id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003403-ypefqm71	Roberts, Christine C.	Assay Challenges for Emerging Infectious Diseases: The Zika Experience	2018-10-02		.txt	text/plain	4957	248	42	When initial Zika vaccine clinical trials were being designed and launched in response to the outbreak, there were no standardized sets of viral and immunological assays, and no approved diagnostic tests for Zika virus infection. In an outbreak situation, such as with Zika, it is important to have the ability to quickly develop both diagnostic kits for public health purposes and vaccine clinical assays to support pre-clinical studies and early stage clinical trials. Additionally, cross-reactivity in a number of immunological assays and the short time frame in which viremia can be detected in bodily fluids necessitated the institution of an algorithm to confirm ZIKV infection that was based on a combination of risk factors, clinical symptoms and diagnostic test results [71] . Rapid response to an emerging infectious disease-lessons learned from development of a synthetic DNA vaccine targeting Zika virus	./cache/cord-003403-ypefqm71.txt	./txt/cord-003403-ypefqm71.txt