id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295351-0zr2e8lh	Mohd Ropidi, Muhammad Izzuddin	Endoplasmic reticulum: a focal point of Zika virus infection	2020-01-20		.txt	text/plain	7845	389	35	Following ZIKV infection, the accumulation of misfolded virus polyproteins in the ER lumen overwhelms the ER protein-folding capacity leading to ER stress and triggers the activation of the UPR (Fig. 2) [47] . Following the dissociation of GRP78 that unmasks the GLS, ATF6 translocate to the Golgi apparatus and undergoes sequential proteolytic processing by Fig. 2 ZIKV-induced ER stress initiates host cell unfolded protein response (UPR). ZIKV infection induces ER stress due to the increased amount of unfolded/misfolded viral (red strand) and host cell (grey strand) protein aggregates in the ER lumen. To summarize, ZIKV virus bypasses the UPR by inhibiting stress granules assembly and reticulophagy to ensure continuous viral protein translation and virion production while simultaneously protecting the virus from host cell defense mechanisms.	./cache/cord-295351-0zr2e8lh.txt	./txt/cord-295351-0zr2e8lh.txt