the DT cord-004297-rm0zbgfm 175 21 variation variation NN cord-004297-rm0zbgfm 175 22 in in IN cord-004297-rm0zbgfm 175 23 the the DT cord-004297-rm0zbgfm 175 24 reported report VBN cord-004297-rm0zbgfm 175 25 effects effect NNS cord-004297-rm0zbgfm 175 26 of of IN cord-004297-rm0zbgfm 175 27 vitamin vitamin NN cord-004297-rm0zbgfm 175 28 C c NN cord-004297-rm0zbgfm 175 29 on on IN cord-004297-rm0zbgfm 175 30 the the DT cord-004297-rm0zbgfm 175 31 mechanical mechanical JJ cord-004297-rm0zbgfm 175 32 ventilation ventilation NN cord-004297-rm0zbgfm 175 33 time time NN cord-004297-rm0zbgfm 175 34 . . . cord-004297-rm0zbgfm 176 1 In in IN cord-004297-rm0zbgfm 176 2 the the DT cord-004297-rm0zbgfm 176 3 standard standard JJ cord-004297-rm0zbgfm 176 4 meta meta NNP cord-004297-rm0zbgfm 176 5 - - HYPH cord-004297-rm0zbgfm 176 6 analysis analysis NN cord-004297-rm0zbgfm 176 7 , , , cord-004297-rm0zbgfm 176 8 there there EX cord-004297-rm0zbgfm 176 9 is be VBZ cord-004297-rm0zbgfm 176 10 high high JJ cord-004297-rm0zbgfm 176 11 - - HYPH cord-004297-rm0zbgfm 176 12 level level NN cord-004297-rm0zbgfm 176 13 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 176 14 with with IN cord-004297-rm0zbgfm 176 15 I I NNP cord-004297-rm0zbgfm 176 16 2 2 CD cord-004297-rm0zbgfm 176 17 = = SYM cord-004297-rm0zbgfm 176 18 83 83 CD cord-004297-rm0zbgfm 176 19 % % NN cord-004297-rm0zbgfm 177 1 ( ( -LRB- cord-004297-rm0zbgfm 177 2 Fig Fig NNP cord-004297-rm0zbgfm 177 3 . . . cord-004297-rm0zbgfm 178 1 3 3 LS cord-004297-rm0zbgfm 178 2 ) ) -RRB- cord-004297-rm0zbgfm 178 3 , , , cord-004297-rm0zbgfm 178 4 whereas whereas IN cord-004297-rm0zbgfm 178 5 in in IN cord-004297-rm0zbgfm 178 6 the the DT cord-004297-rm0zbgfm 178 7 meta meta JJ cord-004297-rm0zbgfm 178 8 - - HYPH cord-004297-rm0zbgfm 178 9 regression regression NN cord-004297-rm0zbgfm 178 10 of of IN cord-004297-rm0zbgfm 178 11 the the DT cord-004297-rm0zbgfm 178 12 vitamin vitamin NN cord-004297-rm0zbgfm 178 13 C c NN cord-004297-rm0zbgfm 178 14 effect effect NN cord-004297-rm0zbgfm 178 15 by by IN cord-004297-rm0zbgfm 178 16 the the DT cord-004297-rm0zbgfm 178 17 control control NN cord-004297-rm0zbgfm 178 18 group group NN cord-004297-rm0zbgfm 178 19 duration duration NN cord-004297-rm0zbgfm 178 20 of of IN cord-004297-rm0zbgfm 178 21 ventilation ventilation NN cord-004297-rm0zbgfm 178 22 , , , cord-004297-rm0zbgfm 178 23 the the DT cord-004297-rm0zbgfm 178 24 residual residual JJ cord-004297-rm0zbgfm 178 25 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 178 26 is be VBZ cord-004297-rm0zbgfm 178 27 small small JJ cord-004297-rm0zbgfm 178 28 with with IN cord-004297-rm0zbgfm 178 29 I -PRON- PRP cord-004297-rm0zbgfm 178 30 2 2 CD cord-004297-rm0zbgfm 178 31 = = SYM cord-004297-rm0zbgfm 178 32 12 12 CD cord-004297-rm0zbgfm 178 33 % % NN cord-004297-rm0zbgfm 179 1 ( ( -LRB- cord-004297-rm0zbgfm 179 2 Fig Fig NNP cord-004297-rm0zbgfm 179 3 . . NNP cord-004297-rm0zbgfm 179 4 4 4 CD cord-004297-rm0zbgfm 179 5 ) ) -RRB- cord-004297-rm0zbgfm 179 6 . . . cord-004297-rm0zbgfm 180 1 Some some DT cord-004297-rm0zbgfm 180 2 of of IN cord-004297-rm0zbgfm 180 3 the the DT cord-004297-rm0zbgfm 180 4 included include VBN cord-004297-rm0zbgfm 180 5 trials trial NNS cord-004297-rm0zbgfm 180 6 examined examine VBD cord-004297-rm0zbgfm 180 7 elective elective JJ cord-004297-rm0zbgfm 180 8 surgical surgical JJ cord-004297-rm0zbgfm 180 9 patients patient NNS cord-004297-rm0zbgfm 180 10 . . . cord-004297-rm0zbgfm 181 1 These these DT cord-004297-rm0zbgfm 181 2 patients patient NNS cord-004297-rm0zbgfm 181 3 are be VBP cord-004297-rm0zbgfm 181 4 not not RB cord-004297-rm0zbgfm 181 5 usually usually RB cord-004297-rm0zbgfm 181 6 critically critically RB cord-004297-rm0zbgfm 181 7 ill ill JJ cord-004297-rm0zbgfm 181 8 ; ; : cord-004297-rm0zbgfm 181 9 however however RB cord-004297-rm0zbgfm 181 10 , , , cord-004297-rm0zbgfm 181 11 as as IN cord-004297-rm0zbgfm 181 12 a a DT cord-004297-rm0zbgfm 181 13 result result NN cord-004297-rm0zbgfm 181 14 of of IN cord-004297-rm0zbgfm 181 15 their -PRON- PRP$ cord-004297-rm0zbgfm 181 16 surgery surgery NN cord-004297-rm0zbgfm 181 17 , , , cord-004297-rm0zbgfm 181 18 they -PRON- PRP cord-004297-rm0zbgfm 181 19 are be VBP cord-004297-rm0zbgfm 181 20 routinely routinely RB cord-004297-rm0zbgfm 181 21 ventilated ventilate VBN cord-004297-rm0zbgfm 181 22 in in IN cord-004297-rm0zbgfm 181 23 the the DT cord-004297-rm0zbgfm 181 24 ICU ICU NNP cord-004297-rm0zbgfm 181 25 for for IN cord-004297-rm0zbgfm 181 26 a a DT cord-004297-rm0zbgfm 181 27 period period NN cord-004297-rm0zbgfm 181 28 of of IN cord-004297-rm0zbgfm 181 29 time time NN cord-004297-rm0zbgfm 181 30 . . . cord-004297-rm0zbgfm 182 1 In in IN cord-004297-rm0zbgfm 182 2 the the DT cord-004297-rm0zbgfm 182 3 metaregression metaregression NN cord-004297-rm0zbgfm 182 4 , , , cord-004297-rm0zbgfm 182 5 such such JJ cord-004297-rm0zbgfm 182 6 patients patient NNS cord-004297-rm0zbgfm 182 7 are be VBP cord-004297-rm0zbgfm 182 8 located locate VBN cord-004297-rm0zbgfm 182 9 on on IN cord-004297-rm0zbgfm 182 10 the the DT cord-004297-rm0zbgfm 182 11 left left JJ cord-004297-rm0zbgfm 182 12 - - HYPH cord-004297-rm0zbgfm 182 13 hand hand NN cord-004297-rm0zbgfm 182 14 side side NN cord-004297-rm0zbgfm 182 15 of of IN cord-004297-rm0zbgfm 182 16 Fig Fig NNP cord-004297-rm0zbgfm 182 17 . . . cord-004297-rm0zbgfm 183 1 4 4 LS cord-004297-rm0zbgfm 183 2 which which WDT cord-004297-rm0zbgfm 183 3 means mean VBZ cord-004297-rm0zbgfm 183 4 that that IN cord-004297-rm0zbgfm 183 5 the the DT cord-004297-rm0zbgfm 183 6 analysis analysis NN cord-004297-rm0zbgfm 183 7 takes take VBZ cord-004297-rm0zbgfm 183 8 into into IN cord-004297-rm0zbgfm 183 9 account account NN cord-004297-rm0zbgfm 183 10 the the DT cord-004297-rm0zbgfm 183 11 low low JJ cord-004297-rm0zbgfm 183 12 level level NN cord-004297-rm0zbgfm 183 13 of of IN cord-004297-rm0zbgfm 183 14 illness illness NN cord-004297-rm0zbgfm 183 15 severity severity NN cord-004297-rm0zbgfm 183 16 . . . cord-004297-rm0zbgfm 184 1 In in IN cord-004297-rm0zbgfm 184 2 contrast contrast NN cord-004297-rm0zbgfm 184 3 , , , cord-004297-rm0zbgfm 184 4 the the DT cord-004297-rm0zbgfm 184 5 inclusion inclusion NN cord-004297-rm0zbgfm 184 6 of of IN cord-004297-rm0zbgfm 184 7 patients patient NNS cord-004297-rm0zbgfm 184 8 with with IN cord-004297-rm0zbgfm 184 9 less less RBR cord-004297-rm0zbgfm 184 10 severe severe JJ cord-004297-rm0zbgfm 184 11 disease disease NN cord-004297-rm0zbgfm 184 12 in in IN cord-004297-rm0zbgfm 184 13 the the DT cord-004297-rm0zbgfm 184 14 standard standard JJ cord-004297-rm0zbgfm 184 15 meta meta JJ cord-004297-rm0zbgfm 184 16 - - HYPH cord-004297-rm0zbgfm 184 17 analysis analysis NN cord-004297-rm0zbgfm 184 18 decreases decrease VBZ cord-004297-rm0zbgfm 184 19 the the DT cord-004297-rm0zbgfm 184 20 average average JJ cord-004297-rm0zbgfm 184 21 effect effect NN cord-004297-rm0zbgfm 184 22 of of IN cord-004297-rm0zbgfm 184 23 vitamin vitamin NN cord-004297-rm0zbgfm 184 24 C c NN cord-004297-rm0zbgfm 184 25 , , , cord-004297-rm0zbgfm 184 26 so so IN cord-004297-rm0zbgfm 184 27 that that IN cord-004297-rm0zbgfm 184 28 the the DT cord-004297-rm0zbgfm 184 29 greater great JJR cord-004297-rm0zbgfm 184 30 effect effect NN cord-004297-rm0zbgfm 184 31 on on IN cord-004297-rm0zbgfm 184 32 the the DT cord-004297-rm0zbgfm 184 33 sicker sick JJR cord-004297-rm0zbgfm 184 34 patients patient NNS cord-004297-rm0zbgfm 184 35 is be VBZ cord-004297-rm0zbgfm 184 36 masked mask VBN cord-004297-rm0zbgfm 185 1 ( ( -LRB- cord-004297-rm0zbgfm 185 2 Fig Fig NNP cord-004297-rm0zbgfm 185 3 . . . cord-004297-rm0zbgfm 185 4 3 3 CD cord-004297-rm0zbgfm 185 5 ) ) -RRB- cord-004297-rm0zbgfm 185 6 . . . cord-004297-rm0zbgfm 186 1 The the DT cord-004297-rm0zbgfm 186 2 substantial substantial JJ cord-004297-rm0zbgfm 186 3 benefit benefit NN cord-004297-rm0zbgfm 186 4 observed observe VBN cord-004297-rm0zbgfm 186 5 in in IN cord-004297-rm0zbgfm 186 6 the the DT cord-004297-rm0zbgfm 186 7 Tanaka Tanaka NNP cord-004297-rm0zbgfm 186 8 [ [ -LRB- cord-004297-rm0zbgfm 186 9 17 17 CD cord-004297-rm0zbgfm 186 10 ] ] -RRB- cord-004297-rm0zbgfm 186 11 trial trial NN cord-004297-rm0zbgfm 186 12 seems seem VBZ cord-004297-rm0zbgfm 186 13 to to TO cord-004297-rm0zbgfm 186 14 be be VB cord-004297-rm0zbgfm 186 15 explained explain VBN cord-004297-rm0zbgfm 186 16 by by IN cord-004297-rm0zbgfm 186 17 the the DT cord-004297-rm0zbgfm 186 18 particularly particularly RB cord-004297-rm0zbgfm 186 19 long long JJ cord-004297-rm0zbgfm 186 20 mechanical mechanical JJ cord-004297-rm0zbgfm 186 21 ventilation ventilation NN cord-004297-rm0zbgfm 186 22 in in IN cord-004297-rm0zbgfm 186 23 the the DT cord-004297-rm0zbgfm 186 24 untreated untreated JJ cord-004297-rm0zbgfm 186 25 control control NN cord-004297-rm0zbgfm 186 26 patients patient NNS cord-004297-rm0zbgfm 186 27 ( ( -LRB- cord-004297-rm0zbgfm 186 28 which which WDT cord-004297-rm0zbgfm 186 29 reflects reflect VBZ cord-004297-rm0zbgfm 186 30 the the DT cord-004297-rm0zbgfm 186 31 greater great JJR cord-004297-rm0zbgfm 186 32 illness illness NN cord-004297-rm0zbgfm 186 33 severity severity NN cord-004297-rm0zbgfm 186 34 ) ) -RRB- cord-004297-rm0zbgfm 186 35 , , , cord-004297-rm0zbgfm 186 36 rather rather RB cord-004297-rm0zbgfm 186 37 than than IN cord-004297-rm0zbgfm 186 38 the the DT cord-004297-rm0zbgfm 186 39 particularly particularly RB cord-004297-rm0zbgfm 186 40 high high JJ cord-004297-rm0zbgfm 186 41 vitamin vitamin NN cord-004297-rm0zbgfm 186 42 C c NN cord-004297-rm0zbgfm 186 43 dosage dosage NN cord-004297-rm0zbgfm 186 44 of of IN cord-004297-rm0zbgfm 186 45 90 90 CD cord-004297-rm0zbgfm 186 46 g g NN cord-004297-rm0zbgfm 186 47 / / SYM cord-004297-rm0zbgfm 186 48 day day NN cord-004297-rm0zbgfm 186 49 in in IN cord-004297-rm0zbgfm 186 50 that that DT cord-004297-rm0zbgfm 186 51 trial trial NN cord-004297-rm0zbgfm 186 52 . . . cord-004297-rm0zbgfm 187 1 All all PDT cord-004297-rm0zbgfm 187 2 the the DT cord-004297-rm0zbgfm 187 3 other other JJ cord-004297-rm0zbgfm 187 4 trials trial NNS cord-004297-rm0zbgfm 187 5 used use VBD cord-004297-rm0zbgfm 187 6 6 6 CD cord-004297-rm0zbgfm 187 7 g g NN cord-004297-rm0zbgfm 187 8 / / SYM cord-004297-rm0zbgfm 187 9 day day NN cord-004297-rm0zbgfm 187 10 or or CC cord-004297-rm0zbgfm 187 11 less less JJR cord-004297-rm0zbgfm 187 12 , , , cord-004297-rm0zbgfm 187 13 but but CC cord-004297-rm0zbgfm 187 14 there there EX cord-004297-rm0zbgfm 187 15 is be VBZ cord-004297-rm0zbgfm 187 16 no no DT cord-004297-rm0zbgfm 187 17 evidence evidence NN cord-004297-rm0zbgfm 187 18 that that IN cord-004297-rm0zbgfm 187 19 the the DT cord-004297-rm0zbgfm 187 20 benefit benefit NN cord-004297-rm0zbgfm 187 21 was be VBD cord-004297-rm0zbgfm 187 22 less less JJR cord-004297-rm0zbgfm 187 23 than than IN cord-004297-rm0zbgfm 187 24 in in IN cord-004297-rm0zbgfm 187 25 the the DT cord-004297-rm0zbgfm 187 26 Tanaka Tanaka NNP cord-004297-rm0zbgfm 187 27 trial trial NN cord-004297-rm0zbgfm 187 28 when when WRB cord-004297-rm0zbgfm 187 29 taking take VBG cord-004297-rm0zbgfm 187 30 into into IN cord-004297-rm0zbgfm 187 31 account account NN cord-004297-rm0zbgfm 187 32 the the DT cord-004297-rm0zbgfm 187 33 ventilation ventilation NN cord-004297-rm0zbgfm 187 34 time time NN cord-004297-rm0zbgfm 187 35 in in IN cord-004297-rm0zbgfm 187 36 the the DT cord-004297-rm0zbgfm 187 37 untreated untreated JJ cord-004297-rm0zbgfm 187 38 control control NN cord-004297-rm0zbgfm 187 39 group group NN cord-004297-rm0zbgfm 187 40 ( ( -LRB- cord-004297-rm0zbgfm 187 41 Fig Fig NNP cord-004297-rm0zbgfm 187 42 . . NNP cord-004297-rm0zbgfm 187 43 4 4 CD cord-004297-rm0zbgfm 187 44 ) ) -RRB- cord-004297-rm0zbgfm 187 45 . . . cord-004297-rm0zbgfm 188 1 There there EX cord-004297-rm0zbgfm 188 2 are be VBP cord-004297-rm0zbgfm 188 3 a a DT cord-004297-rm0zbgfm 188 4 few few JJ cord-004297-rm0zbgfm 188 5 reports report NNS cord-004297-rm0zbgfm 188 6 of of IN cord-004297-rm0zbgfm 188 7 deaths death NNS cord-004297-rm0zbgfm 188 8 caused cause VBN cord-004297-rm0zbgfm 188 9 by by IN cord-004297-rm0zbgfm 188 10 intravenous intravenous JJ cord-004297-rm0zbgfm 188 11 vitamin vitamin NN cord-004297-rm0zbgfm 188 12 C c NN cord-004297-rm0zbgfm 188 13 in in IN cord-004297-rm0zbgfm 188 14 doses dose NNS cord-004297-rm0zbgfm 188 15 of of IN cord-004297-rm0zbgfm 188 16 80 80 CD cord-004297-rm0zbgfm 188 17 to to TO cord-004297-rm0zbgfm 188 18 224 224 CD cord-004297-rm0zbgfm 188 19 g g NN cord-004297-rm0zbgfm 188 20 / / SYM cord-004297-rm0zbgfm 188 21 day day NN cord-004297-rm0zbgfm 188 22 [ [ -LRB- cord-004297-rm0zbgfm 188 23 32 32 CD cord-004297-rm0zbgfm 188 24 , , , cord-004297-rm0zbgfm 188 25 33 33 CD cord-004297-rm0zbgfm 188 26 ] ] -RRB- cord-004297-rm0zbgfm 188 27 . . . cord-004297-rm0zbgfm 189 1 Therefore therefore RB cord-004297-rm0zbgfm 189 2 , , , cord-004297-rm0zbgfm 189 3 the the DT cord-004297-rm0zbgfm 189 4 interpretation interpretation NN cord-004297-rm0zbgfm 189 5 that that IN cord-004297-rm0zbgfm 189 6 the the DT cord-004297-rm0zbgfm 189 7 benefit benefit NN cord-004297-rm0zbgfm 189 8 in in IN cord-004297-rm0zbgfm 189 9 the the DT cord-004297-rm0zbgfm 189 10 Tanaka Tanaka NNP cord-004297-rm0zbgfm 189 11 trial trial NN cord-004297-rm0zbgfm 189 12 may may MD cord-004297-rm0zbgfm 189 13 be be VB cord-004297-rm0zbgfm 189 14 caused cause VBN cord-004297-rm0zbgfm 189 15 by by IN cord-004297-rm0zbgfm 189 16 the the DT cord-004297-rm0zbgfm 189 17 type type NN cord-004297-rm0zbgfm 189 18 of of IN cord-004297-rm0zbgfm 189 19 patients patient NNS cord-004297-rm0zbgfm 189 20 and and CC cord-004297-rm0zbgfm 189 21 not not RB cord-004297-rm0zbgfm 189 22 by by IN cord-004297-rm0zbgfm 189 23 the the DT cord-004297-rm0zbgfm 189 24 very very RB cord-004297-rm0zbgfm 189 25 high high JJ cord-004297-rm0zbgfm 189 26 vitamin vitamin NN cord-004297-rm0zbgfm 189 27 C c NN cord-004297-rm0zbgfm 189 28 dose dose NN cord-004297-rm0zbgfm 189 29 is be VBZ cord-004297-rm0zbgfm 189 30 important important JJ cord-004297-rm0zbgfm 189 31 for for IN cord-004297-rm0zbgfm 189 32 planning plan VBG cord-004297-rm0zbgfm 189 33 further further JJ cord-004297-rm0zbgfm 189 34 trials trial NNS cord-004297-rm0zbgfm 189 35 . . . cord-004297-rm0zbgfm 190 1 Our -PRON- PRP$ cord-004297-rm0zbgfm 190 2 previous previous JJ cord-004297-rm0zbgfm 190 3 analysis analysis NN cord-004297-rm0zbgfm 190 4 of of IN cord-004297-rm0zbgfm 190 5 the the DT cord-004297-rm0zbgfm 190 6 length length NN cord-004297-rm0zbgfm 190 7 of of IN cord-004297-rm0zbgfm 190 8 ICU ICU NNP cord-004297-rm0zbgfm 190 9 stay stay NN cord-004297-rm0zbgfm 190 10 also also RB cord-004297-rm0zbgfm 190 11 found find VBD cord-004297-rm0zbgfm 190 12 that that IN cord-004297-rm0zbgfm 190 13 the the DT cord-004297-rm0zbgfm 190 14 effect effect NN cord-004297-rm0zbgfm 190 15 of of IN cord-004297-rm0zbgfm 190 16 vitamin vitamin NN cord-004297-rm0zbgfm 190 17 C c NN cord-004297-rm0zbgfm 190 18 appeared appear VBD cord-004297-rm0zbgfm 190 19 greater great JJR cord-004297-rm0zbgfm 190 20 for for IN cord-004297-rm0zbgfm 190 21 the the DT cord-004297-rm0zbgfm 190 22 sicker sick JJR cord-004297-rm0zbgfm 190 23 patients patient NNS cord-004297-rm0zbgfm 190 24 . . . cord-004297-rm0zbgfm 191 1 The the DT cord-004297-rm0zbgfm 191 2 length length NN cord-004297-rm0zbgfm 191 3 of of IN cord-004297-rm0zbgfm 191 4 ICU ICU NNP cord-004297-rm0zbgfm 191 5 stay stay NN cord-004297-rm0zbgfm 191 6 was be VBD cord-004297-rm0zbgfm 191 7 reduced reduce VBN cord-004297-rm0zbgfm 191 8 by by IN cord-004297-rm0zbgfm 191 9 10.1 10.1 CD cord-004297-rm0zbgfm 191 10 % % NN cord-004297-rm0zbgfm 191 11 ( ( -LRB- cord-004297-rm0zbgfm 191 12 P p NN cord-004297-rm0zbgfm 191 13 = = SYM cord-004297-rm0zbgfm 191 14 0.0001 0.0001 CD cord-004297-rm0zbgfm 191 15 ) ) -RRB- cord-004297-rm0zbgfm 191 16 in in IN cord-004297-rm0zbgfm 191 17 patients patient NNS cord-004297-rm0zbgfm 191 18 who who WP cord-004297-rm0zbgfm 191 19 required require VBD cord-004297-rm0zbgfm 191 20 an an DT cord-004297-rm0zbgfm 191 21 ICU ICU NNP cord-004297-rm0zbgfm 191 22 stay stay NN cord-004297-rm0zbgfm 191 23 of of IN cord-004297-rm0zbgfm 191 24 3 3 CD cord-004297-rm0zbgfm 191 25 days day NNS cord-004297-rm0zbgfm 191 26 or or CC cord-004297-rm0zbgfm 191 27 longer long JJR cord-004297-rm0zbgfm 191 28 , , , cord-004297-rm0zbgfm 191 29 but but CC cord-004297-rm0zbgfm 191 30 by by IN cord-004297-rm0zbgfm 191 31 just just RB cord-004297-rm0zbgfm 191 32 5.7 5.7 CD cord-004297-rm0zbgfm 191 33 % % NN cord-004297-rm0zbgfm 191 34 ( ( -LRB- cord-004297-rm0zbgfm 191 35 P p NN cord-004297-rm0zbgfm 191 36 = = SYM cord-004297-rm0zbgfm 191 37 0.03 0.03 CD cord-004297-rm0zbgfm 191 38 ) ) -RRB- cord-004297-rm0zbgfm 191 39 in in IN cord-004297-rm0zbgfm 191 40 those those DT cord-004297-rm0zbgfm 191 41 who who WP cord-004297-rm0zbgfm 191 42 needed need VBD cord-004297-rm0zbgfm 191 43 only only RB cord-004297-rm0zbgfm 191 44 1 1 CD cord-004297-rm0zbgfm 191 45 - - SYM cord-004297-rm0zbgfm 191 46 2 2 CD cord-004297-rm0zbgfm 191 47 days day NNS cord-004297-rm0zbgfm 191 48 in in IN cord-004297-rm0zbgfm 191 49 the the DT cord-004297-rm0zbgfm 191 50 ICU ICU NNP cord-004297-rm0zbgfm 191 51 [ [ -LRB- cord-004297-rm0zbgfm 191 52 1 1 CD cord-004297-rm0zbgfm 191 53 ] ] -RRB- cord-004297-rm0zbgfm 191 54 . . . cord-004297-rm0zbgfm 192 1 There there EX cord-004297-rm0zbgfm 192 2 are be VBP cord-004297-rm0zbgfm 192 3 also also RB cord-004297-rm0zbgfm 192 4 other other JJ cord-004297-rm0zbgfm 192 5 findings finding NNS cord-004297-rm0zbgfm 192 6 that that WDT cord-004297-rm0zbgfm 192 7 are be VBP cord-004297-rm0zbgfm 192 8 consistent consistent JJ cord-004297-rm0zbgfm 192 9 with with IN cord-004297-rm0zbgfm 192 10 vitamin vitamin NN cord-004297-rm0zbgfm 192 11 C c NN cord-004297-rm0zbgfm 192 12 having have VBG cord-004297-rm0zbgfm 192 13 a a DT cord-004297-rm0zbgfm 192 14 greater great JJR cord-004297-rm0zbgfm 192 15 effect effect NN cord-004297-rm0zbgfm 192 16 on on IN cord-004297-rm0zbgfm 192 17 patients patient NNS cord-004297-rm0zbgfm 192 18 with with IN cord-004297-rm0zbgfm 192 19 more more RBR cord-004297-rm0zbgfm 192 20 severe severe JJ cord-004297-rm0zbgfm 192 21 medical medical JJ cord-004297-rm0zbgfm 192 22 conditions condition NNS cord-004297-rm0zbgfm 192 23 . . . cord-004297-rm0zbgfm 193 1 A a DT cord-004297-rm0zbgfm 193 2 meta meta JJ cord-004297-rm0zbgfm 193 3 - - HYPH cord-004297-rm0zbgfm 193 4 analysis analysis NN cord-004297-rm0zbgfm 193 5 of of IN cord-004297-rm0zbgfm 193 6 vitamin vitamin NN cord-004297-rm0zbgfm 193 7 C c NN cord-004297-rm0zbgfm 193 8 effect effect NN cord-004297-rm0zbgfm 193 9 on on IN cord-004297-rm0zbgfm 193 10 exercise exercise NN cord-004297-rm0zbgfm 193 11 - - HYPH cord-004297-rm0zbgfm 193 12 induced induce VBN cord-004297-rm0zbgfm 193 13 bronchoconstriction bronchoconstriction NN cord-004297-rm0zbgfm 193 14 found find VBD cord-004297-rm0zbgfm 193 15 that that IN cord-004297-rm0zbgfm 193 16 vitamin vitamin NN cord-004297-rm0zbgfm 193 17 C c NN cord-004297-rm0zbgfm 193 18 halved halve VBD cord-004297-rm0zbgfm 193 19 FEV FEV NNP cord-004297-rm0zbgfm 193 20 1 1 CD cord-004297-rm0zbgfm 193 21 decline decline NN cord-004297-rm0zbgfm 193 22 caused cause VBN cord-004297-rm0zbgfm 193 23 by by IN cord-004297-rm0zbgfm 193 24 exercise exercise NN cord-004297-rm0zbgfm 193 25 [ [ -LRB- cord-004297-rm0zbgfm 193 26 34 34 CD cord-004297-rm0zbgfm 193 27 ] ] -RRB- cord-004297-rm0zbgfm 193 28 . . . cord-004297-rm0zbgfm 194 1 The the DT cord-004297-rm0zbgfm 194 2 constant constant JJ cord-004297-rm0zbgfm 194 3 relative relative JJ cord-004297-rm0zbgfm 194 4 effect effect NN cord-004297-rm0zbgfm 194 5 indicates indicate VBZ cord-004297-rm0zbgfm 194 6 that that IN cord-004297-rm0zbgfm 194 7 the the DT cord-004297-rm0zbgfm 194 8 absolute absolute JJ cord-004297-rm0zbgfm 194 9 effect effect NN cord-004297-rm0zbgfm 194 10 was be VBD cord-004297-rm0zbgfm 194 11 greatest great JJS cord-004297-rm0zbgfm 194 12 for for IN cord-004297-rm0zbgfm 194 13 patients patient NNS cord-004297-rm0zbgfm 194 14 who who WP cord-004297-rm0zbgfm 194 15 had have VBD cord-004297-rm0zbgfm 194 16 the the DT cord-004297-rm0zbgfm 194 17 greatest great JJS cord-004297-rm0zbgfm 194 18 bronchoconstriction bronchoconstriction NN cord-004297-rm0zbgfm 194 19 in in IN cord-004297-rm0zbgfm 194 20 the the DT cord-004297-rm0zbgfm 194 21 exercise exercise NN cord-004297-rm0zbgfm 194 22 test test NN cord-004297-rm0zbgfm 194 23 . . . cord-004297-rm0zbgfm 195 1 Finally finally RB cord-004297-rm0zbgfm 195 2 , , , cord-004297-rm0zbgfm 195 3 a a DT cord-004297-rm0zbgfm 195 4 trial trial NN cord-004297-rm0zbgfm 196 1 The the DT cord-004297-rm0zbgfm 196 2 results result NNS cord-004297-rm0zbgfm 196 3 of of IN cord-004297-rm0zbgfm 196 4 the the DT cord-004297-rm0zbgfm 196 5 three three CD cord-004297-rm0zbgfm 196 6 trials trial NNS cord-004297-rm0zbgfm 196 7 [ [ -LRB- cord-004297-rm0zbgfm 196 8 29 29 CD cord-004297-rm0zbgfm 196 9 ] ] -RRB- cord-004297-rm0zbgfm 196 10 [ [ -LRB- cord-004297-rm0zbgfm 196 11 30 30 CD cord-004297-rm0zbgfm 196 12 ] ] -RRB- cord-004297-rm0zbgfm 196 13 [ [ -LRB- cord-004297-rm0zbgfm 196 14 31 31 CD cord-004297-rm0zbgfm 196 15 ] ] -RRB- cord-004297-rm0zbgfm 196 16 and and CC cord-004297-rm0zbgfm 196 17 their -PRON- PRP$ cord-004297-rm0zbgfm 196 18 95 95 CD cord-004297-rm0zbgfm 196 19 % % NN cord-004297-rm0zbgfm 196 20 CIs ci NNS cord-004297-rm0zbgfm 196 21 are be VBP cord-004297-rm0zbgfm 196 22 shown show VBN cord-004297-rm0zbgfm 196 23 . . . cord-004297-rm0zbgfm 197 1 For for IN cord-004297-rm0zbgfm 197 2 calculations calculation NNS cord-004297-rm0zbgfm 197 3 , , , cord-004297-rm0zbgfm 197 4 see see VB cord-004297-rm0zbgfm 197 5 Additional additional JJ cord-004297-rm0zbgfm 197 6 file file NN cord-004297-rm0zbgfm 197 7 2 2 CD cord-004297-rm0zbgfm 197 8 . . . cord-004297-rm0zbgfm 198 1 RoM rom NN cord-004297-rm0zbgfm 198 2 ratio ratio NN cord-004297-rm0zbgfm 198 3 of of IN cord-004297-rm0zbgfm 198 4 means mean NNS cord-004297-rm0zbgfm 198 5 [ [ -LRB- cord-004297-rm0zbgfm 198 6 22 22 CD cord-004297-rm0zbgfm 198 7 ] ] -RRB- cord-004297-rm0zbgfm 198 8 with with IN cord-004297-rm0zbgfm 198 9 common common JJ cord-004297-rm0zbgfm 198 10 cold cold JJ cord-004297-rm0zbgfm 198 11 patients patient NNS cord-004297-rm0zbgfm 198 12 indicated indicate VBD cord-004297-rm0zbgfm 198 13 that that IN cord-004297-rm0zbgfm 198 14 the the DT cord-004297-rm0zbgfm 198 15 bronchodilatory bronchodilatory JJ cord-004297-rm0zbgfm 198 16 effect effect NN cord-004297-rm0zbgfm 198 17 of of IN cord-004297-rm0zbgfm 198 18 vitamin vitamin NN cord-004297-rm0zbgfm 198 19 C c NN cord-004297-rm0zbgfm 198 20 was be VBD cord-004297-rm0zbgfm 198 21 most most RBS cord-004297-rm0zbgfm 198 22 beneficial beneficial JJ cord-004297-rm0zbgfm 198 23 for for IN cord-004297-rm0zbgfm 198 24 those those DT cord-004297-rm0zbgfm 198 25 with with IN cord-004297-rm0zbgfm 198 26 the the DT cord-004297-rm0zbgfm 198 27 greatest great JJS cord-004297-rm0zbgfm 198 28 bronchial bronchial JJ cord-004297-rm0zbgfm 198 29 hypersensitivity hypersensitivity NN cord-004297-rm0zbgfm 198 30 to to IN cord-004297-rm0zbgfm 198 31 histamine histamine NN cord-004297-rm0zbgfm 198 32 [ [ -LRB- cord-004297-rm0zbgfm 198 33 35 35 CD cord-004297-rm0zbgfm 198 34 , , , cord-004297-rm0zbgfm 198 35 36 36 CD cord-004297-rm0zbgfm 198 36 ] ] -RRB- cord-004297-rm0zbgfm 198 37 . . . cord-004297-rm0zbgfm 199 1 There there EX cord-004297-rm0zbgfm 199 2 is be VBZ cord-004297-rm0zbgfm 199 3 much much JJ cord-004297-rm0zbgfm 199 4 evidence evidence NN cord-004297-rm0zbgfm 199 5 indicating indicate VBG cord-004297-rm0zbgfm 199 6 that that IN cord-004297-rm0zbgfm 199 7 vitamins vitamin NNS cord-004297-rm0zbgfm 199 8 C c NN cord-004297-rm0zbgfm 199 9 and and CC cord-004297-rm0zbgfm 199 10 E E NNS cord-004297-rm0zbgfm 199 11 have have VBP cord-004297-rm0zbgfm 199 12 an an DT cord-004297-rm0zbgfm 199 13 interaction interaction NN cord-004297-rm0zbgfm 199 14 in in IN cord-004297-rm0zbgfm 199 15 vitro vitro FW cord-004297-rm0zbgfm 199 16 and and CC cord-004297-rm0zbgfm 199 17 in in IN cord-004297-rm0zbgfm 199 18 vivo vivo NNP cord-004297-rm0zbgfm 199 19 [ [ -LRB- cord-004297-rm0zbgfm 199 20 37 37 CD cord-004297-rm0zbgfm 199 21 ] ] -RRB- cord-004297-rm0zbgfm 199 22 [ [ -LRB- cord-004297-rm0zbgfm 199 23 38 38 CD cord-004297-rm0zbgfm 199 24 ] ] -RRB- cord-004297-rm0zbgfm 199 25 [ [ -LRB- cord-004297-rm0zbgfm 199 26 39 39 CD cord-004297-rm0zbgfm 199 27 ] ] -RRB- cord-004297-rm0zbgfm 199 28 [ [ -LRB- cord-004297-rm0zbgfm 199 29 40 40 CD cord-004297-rm0zbgfm 199 30 ] ] -RRB- cord-004297-rm0zbgfm 199 31 [ [ -LRB- cord-004297-rm0zbgfm 199 32 41 41 CD cord-004297-rm0zbgfm 199 33 ] ] -RRB- cord-004297-rm0zbgfm 199 34 , , , cord-004297-rm0zbgfm 199 35 and and CC cord-004297-rm0zbgfm 200 1 three three CD cord-004297-rm0zbgfm 200 2 trials trial NNS cord-004297-rm0zbgfm 200 3 have have VBP cord-004297-rm0zbgfm 200 4 examined examine VBN cord-004297-rm0zbgfm 200 5 the the DT cord-004297-rm0zbgfm 200 6 effect effect NN cord-004297-rm0zbgfm 200 7 of of IN cord-004297-rm0zbgfm 200 8 the the DT cord-004297-rm0zbgfm 200 9 combination combination NN cord-004297-rm0zbgfm 200 10 of of IN cord-004297-rm0zbgfm 200 11 vitamins vitamin NNS cord-004297-rm0zbgfm 200 12 C c NN cord-004297-rm0zbgfm 200 13 and and CC cord-004297-rm0zbgfm 200 14 E e NN cord-004297-rm0zbgfm 200 15 on on IN cord-004297-rm0zbgfm 200 16 the the DT cord-004297-rm0zbgfm 200 17 duration duration NN cord-004297-rm0zbgfm 200 18 of of IN cord-004297-rm0zbgfm 200 19 mechanical mechanical JJ cord-004297-rm0zbgfm 200 20 ventilation ventilation NN cord-004297-rm0zbgfm 200 21 [ [ -LRB- cord-004297-rm0zbgfm 200 22 29 29 CD cord-004297-rm0zbgfm 200 23 ] ] -RRB- cord-004297-rm0zbgfm 200 24 [ [ -LRB- cord-004297-rm0zbgfm 200 25 30 30 CD cord-004297-rm0zbgfm 200 26 ] ] -RRB- cord-004297-rm0zbgfm 200 27 [ [ -LRB- cord-004297-rm0zbgfm 200 28 31 31 CD cord-004297-rm0zbgfm 200 29 ] ] -RRB- cord-004297-rm0zbgfm 200 30 . . . cord-004297-rm0zbgfm 201 1 The the DT cord-004297-rm0zbgfm 201 2 reported report VBN cord-004297-rm0zbgfm 201 3 effects effect NNS cord-004297-rm0zbgfm 201 4 from from IN cord-004297-rm0zbgfm 201 5 the the DT cord-004297-rm0zbgfm 201 6 three three CD cord-004297-rm0zbgfm 201 7 trials trial NNS cord-004297-rm0zbgfm 201 8 are be VBP cord-004297-rm0zbgfm 201 9 largely largely RB cord-004297-rm0zbgfm 201 10 consistent consistent JJ cord-004297-rm0zbgfm 201 11 with with IN cord-004297-rm0zbgfm 201 12 the the DT cord-004297-rm0zbgfm 201 13 meta meta JJ cord-004297-rm0zbgfm 201 14 - - HYPH cord-004297-rm0zbgfm 201 15 regression regression NN cord-004297-rm0zbgfm 201 16 model model NN cord-004297-rm0zbgfm 201 17 based base VBN cord-004297-rm0zbgfm 201 18 on on IN cord-004297-rm0zbgfm 201 19 the the DT cord-004297-rm0zbgfm 201 20 eight eight CD cord-004297-rm0zbgfm 201 21 trials trial NNS cord-004297-rm0zbgfm 201 22 using use VBG cord-004297-rm0zbgfm 201 23 vitamin vitamin NN cord-004297-rm0zbgfm 201 24 C c NN cord-004297-rm0zbgfm 201 25 alone alone JJ cord-004297-rm0zbgfm 202 1 ( ( -LRB- cord-004297-rm0zbgfm 202 2 Fig Fig NNP cord-004297-rm0zbgfm 202 3 . . NNP cord-004297-rm0zbgfm 202 4 5 5 CD cord-004297-rm0zbgfm 202 5 ) ) -RRB- cord-004297-rm0zbgfm 202 6 , , , cord-004297-rm0zbgfm 202 7 though though IN cord-004297-rm0zbgfm 202 8 the the DT cord-004297-rm0zbgfm 202 9 confidence confidence NN cord-004297-rm0zbgfm 202 10 interval interval NN cord-004297-rm0zbgfm 202 11 of of IN cord-004297-rm0zbgfm 202 12 the the DT cord-004297-rm0zbgfm 202 13 Nathens Nathens NNPS cord-004297-rm0zbgfm 202 14 et et NNP cord-004297-rm0zbgfm 202 15 al al NNP cord-004297-rm0zbgfm 202 16 . . . cord-004297-rm0zbgfm 203 1 trial trial NN cord-004297-rm0zbgfm 203 2 does do VBZ cord-004297-rm0zbgfm 203 3 not not RB cord-004297-rm0zbgfm 203 4 cross cross VB cord-004297-rm0zbgfm 203 5 the the DT cord-004297-rm0zbgfm 203 6 regression regression NN cord-004297-rm0zbgfm 203 7 line line NN cord-004297-rm0zbgfm 203 8 . . . cord-004297-rm0zbgfm 204 1 Thus thus RB cord-004297-rm0zbgfm 204 2 , , , cord-004297-rm0zbgfm 204 3 the the DT cord-004297-rm0zbgfm 204 4 statistically statistically RB cord-004297-rm0zbgfm 204 5 significant significant JJ cord-004297-rm0zbgfm 204 6 benefit benefit NN cord-004297-rm0zbgfm 204 7 observed observe VBN cord-004297-rm0zbgfm 204 8 in in IN cord-004297-rm0zbgfm 204 9 each each DT cord-004297-rm0zbgfm 204 10 of of IN cord-004297-rm0zbgfm 204 11 these these DT cord-004297-rm0zbgfm 204 12 three three CD cord-004297-rm0zbgfm 204 13 trials trial NNS cord-004297-rm0zbgfm 204 14 might may MD cord-004297-rm0zbgfm 204 15 be be VB cord-004297-rm0zbgfm 204 16 explained explain VBN cord-004297-rm0zbgfm 204 17 by by IN cord-004297-rm0zbgfm 204 18 the the DT cord-004297-rm0zbgfm 204 19 long long JJ cord-004297-rm0zbgfm 204 20 ventilation ventilation NN cord-004297-rm0zbgfm 204 21 time time NN cord-004297-rm0zbgfm 204 22 in in IN cord-004297-rm0zbgfm 204 23 the the DT cord-004297-rm0zbgfm 204 24 control control NN cord-004297-rm0zbgfm 204 25 groups group NNS cord-004297-rm0zbgfm 204 26 , , , cord-004297-rm0zbgfm 204 27 indicating indicate VBG cord-004297-rm0zbgfm 204 28 greater great JJR cord-004297-rm0zbgfm 204 29 severity severity NN cord-004297-rm0zbgfm 204 30 of of IN cord-004297-rm0zbgfm 204 31 illness illness NN cord-004297-rm0zbgfm 204 32 in in IN cord-004297-rm0zbgfm 204 33 the the DT cord-004297-rm0zbgfm 204 34 patients patient NNS cord-004297-rm0zbgfm 204 35 , , , cord-004297-rm0zbgfm 204 36 rather rather RB cord-004297-rm0zbgfm 204 37 than than IN cord-004297-rm0zbgfm 204 38 by by IN cord-004297-rm0zbgfm 204 39 the the DT cord-004297-rm0zbgfm 204 40 addition addition NN cord-004297-rm0zbgfm 204 41 of of IN cord-004297-rm0zbgfm 204 42 vitamin vitamin NN cord-004297-rm0zbgfm 204 43 E e NN cord-004297-rm0zbgfm 204 44 to to IN cord-004297-rm0zbgfm 204 45 the the DT cord-004297-rm0zbgfm 204 46 intervention intervention NN cord-004297-rm0zbgfm 204 47 . . . cord-004297-rm0zbgfm 205 1 To to TO cord-004297-rm0zbgfm 205 2 test test VB cord-004297-rm0zbgfm 205 3 the the DT cord-004297-rm0zbgfm 205 4 possible possible JJ cord-004297-rm0zbgfm 205 5 additional additional JJ cord-004297-rm0zbgfm 205 6 benefit benefit NN cord-004297-rm0zbgfm 205 7 of of IN cord-004297-rm0zbgfm 205 8 vitamin vitamin NN cord-004297-rm0zbgfm 205 9 E e NN cord-004297-rm0zbgfm 205 10 over over IN cord-004297-rm0zbgfm 205 11 vitamin vitamin NN cord-004297-rm0zbgfm 205 12 C C NNP cord-004297-rm0zbgfm 205 13 would would MD cord-004297-rm0zbgfm 205 14 require require VB cord-004297-rm0zbgfm 205 15 2 2 CD cord-004297-rm0zbgfm 205 16 × × NN cord-004297-rm0zbgfm 205 17 2 2 CD cord-004297-rm0zbgfm 205 18 factorial factorial JJ cord-004297-rm0zbgfm 205 19 trials trial NNS cord-004297-rm0zbgfm 205 20 . . . cord-004297-rm0zbgfm 206 1 Although although IN cord-004297-rm0zbgfm 206 2 our -PRON- PRP$ cord-004297-rm0zbgfm 206 3 meta meta JJ cord-004297-rm0zbgfm 206 4 - - HYPH cord-004297-rm0zbgfm 206 5 regression regression NN cord-004297-rm0zbgfm 206 6 analysis analysis NN cord-004297-rm0zbgfm 206 7 by by IN cord-004297-rm0zbgfm 206 8 the the DT cord-004297-rm0zbgfm 206 9 ventilation ventilation NN cord-004297-rm0zbgfm 206 10 time time NN cord-004297-rm0zbgfm 206 11 in in IN cord-004297-rm0zbgfm 206 12 the the DT cord-004297-rm0zbgfm 206 13 control control NN cord-004297-rm0zbgfm 206 14 group group NN cord-004297-rm0zbgfm 206 15 explains explain VBZ cord-004297-rm0zbgfm 206 16 the the DT cord-004297-rm0zbgfm 206 17 heterogeneity heterogeneity NN cord-004297-rm0zbgfm 206 18 in in IN cord-004297-rm0zbgfm 206 19 the the DT cord-004297-rm0zbgfm 206 20 published publish VBN cord-004297-rm0zbgfm 206 21 trials trial NNS cord-004297-rm0zbgfm 206 22 , , , cord-004297-rm0zbgfm 206 23 it -PRON- PRP cord-004297-rm0zbgfm 206 24 seems seem VBZ cord-004297-rm0zbgfm 206 25 evident evident JJ cord-004297-rm0zbgfm 206 26 that that IN cord-004297-rm0zbgfm 206 27 other other JJ cord-004297-rm0zbgfm 206 28 variables variable NNS cord-004297-rm0zbgfm 206 29 influence influence VBP cord-004297-rm0zbgfm 206 30 the the DT cord-004297-rm0zbgfm 206 31 effects effect NNS cord-004297-rm0zbgfm 206 32 of of IN cord-004297-rm0zbgfm 206 33 vitamin vitamin NN cord-004297-rm0zbgfm 206 34 C. c. NN cord-004297-rm0zbgfm 207 1 For for IN cord-004297-rm0zbgfm 207 2 example example NN cord-004297-rm0zbgfm 207 3 , , , cord-004297-rm0zbgfm 207 4 there there EX cord-004297-rm0zbgfm 207 5 are be VBP cord-004297-rm0zbgfm 207 6 indications indication NNS cord-004297-rm0zbgfm 207 7 that that IN cord-004297-rm0zbgfm 207 8 treatment treatment NN cord-004297-rm0zbgfm 207 9 effects effect NNS cord-004297-rm0zbgfm 207 10 can can MD cord-004297-rm0zbgfm 207 11 differ differ VB cord-004297-rm0zbgfm 207 12 between between IN cord-004297-rm0zbgfm 207 13 less less JJR cord-004297-rm0zbgfm 207 14 and and CC cord-004297-rm0zbgfm 207 15 more more RBR cord-004297-rm0zbgfm 207 16 developed developed JJ cord-004297-rm0zbgfm 207 17 countries country NNS cord-004297-rm0zbgfm 207 18 . . . cord-004297-rm0zbgfm 208 1 Panagiotou Panagiotou NNP cord-004297-rm0zbgfm 208 2 et et NNP cord-004297-rm0zbgfm 208 3 al al NNP cord-004297-rm0zbgfm 208 4 . . NNP cord-004297-rm0zbgfm 208 5 identified identify VBD cord-004297-rm0zbgfm 208 6 several several JJ cord-004297-rm0zbgfm 208 7 studies study NNS cord-004297-rm0zbgfm 208 8 that that WDT cord-004297-rm0zbgfm 208 9 reported report VBD cord-004297-rm0zbgfm 208 10 greater great JJR cord-004297-rm0zbgfm 208 11 treatment treatment NN cord-004297-rm0zbgfm 208 12 effects effect NNS cord-004297-rm0zbgfm 208 13 in in IN cord-004297-rm0zbgfm 208 14 less less RBR cord-004297-rm0zbgfm 208 15 developed developed JJ cord-004297-rm0zbgfm 208 16 countries country NNS cord-004297-rm0zbgfm 208 17 than than IN cord-004297-rm0zbgfm 208 18 in in IN cord-004297-rm0zbgfm 208 19 more more RBR cord-004297-rm0zbgfm 208 20 developed developed JJ cord-004297-rm0zbgfm 208 21 countries country NNS cord-004297-rm0zbgfm 208 22 [ [ -LRB- cord-004297-rm0zbgfm 208 23 42 42 CD cord-004297-rm0zbgfm 208 24 ] ] -RRB- cord-004297-rm0zbgfm 208 25 . . . cord-004297-rm0zbgfm 209 1 Although although IN cord-004297-rm0zbgfm 209 2 methodological methodological JJ cord-004297-rm0zbgfm 209 3 variations variation NNS cord-004297-rm0zbgfm 209 4 may may MD cord-004297-rm0zbgfm 209 5 explain explain VB cord-004297-rm0zbgfm 209 6 some some DT cord-004297-rm0zbgfm 209 7 of of IN cord-004297-rm0zbgfm 209 8 the the DT cord-004297-rm0zbgfm 209 9 differences difference NNS cord-004297-rm0zbgfm 209 10 , , , cord-004297-rm0zbgfm 209 11 there there EX cord-004297-rm0zbgfm 209 12 can can MD cord-004297-rm0zbgfm 209 13 also also RB cord-004297-rm0zbgfm 209 14 be be VB cord-004297-rm0zbgfm 209 15 genuine genuine JJ cord-004297-rm0zbgfm 209 16 treatment treatment NN cord-004297-rm0zbgfm 209 17 differences difference NNS cord-004297-rm0zbgfm 209 18 between between IN cord-004297-rm0zbgfm 209 19 substantially substantially RB cord-004297-rm0zbgfm 209 20 different different JJ cord-004297-rm0zbgfm 209 21 cultures culture NNS cord-004297-rm0zbgfm 209 22 , , , cord-004297-rm0zbgfm 209 23 since since IN cord-004297-rm0zbgfm 209 24 wealth wealth NN cord-004297-rm0zbgfm 209 25 is be VBZ cord-004297-rm0zbgfm 209 26 strongly strongly RB cord-004297-rm0zbgfm 209 27 correlated correlate VBN cord-004297-rm0zbgfm 209 28 with with IN cord-004297-rm0zbgfm 209 29 life life NN cord-004297-rm0zbgfm 209 30 - - HYPH cord-004297-rm0zbgfm 209 31 style style NN cord-004297-rm0zbgfm 209 32 factors factor NNS cord-004297-rm0zbgfm 209 33 including include VBG cord-004297-rm0zbgfm 209 34 nutrition nutrition NN cord-004297-rm0zbgfm 209 35 and and CC cord-004297-rm0zbgfm 209 36 with with IN cord-004297-rm0zbgfm 209 37 differences difference NNS cord-004297-rm0zbgfm 209 38 in in IN cord-004297-rm0zbgfm 209 39 hospital hospital NN cord-004297-rm0zbgfm 209 40 treatments treatment NNS cord-004297-rm0zbgfm 209 41 . . . cord-004297-rm0zbgfm 210 1 Previously previously RB cord-004297-rm0zbgfm 210 2 , , , cord-004297-rm0zbgfm 210 3 vitamin vitamin NN cord-004297-rm0zbgfm 210 4 C c NN cord-004297-rm0zbgfm 210 5 was be VBD cord-004297-rm0zbgfm 210 6 found find VBN cord-004297-rm0zbgfm 210 7 to to TO cord-004297-rm0zbgfm 210 8 prevent prevent VB cord-004297-rm0zbgfm 210 9 post post JJ cord-004297-rm0zbgfm 210 10 - - JJ cord-004297-rm0zbgfm 210 11 operative operative JJ cord-004297-rm0zbgfm 210 12 atrial atrial JJ cord-004297-rm0zbgfm 210 13 fibrillation fibrillation NN cord-004297-rm0zbgfm 210 14 in in IN cord-004297-rm0zbgfm 210 15 non non JJ cord-004297-rm0zbgfm 210 16 - - JJ cord-004297-rm0zbgfm 210 17 US US NNP cord-004297-rm0zbgfm 210 18 trials trial NNS cord-004297-rm0zbgfm 210 19 , , , cord-004297-rm0zbgfm 210 20 but but CC cord-004297-rm0zbgfm 210 21 not not RB cord-004297-rm0zbgfm 210 22 in in IN cord-004297-rm0zbgfm 210 23 US US NNP cord-004297-rm0zbgfm 210 24 - - HYPH cord-004297-rm0zbgfm 210 25 based base VBN cord-004297-rm0zbgfm 210 26 trials trial NNS cord-004297-rm0zbgfm 210 27 [ [ -LRB- cord-004297-rm0zbgfm 210 28 43 43 CD cord-004297-rm0zbgfm 210 29 ] ] -RRB- cord-004297-rm0zbgfm 210 30 , , , cord-004297-rm0zbgfm 210 31 which which WDT cord-004297-rm0zbgfm 210 32 may may MD cord-004297-rm0zbgfm 210 33 also also RB cord-004297-rm0zbgfm 210 34 indicate indicate VB cord-004297-rm0zbgfm 210 35 that that IN cord-004297-rm0zbgfm 210 36 the the DT cord-004297-rm0zbgfm 210 37 effects effect NNS cord-004297-rm0zbgfm 210 38 of of IN cord-004297-rm0zbgfm 210 39 vitamin vitamin NN cord-004297-rm0zbgfm 210 40 C c NN cord-004297-rm0zbgfm 210 41 can can MD cord-004297-rm0zbgfm 210 42 depend depend VB cord-004297-rm0zbgfm 210 43 on on IN cord-004297-rm0zbgfm 210 44 cultural cultural JJ cord-004297-rm0zbgfm 210 45 context context NN cord-004297-rm0zbgfm 210 46 . . . cord-004297-rm0zbgfm 211 1 Thus thus RB cord-004297-rm0zbgfm 211 2 , , , cord-004297-rm0zbgfm 211 3 although although IN cord-004297-rm0zbgfm 211 4 the the DT cord-004297-rm0zbgfm 211 5 fit fit NN cord-004297-rm0zbgfm 211 6 of of IN cord-004297-rm0zbgfm 211 7 the the DT cord-004297-rm0zbgfm 211 8 meta meta JJ cord-004297-rm0zbgfm 211 9 - - HYPH cord-004297-rm0zbgfm 211 10 regression regression JJ cord-004297-rm0zbgfm 211 11 line line NN cord-004297-rm0zbgfm 211 12 in in IN cord-004297-rm0zbgfm 211 13 Fig Fig NNP cord-004297-rm0zbgfm 211 14 . . NNP cord-004297-rm0zbgfm 211 15 4 4 CD cord-004297-rm0zbgfm 211 16 is be VBZ cord-004297-rm0zbgfm 211 17 good good JJ cord-004297-rm0zbgfm 211 18 , , , cord-004297-rm0zbgfm 211 19 the the DT cord-004297-rm0zbgfm 211 20 findings finding NNS cord-004297-rm0zbgfm 211 21 should should MD cord-004297-rm0zbgfm 211 22 not not RB cord-004297-rm0zbgfm 211 23 be be VB cord-004297-rm0zbgfm 211 24 extrapolated extrapolate VBN cord-004297-rm0zbgfm 211 25 directly directly RB cord-004297-rm0zbgfm 211 26 to to IN cord-004297-rm0zbgfm 211 27 other other JJ cord-004297-rm0zbgfm 211 28 contexts context NNS cord-004297-rm0zbgfm 211 29 . . . cord-004297-rm0zbgfm 212 1 Two two CD cord-004297-rm0zbgfm 212 2 recent recent JJ cord-004297-rm0zbgfm 212 3 meta meta JJ cord-004297-rm0zbgfm 212 4 - - HYPH cord-004297-rm0zbgfm 212 5 analyses analysis NNS cord-004297-rm0zbgfm 212 6 concluded conclude VBD cord-004297-rm0zbgfm 212 7 that that IN cord-004297-rm0zbgfm 212 8 vitamin vitamin NN cord-004297-rm0zbgfm 212 9 C c NN cord-004297-rm0zbgfm 212 10 is be VBZ cord-004297-rm0zbgfm 212 11 not not RB cord-004297-rm0zbgfm 212 12 beneficial beneficial JJ cord-004297-rm0zbgfm 212 13 for for IN cord-004297-rm0zbgfm 212 14 critically critically RB cord-004297-rm0zbgfm 212 15 ill ill JJ cord-004297-rm0zbgfm 212 16 patients patient NNS cord-004297-rm0zbgfm 212 17 [ [ -LRB- cord-004297-rm0zbgfm 212 18 44 44 CD cord-004297-rm0zbgfm 212 19 , , , cord-004297-rm0zbgfm 212 20 45 45 CD cord-004297-rm0zbgfm 212 21 ] ] -RRB- cord-004297-rm0zbgfm 212 22 , , , cord-004297-rm0zbgfm 212 23 whereas whereas IN cord-004297-rm0zbgfm 212 24 a a DT cord-004297-rm0zbgfm 212 25 third third NN cord-004297-rm0zbgfm 212 26 concluded conclude VBD cord-004297-rm0zbgfm 212 27 that that IN cord-004297-rm0zbgfm 212 28 vitamin vitamin NN cord-004297-rm0zbgfm 212 29 C c NN cord-004297-rm0zbgfm 212 30 was be VBD cord-004297-rm0zbgfm 212 31 beneficial beneficial JJ cord-004297-rm0zbgfm 212 32 for for IN cord-004297-rm0zbgfm 212 33 sepsis sepsis NN cord-004297-rm0zbgfm 212 34 patients patient NNS cord-004297-rm0zbgfm 212 35 [ [ -LRB- cord-004297-rm0zbgfm 212 36 46 46 CD cord-004297-rm0zbgfm 212 37 ] ] -RRB- cord-004297-rm0zbgfm 212 38 . . . cord-004297-rm0zbgfm 213 1 However however RB cord-004297-rm0zbgfm 213 2 , , , cord-004297-rm0zbgfm 213 3 all all DT cord-004297-rm0zbgfm 213 4 three three CD cord-004297-rm0zbgfm 213 5 meta meta JJ cord-004297-rm0zbgfm 213 6 - - HYPH cord-004297-rm0zbgfm 213 7 analyses analysis NNS cord-004297-rm0zbgfm 213 8 included include VBD cord-004297-rm0zbgfm 213 9 studies study NNS cord-004297-rm0zbgfm 213 10 that that WDT cord-004297-rm0zbgfm 213 11 administered administer VBD cord-004297-rm0zbgfm 213 12 vitamin vitamin NN cord-004297-rm0zbgfm 213 13 C c NN cord-004297-rm0zbgfm 213 14 in in IN cord-004297-rm0zbgfm 213 15 combination combination NN cord-004297-rm0zbgfm 213 16 with with IN cord-004297-rm0zbgfm 213 17 numerous numerous JJ cord-004297-rm0zbgfm 213 18 other other JJ cord-004297-rm0zbgfm 213 19 substances substance NNS cord-004297-rm0zbgfm 213 20 , , , cord-004297-rm0zbgfm 213 21 such such JJ cord-004297-rm0zbgfm 213 22 as as IN cord-004297-rm0zbgfm 213 23 vitamins vitamin NNS cord-004297-rm0zbgfm 213 24 A A NNP cord-004297-rm0zbgfm 213 25 , , , cord-004297-rm0zbgfm 213 26 B b NN cord-004297-rm0zbgfm 213 27 , , , cord-004297-rm0zbgfm 213 28 and and CC cord-004297-rm0zbgfm 213 29 E e NN cord-004297-rm0zbgfm 213 30 , , , cord-004297-rm0zbgfm 213 31 selenium selenium NN cord-004297-rm0zbgfm 213 32 , , , cord-004297-rm0zbgfm 213 33 and and CC cord-004297-rm0zbgfm 213 34 zinc zinc NN cord-004297-rm0zbgfm 213 35 [ [ -LRB- cord-004297-rm0zbgfm 213 36 47 47 CD cord-004297-rm0zbgfm 213 37 ] ] -RRB- cord-004297-rm0zbgfm 213 38 [ [ -LRB- cord-004297-rm0zbgfm 213 39 48 48 CD cord-004297-rm0zbgfm 213 40 ] ] -RRB- cord-004297-rm0zbgfm 213 41 [ [ -LRB- cord-004297-rm0zbgfm 213 42 49 49 CD cord-004297-rm0zbgfm 213 43 ] ] -RRB- cord-004297-rm0zbgfm 213 44 . . . cord-004297-rm0zbgfm 214 1 Such such JJ cord-004297-rm0zbgfm 214 2 trials trial NNS cord-004297-rm0zbgfm 214 3 do do VBP cord-004297-rm0zbgfm 214 4 not not RB cord-004297-rm0zbgfm 214 5 test test VB cord-004297-rm0zbgfm 214 6 the the DT cord-004297-rm0zbgfm 214 7 specific specific JJ cord-004297-rm0zbgfm 214 8 effect effect NN cord-004297-rm0zbgfm 214 9 of of IN cord-004297-rm0zbgfm 214 10 vitamin vitamin NN cord-004297-rm0zbgfm 214 11 C. c. NN cord-004297-rm0zbgfm 215 1 The the DT cord-004297-rm0zbgfm 215 2 other other JJ cord-004297-rm0zbgfm 215 3 substances substance NNS cord-004297-rm0zbgfm 215 4 can can MD cord-004297-rm0zbgfm 215 5 have have VB cord-004297-rm0zbgfm 215 6 negative negative JJ cord-004297-rm0zbgfm 215 7 or or CC cord-004297-rm0zbgfm 215 8 positive positive JJ cord-004297-rm0zbgfm 215 9 effects effect NNS cord-004297-rm0zbgfm 215 10 , , , cord-004297-rm0zbgfm 215 11 and and CC cord-004297-rm0zbgfm 215 12 they -PRON- PRP cord-004297-rm0zbgfm 215 13 can can MD cord-004297-rm0zbgfm 215 14 also also RB cord-004297-rm0zbgfm 215 15 modify modify VB cord-004297-rm0zbgfm 215 16 the the DT cord-004297-rm0zbgfm 215 17 effect effect NN cord-004297-rm0zbgfm 215 18 of of IN cord-004297-rm0zbgfm 215 19 vitamin vitamin NN cord-004297-rm0zbgfm 215 20 C. c. NN cord-004297-rm0zbgfm 216 1 The the DT cord-004297-rm0zbgfm 216 2 three three CD cord-004297-rm0zbgfm 216 3 meta meta NNP cord-004297-rm0zbgfm 216 4 - - HYPH cord-004297-rm0zbgfm 216 5 analyses analysis NNS cord-004297-rm0zbgfm 216 6 also also RB cord-004297-rm0zbgfm 216 7 had have VBD cord-004297-rm0zbgfm 216 8 statistical statistical JJ cord-004297-rm0zbgfm 216 9 shortcomings shortcoming NNS cord-004297-rm0zbgfm 216 10 [ [ -LRB- cord-004297-rm0zbgfm 216 11 47 47 CD cord-004297-rm0zbgfm 216 12 ] ] -RRB- cord-004297-rm0zbgfm 216 13 [ [ -LRB- cord-004297-rm0zbgfm 216 14 48 48 CD cord-004297-rm0zbgfm 216 15 ] ] -RRB- cord-004297-rm0zbgfm 216 16 [ [ -LRB- cord-004297-rm0zbgfm 216 17 49 49 CD cord-004297-rm0zbgfm 216 18 ] ] -RRB- cord-004297-rm0zbgfm 216 19 . . . cord-004297-rm0zbgfm 217 1 Our -PRON- PRP$ cord-004297-rm0zbgfm 217 2 current current JJ cord-004297-rm0zbgfm 217 3 metaanalysis metaanalysis NN cord-004297-rm0zbgfm 217 4 was be VBD cord-004297-rm0zbgfm 217 5 restricted restrict VBN cord-004297-rm0zbgfm 217 6 to to IN cord-004297-rm0zbgfm 217 7 trials trial NNS cord-004297-rm0zbgfm 217 8 that that WDT cord-004297-rm0zbgfm 217 9 tested test VBD cord-004297-rm0zbgfm 217 10 vitamin vitamin NN cord-004297-rm0zbgfm 217 11 C c NN cord-004297-rm0zbgfm 217 12 alone alone RB cord-004297-rm0zbgfm 217 13 . . . cord-004297-rm0zbgfm 218 1 A a DT cord-004297-rm0zbgfm 218 2 fourth fourth JJ cord-004297-rm0zbgfm 218 3 recent recent JJ cord-004297-rm0zbgfm 218 4 meta meta JJ cord-004297-rm0zbgfm 218 5 - - HYPH cord-004297-rm0zbgfm 218 6 analysis analysis NN cord-004297-rm0zbgfm 218 7 concluded conclude VBD cord-004297-rm0zbgfm 218 8 that that IN cord-004297-rm0zbgfm 218 9 vitamin vitamin NN cord-004297-rm0zbgfm 218 10 C c NN cord-004297-rm0zbgfm 218 11 shortens shorten VBZ cord-004297-rm0zbgfm 218 12 ventilation ventilation NN cord-004297-rm0zbgfm 218 13 time time NN cord-004297-rm0zbgfm 218 14 in in IN cord-004297-rm0zbgfm 218 15 cardiac cardiac JJ cord-004297-rm0zbgfm 218 16 surgery surgery NN cord-004297-rm0zbgfm 218 17 patients patient NNS cord-004297-rm0zbgfm 218 18 [ [ -LRB- cord-004297-rm0zbgfm 218 19 50 50 CD cord-004297-rm0zbgfm 218 20 ] ] -RRB- cord-004297-rm0zbgfm 218 21 ; ; : cord-004297-rm0zbgfm 218 22 however however RB cord-004297-rm0zbgfm 218 23 , , , cord-004297-rm0zbgfm 218 24 the the DT cord-004297-rm0zbgfm 218 25 study study NN cord-004297-rm0zbgfm 218 26 was be VBD cord-004297-rm0zbgfm 218 27 shown show VBN cord-004297-rm0zbgfm 218 28 to to TO cord-004297-rm0zbgfm 218 29 contain contain VB cord-004297-rm0zbgfm 218 30 several several JJ cord-004297-rm0zbgfm 218 31 substantial substantial JJ cord-004297-rm0zbgfm 218 32 statistical statistical JJ cord-004297-rm0zbgfm 218 33 errors error NNS cord-004297-rm0zbgfm 218 34 [ [ -LRB- cord-004297-rm0zbgfm 218 35 51 51 CD cord-004297-rm0zbgfm 218 36 ] ] -RRB- cord-004297-rm0zbgfm 218 37 . . . cord-004297-rm0zbgfm 219 1 In in IN cord-004297-rm0zbgfm 219 2 systematic systematic JJ cord-004297-rm0zbgfm 219 3 reviews review NNS cord-004297-rm0zbgfm 219 4 , , , cord-004297-rm0zbgfm 219 5 one one CD cord-004297-rm0zbgfm 219 6 potential potential JJ cord-004297-rm0zbgfm 219 7 concern concern NN cord-004297-rm0zbgfm 219 8 is be VBZ cord-004297-rm0zbgfm 219 9 publication publication NN cord-004297-rm0zbgfm 219 10 bias bias NN cord-004297-rm0zbgfm 219 11 , , , cord-004297-rm0zbgfm 219 12 in in IN cord-004297-rm0zbgfm 219 13 that that DT cord-004297-rm0zbgfm 219 14 negative negative JJ cord-004297-rm0zbgfm 219 15 trials trial NNS cord-004297-rm0zbgfm 219 16 may may MD cord-004297-rm0zbgfm 219 17 remain remain VB cord-004297-rm0zbgfm 219 18 unpublished unpublished JJ cord-004297-rm0zbgfm 219 19 . . . cord-004297-rm0zbgfm 220 1 However however RB cord-004297-rm0zbgfm 220 2 , , , cord-004297-rm0zbgfm 220 3 publication publication NN cord-004297-rm0zbgfm 220 4 bias bias NN cord-004297-rm0zbgfm 220 5 can can MD cord-004297-rm0zbgfm 220 6 not not RB cord-004297-rm0zbgfm 220 7 realistically realistically RB cord-004297-rm0zbgfm 220 8 generate generate VB cord-004297-rm0zbgfm 220 9 the the DT cord-004297-rm0zbgfm 220 10 close close JJ cord-004297-rm0zbgfm 220 11 association association NN cord-004297-rm0zbgfm 220 12 shown show VBN cord-004297-rm0zbgfm 220 13 in in IN cord-004297-rm0zbgfm 220 14 Fig Fig NNP cord-004297-rm0zbgfm 220 15 . . . cord-004297-rm0zbgfm 221 1 4 4 LS cord-004297-rm0zbgfm 221 2 . . . cord-004297-rm0zbgfm 222 1 To to TO cord-004297-rm0zbgfm 222 2 explain explain VB cord-004297-rm0zbgfm 222 3 this this DT cord-004297-rm0zbgfm 222 4 association association NN cord-004297-rm0zbgfm 222 5 by by IN cord-004297-rm0zbgfm 222 6 publication publication NN cord-004297-rm0zbgfm 222 7 bias bias NN cord-004297-rm0zbgfm 222 8 would would MD cord-004297-rm0zbgfm 222 9 require require VB cord-004297-rm0zbgfm 222 10 that that IN cord-004297-rm0zbgfm 222 11 positive positive JJ cord-004297-rm0zbgfm 222 12 studies study NNS cord-004297-rm0zbgfm 222 13 with with IN cord-004297-rm0zbgfm 222 14 less less RBR cord-004297-rm0zbgfm 222 15 ill ill JJ cord-004297-rm0zbgfm 222 16 patients patient NNS cord-004297-rm0zbgfm 222 17 remain remain VBP cord-004297-rm0zbgfm 222 18 unpublished unpublished JJ cord-004297-rm0zbgfm 222 19 , , , cord-004297-rm0zbgfm 222 20 and and CC cord-004297-rm0zbgfm 222 21 negative negative JJ cord-004297-rm0zbgfm 222 22 studies study NNS cord-004297-rm0zbgfm 222 23 with with IN cord-004297-rm0zbgfm 222 24 severely severely RB cord-004297-rm0zbgfm 222 25 ill ill JJ cord-004297-rm0zbgfm 222 26 patients patient NNS cord-004297-rm0zbgfm 222 27 also also RB cord-004297-rm0zbgfm 222 28 remain remain VBP cord-004297-rm0zbgfm 222 29 unpublished unpublished JJ cord-004297-rm0zbgfm 222 30 . . . cord-004297-rm0zbgfm 223 1 Five five CD cord-004297-rm0zbgfm 223 2 trials trial NNS cord-004297-rm0zbgfm 223 3 did do VBD cord-004297-rm0zbgfm 223 4 not not RB cord-004297-rm0zbgfm 223 5 use use VB cord-004297-rm0zbgfm 223 6 an an DT cord-004297-rm0zbgfm 223 7 explicit explicit JJ cord-004297-rm0zbgfm 223 8 placebo placebo NN cord-004297-rm0zbgfm 223 9 [ [ -LRB- cord-004297-rm0zbgfm 223 10 12 12 CD cord-004297-rm0zbgfm 223 11 ] ] -RRB- cord-004297-rm0zbgfm 223 12 [ [ -LRB- cord-004297-rm0zbgfm 223 13 13 13 CD cord-004297-rm0zbgfm 223 14 ] ] -RRB- cord-004297-rm0zbgfm 223 15 [ [ -LRB- cord-004297-rm0zbgfm 223 16 14 14 CD cord-004297-rm0zbgfm 223 17 ] ] -RRB- cord-004297-rm0zbgfm 223 18 [ [ -LRB- cord-004297-rm0zbgfm 223 19 15 15 CD cord-004297-rm0zbgfm 223 20 ] ] -RRB- cord-004297-rm0zbgfm 223 21 17 17 CD cord-004297-rm0zbgfm 223 22 ] ] -RRB- cord-004297-rm0zbgfm 223 23 , , , cord-004297-rm0zbgfm 223 24 but but CC cord-004297-rm0zbgfm 223 25 we -PRON- PRP cord-004297-rm0zbgfm 223 26 do do VBP cord-004297-rm0zbgfm 223 27 not not RB cord-004297-rm0zbgfm 223 28 consider consider VB cord-004297-rm0zbgfm 223 29 that that IN cord-004297-rm0zbgfm 223 30 the the DT cord-004297-rm0zbgfm 223 31 lack lack NN cord-004297-rm0zbgfm 223 32 of of IN cord-004297-rm0zbgfm 223 33 placebo placebo NN cord-004297-rm0zbgfm 223 34 undermines undermine VBZ cord-004297-rm0zbgfm 223 35 the the DT cord-004297-rm0zbgfm 223 36 validity validity NN cord-004297-rm0zbgfm 223 37 of of IN cord-004297-rm0zbgfm 223 38 those those DT cord-004297-rm0zbgfm 223 39 trials trial NNS cord-004297-rm0zbgfm 223 40 , , , cord-004297-rm0zbgfm 223 41 since since IN cord-004297-rm0zbgfm 223 42 ICU ICU NNP cord-004297-rm0zbgfm 223 43 patients patient NNS cord-004297-rm0zbgfm 223 44 receive receive VBP cord-004297-rm0zbgfm 223 45 numerous numerous JJ cord-004297-rm0zbgfm 223 46 treatments treatment NNS cord-004297-rm0zbgfm 223 47 and and CC cord-004297-rm0zbgfm 223 48 it -PRON- PRP cord-004297-rm0zbgfm 223 49 is be VBZ cord-004297-rm0zbgfm 223 50 unlikely unlikely JJ cord-004297-rm0zbgfm 223 51 that that IN cord-004297-rm0zbgfm 223 52 one one CD cord-004297-rm0zbgfm 223 53 additional additional JJ cord-004297-rm0zbgfm 223 54 tablet tablet NN cord-004297-rm0zbgfm 223 55 or or CC cord-004297-rm0zbgfm 223 56 infusion infusion NN cord-004297-rm0zbgfm 223 57 would would MD cord-004297-rm0zbgfm 223 58 cause cause VB cord-004297-rm0zbgfm 223 59 a a DT cord-004297-rm0zbgfm 223 60 substantial substantial JJ cord-004297-rm0zbgfm 223 61 placebo placebo NN cord-004297-rm0zbgfm 223 62 effect effect NN cord-004297-rm0zbgfm 223 63 for for IN cord-004297-rm0zbgfm 223 64 ventilated ventilate VBN cord-004297-rm0zbgfm 223 65 patients patient NNS cord-004297-rm0zbgfm 223 66 . . . cord-004297-rm0zbgfm 224 1 The the DT cord-004297-rm0zbgfm 224 2 lack lack NN cord-004297-rm0zbgfm 224 3 of of IN cord-004297-rm0zbgfm 224 4 a a DT cord-004297-rm0zbgfm 224 5 placebo placebo NN cord-004297-rm0zbgfm 224 6 may may MD cord-004297-rm0zbgfm 224 7 cause cause VB cord-004297-rm0zbgfm 224 8 bias bias NN cord-004297-rm0zbgfm 224 9 in in IN cord-004297-rm0zbgfm 224 10 research research NN cord-004297-rm0zbgfm 224 11 on on IN cord-004297-rm0zbgfm 224 12 subjective subjective JJ cord-004297-rm0zbgfm 224 13 outcomes outcome NNS cord-004297-rm0zbgfm 224 14 , , , cord-004297-rm0zbgfm 224 15 but but CC cord-004297-rm0zbgfm 224 16 less less RBR cord-004297-rm0zbgfm 224 17 so so RB cord-004297-rm0zbgfm 224 18 on on IN cord-004297-rm0zbgfm 224 19 objective objective JJ cord-004297-rm0zbgfm 224 20 outcomes outcome NNS cord-004297-rm0zbgfm 224 21 [ [ -LRB- cord-004297-rm0zbgfm 224 22 52 52 CD cord-004297-rm0zbgfm 224 23 ] ] -RRB- cord-004297-rm0zbgfm 224 24 . . . cord-004297-rm0zbgfm 225 1 Thus thus RB cord-004297-rm0zbgfm 225 2 , , , cord-004297-rm0zbgfm 225 3 it -PRON- PRP cord-004297-rm0zbgfm 225 4 is be VBZ cord-004297-rm0zbgfm 225 5 unlikely unlikely JJ cord-004297-rm0zbgfm 225 6 to to TO cord-004297-rm0zbgfm 225 7 bias bias VB cord-004297-rm0zbgfm 225 8 studies study NNS cord-004297-rm0zbgfm 225 9 with with IN cord-004297-rm0zbgfm 225 10 outcomes outcome NNS cord-004297-rm0zbgfm 225 11 such such JJ cord-004297-rm0zbgfm 225 12 as as IN cord-004297-rm0zbgfm 225 13 the the DT cord-004297-rm0zbgfm 225 14 duration duration NN cord-004297-rm0zbgfm 225 15 of of IN cord-004297-rm0zbgfm 225 16 mechanical mechanical JJ cord-004297-rm0zbgfm 225 17 ventilation ventilation NN cord-004297-rm0zbgfm 225 18 . . . cord-004297-rm0zbgfm 226 1 It -PRON- PRP cord-004297-rm0zbgfm 226 2 may may MD cord-004297-rm0zbgfm 226 3 not not RB cord-004297-rm0zbgfm 226 4 be be VB cord-004297-rm0zbgfm 226 5 worthwhile worthwhile JJ cord-004297-rm0zbgfm 226 6 to to TO cord-004297-rm0zbgfm 226 7 carry carry VB cord-004297-rm0zbgfm 226 8 out out RP cord-004297-rm0zbgfm 226 9 further further JJ cord-004297-rm0zbgfm 226 10 research research NN cord-004297-rm0zbgfm 226 11 on on IN cord-004297-rm0zbgfm 226 12 the the DT cord-004297-rm0zbgfm 226 13 effects effect NNS cord-004297-rm0zbgfm 226 14 of of IN cord-004297-rm0zbgfm 226 15 vitamin vitamin NN cord-004297-rm0zbgfm 226 16 C c NN cord-004297-rm0zbgfm 226 17 on on IN cord-004297-rm0zbgfm 226 18 mechanical mechanical JJ cord-004297-rm0zbgfm 226 19 ventilation ventilation NN cord-004297-rm0zbgfm 226 20 for for IN cord-004297-rm0zbgfm 226 21 patient patient JJ cord-004297-rm0zbgfm 226 22 groups group NNS cord-004297-rm0zbgfm 226 23 that that WDT cord-004297-rm0zbgfm 226 24 require require VBP cord-004297-rm0zbgfm 226 25 on on IN cord-004297-rm0zbgfm 226 26 average average JJ cord-004297-rm0zbgfm 226 27 less less JJR cord-004297-rm0zbgfm 226 28 than than IN cord-004297-rm0zbgfm 226 29 10 10 CD cord-004297-rm0zbgfm 226 30 h h NN cord-004297-rm0zbgfm 226 31 of of IN cord-004297-rm0zbgfm 226 32 ventilation ventilation NN cord-004297-rm0zbgfm 226 33 . . . cord-004297-rm0zbgfm 227 1 The the DT cord-004297-rm0zbgfm 227 2 level level NN cord-004297-rm0zbgfm 227 3 of of IN cord-004297-rm0zbgfm 227 4 sickness sickness NN cord-004297-rm0zbgfm 227 5 severity severity NN cord-004297-rm0zbgfm 227 6 should should MD cord-004297-rm0zbgfm 227 7 be be VB cord-004297-rm0zbgfm 227 8 taken take VBN cord-004297-rm0zbgfm 227 9 into into IN cord-004297-rm0zbgfm 227 10 account account NN cord-004297-rm0zbgfm 227 11 in in IN cord-004297-rm0zbgfm 227 12 future future JJ cord-004297-rm0zbgfm 227 13 studies study NNS cord-004297-rm0zbgfm 227 14 , , , cord-004297-rm0zbgfm 227 15 for for IN cord-004297-rm0zbgfm 227 16 example example NN cord-004297-rm0zbgfm 227 17 , , , cord-004297-rm0zbgfm 227 18 by by IN cord-004297-rm0zbgfm 227 19 evaluating evaluate VBG cord-004297-rm0zbgfm 227 20 prognostic prognostic JJ cord-004297-rm0zbgfm 227 21 scores score NNS cord-004297-rm0zbgfm 227 22 at at IN cord-004297-rm0zbgfm 227 23 the the DT cord-004297-rm0zbgfm 227 24 start start NN cord-004297-rm0zbgfm 227 25 of of IN cord-004297-rm0zbgfm 227 26 the the DT cord-004297-rm0zbgfm 227 27 trial trial NN cord-004297-rm0zbgfm 227 28 . . . cord-004297-rm0zbgfm 228 1 Our -PRON- PRP$ cord-004297-rm0zbgfm 228 2 analysis analysis NN cord-004297-rm0zbgfm 228 3 did do VBD cord-004297-rm0zbgfm 228 4 not not RB cord-004297-rm0zbgfm 228 5 find find VB cord-004297-rm0zbgfm 228 6 differences difference NNS cord-004297-rm0zbgfm 228 7 between between IN cord-004297-rm0zbgfm 228 8 oral oral JJ cord-004297-rm0zbgfm 228 9 and and CC cord-004297-rm0zbgfm 228 10 intravenous intravenous JJ cord-004297-rm0zbgfm 228 11 vitamin vitamin NN cord-004297-rm0zbgfm 228 12 C c NN cord-004297-rm0zbgfm 228 13 , , , cord-004297-rm0zbgfm 228 14 but but CC cord-004297-rm0zbgfm 228 15 oral oral JJ cord-004297-rm0zbgfm 228 16 administration administration NN cord-004297-rm0zbgfm 228 17 is be VBZ cord-004297-rm0zbgfm 228 18 rarely rarely RB cord-004297-rm0zbgfm 228 19 an an DT cord-004297-rm0zbgfm 228 20 option option NN cord-004297-rm0zbgfm 228 21 for for IN cord-004297-rm0zbgfm 228 22 the the DT cord-004297-rm0zbgfm 228 23 sickest sick JJS cord-004297-rm0zbgfm 228 24 patients patient NNS cord-004297-rm0zbgfm 228 25 , , , cord-004297-rm0zbgfm 228 26 for for IN cord-004297-rm0zbgfm 228 27 whom whom WP cord-004297-rm0zbgfm 228 28 the the DT cord-004297-rm0zbgfm 228 29 effects effect NNS cord-004297-rm0zbgfm 228 30 of of IN cord-004297-rm0zbgfm 228 31 vitamin vitamin NN cord-004297-rm0zbgfm 228 32 C c NN cord-004297-rm0zbgfm 228 33 appear appear VBP cord-004297-rm0zbgfm 228 34 greatest great JJS cord-004297-rm0zbgfm 228 35 . . . cord-004297-rm0zbgfm 229 1 Our -PRON- PRP$ cord-004297-rm0zbgfm 229 2 analysis analysis NN cord-004297-rm0zbgfm 229 3 is be VBZ cord-004297-rm0zbgfm 229 4 not not RB cord-004297-rm0zbgfm 229 5 informative informative JJ cord-004297-rm0zbgfm 229 6 about about IN cord-004297-rm0zbgfm 229 7 the the DT cord-004297-rm0zbgfm 229 8 optimal optimal JJ cord-004297-rm0zbgfm 229 9 dosage dosage NN cord-004297-rm0zbgfm 229 10 of of IN cord-004297-rm0zbgfm 229 11 vitamin vitamin NN cord-004297-rm0zbgfm 229 12 C. C. NNP cord-004297-rm0zbgfm 229 13 Future Future NNP cord-004297-rm0zbgfm 229 14 trials trial NNS cord-004297-rm0zbgfm 229 15 should should MD cord-004297-rm0zbgfm 229 16 directly directly RB cord-004297-rm0zbgfm 229 17 compare compare VB cord-004297-rm0zbgfm 229 18 different different JJ cord-004297-rm0zbgfm 229 19 dosage dosage NN cord-004297-rm0zbgfm 229 20 levels level NNS cord-004297-rm0zbgfm 229 21 . . . cord-004297-rm0zbgfm 230 1 Supplementary supplementary JJ cord-004297-rm0zbgfm 230 2 information information NN cord-004297-rm0zbgfm 230 3 accompanies accompany VBZ cord-004297-rm0zbgfm 230 4 this this DT cord-004297-rm0zbgfm 230 5 paper paper NN cord-004297-rm0zbgfm 230 6 at at IN cord-004297-rm0zbgfm 230 7 https://doi.org/10 https://doi.org/10 NNP cord-004297-rm0zbgfm 230 8 . . . cord-004297-rm0zbgfm 231 1 1186 1186 CD cord-004297-rm0zbgfm 231 2 / / SYM cord-004297-rm0zbgfm 231 3 s40560 s40560 NNP cord-004297-rm0zbgfm 231 4 - - HYPH cord-004297-rm0zbgfm 231 5 020 020 CD cord-004297-rm0zbgfm 231 6 - - HYPH cord-004297-rm0zbgfm 231 7 0432-y 0432-y CD cord-004297-rm0zbgfm 231 8 . . . cord-004297-rm0zbgfm 232 1 Additional additional JJ cord-004297-rm0zbgfm 232 2 file file NN cord-004297-rm0zbgfm 232 3 1 1 CD cord-004297-rm0zbgfm 232 4 Calculations Calculations NNPS cord-004297-rm0zbgfm 232 5 ; ; : cord-004297-rm0zbgfm 232 6 Table Table NNP cord-004297-rm0zbgfm 232 7 S1 S1 NNP cord-004297-rm0zbgfm 232 8 . . . cord-004297-rm0zbgfm 233 1 Detailed detailed JJ cord-004297-rm0zbgfm 233 2 description description NN cord-004297-rm0zbgfm 233 3 of of IN cord-004297-rm0zbgfm 233 4 the the DT cord-004297-rm0zbgfm 233 5 included include VBN cord-004297-rm0zbgfm 233 6 trials trial NNS cord-004297-rm0zbgfm 233 7 . . . cord-004297-rm0zbgfm 234 1 Additional additional JJ cord-004297-rm0zbgfm 234 2 file file NN cord-004297-rm0zbgfm 234 3 2 2 CD cord-004297-rm0zbgfm 234 4 . . . cord-004297-rm0zbgfm 235 1 The the DT cord-004297-rm0zbgfm 235 2 data datum NNS cord-004297-rm0zbgfm 235 3 set set VBN cord-004297-rm0zbgfm 235 4 used use VBN cord-004297-rm0zbgfm 235 5 in in IN cord-004297-rm0zbgfm 235 6 this this DT cord-004297-rm0zbgfm 235 7 analysis analysis NN cord-004297-rm0zbgfm 235 8 . . . cord-004297-rm0zbgfm 236 1 Authors author NNS cord-004297-rm0zbgfm 236 2 ' ' POS cord-004297-rm0zbgfm 236 3 contributions contribution NNS cord-004297-rm0zbgfm 236 4 HH HH NNP cord-004297-rm0zbgfm 236 5 and and CC cord-004297-rm0zbgfm 236 6 EC EC NNP cord-004297-rm0zbgfm 236 7 planned plan VBD cord-004297-rm0zbgfm 236 8 the the DT cord-004297-rm0zbgfm 236 9 study study NN cord-004297-rm0zbgfm 236 10 and and CC cord-004297-rm0zbgfm 236 11 searched search VBD cord-004297-rm0zbgfm 236 12 the the DT cord-004297-rm0zbgfm 236 13 literature literature NN cord-004297-rm0zbgfm 236 14 and and CC cord-004297-rm0zbgfm 236 15 selected select VBD cord-004297-rm0zbgfm 236 16 the the DT cord-004297-rm0zbgfm 236 17 trials trial NNS cord-004297-rm0zbgfm 236 18 to to TO cord-004297-rm0zbgfm 236 19 be be VB cord-004297-rm0zbgfm 236 20 included include VBN cord-004297-rm0zbgfm 236 21 . . . cord-004297-rm0zbgfm 237 1 HH HH NNP cord-004297-rm0zbgfm 237 2 entered enter VBD cord-004297-rm0zbgfm 237 3 the the DT cord-004297-rm0zbgfm 237 4 data datum NNS cord-004297-rm0zbgfm 237 5 into into IN cord-004297-rm0zbgfm 237 6 a a DT cord-004297-rm0zbgfm 237 7 spreadsheet spreadsheet NN cord-004297-rm0zbgfm 237 8 and and CC cord-004297-rm0zbgfm 237 9 carried carry VBD cord-004297-rm0zbgfm 237 10 out out RP cord-004297-rm0zbgfm 237 11 the the DT cord-004297-rm0zbgfm 237 12 statistical statistical JJ cord-004297-rm0zbgfm 237 13 analysis analysis NN cord-004297-rm0zbgfm 237 14 . . . cord-004297-rm0zbgfm 238 1 EC EC NNP cord-004297-rm0zbgfm 238 2 checked check VBD cord-004297-rm0zbgfm 238 3 that that IN cord-004297-rm0zbgfm 238 4 the the DT cord-004297-rm0zbgfm 238 5 entered enter VBN cord-004297-rm0zbgfm 238 6 data datum NNS cord-004297-rm0zbgfm 238 7 were be VBD cord-004297-rm0zbgfm 238 8 consistent consistent JJ cord-004297-rm0zbgfm 238 9 with with IN cord-004297-rm0zbgfm 238 10 original original JJ cord-004297-rm0zbgfm 238 11 reports report NNS cord-004297-rm0zbgfm 238 12 . . . cord-004297-rm0zbgfm 239 1 HH HH NNP cord-004297-rm0zbgfm 239 2 wrote write VBD cord-004297-rm0zbgfm 239 3 the the DT cord-004297-rm0zbgfm 239 4 draft draft NN cord-004297-rm0zbgfm 239 5 manuscript manuscript NN cord-004297-rm0zbgfm 239 6 and and CC cord-004297-rm0zbgfm 239 7 EC EC NNP cord-004297-rm0zbgfm 239 8 participated participate VBD cord-004297-rm0zbgfm 239 9 in in IN cord-004297-rm0zbgfm 239 10 the the DT cord-004297-rm0zbgfm 239 11 critical critical JJ cord-004297-rm0zbgfm 239 12 revision revision NN cord-004297-rm0zbgfm 239 13 of of IN cord-004297-rm0zbgfm 239 14 the the DT cord-004297-rm0zbgfm 239 15 manuscript manuscript NN cord-004297-rm0zbgfm 239 16 . . . cord-004297-rm0zbgfm 240 1 Both both DT cord-004297-rm0zbgfm 240 2 authors author NNS cord-004297-rm0zbgfm 240 3 read read VBP cord-004297-rm0zbgfm 240 4 and and CC cord-004297-rm0zbgfm 240 5 approved approve VBD cord-004297-rm0zbgfm 240 6 the the DT cord-004297-rm0zbgfm 240 7 final final JJ cord-004297-rm0zbgfm 240 8 manuscript manuscript NN cord-004297-rm0zbgfm 240 9 . . . cord-004297-rm0zbgfm 241 1 Availability availability NN cord-004297-rm0zbgfm 241 2 of of IN cord-004297-rm0zbgfm 241 3 data datum NNS cord-004297-rm0zbgfm 241 4 and and CC cord-004297-rm0zbgfm 241 5 materials material NNS cord-004297-rm0zbgfm 241 6 Descriptions description NNS cord-004297-rm0zbgfm 241 7 of of IN cord-004297-rm0zbgfm 241 8 the the DT cord-004297-rm0zbgfm 241 9 included include VBN cord-004297-rm0zbgfm 241 10 trials trial NNS cord-004297-rm0zbgfm 241 11 , , , cord-004297-rm0zbgfm 241 12 and and CC cord-004297-rm0zbgfm 241 13 the the DT cord-004297-rm0zbgfm 241 14 risk risk NN cord-004297-rm0zbgfm 241 15 of of IN cord-004297-rm0zbgfm 241 16 bias bias NN cord-004297-rm0zbgfm 241 17 assessment assessment NN cord-004297-rm0zbgfm 241 18 , , , cord-004297-rm0zbgfm 241 19 and and CC cord-004297-rm0zbgfm 241 20 the the DT cord-004297-rm0zbgfm 241 21 analyzed analyze VBN cord-004297-rm0zbgfm 241 22 data datum NNS cord-004297-rm0zbgfm 241 23 are be VBP cord-004297-rm0zbgfm 241 24 available available JJ cord-004297-rm0zbgfm 241 25 as as IN cord-004297-rm0zbgfm 241 26 Additional additional JJ cord-004297-rm0zbgfm 241 27 files file NNS cord-004297-rm0zbgfm 241 28 1 1 CD cord-004297-rm0zbgfm 241 29 and and CC cord-004297-rm0zbgfm 241 30 2 2 CD cord-004297-rm0zbgfm 241 31 . . . cord-004297-rm0zbgfm 242 1 Vitamin vitamin NN cord-004297-rm0zbgfm 242 2 C c NN cord-004297-rm0zbgfm 242 3 can can MD cord-004297-rm0zbgfm 242 4 shorten shorten VB cord-004297-rm0zbgfm 242 5 the the DT cord-004297-rm0zbgfm 242 6 length length NN cord-004297-rm0zbgfm 242 7 of of IN cord-004297-rm0zbgfm 242 8 stay stay NN cord-004297-rm0zbgfm 242 9 in in IN cord-004297-rm0zbgfm 242 10 the the DT cord-004297-rm0zbgfm 242 11 ICU ICU NNP cord-004297-rm0zbgfm 242 12 : : : cord-004297-rm0zbgfm 242 13 a a DT cord-004297-rm0zbgfm 242 14 meta meta JJ cord-004297-rm0zbgfm 242 15 - - HYPH cord-004297-rm0zbgfm 242 16 analysis analysis NN cord-004297-rm0zbgfm 242 17 Ascorbic ascorbic NN cord-004297-rm0zbgfm 242 18 acid acid NN cord-004297-rm0zbgfm 242 19 dynamics dynamic NNS cord-004297-rm0zbgfm 242 20 in in IN cord-004297-rm0zbgfm 242 21 the the DT cord-004297-rm0zbgfm 242 22 seriously seriously RB cord-004297-rm0zbgfm 242 23 ill ill JJ cord-004297-rm0zbgfm 242 24 and and CC cord-004297-rm0zbgfm 242 25 injured injured JJ cord-004297-rm0zbgfm 242 26 Early early JJ cord-004297-rm0zbgfm 242 27 postoperative postoperative JJ cord-004297-rm0zbgfm 242 28 substitution substitution NN cord-004297-rm0zbgfm 242 29 procedure procedure NN cord-004297-rm0zbgfm 242 30 of of IN cord-004297-rm0zbgfm 242 31 the the DT cord-004297-rm0zbgfm 242 32 antioxidant antioxidant JJ cord-004297-rm0zbgfm 242 33 ascorbic ascorbic NN cord-004297-rm0zbgfm 242 34 acid acid NN cord-004297-rm0zbgfm 242 35 Metabolic metabolic JJ cord-004297-rm0zbgfm 242 36 clearance clearance NN cord-004297-rm0zbgfm 242 37 of of IN cord-004297-rm0zbgfm 242 38 the the DT cord-004297-rm0zbgfm 242 39 antioxidant antioxidant JJ cord-004297-rm0zbgfm 242 40 ascorbic ascorbic NN cord-004297-rm0zbgfm 242 41 acid acid NN cord-004297-rm0zbgfm 242 42 in in IN cord-004297-rm0zbgfm 242 43 surgical surgical JJ cord-004297-rm0zbgfm 242 44 patients patient NNS cord-004297-rm0zbgfm 242 45 Vitamin vitamin NN cord-004297-rm0zbgfm 242 46 C c NN cord-004297-rm0zbgfm 242 47 pharmacokinetics pharmacokinetic NNS cord-004297-rm0zbgfm 242 48 in in IN cord-004297-rm0zbgfm 242 49 critically critically RB cord-004297-rm0zbgfm 242 50 ill ill JJ cord-004297-rm0zbgfm 242 51 patients patient NNS cord-004297-rm0zbgfm 242 52 : : : cord-004297-rm0zbgfm 242 53 a a DT cord-004297-rm0zbgfm 242 54 randomized randomized JJ cord-004297-rm0zbgfm 242 55 trial trial NN cord-004297-rm0zbgfm 242 56 of of IN cord-004297-rm0zbgfm 242 57 four four CD cord-004297-rm0zbgfm 242 58 iv iv NNP cord-004297-rm0zbgfm 242 59 regimens regimen NNS cord-004297-rm0zbgfm 242 60 Total total JJ cord-004297-rm0zbgfm 242 61 vitamin vitamin NN cord-004297-rm0zbgfm 242 62 C c NN cord-004297-rm0zbgfm 242 63 , , , cord-004297-rm0zbgfm 242 64 ascorbic ascorbic NN cord-004297-rm0zbgfm 242 65 acid acid NN cord-004297-rm0zbgfm 242 66 , , , cord-004297-rm0zbgfm 242 67 and and CC cord-004297-rm0zbgfm 242 68 dehydroascorbic dehydroascorbic JJ cord-004297-rm0zbgfm 242 69 acid acid NN cord-004297-rm0zbgfm 242 70 concentrations concentration NNS cord-004297-rm0zbgfm 242 71 in in IN cord-004297-rm0zbgfm 242 72 plasma plasma NN cord-004297-rm0zbgfm 242 73 of of IN cord-004297-rm0zbgfm 242 74 critically critically RB cord-004297-rm0zbgfm 242 75 ill ill JJ cord-004297-rm0zbgfm 242 76 patients patient NNS cord-004297-rm0zbgfm 243 1 Ascorbyl ascorbyl NN cord-004297-rm0zbgfm 243 2 radical radical JJ cord-004297-rm0zbgfm 243 3 formation formation NN cord-004297-rm0zbgfm 243 4 in in IN cord-004297-rm0zbgfm 243 5 patients patient NNS cord-004297-rm0zbgfm 243 6 with with IN cord-004297-rm0zbgfm 243 7 sepsis sepsis NN cord-004297-rm0zbgfm 243 8 : : : cord-004297-rm0zbgfm 243 9 effect effect NN cord-004297-rm0zbgfm 243 10 of of IN cord-004297-rm0zbgfm 243 11 ascorbate ascorbate NN cord-004297-rm0zbgfm 243 12 loading load VBG cord-004297-rm0zbgfm 243 13 Metabolic metabolic JJ cord-004297-rm0zbgfm 243 14 origin origin NN cord-004297-rm0zbgfm 243 15 of of IN cord-004297-rm0zbgfm 243 16 hypovitaminosis hypovitaminosis NNP cord-004297-rm0zbgfm 243 17 C C NNP cord-004297-rm0zbgfm 243 18 in in IN cord-004297-rm0zbgfm 243 19 acutely acutely RB cord-004297-rm0zbgfm 243 20 hospitalized hospitalize VBN cord-004297-rm0zbgfm 243 21 patients patient NNS cord-004297-rm0zbgfm 243 22 Massive massive JJ cord-004297-rm0zbgfm 243 23 and and CC cord-004297-rm0zbgfm 243 24 long long RB cord-004297-rm0zbgfm 243 25 - - HYPH cord-004297-rm0zbgfm 243 26 lasting last VBG cord-004297-rm0zbgfm 243 27 decrease decrease NN cord-004297-rm0zbgfm 243 28 in in IN cord-004297-rm0zbgfm 243 29 vitamin vitamin NN cord-004297-rm0zbgfm 243 30 C c NN cord-004297-rm0zbgfm 243 31 plasma plasma NN cord-004297-rm0zbgfm 243 32 levels level NNS cord-004297-rm0zbgfm 243 33 as as IN cord-004297-rm0zbgfm 243 34 a a DT cord-004297-rm0zbgfm 243 35 consequence consequence NN cord-004297-rm0zbgfm 243 36 of of IN cord-004297-rm0zbgfm 243 37 extracorporeal extracorporeal JJ cord-004297-rm0zbgfm 243 38 circulation circulation NN cord-004297-rm0zbgfm 243 39 Hypovitaminosis Hypovitaminosis NNP cord-004297-rm0zbgfm 243 40 C C NNP cord-004297-rm0zbgfm 243 41 and and CC cord-004297-rm0zbgfm 243 42 vitamin vitamin NN cord-004297-rm0zbgfm 243 43 C C NNP cord-004297-rm0zbgfm 243 44 deficiency deficiency NN cord-004297-rm0zbgfm 243 45 in in IN cord-004297-rm0zbgfm 243 46 critically critically RB cord-004297-rm0zbgfm 243 47 ill ill JJ cord-004297-rm0zbgfm 243 48 patients patient NNS cord-004297-rm0zbgfm 243 49 despite despite IN cord-004297-rm0zbgfm 243 50 recommended recommend VBN cord-004297-rm0zbgfm 243 51 enteral enteral NN cord-004297-rm0zbgfm 243 52 and and CC cord-004297-rm0zbgfm 243 53 parenteral parenteral JJ cord-004297-rm0zbgfm 243 54 intakes intake NNS cord-004297-rm0zbgfm 243 55 Perioperative Perioperative NNP cord-004297-rm0zbgfm 243 56 supplementation supplementation NN cord-004297-rm0zbgfm 243 57 with with IN cord-004297-rm0zbgfm 243 58 ascorbic ascorbic NN cord-004297-rm0zbgfm 243 59 acid acid NN cord-004297-rm0zbgfm 243 60 does do VBZ cord-004297-rm0zbgfm 243 61 not not RB cord-004297-rm0zbgfm 243 62 prevent prevent VB cord-004297-rm0zbgfm 243 63 atrial atrial JJ cord-004297-rm0zbgfm 243 64 fibrillation fibrillation NN cord-004297-rm0zbgfm 243 65 in in IN cord-004297-rm0zbgfm 243 66 coronary coronary JJ cord-004297-rm0zbgfm 243 67 artery artery NN cord-004297-rm0zbgfm 243 68 bypass bypass NN cord-004297-rm0zbgfm 243 69 graft graft NN cord-004297-rm0zbgfm 243 70 patients patient NNS cord-004297-rm0zbgfm 243 71 Selenium Selenium NNP cord-004297-rm0zbgfm 243 72 , , , cord-004297-rm0zbgfm 243 73 vitamin vitamin NN cord-004297-rm0zbgfm 243 74 C C NNP cord-004297-rm0zbgfm 243 75 and and CC cord-004297-rm0zbgfm 243 76 Nacetylcysteine Nacetylcysteine NNP cord-004297-rm0zbgfm 243 77 do do VBP cord-004297-rm0zbgfm 243 78 not not RB cord-004297-rm0zbgfm 243 79 reduce reduce VB cord-004297-rm0zbgfm 243 80 the the DT cord-004297-rm0zbgfm 243 81 risk risk NN cord-004297-rm0zbgfm 243 82 of of IN cord-004297-rm0zbgfm 243 83 acute acute JJ cord-004297-rm0zbgfm 243 84 kidney kidney NN cord-004297-rm0zbgfm 243 85 injury injury NN cord-004297-rm0zbgfm 243 86 after after IN cord-004297-rm0zbgfm 243 87 off off IN cord-004297-rm0zbgfm 243 88 - - HYPH cord-004297-rm0zbgfm 243 89 pump pump NN cord-004297-rm0zbgfm 243 90 CABG CABG NNP cord-004297-rm0zbgfm 243 91 : : : cord-004297-rm0zbgfm 243 92 a a DT cord-004297-rm0zbgfm 243 93 randomized randomized JJ cord-004297-rm0zbgfm 243 94 clinical clinical JJ cord-004297-rm0zbgfm 243 95 trial trial NN cord-004297-rm0zbgfm 243 96 Effect effect NN cord-004297-rm0zbgfm 243 97 of of IN cord-004297-rm0zbgfm 243 98 oral oral JJ cord-004297-rm0zbgfm 243 99 vitamin vitamin NN cord-004297-rm0zbgfm 243 100 C c NN cord-004297-rm0zbgfm 243 101 on on IN cord-004297-rm0zbgfm 243 102 atrial atrial JJ cord-004297-rm0zbgfm 243 103 fibrillation fibrillation NN cord-004297-rm0zbgfm 243 104 development development NN cord-004297-rm0zbgfm 243 105 after after IN cord-004297-rm0zbgfm 243 106 isolated isolate VBN cord-004297-rm0zbgfm 243 107 coronary coronary JJ cord-004297-rm0zbgfm 243 108 artery artery NN cord-004297-rm0zbgfm 243 109 bypass bypass NN cord-004297-rm0zbgfm 243 110 grafting grafting NN cord-004297-rm0zbgfm 243 111 surgery surgery NN cord-004297-rm0zbgfm 243 112 : : : cord-004297-rm0zbgfm 243 113 a a DT cord-004297-rm0zbgfm 243 114 prospective prospective JJ cord-004297-rm0zbgfm 243 115 randomized randomized JJ cord-004297-rm0zbgfm 243 116 clinical clinical JJ cord-004297-rm0zbgfm 243 117 trial trial NN cord-004297-rm0zbgfm 243 118 Early early JJ cord-004297-rm0zbgfm 243 119 adjuvant adjuvant JJ cord-004297-rm0zbgfm 243 120 intravenous intravenous JJ cord-004297-rm0zbgfm 243 121 vitamin vitamin NN cord-004297-rm0zbgfm 243 122 C c NN cord-004297-rm0zbgfm 243 123 treatment treatment NN cord-004297-rm0zbgfm 243 124 in in IN cord-004297-rm0zbgfm 243 125 septic septic JJ cord-004297-rm0zbgfm 243 126 shock shock NN cord-004297-rm0zbgfm 243 127 may may MD cord-004297-rm0zbgfm 243 128 resolve resolve VB cord-004297-rm0zbgfm 243 129 the the DT cord-004297-rm0zbgfm 243 130 vasopressor vasopressor NN cord-004297-rm0zbgfm 243 131 dependence dependence NN cord-004297-rm0zbgfm 243 132 Comparative comparative JJ cord-004297-rm0zbgfm 243 133 effect effect NN cord-004297-rm0zbgfm 243 134 of of IN cord-004297-rm0zbgfm 243 135 grape grape NN cord-004297-rm0zbgfm 243 136 seed seed NN cord-004297-rm0zbgfm 243 137 extract extract NN cord-004297-rm0zbgfm 243 138 ( ( -LRB- cord-004297-rm0zbgfm 243 139 vitis vitis JJ cord-004297-rm0zbgfm 243 140 vinifera vinifera NN cord-004297-rm0zbgfm 243 141 ) ) -RRB- cord-004297-rm0zbgfm 243 142 and and CC cord-004297-rm0zbgfm 243 143 ascorbic ascorbic NN cord-004297-rm0zbgfm 243 144 acid acid NN cord-004297-rm0zbgfm 243 145 in in IN cord-004297-rm0zbgfm 243 146 oxidative oxidative JJ cord-004297-rm0zbgfm 243 147 stress stress NN cord-004297-rm0zbgfm 243 148 induced induce VBN cord-004297-rm0zbgfm 243 149 by by IN cord-004297-rm0zbgfm 243 150 on on IN cord-004297-rm0zbgfm 243 151 - - HYPH cord-004297-rm0zbgfm 243 152 pump pump NN cord-004297-rm0zbgfm 243 153 coronary coronary JJ cord-004297-rm0zbgfm 243 154 artery artery NN cord-004297-rm0zbgfm 243 155 bypass bypass NN cord-004297-rm0zbgfm 243 156 surgery surgery NN cord-004297-rm0zbgfm 243 157 Ascorbic ascorbic NN cord-004297-rm0zbgfm 243 158 acid acid NN cord-004297-rm0zbgfm 243 159 versus versus IN cord-004297-rm0zbgfm 243 160 magnesium magnesium NN cord-004297-rm0zbgfm 243 161 for for IN cord-004297-rm0zbgfm 243 162 the the DT cord-004297-rm0zbgfm 243 163 prevention prevention NN cord-004297-rm0zbgfm 243 164 of of IN cord-004297-rm0zbgfm 243 165 atrial atrial JJ cord-004297-rm0zbgfm 243 166 fibrillation fibrillation NN cord-004297-rm0zbgfm 243 167 after after IN cord-004297-rm0zbgfm 243 168 coronary coronary JJ cord-004297-rm0zbgfm 243 169 artery artery NN cord-004297-rm0zbgfm 243 170 bypass bypass NN cord-004297-rm0zbgfm 243 171 grafting grafting NN cord-004297-rm0zbgfm 243 172 surgery surgery NN cord-004297-rm0zbgfm 243 173 Reduction reduction NN cord-004297-rm0zbgfm 243 174 of of IN cord-004297-rm0zbgfm 243 175 resuscitation resuscitation NN cord-004297-rm0zbgfm 243 176 fluid fluid NN cord-004297-rm0zbgfm 243 177 volumes volume NNS cord-004297-rm0zbgfm 243 178 in in IN cord-004297-rm0zbgfm 243 179 severely severely RB cord-004297-rm0zbgfm 243 180 burned burn VBN cord-004297-rm0zbgfm 243 181 patients patient NNS cord-004297-rm0zbgfm 243 182 using use VBG cord-004297-rm0zbgfm 243 183 ascorbic ascorbic NN cord-004297-rm0zbgfm 243 184 acid acid NNP cord-004297-rm0zbgfm 243 185 administration administration NNP cord-004297-rm0zbgfm 243 186 : : : cord-004297-rm0zbgfm 243 187 a a DT cord-004297-rm0zbgfm 243 188 randomized randomized JJ cord-004297-rm0zbgfm 243 189 prospective prospective JJ cord-004297-rm0zbgfm 243 190 study study NN cord-004297-rm0zbgfm 243 191 Effect effect NN cord-004297-rm0zbgfm 243 192 of of IN cord-004297-rm0zbgfm 243 193 high high JJ cord-004297-rm0zbgfm 243 194 - - HYPH cord-004297-rm0zbgfm 243 195 dose dose NN cord-004297-rm0zbgfm 243 196 ascorbic ascorbic NN cord-004297-rm0zbgfm 243 197 acid acid NN cord-004297-rm0zbgfm 243 198 on on IN cord-004297-rm0zbgfm 243 199 vasopressor vasopressor NN cord-004297-rm0zbgfm 243 200 's 's POS cord-004297-rm0zbgfm 243 201 requirement requirement NN cord-004297-rm0zbgfm 243 202 in in IN cord-004297-rm0zbgfm 243 203 septic septic JJ cord-004297-rm0zbgfm 243 204 shock shock NN cord-004297-rm0zbgfm 243 205 Impact Impact NNP cord-004297-rm0zbgfm 243 206 of of IN cord-004297-rm0zbgfm 243 207 vitamin vitamin NN cord-004297-rm0zbgfm 243 208 C c NN cord-004297-rm0zbgfm 243 209 supplementation supplementation NN cord-004297-rm0zbgfm 243 210 on on IN cord-004297-rm0zbgfm 243 211 postcardiac postcardiac NNP cord-004297-rm0zbgfm 243 212 surgery surgery NN cord-004297-rm0zbgfm 243 213 ICU ICU NNP cord-004297-rm0zbgfm 243 214 and and CC cord-004297-rm0zbgfm 243 215 hospital hospital NN cord-004297-rm0zbgfm 243 216 length length NN cord-004297-rm0zbgfm 243 217 of of IN cord-004297-rm0zbgfm 243 218 stay stay NN cord-004297-rm0zbgfm 244 1 Medical Medical NNP cord-004297-rm0zbgfm 244 2 Respiratory Respiratory NNP cord-004297-rm0zbgfm 244 3 Intensive Intensive NNP cord-004297-rm0zbgfm 244 4 Care Care NNP cord-004297-rm0zbgfm 244 5 Unit Unit NNP cord-004297-rm0zbgfm 244 6 Nursing Nursing NNP cord-004297-rm0zbgfm 244 7 , , , cord-004297-rm0zbgfm 244 8 Fisher Fisher NNP cord-004297-rm0zbgfm 244 9 BJ BJ NNP cord-004297-rm0zbgfm 244 10 , , , cord-004297-rm0zbgfm 244 11 Natarajan Natarajan NNP cord-004297-rm0zbgfm 244 12 R. R. NNP cord-004297-rm0zbgfm 244 13 Phase Phase NNP cord-004297-rm0zbgfm 245 1 I -PRON- PRP cord-004297-rm0zbgfm 245 2 safety safety VBP cord-004297-rm0zbgfm 245 3 trial trial NN cord-004297-rm0zbgfm 245 4 of of IN cord-004297-rm0zbgfm 245 5 intravenous intravenous JJ cord-004297-rm0zbgfm 245 6 ascorbic ascorbic NN cord-004297-rm0zbgfm 245 7 acid acid NN cord-004297-rm0zbgfm 245 8 in in IN cord-004297-rm0zbgfm 245 9 patients patient NNS cord-004297-rm0zbgfm 245 10 with with IN cord-004297-rm0zbgfm 245 11 severe severe JJ cord-004297-rm0zbgfm 245 12 sepsis sepsis NN cord-004297-rm0zbgfm 245 13 Effect effect NN cord-004297-rm0zbgfm 245 14 of of IN cord-004297-rm0zbgfm 245 15 vitamin vitamin NN cord-004297-rm0zbgfm 245 16 C c NN cord-004297-rm0zbgfm 245 17 infusion infusion NN cord-004297-rm0zbgfm 245 18 on on IN cord-004297-rm0zbgfm 245 19 organ organ NN cord-004297-rm0zbgfm 245 20 failure failure NN cord-004297-rm0zbgfm 245 21 and and CC cord-004297-rm0zbgfm 245 22 biomarkers biomarker NNS cord-004297-rm0zbgfm 245 23 of of IN cord-004297-rm0zbgfm 245 24 inflammation inflammation NN cord-004297-rm0zbgfm 245 25 and and CC cord-004297-rm0zbgfm 245 26 vascular vascular JJ cord-004297-rm0zbgfm 245 27 injury injury NN cord-004297-rm0zbgfm 245 28 in in IN cord-004297-rm0zbgfm 245 29 patients patient NNS cord-004297-rm0zbgfm 245 30 with with IN cord-004297-rm0zbgfm 245 31 sepsis sepsis NN cord-004297-rm0zbgfm 245 32 and and CC cord-004297-rm0zbgfm 245 33 severe severe JJ cord-004297-rm0zbgfm 245 34 acute acute JJ cord-004297-rm0zbgfm 245 35 respiratory respiratory JJ cord-004297-rm0zbgfm 245 36 failure failure NN cord-004297-rm0zbgfm 245 37 : : : cord-004297-rm0zbgfm 245 38 the the DT cord-004297-rm0zbgfm 245 39 CITRIS CITRIS NNP cord-004297-rm0zbgfm 245 40 - - HYPH cord-004297-rm0zbgfm 245 41 ALI ALI NNP cord-004297-rm0zbgfm 245 42 randomized randomize VBD cord-004297-rm0zbgfm 245 43 clinical clinical JJ cord-004297-rm0zbgfm 245 44 trial trial NN cord-004297-rm0zbgfm 245 45 Ratio Ratio NNP cord-004297-rm0zbgfm 245 46 of of IN cord-004297-rm0zbgfm 245 47 means mean NNS cord-004297-rm0zbgfm 245 48 for for IN cord-004297-rm0zbgfm 245 49 analyzing analyze VBG cord-004297-rm0zbgfm 245 50 continuous continuous JJ cord-004297-rm0zbgfm 245 51 outcomes outcome NNS cord-004297-rm0zbgfm 245 52 in in IN cord-004297-rm0zbgfm 245 53 meta meta NNP cord-004297-rm0zbgfm 245 54 - - HYPH cord-004297-rm0zbgfm 245 55 analysis analysis NN cord-004297-rm0zbgfm 245 56 performed perform VBN cord-004297-rm0zbgfm 245 57 as as RB cord-004297-rm0zbgfm 245 58 well well RB cord-004297-rm0zbgfm 245 59 as as IN cord-004297-rm0zbgfm 245 60 mean mean JJ cord-004297-rm0zbgfm 245 61 difference difference NN cord-004297-rm0zbgfm 245 62 methods method NNS cord-004297-rm0zbgfm 246 1 Many many JJ cord-004297-rm0zbgfm 246 2 continuous continuous JJ cord-004297-rm0zbgfm 246 3 variables variable NNS cord-004297-rm0zbgfm 246 4 such such JJ cord-004297-rm0zbgfm 246 5 as as IN cord-004297-rm0zbgfm 246 6 the the DT cord-004297-rm0zbgfm 246 7 duration duration NN cord-004297-rm0zbgfm 246 8 of of IN cord-004297-rm0zbgfm 246 9 the the DT cord-004297-rm0zbgfm 246 10 common common JJ cord-004297-rm0zbgfm 246 11 cold cold NN cord-004297-rm0zbgfm 246 12 should should MD cord-004297-rm0zbgfm 246 13 be be VB cord-004297-rm0zbgfm 246 14 analyzed analyze VBN cord-004297-rm0zbgfm 246 15 using use VBG cord-004297-rm0zbgfm 246 16 the the DT cord-004297-rm0zbgfm 246 17 relative relative JJ cord-004297-rm0zbgfm 246 18 scale scale NN cord-004297-rm0zbgfm 246 19 Duration duration NN cord-004297-rm0zbgfm 246 20 of of IN cord-004297-rm0zbgfm 246 21 the the DT cord-004297-rm0zbgfm 246 22 common common JJ cord-004297-rm0zbgfm 246 23 cold cold JJ cord-004297-rm0zbgfm 246 24 and and CC cord-004297-rm0zbgfm 246 25 similar similar JJ cord-004297-rm0zbgfm 246 26 continuous continuous JJ cord-004297-rm0zbgfm 246 27 outcomes outcome NNS cord-004297-rm0zbgfm 246 28 should should MD cord-004297-rm0zbgfm 246 29 be be VB cord-004297-rm0zbgfm 246 30 analyzed analyze VBN cord-004297-rm0zbgfm 246 31 on on IN cord-004297-rm0zbgfm 246 32 the the DT cord-004297-rm0zbgfm 246 33 relative relative JJ cord-004297-rm0zbgfm 246 34 scale scale NN cord-004297-rm0zbgfm 246 35 : : : cord-004297-rm0zbgfm 246 36 a a DT cord-004297-rm0zbgfm 246 37 case case NN cord-004297-rm0zbgfm 246 38 study study NN cord-004297-rm0zbgfm 246 39 of of IN cord-004297-rm0zbgfm 246 40 two two CD cord-004297-rm0zbgfm 246 41 zinc zinc NN cord-004297-rm0zbgfm 246 42 lozenge lozenge NN cord-004297-rm0zbgfm 246 43 trials trial NNS cord-004297-rm0zbgfm 246 44 R R NNP cord-004297-rm0zbgfm 246 45 Project Project NNP cord-004297-rm0zbgfm 246 46 for for IN cord-004297-rm0zbgfm 246 47 Statistical Statistical NNP cord-004297-rm0zbgfm 246 48 Computing Computing NNP cord-004297-rm0zbgfm 246 49 meta meta NNP cord-004297-rm0zbgfm 246 50 : : : cord-004297-rm0zbgfm 246 51 an an DT cord-004297-rm0zbgfm 246 52 R r NN cord-004297-rm0zbgfm 246 53 package package NN cord-004297-rm0zbgfm 246 54 for for IN cord-004297-rm0zbgfm 246 55 meta meta NN cord-004297-rm0zbgfm 246 56 - - HYPH cord-004297-rm0zbgfm 246 57 analysis analysis NN cord-004297-rm0zbgfm 246 58 . . . cord-004297-rm0zbgfm 247 1 R R NNP cord-004297-rm0zbgfm 247 2 News News NNP cord-004297-rm0zbgfm 247 3 Measuring Measuring NNP cord-004297-rm0zbgfm 247 4 inconsistency inconsistency NN cord-004297-rm0zbgfm 247 5 in in IN cord-004297-rm0zbgfm 247 6 meta meta NNP cord-004297-rm0zbgfm 247 7 - - HYPH cord-004297-rm0zbgfm 247 8 analysis analysis NN cord-004297-rm0zbgfm 247 9 Randomized Randomized NNP cord-004297-rm0zbgfm 247 10 , , , cord-004297-rm0zbgfm 247 11 prospective prospective JJ cord-004297-rm0zbgfm 247 12 trial trial NN cord-004297-rm0zbgfm 247 13 of of IN cord-004297-rm0zbgfm 247 14 antioxidant antioxidant JJ cord-004297-rm0zbgfm 247 15 supplementation supplementation NN cord-004297-rm0zbgfm 247 16 in in IN cord-004297-rm0zbgfm 247 17 critically critically RB cord-004297-rm0zbgfm 247 18 ill ill JJ cord-004297-rm0zbgfm 247 19 surgical surgical JJ cord-004297-rm0zbgfm 247 20 patients patient NNS cord-004297-rm0zbgfm 248 1 The the DT cord-004297-rm0zbgfm 248 2 beneficial beneficial JJ cord-004297-rm0zbgfm 248 3 effects effect NNS cord-004297-rm0zbgfm 248 4 of of IN cord-004297-rm0zbgfm 248 5 antioxidant antioxidant JJ cord-004297-rm0zbgfm 248 6 supplementation supplementation NN cord-004297-rm0zbgfm 248 7 in in IN cord-004297-rm0zbgfm 248 8 enteral enteral JJ cord-004297-rm0zbgfm 248 9 feeding feeding NN cord-004297-rm0zbgfm 248 10 in in IN cord-004297-rm0zbgfm 248 11 critically critically RB cord-004297-rm0zbgfm 248 12 ill ill JJ cord-004297-rm0zbgfm 248 13 patients patient NNS cord-004297-rm0zbgfm 248 14 : : : cord-004297-rm0zbgfm 248 15 a a DT cord-004297-rm0zbgfm 248 16 prospective prospective NN cord-004297-rm0zbgfm 248 17 , , , cord-004297-rm0zbgfm 248 18 randomized randomized JJ cord-004297-rm0zbgfm 248 19 , , , cord-004297-rm0zbgfm 248 20 double double JJ cord-004297-rm0zbgfm 248 21 - - HYPH cord-004297-rm0zbgfm 248 22 blind blind JJ cord-004297-rm0zbgfm 248 23 , , , cord-004297-rm0zbgfm 248 24 placebo placebo NN cord-004297-rm0zbgfm 248 25 - - HYPH cord-004297-rm0zbgfm 248 26 controlled control VBN cord-004297-rm0zbgfm 248 27 trial trial NN cord-004297-rm0zbgfm 248 28 Mechanical mechanical JJ cord-004297-rm0zbgfm 248 29 ventilation ventilation NN cord-004297-rm0zbgfm 248 30 antioxidant antioxidant NN cord-004297-rm0zbgfm 248 31 trial trial NN cord-004297-rm0zbgfm 248 32 Ascorbic ascorbic NN cord-004297-rm0zbgfm 248 33 acid acid NN cord-004297-rm0zbgfm 248 34 - - HYPH cord-004297-rm0zbgfm 248 35 induced induce VBN cord-004297-rm0zbgfm 248 36 hemolysis hemolysis NN cord-004297-rm0zbgfm 248 37 in in IN cord-004297-rm0zbgfm 248 38 G-6-PD G-6-PD NNP cord-004297-rm0zbgfm 248 39 deficiency deficiency NN cord-004297-rm0zbgfm 248 40 Oxalate oxalate NN cord-004297-rm0zbgfm 248 41 nephropathy nephropathy NN cord-004297-rm0zbgfm 248 42 after after IN cord-004297-rm0zbgfm 248 43 continuous continuous JJ cord-004297-rm0zbgfm 248 44 infusion infusion NN cord-004297-rm0zbgfm 248 45 of of IN cord-004297-rm0zbgfm 248 46 high high JJ cord-004297-rm0zbgfm 248 47 - - HYPH cord-004297-rm0zbgfm 248 48 dose dose NN cord-004297-rm0zbgfm 248 49 vitamin vitamin NN cord-004297-rm0zbgfm 248 50 C c NN cord-004297-rm0zbgfm 248 51 as as IN cord-004297-rm0zbgfm 248 52 an an DT cord-004297-rm0zbgfm 248 53 adjunct adjunct NN cord-004297-rm0zbgfm 248 54 to to TO cord-004297-rm0zbgfm 248 55 burn burn VB cord-004297-rm0zbgfm 248 56 resuscitation resuscitation NN cord-004297-rm0zbgfm 248 57 Vitamin vitamin NN cord-004297-rm0zbgfm 248 58 C c NN cord-004297-rm0zbgfm 248 59 may may MD cord-004297-rm0zbgfm 248 60 alleviate alleviate VB cord-004297-rm0zbgfm 248 61 exercise exercise NN cord-004297-rm0zbgfm 248 62 - - HYPH cord-004297-rm0zbgfm 248 63 induced induce VBN cord-004297-rm0zbgfm 248 64 bronchoconstriction bronchoconstriction NN cord-004297-rm0zbgfm 248 65 : : : cord-004297-rm0zbgfm 248 66 a a DT cord-004297-rm0zbgfm 248 67 meta meta JJ cord-004297-rm0zbgfm 248 68 - - HYPH cord-004297-rm0zbgfm 248 69 analysis analysis NN cord-004297-rm0zbgfm 248 70 Effect effect NN cord-004297-rm0zbgfm 248 71 of of IN cord-004297-rm0zbgfm 248 72 ascorbic ascorbic NN cord-004297-rm0zbgfm 248 73 acid acid NN cord-004297-rm0zbgfm 248 74 on on IN cord-004297-rm0zbgfm 248 75 increased increase VBN cord-004297-rm0zbgfm 248 76 bronchial bronchial JJ cord-004297-rm0zbgfm 248 77 responsiveness responsiveness NN cord-004297-rm0zbgfm 248 78 during during IN cord-004297-rm0zbgfm 248 79 upper upper JJ cord-004297-rm0zbgfm 248 80 airway airway NN cord-004297-rm0zbgfm 248 81 infection infection NN cord-004297-rm0zbgfm 248 82 Vitamin vitamin NN cord-004297-rm0zbgfm 248 83 C c NN cord-004297-rm0zbgfm 248 84 and and CC cord-004297-rm0zbgfm 248 85 common common JJ cord-004297-rm0zbgfm 248 86 cold cold NN cord-004297-rm0zbgfm 248 87 - - HYPH cord-004297-rm0zbgfm 248 88 induced induce VBN cord-004297-rm0zbgfm 248 89 asthma asthma NN cord-004297-rm0zbgfm 248 90 : : : cord-004297-rm0zbgfm 248 91 a a DT cord-004297-rm0zbgfm 248 92 systematic systematic JJ cord-004297-rm0zbgfm 248 93 review review NN cord-004297-rm0zbgfm 248 94 and and CC cord-004297-rm0zbgfm 248 95 statistical statistical JJ cord-004297-rm0zbgfm 248 96 analysis analysis NN cord-004297-rm0zbgfm 248 97 Interaction Interaction NNP cord-004297-rm0zbgfm 248 98 of of IN cord-004297-rm0zbgfm 248 99 vitamin vitamin NN cord-004297-rm0zbgfm 248 100 C c NN cord-004297-rm0zbgfm 248 101 and and CC cord-004297-rm0zbgfm 248 102 vitamin vitamin NN cord-004297-rm0zbgfm 248 103 E e NN cord-004297-rm0zbgfm 248 104 during during IN cord-004297-rm0zbgfm 248 105 free free JJ cord-004297-rm0zbgfm 248 106 radical radical JJ cord-004297-rm0zbgfm 248 107 stress stress NN cord-004297-rm0zbgfm 248 108 in in IN cord-004297-rm0zbgfm 248 109 plasma plasma NN cord-004297-rm0zbgfm 248 110 : : : cord-004297-rm0zbgfm 248 111 an an DT cord-004297-rm0zbgfm 248 112 ESR ESR NNP cord-004297-rm0zbgfm 248 113 study study NN cord-004297-rm0zbgfm 248 114 Ascorbic ascorbic NN cord-004297-rm0zbgfm 248 115 acid acid NN cord-004297-rm0zbgfm 248 116 spares spare VBZ cord-004297-rm0zbgfm 248 117 alpha alpha NN cord-004297-rm0zbgfm 248 118 - - HYPH cord-004297-rm0zbgfm 248 119 tocopherol tocopherol NN cord-004297-rm0zbgfm 248 120 and and CC cord-004297-rm0zbgfm 248 121 prevents prevent VBZ cord-004297-rm0zbgfm 248 122 lipid lipid NN cord-004297-rm0zbgfm 248 123 peroxidation peroxidation NN cord-004297-rm0zbgfm 248 124 in in IN cord-004297-rm0zbgfm 248 125 cultured cultured JJ cord-004297-rm0zbgfm 248 126 H4IIE H4IIE NNP cord-004297-rm0zbgfm 248 127 liver liver NN cord-004297-rm0zbgfm 248 128 cells cell NNS cord-004297-rm0zbgfm 249 1 Combined combined JJ cord-004297-rm0zbgfm 249 2 deficiency deficiency NN cord-004297-rm0zbgfm 249 3 of of IN cord-004297-rm0zbgfm 249 4 vitamins vitamin NNS cord-004297-rm0zbgfm 249 5 E e NN cord-004297-rm0zbgfm 249 6 and and CC cord-004297-rm0zbgfm 249 7 C c NN cord-004297-rm0zbgfm 249 8 causes cause VBZ cord-004297-rm0zbgfm 249 9 paralysis paralysis NN cord-004297-rm0zbgfm 249 10 and and CC cord-004297-rm0zbgfm 249 11 death death NN cord-004297-rm0zbgfm 249 12 in in IN cord-004297-rm0zbgfm 249 13 Guinea Guinea NNP cord-004297-rm0zbgfm 249 14 pigs pig NNS cord-004297-rm0zbgfm 250 1 Faster fast JJR cord-004297-rm0zbgfm 250 2 plasma plasma NN cord-004297-rm0zbgfm 250 3 vitamin vitamin NN cord-004297-rm0zbgfm 250 4 E e NN cord-004297-rm0zbgfm 250 5 disappearance disappearance NN cord-004297-rm0zbgfm 250 6 in in IN cord-004297-rm0zbgfm 250 7 smokers smoker NNS cord-004297-rm0zbgfm 250 8 is be VBZ cord-004297-rm0zbgfm 250 9 normalized normalize VBN cord-004297-rm0zbgfm 250 10 by by IN cord-004297-rm0zbgfm 250 11 vitamin vitamin NN cord-004297-rm0zbgfm 250 12 C C NNP cord-004297-rm0zbgfm 250 13 supplementation supplementation NN cord-004297-rm0zbgfm 250 14 Modification modification NN cord-004297-rm0zbgfm 250 15 of of IN cord-004297-rm0zbgfm 250 16 the the DT cord-004297-rm0zbgfm 250 17 effect effect NN cord-004297-rm0zbgfm 250 18 of of IN cord-004297-rm0zbgfm 250 19 vitamin vitamin NN cord-004297-rm0zbgfm 250 20 E e NN cord-004297-rm0zbgfm 250 21 supplementation supplementation NN cord-004297-rm0zbgfm 250 22 on on IN cord-004297-rm0zbgfm 250 23 the the DT cord-004297-rm0zbgfm 250 24 mortality mortality NN cord-004297-rm0zbgfm 250 25 of of IN cord-004297-rm0zbgfm 250 26 male male JJ cord-004297-rm0zbgfm 250 27 smokers smoker NNS cord-004297-rm0zbgfm 250 28 by by IN cord-004297-rm0zbgfm 250 29 age age NN cord-004297-rm0zbgfm 250 30 and and CC cord-004297-rm0zbgfm 250 31 dietary dietary JJ cord-004297-rm0zbgfm 250 32 vitamin vitamin NN cord-004297-rm0zbgfm 250 33 C c NN cord-004297-rm0zbgfm 250 34 Comparative Comparative NNP cord-004297-rm0zbgfm 250 35 effect effect NN cord-004297-rm0zbgfm 250 36 sizes size NNS cord-004297-rm0zbgfm 250 37 in in IN cord-004297-rm0zbgfm 250 38 randomised randomised JJ cord-004297-rm0zbgfm 250 39 trials trial NNS cord-004297-rm0zbgfm 250 40 from from IN cord-004297-rm0zbgfm 250 41 less less RBR cord-004297-rm0zbgfm 250 42 developed developed JJ cord-004297-rm0zbgfm 250 43 and and CC cord-004297-rm0zbgfm 250 44 more more RBR cord-004297-rm0zbgfm 250 45 developed developed JJ cord-004297-rm0zbgfm 250 46 countries country NNS cord-004297-rm0zbgfm 250 47 : : : cord-004297-rm0zbgfm 250 48 meta meta JJ cord-004297-rm0zbgfm 250 49 - - HYPH cord-004297-rm0zbgfm 250 50 epidemiological epidemiological JJ cord-004297-rm0zbgfm 250 51 assessment assessment NN cord-004297-rm0zbgfm 250 52 Vitamin vitamin NN cord-004297-rm0zbgfm 250 53 C c NN cord-004297-rm0zbgfm 250 54 for for IN cord-004297-rm0zbgfm 250 55 preventing prevent VBG cord-004297-rm0zbgfm 250 56 atrial atrial JJ cord-004297-rm0zbgfm 250 57 fibrillation fibrillation NN cord-004297-rm0zbgfm 250 58 in in IN cord-004297-rm0zbgfm 250 59 high high JJ cord-004297-rm0zbgfm 250 60 risk risk NN cord-004297-rm0zbgfm 250 61 patients patient NNS cord-004297-rm0zbgfm 250 62 : : : cord-004297-rm0zbgfm 250 63 a a DT cord-004297-rm0zbgfm 250 64 systematic systematic JJ cord-004297-rm0zbgfm 250 65 review review NN cord-004297-rm0zbgfm 250 66 and and CC cord-004297-rm0zbgfm 250 67 meta meta NNP cord-004297-rm0zbgfm 250 68 - - HYPH cord-004297-rm0zbgfm 250 69 analysis analysis NN cord-004297-rm0zbgfm 250 70 Vitamin vitamin NN cord-004297-rm0zbgfm 250 71 C C NNP cord-004297-rm0zbgfm 250 72 administration administration NN cord-004297-rm0zbgfm 250 73 to to IN cord-004297-rm0zbgfm 250 74 the the DT cord-004297-rm0zbgfm 250 75 critically critically RB cord-004297-rm0zbgfm 250 76 ill ill JJ cord-004297-rm0zbgfm 250 77 : : : cord-004297-rm0zbgfm 250 78 a a DT cord-004297-rm0zbgfm 250 79 systematic systematic JJ cord-004297-rm0zbgfm 250 80 review review NN cord-004297-rm0zbgfm 250 81 and and CC cord-004297-rm0zbgfm 250 82 meta meta NNP cord-004297-rm0zbgfm 250 83 - - HYPH cord-004297-rm0zbgfm 250 84 analysis analysis NN cord-004297-rm0zbgfm 251 1 The the DT cord-004297-rm0zbgfm 251 2 effect effect NN cord-004297-rm0zbgfm 251 3 of of IN cord-004297-rm0zbgfm 251 4 vitamin vitamin NN cord-004297-rm0zbgfm 251 5 C c NN cord-004297-rm0zbgfm 251 6 on on IN cord-004297-rm0zbgfm 251 7 clinical clinical JJ cord-004297-rm0zbgfm 251 8 outcome outcome NN cord-004297-rm0zbgfm 251 9 in in IN cord-004297-rm0zbgfm 251 10 critically critically RB cord-004297-rm0zbgfm 251 11 ill ill JJ cord-004297-rm0zbgfm 251 12 patients patient NNS cord-004297-rm0zbgfm 251 13 : : : cord-004297-rm0zbgfm 251 14 a a DT cord-004297-rm0zbgfm 251 15 systematic systematic JJ cord-004297-rm0zbgfm 251 16 review review NN cord-004297-rm0zbgfm 251 17 with with IN cord-004297-rm0zbgfm 251 18 meta meta NNP cord-004297-rm0zbgfm 251 19 - - HYPH cord-004297-rm0zbgfm 251 20 analysis analysis NN cord-004297-rm0zbgfm 251 21 of of IN cord-004297-rm0zbgfm 252 1 randomized randomized JJ cord-004297-rm0zbgfm 252 2 controlled control VBN cord-004297-rm0zbgfm 252 3 trials trial NNS cord-004297-rm0zbgfm 252 4 Evidence evidence NN cord-004297-rm0zbgfm 252 5 is be VBZ cord-004297-rm0zbgfm 252 6 stronger strong JJR cord-004297-rm0zbgfm 252 7 than than IN cord-004297-rm0zbgfm 252 8 you -PRON- PRP cord-004297-rm0zbgfm 252 9 think think VBP cord-004297-rm0zbgfm 252 10 : : : cord-004297-rm0zbgfm 252 11 a a DT cord-004297-rm0zbgfm 252 12 meta meta JJ cord-004297-rm0zbgfm 252 13 - - HYPH cord-004297-rm0zbgfm 252 14 analysis analysis NN cord-004297-rm0zbgfm 252 15 of of IN cord-004297-rm0zbgfm 252 16 vitamin vitamin NN cord-004297-rm0zbgfm 252 17 C c NN cord-004297-rm0zbgfm 252 18 use use NN cord-004297-rm0zbgfm 252 19 in in IN cord-004297-rm0zbgfm 252 20 patients patient NNS cord-004297-rm0zbgfm 252 21 with with IN cord-004297-rm0zbgfm 252 22 sepsis sepsis NN cord-004297-rm0zbgfm 253 1 Misleading mislead VBG cord-004297-rm0zbgfm 253 2 meta meta NN cord-004297-rm0zbgfm 253 3 - - HYPH cord-004297-rm0zbgfm 253 4 analysis analysis NN cord-004297-rm0zbgfm 253 5 on on IN cord-004297-rm0zbgfm 253 6 vitamin vitamin NN cord-004297-rm0zbgfm 253 7 C c NN cord-004297-rm0zbgfm 253 8 and and CC cord-004297-rm0zbgfm 253 9 critically critically RB cord-004297-rm0zbgfm 253 10 ill ill JJ cord-004297-rm0zbgfm 253 11 patients patient NNS cord-004297-rm0zbgfm 254 1 B8ACCD32DFC B8ACCD32DFC NNP cord-004297-rm0zbgfm 255 1 Accessed access VBN cord-004297-rm0zbgfm 255 2 5 5 CD cord-004297-rm0zbgfm 255 3 Statistical statistical JJ cord-004297-rm0zbgfm 255 4 problems problem NNS cord-004297-rm0zbgfm 255 5 in in IN cord-004297-rm0zbgfm 255 6 a a DT cord-004297-rm0zbgfm 255 7 meta meta JJ cord-004297-rm0zbgfm 255 8 - - HYPH cord-004297-rm0zbgfm 255 9 analysis analysis NN cord-004297-rm0zbgfm 255 10 on on IN cord-004297-rm0zbgfm 255 11 vitamin vitamin NN cord-004297-rm0zbgfm 255 12 C c NN cord-004297-rm0zbgfm 255 13 and and CC cord-004297-rm0zbgfm 255 14 critically critically RB cord-004297-rm0zbgfm 255 15 ill ill JJ cord-004297-rm0zbgfm 255 16 patients patient NNS cord-004297-rm0zbgfm 256 1 Misleading mislead VBG cord-004297-rm0zbgfm 256 2 meta meta NN cord-004297-rm0zbgfm 256 3 - - HYPH cord-004297-rm0zbgfm 256 4 analysis analysis NN cord-004297-rm0zbgfm 256 5 on on IN cord-004297-rm0zbgfm 256 6 vitamin vitamin NN cord-004297-rm0zbgfm 256 7 C c NN cord-004297-rm0zbgfm 256 8 for for IN cord-004297-rm0zbgfm 256 9 sepsis sepsis NN cord-004297-rm0zbgfm 256 10 patients patient NNS cord-004297-rm0zbgfm 257 1 0D89AD26D7 0D89AD26D7 NNP cord-004297-rm0zbgfm 257 2 Accessed accessed JJ cord-004297-rm0zbgfm 257 3 5 5 CD cord-004297-rm0zbgfm 257 4 Effects effect NNS cord-004297-rm0zbgfm 257 5 of of IN cord-004297-rm0zbgfm 257 6 vitamin vitamin NN cord-004297-rm0zbgfm 257 7 C c NN cord-004297-rm0zbgfm 257 8 on on IN cord-004297-rm0zbgfm 257 9 organ organ NN cord-004297-rm0zbgfm 257 10 function function NN cord-004297-rm0zbgfm 257 11 in in IN cord-004297-rm0zbgfm 257 12 cardiac cardiac JJ cord-004297-rm0zbgfm 257 13 surgery surgery NN cord-004297-rm0zbgfm 257 14 patients patient NNS cord-004297-rm0zbgfm 257 15 : : : cord-004297-rm0zbgfm 257 16 a a DT cord-004297-rm0zbgfm 257 17 systematic systematic JJ cord-004297-rm0zbgfm 257 18 review review NN cord-004297-rm0zbgfm 257 19 and and CC cord-004297-rm0zbgfm 257 20 meta meta NNP cord-004297-rm0zbgfm 257 21 - - HYPH cord-004297-rm0zbgfm 257 22 analysis analysis NN cord-004297-rm0zbgfm 257 23 Vitamin vitamin NN cord-004297-rm0zbgfm 257 24 C c NN cord-004297-rm0zbgfm 257 25 for for IN cord-004297-rm0zbgfm 257 26 cardiac cardiac JJ cord-004297-rm0zbgfm 257 27 surgery surgery NN cord-004297-rm0zbgfm 257 28 patients patient NNS cord-004297-rm0zbgfm 257 29 : : : cord-004297-rm0zbgfm 258 1 several several JJ cord-004297-rm0zbgfm 258 2 errors error NNS cord-004297-rm0zbgfm 258 3 in in IN cord-004297-rm0zbgfm 258 4 a a DT cord-004297-rm0zbgfm 258 5 published publish VBN cord-004297-rm0zbgfm 258 6 meta meta NN cord-004297-rm0zbgfm 258 7 - - HYPH cord-004297-rm0zbgfm 258 8 analysis analysis NN cord-004297-rm0zbgfm 258 9 . . . cord-004297-rm0zbgfm 259 1 Comment comment VB cord-004297-rm0zbgfm 259 2 on on IN cord-004297-rm0zbgfm 259 3 " " `` cord-004297-rm0zbgfm 259 4 Effects effect NNS cord-004297-rm0zbgfm 259 5 of of IN cord-004297-rm0zbgfm 259 6 Vitamin vitamin NN cord-004297-rm0zbgfm 259 7 C c NN cord-004297-rm0zbgfm 259 8 on on IN cord-004297-rm0zbgfm 259 9 Organ Organ NNP cord-004297-rm0zbgfm 259 10 Function Function NNP cord-004297-rm0zbgfm 259 11 in in IN cord-004297-rm0zbgfm 259 12 Cardiac Cardiac NNP cord-004297-rm0zbgfm 259 13 Surgery Surgery NNP cord-004297-rm0zbgfm 259 14 Patients patient NNS cord-004297-rm0zbgfm 259 15 : : : cord-004297-rm0zbgfm 260 1 A a DT cord-004297-rm0zbgfm 260 2 Systematic Systematic NNP cord-004297-rm0zbgfm 260 3 Review Review NNP cord-004297-rm0zbgfm 260 4 and and CC cord-004297-rm0zbgfm 260 5 Meta Meta NNP cord-004297-rm0zbgfm 260 6 - - HYPH cord-004297-rm0zbgfm 260 7 Analysis Analysis NNP cord-004297-rm0zbgfm 260 8 Is be VBZ cord-004297-rm0zbgfm 260 9 the the DT cord-004297-rm0zbgfm 260 10 placebo placebo NN cord-004297-rm0zbgfm 260 11 powerless powerless JJ cord-004297-rm0zbgfm 260 12 ? ? . cord-004297-rm0zbgfm 261 1 An an DT cord-004297-rm0zbgfm 261 2 analysis analysis NN cord-004297-rm0zbgfm 261 3 of of IN cord-004297-rm0zbgfm 261 4 clinical clinical JJ cord-004297-rm0zbgfm 261 5 trials trial NNS cord-004297-rm0zbgfm 261 6 comparing compare VBG cord-004297-rm0zbgfm 261 7 placebo placebo NN cord-004297-rm0zbgfm 261 8 with with IN cord-004297-rm0zbgfm 261 9 no no DT cord-004297-rm0zbgfm 261 10 treatment treatment NN cord-004297-rm0zbgfm 261 11 Publisher publisher NN cord-004297-rm0zbgfm 261 12 's 's POS cord-004297-rm0zbgfm 261 13 Note Note NNP cord-004297-rm0zbgfm 261 14 Springer Springer NNP cord-004297-rm0zbgfm 261 15 Nature Nature NNP cord-004297-rm0zbgfm 261 16 remains remain VBZ cord-004297-rm0zbgfm 261 17 neutral neutral JJ cord-004297-rm0zbgfm 261 18 with with IN cord-004297-rm0zbgfm 261 19 regard regard NN cord-004297-rm0zbgfm 261 20 to to IN cord-004297-rm0zbgfm 261 21 jurisdictional jurisdictional JJ cord-004297-rm0zbgfm 261 22 claims claim NNS cord-004297-rm0zbgfm 261 23 in in IN cord-004297-rm0zbgfm 261 24 published publish VBN cord-004297-rm0zbgfm 261 25 maps map NNS cord-004297-rm0zbgfm 261 26 and and CC cord-004297-rm0zbgfm 261 27 institutional institutional JJ cord-004297-rm0zbgfm 261 28 affiliations affiliation NNS cord-004297-rm0zbgfm 261 29 Ethics Ethics NNP cord-004297-rm0zbgfm 261 30 approval approval NN cord-004297-rm0zbgfm 261 31 and and CC cord-004297-rm0zbgfm 261 32 consent consent NN cord-004297-rm0zbgfm 261 33 to to TO cord-004297-rm0zbgfm 261 34 participate participate VB cord-004297-rm0zbgfm 261 35 Not not RB cord-004297-rm0zbgfm 261 36 applicable applicable JJ cord-004297-rm0zbgfm 261 37 ; ; : cord-004297-rm0zbgfm 261 38 this this DT cord-004297-rm0zbgfm 261 39 is be VBZ cord-004297-rm0zbgfm 261 40 a a DT cord-004297-rm0zbgfm 261 41 meta meta JJ cord-004297-rm0zbgfm 261 42 - - HYPH cord-004297-rm0zbgfm 261 43 analysis analysis NN cord-004297-rm0zbgfm 261 44 of of IN cord-004297-rm0zbgfm 261 45 studies study NNS cord-004297-rm0zbgfm 261 46 already already RB cord-004297-rm0zbgfm 261 47 published publish VBN cord-004297-rm0zbgfm 261 48 . . . cord-004297-rm0zbgfm 262 1 The the DT cord-004297-rm0zbgfm 262 2 authors author NNS cord-004297-rm0zbgfm 262 3 declare declare VBP cord-004297-rm0zbgfm 262 4 that that IN cord-004297-rm0zbgfm 262 5 they -PRON- PRP cord-004297-rm0zbgfm 262 6 have have VBP cord-004297-rm0zbgfm 262 7 no no DT cord-004297-rm0zbgfm 262 8 competing compete VBG cord-004297-rm0zbgfm 262 9 interests interest NNS cord-004297-rm0zbgfm 262 10 . . . cord-004297-rm0zbgfm 262 11 _SP