id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000716-fhm8abxp	Wang, Hao	Analysis on the Pathogenesis of Symptomatic Pulmonary Embolism with Human Genomics	2012-07-11		.txt	text/plain	2770	154	45	BACKGROUND: In the present study, the whole human genome oligo microarray was employed to investigate the gene expression profile in symptomatic pulmonary embolism (PE). Gene Ontology analysis showed the genes with down-regulated expressions mainly explain the compromised T cell immunity. However, mRNA expression of P-selectin (mainly distributed on the surface of ECs and platelets) and E-selection (mainly distributed on the surface of activated ECs) are not elevated in PE group which indicate venous endothelial cells are not impaired in patients with PE (Fig.2) . Gene ontology analysis exhibited compromised T cell mediated immune function, and t test indicated associated genes were significantly down-regulated in patients with PE than in control groups. Two genes with down-regulated expressions are closely related to the T cell mediated immunity according to GO analysis (with high value of Enrichment). Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study	./cache/cord-000716-fhm8abxp.txt	./txt/cord-000716-fhm8abxp.txt