id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002164-oqc9h2lu	Kumar, Ashutosh	A Possible Mechanism of Zika Virus Associated Microcephaly: Imperative Role of Retinoic Acid Response Element (RARE) Consensus Sequence Repeats in the Viral Genome	2016-08-09		.txt	text/plain	5809	256	40	We, for this important reason, searched for the RARE consensus sequence (5 ′ -AGGTCA-3 ′ ) repeats in the genomic sequences of the ZIKV strains with a hypothesis that the virus might act through disruption of normal retinoic acid signaling mediated by incorporation of these sequences into the DNA of developing host brain cells. In view of (1) the bioinformatic evidence of the presence of RARE sequence repeats in genome sequences of ZIKV strains and in other viruses known to cause congenital brain malformation (Table 3) and (2) confirmed role of retinoic acid in neural tube formation and further brain development mediated through RARE sequences, it is scientifically coherent to assume that a RARE sequence dependent mechanism could be the underlying mechanism of microcephaly seen in ZIKV infected fetuses.	./cache/cord-002164-oqc9h2lu.txt	./txt/cord-002164-oqc9h2lu.txt