id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_tgof7cy3izcktkx6pljqn6qlnu	A. E. Willis	Structural alterations of DNA ligase I in Bloom syndrome	1987	5	.pdf	application/pdf	4149	632	76	Cells from BS patients exhibit frequent chromosome rearrangements [in particular, symmetrical quadriradials indicative of exchanges between homologous chromatids at homologous sites (6, 7)], and a 15to 20-fold increased level of of DNA exhibit delayed maturation into a very high-molecular weight form in BS cells and suggested that the fundamental defect involves a step in DNA replication. Furthermore, the ligase I in these cells is anomalously heatlabile, indicating a mutation in the structural gene for DNA anomalously low levels of DNA ligase I activity in cell that, in line 1032 cells, ligase I is present as a dimer (or, less ligase I activity in the Ashkenazi BS line W67-4 (Fig. 3b); the 1. Size fractionation of DNA ligase activities in representative BS cell lines. 2. DNA ligase activities in BS lymphoid cell lines with low SCE and in a heterozygote line. DNA ligase I activity was present in the BS lymphoid cell line	./cache/work_tgof7cy3izcktkx6pljqn6qlnu.pdf	./txt/work_tgof7cy3izcktkx6pljqn6qlnu.txt