id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_kwe4smw5yvenbmf2fzahvoxci4	R. C. Wilson	A genetic defect resulting in mild low-renin hypertension	1998	6	.pdf	application/pdf	6380	987	78	gene (HSD11B2) encoding the 11b-hydroxysteroid dehydrogenase type 2 enzyme (11b-HSD2) cause AME. Biochemical analysis in this patient revealed a moderately elevated cortisol to cortisone metabolite ratio. hypertension demonstrate low renin, we suggest that such patients should undergo genetic analysis of the HSD11B2 gene. A form of severe low-renin hypertension called apparent mineralocorticoid excess (AME) first was described biochemically in The deficiency of 11bhydroxysteroid dehydrogenase type 2 enzyme has been demonstrated in patients with AME and explains the pathogenesis of the with AME, this new patient has low-renin hypertension and severe low-renin hypertension caused by AME (Patients 1–14, To study the patient's cortisol secretion 2. Mutations in the gene for 11b-hydroxysteroid dehydrogenase type 2 in patients with AME. analysis has now been performed in 29 patients with AME (Table expression study of a severely affected patient with AME, which Most reported patients with AME have homozygous mutations.	./cache/work_kwe4smw5yvenbmf2fzahvoxci4.pdf	./txt/work_kwe4smw5yvenbmf2fzahvoxci4.txt