id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102796-rr8qet8c	Counotte, Michel J	Emergence of evidence during disease outbreaks: lessons learnt from the Zika virus outbreak	2020-03-18		.txt	text/plain	3046	198	56	We are continuously facing new disease outbreaks, including the new coronavirus (SARS-nCoV-2) in December 2019.The objective of this study was to describe the accumulation of evidence during the 2013-2016 Zika virus (ZIKV) outbreak in the Pacific and the Americas related to aetiological causal questions about congenital abnormalities and Guillain-Barre syndrome. In the 2013-2016 ZIKV outbreak, case reports, case series and basic research studies were published first. A strength of this study is the pre-specified hypothesis about the time to publication of aetiological 139 research and the use of data from systematic reviews that had screened and selected studies that 140 addressed the causal relationship between ZIKV infection and its adverse outcomes. The accumulation of evidence over time in new causal problems seems to follow a hierarchy where 225 case reports and case series were rapidly followed by basic research. Syndrome outbreak associated with Zika virus infection in French Polynesia: A case-control study	./cache/cord-102796-rr8qet8c.txt	./txt/cord-102796-rr8qet8c.txt