id author title date pages extension mime words sentences flesch summary cache txt cord-263868-ewnf96cz Srivastava, Mayank Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor 2020-08-04 .txt text/plain 7614 429 52 ZIKV was labeled on its surface with a chemical probe, which carries a photocrosslinker to covalently link virus-interacting proteins in living cells on UV exposure at different time points, and a biotin tag for subsequent enrichment and mass spectrometric identification of the receptor or other host proteins critical for virus internalization. We used the labeled ZIKV to infect Vero cells and interacting proteins were crosslinked at fixed time points to identify the virus-host factors and elucidate the virus entry mechanism (Fig. 1c) . To further investigate whether the strategy was also capable of correlating spatial information with the virus crosslinked proteins, we performed the STRING analysis to determine whether there is statistical overrepresentation of specific genes or proteins in the sample at specific time points and identify proteins specific at the attachment or cellular entry stages ( Supplementary Fig. 6 ). ./cache/cord-263868-ewnf96cz.txt ./txt/cord-263868-ewnf96cz.txt