id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310004-h9ixhhzz	Yuan, Shuofeng	Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target	2020-08-28		.txt	text/plain	9521	502	48	A library chemical, N-(p-amylcinnamoyl)anthranilic acid (ACA), was identified to interrupt AP2M1-virus interaction and exhibit potent antiviral efficacy against a number of viruses in vitro and in vivo, including the influenza A viruses (IAVs), Zika virus (ZIKV), human immunodeficiency virus, and coronaviruses including MERS-CoV and SARS-CoV-2. To prioritize these five compounds, we evaluated their antiviral efficacy against other emerging viruses and identified ACA as the only inhibitor that exhibited a broad-spectrum antiviral effect against influenza A H1N1, ZIKV, HIV-1, SARS-CoV-2, EV-A71, human adenovirus 5 (AdV5), and severe fever with thrombocytopenia syndrome virus (SFTSV) (Fig. 1C and fig. Using our previously established proximal differentiated threedimensional (3D) human airway organoids (AOs) for predicting the infectivity of influenza viruses in humans (14) , we confirmed that ACA reduced virus replication by >4 logs (Fig. 2D) , with markedly decreased expression of viral nucleoprotein (NP) antigen (Fig. 2E) .	./cache/cord-310004-h9ixhhzz.txt	./txt/cord-310004-h9ixhhzz.txt