id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_d564c4w5ezbfnfgh3mkq7eb4ua	Misha Angrist	Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease	1998	6	.pdf	application/pdf	4536	683	75	domain-containing protein GRB10 and evaluation of its role in domain-containing protein Grb10 has been shown to In order to assess GRB10's role in HSCR and (BACs) containing human genomic GRB10 sequence, Initially, GRB10 was mapped to human chromosome 7 by somatic cell hybrid mapping. primers from the GRB10-derived expressed sequence Genomic DNA containing GRB10 was obtained by the sequence of human GRB-IR (Liu and Roth, 1995). Hybridizations, isolation of BAC DNA and manual sequencing were performed as described (Angrist et al. Table 1 Human GRB10 genomic structure Position based on additional GRB10 splice variants reported by others (Frantz et al., 1997). 16 exons of human GRB10 (Table 3). Table 3 Primers used for genomic ampli®cation of human GRB10 exons Table 4 Polymorphisms detected in human GRB10 gene suggests that GRB10 mutations cannot account PH domains in the Grb10 family of proteins suggest a	./cache/work_d564c4w5ezbfnfgh3mkq7eb4ua.pdf	./txt/work_d564c4w5ezbfnfgh3mkq7eb4ua.txt