id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340907-j9i1wlak	Zarai, Yoram	Evolutionary selection against short nucleotide sequences in viruses and their related hosts	2020-04-27		.txt	text/plain	8162	415	45	Here, based on a novel statistical framework and a large-scale genomic analysis of 2,625 viruses from all classes infecting 439 host organisms from all kingdoms of life, we identify short nucleotide sequences that are under-represented in the coding regions of viruses and their hosts. Figure 3A and B depicts the average number of under-represented sequences of size m ¼ 3, 4, and 5 nucleotides, identified in few subsets of viruses in both the original and random variants of the virus. A sampling analysis that we performed (see Supplementary document, Section 2.8) suggests that the number of under-represented sequences identified in dsDNA viruses matches their genomic size, when compared with RNA viruses. To show that the correspondence between selection against short palindromic sequences in viruses and restriction sites cannot be explained by basic coding region features such as amino-acid content and order, codon usage bias and dinucleotide distribution, we also evaluated the overlap between restriction sites and common under-represented sequences of random variants of viruses.	./cache/cord-340907-j9i1wlak.txt	./txt/cord-340907-j9i1wlak.txt