id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272405-jmwn8pdn	Parvez, Mohammad K.	Evolution and Emergence of Pathogenic Viruses: Past, Present, and Future	2017-08-04		.txt	text/plain	4192	210	43	Despite substantial advancements in the understanding of the biology of pathogens, the breakthroughs in prevention, and their effects on public health and the global economy, the emergence of novel pandemic viruses remains an enduring puzzle. This review presents an update on the knowledge of important emerging/re-emerging viral infections worldwide, discussing their possible origin, evolution, natural reservoirs, human adaptations, and risk factors ( Fig. 1 ). To understand this further, a recently isolated HEV genotype 3 from a chronic hepatitis E patient containing a recombinant virus-host RNA genome was shown to infect cultured human, pig, and deer hepatocytes [39] . The field of phylodynamics, combining a modeling framework for host, epidemiological, and molecular data, especially for RNA viruses, shows particular promise for Parvez understanding the patterns of viral evolution during epidemics [40, 41] . Despite landmark advances in understanding the nature and biology of many pathogenic viruses, there is limited knowledge on emerging novel viruses, their potential reservoirs, and their modes of transmission.	./cache/cord-272405-jmwn8pdn.txt	./txt/cord-272405-jmwn8pdn.txt